Month: October 2022

Easmon, Johnny; Heinisch, Gottfried; Puerstinger, Gerhard; Langer, Thierry; Oesterreicher, Juergen K.; Grunicke, Hans H.; Hofmann, Johann published the artcile< Azinyl and Diazinyl Hydrazones Derived from Aryl N-Heteroaryl Ketones: Synthesis and Antiproliferative Activity>, Quality Control of 112-63-0, the main research area is azinyl hydrazone preparation antiproliferative activity; hydrazone diazinyl preparation antiproliferative activity; antiproliferative structure activity azinyl hydrazone preparation.

A series of N-heteroaryl hydrazones derived from aryl N-heteroaryl or bis-N-heteroaryl methanones was prepared in search for potential novel antitumor agents. The stereochem. of these compounds was established by NMR. Antiproliferative activity was determined in a panel of human tumor cell lines (CCRF-CEM, Burkitt’s lymphoma, HeLa, ZR-75-1, HT-29, and MEXF 276L) in vitro. Generally, the new compounds were more potent (IC50 = 0.011-0.436 μM) than the ribonucleotide reductase inhibitor hydroxyurea (IC50 = 140 μM). Most of the compounds exhibited the highest activity against Burkitt’s lymphoma with IC50 = 0.011-0.035 μM. [14C]Cytidine incorporation into DNA was quantitated for selected hydrazones as a measure of the inhibition of ribonucleotide reductase in Burkitt’s lymphoma cells. (E)-Hydrazones inhibit [14C]cytidine incorporation to a greater extent (IC50 = 0.67-5.05 μM) than the (Z)-isomers (IC50 = 7.20 to >10 μM). Principal component anal. of the IC50 values obtained for inhibition of cell proliferation revealed that the cell lines tested can be grouped into three main families showing different sensitivities toward the compounds in our series (i, CCRF-CEM, Burkitt’s lymphoma, and HeLa; ii, HT-29; and iii, MEXF 276 L).

Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Son, Hyunjoo; Ku, Jayoung; Kim, Yoosik; Li, Sheng; Char, Kookheon published the artcile< Amine-Reactive Poly(pentafluorophenyl acrylate) Brush Platforms for Cleaner Protein Purification>, HPLC of Formula: 71195-85-2, the main research area is protein purification polymer brush polypentafluorophenyl acrylate.

Reactive pentafluorophenyl acrylate (PFPA) polymer brushes grafted on silica particles were prepared using surface-initiated reversible addition and fragmentation chain transfer polymerization The polymer brush was successfully immobilized with antibody, then used for protein separation The immunoprecipitated proteins showed successful enrichment of target protein, with reduced nonspecific background and less contamination from eluted antibodies. To further improve protein recovery, the hydrophobic poly(PFPA) brush was modified with hydrophilic poly(ethylene glycol) (PEG). The partially PEG-substituted poly(PFPA) brush showed better dispersion in aqueous solution, leading to improved antibody immobilization efficiency. By optimizing both the brush mol. weight and the degree of PEG substitution, an optimal balance between surface hydrophilicity and number of available PFP units was found, leading to efficient target protein purification This study shows that poly(PFPA) platform offers a versatile approach to prepare biomol.-activated surfaces with tunable surface property, which has potential applications in protein separation and other areas.

Biomacromolecules published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Caltagirone, Claudia; Gale, Philip A.; Hiscock, Jennifer R.; Hursthouse, Michael B.; Light, Mark E.; Tizzard, Graham J. published the artcile< 2-Amidoindole-based anion receptors>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is indolecarboxamide dimer preparation anion receptor stability constant; dihydrogen phosphate ligand indolecarboxamide.

The title compounds were obtained by a reaction of diamines [i.e., 1,5-pentanediamine, 1,3-benzenedimethanamine] with 1H-indole-2-carboxylic acid derivatives The above-mentioned product structures were confirmed by NMR, elemental anal., and IR. X-ray crystal structure elucidation reveals that N,N’-1,5-pentanediylbis[1H-indole-2-carboxamide] complexes dihydrogen phosphate ion pairs in the solid state, which are part of a continuous chain. While this receptor binds dihydrogen phosphate in a 1:1 stoichiometry in solution, N,N’-[1,3-phenylenebis(methylene)]bis[7-nitro-1H-indole-2-carboxamide] (i.e., a 7-nitroindole derivative), forms 1:2 receptor:dihydrogen phosphate complexes in DMSO-d6/0.5% water.

Supramolecular Chemistry published new progress about Amidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pastore, Carlo; D’Ambrosio, Valeria published the artcile< Intensification of processes for the production of ethyl levulinate using AlCl3·6H2O>, Category: esters-buliding-blocks, the main research area is aluminum chloride catalyst ethyl levulinate esterification thermodn property.

A process for obtaining Et levulinate through the direct esterification of levulinic acid and ethanol using AlCl3·6H2O as a catalyst was investigated. AlCl3·6H2O was very active in promoting the reaction and, the correspondent kinetic and thermodn. data were determined The reaction followed a homogeneous second-order reversible reaction model: in the temperature range of 318-348 K, Ea was 56.3 kJ·K-1·mol-1, whereas Keq was in the field 2.37-3.31. The activity of AlCl3·6H2O was comparable to that of conventional mineral acids. Besides, AlCl3·6H2O also induced a separation of phases in which Et levulinate resulted mainly (>98 wt%) dissolved into the organic upper layer, well separated by most of the co-formed water, which decanted in the bottom. The catalyst resulted wholly dissolved into the aqueous phase (>95 wt%), allowing at the end of a reaction cycle, complete recovery, and possible reuse for several runs. With the increase of the AlCl3·6H2O content (from 1 to 5 mol%), the reaction proceeded fast, and the phases’ separation improved. Such a behavior eventually results in an intensification of processes of reaction and separation of products and catalyst in a single step. The use of AlCl3·6H2O leads to a significant reduction of energy consumed for the final achievement of Et levulinate, and a simplification of line-processes can be achieved.

Energies (Basel, Switzerland) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enders, Dieter; Henseler, Alexander published the artcile< A Direct Intermolecular Cross-Benzoin Type Reaction: N-Heterocyclic Carbene-Catalyzed Coupling of Aromatic Aldehydes with Trifluoromethyl Ketones>, Reference of 112-63-0, the main research area is aldehyde aromatic coupling ketone trifluoromethyl benzoin heterocyclic carbene coupling.

A direct intermol. cross-benzoin-type condensation catalyzed by an N-heterocyclic carbene has been developed. The cross-coupling of com. available aromatic aldehydes R1CHO (R1 = Ph, 4-ClC6H4, 4-MeC6H4, etc.) and trifluoromethyl ketones R2COCF3 (R2 = Ph, 4-ClC6H4, 4-FC6H4) gave α-hydroxy-α-trifluoromethyl ketones R1C(O)C(OH)(CF3)R2 bearing a quaternary stereocenter with excellent chemoselectivity and good to excellent yields.

Advanced Synthesis & Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Kai; Schaefer, Agnes; Zhang, Zhuo; Elsaesser, Katharina; Culmsee, Carsten; Zhong, Li; Pagenstecher, Axel; Nimsky, Christopher; Bartsch, Joerg W. published the artcile< Inhibition of Carbonic Anhydrase 2 Overcomes Temozolomide Resistance in Glioblastoma Cells>, HPLC of Formula: 112-63-0, the main research area is temozolomide anticancer agent carbonic anhydrase2 glioblastoma; GBM recurrence; GBM stem-like cells; acetazolamide; autophagy; brinzolamide; carbonic anhydrase 2; chemoresistance; glioblastoma; temozolomide.

About 95% of Glioblastoma (GBM) patients experience tumor relapse as a consequence of resistance to the first-line standard chemotherapy using temozolomide (TMZ). Recent studies reported consistently elevated expression levels of carbonic anhydrase CA2 in recurrent glioblastoma and temozolomide-resistant glioblastoma stem-like cells (GSCs). Here we show that CA2 is preferentially expressed in GSCs and upregulated by TMZ treatment. When expressed in GBM cell lines, CA2 exerts significant metabolic changes reflected by enhanced oxygen consumption and increased extracellular acidification causing higher rates of cell invasion. Notably, GBM cells expressing CA2 respond to combined treatment with TMZ and brinzolamide (BRZ), a non-toxic and potent CA2 inhibitor. Interestingly, brinzolamide was more effective than the pan-CA inhibitor Acetazolamide (ACZ) to sensitize naive GSCs and TMZ-resistant GSCs to TMZ induced cell death. Mechanistically, we demonstrated that the combined treatment of GBM stem cells with TMZ and BRZ caused autophagy of GBM cell lines and GSCs, reflected by enhanced LC3 cleavage (LC3-II) and p62 reduction Our findings illustrate the potential of CA2 as a chemo-sensitizing drug target in recurrent GBM and propose a combined treatment of TMZ with CA2 inhibitor to tackle GBM chemoresistance and recurrence.

International Journal of Molecular Sciences published new progress about Acidification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Modrocka, Viktoria; Veverkova, Eva; Baran, Rastislav; Sebesta, Radovan published the artcile< Enantioselective Synthesis of 2,3-Dihydrofurocoumarins by Squaramide-Catalyzed Michael Addition/Cyclization of 4-Hydroxycoumarins with β-Nitrostyrenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hydroxycoumarin nitrostyrene squaramide organocatalyst enantioselective diastereoselective Michael addition heterocyclization; hydroxyimino phenyl furochromenone preparation.

The enantioselective synthesis of chiral 2,3-dihydrofurocoumarins by squaramide-catalyzed Michael addition of 4-hydroxycoumarins to β-nitrostyrenes, followed by a cyclization reaction was described. A coumarin moiety was present in many chiral bioactive compounds, but the organocatalysis has still not reached its full potential in the synthesis of chiral coumarins. Squaramide catalysts comprising two chiral units, (S)-phenylethylamine and cyclohexane-1,2-diamine was used. These catalysts showed high reactivity and enantioselectivity in this transformation. Following this procedure, a series of 2,3-dihydrofurocoumarin derivatives in 47-93% yields and enantiomeric purities in the range of 78-94% ee were prepared Polystyrene-immobilized squaramide catalyst performed well for the initial two reaction cycles but then slowly degraded. The absolute configuration of 2,3-dihydrofurocoumarin products was determined by the comparison of the exptl. and d. functional theory-calculated electronic CD spectra.

ChemistrySelect published new progress about Circular dichroism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mutlu, Tutku; Demir-Cakan, Rezan published the artcile< Carbonate or ether based electrolyte for Li-Se batteries: An in-situ study of intermediate polyselenide formation>, Application In Synthesis of 112-63-0, the main research area is carbonate ether electrolyte lithium selenium battery intermediate polyselenide formation.

Li-Se batteries have recently been considered as one of the most promising battery systems to satisfy the future energy storage needs. However, to further improve the electrochem. cell performances, understanding of the Li-Se cell working mechanism, especially focusing on the formation of dissolved Li polyselenides, is essential. An in-situ study of intermediate polyselenide formation based on the 4-electrode cycling voltammetry (CV) and 3-electrode electrochem. impedance spectroscopy (EIS) were used to detect the existence of polyselenides in carbonate and ether-based electrolytes. CV measurements reveal dissolved polyselenide intermediate formations in ether-based solvent while no signatures are observed in carbonate-based electrolytes. Similar findings are also observed by EIS measurements as well as studying the self-discharge behavior. Therefore, these two electrochem. characterizations can be easily implemented as prompt and cost-effective techniques to study the impact of the electrolyte solvents. Contrary to the Li-S counterparts, the outcome of the work suggests that carbonate-based electrolytes can be simply employed in the field of Li-Se batteries.

Electrochimica Acta published new progress about Battery electrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nogales-Delgado, Sergio; Encinar Martin, Jose Maria; Sanchez Ocana, Mercedes published the artcile< Use of mild reaction conditions to improve quality parameters and sustainability during biolubricant production>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is safflower oil biolubricant production oxidative stability biodegradability sustainability viscosity.

The use of alternative sources to produce less pollutant biofuels and biomaterials, replacing petroleum-derived products, is becoming an important issue for international organizations, governments, and society. Thus, biodiesel and biolubricant production has been increasingly researched, offering promising results. These products present some advantages such as sustainability or biodegradability, among others. However, some of their quality parameters can be altered during storage, mainly due to their low oxidative stability. Consequently, auto-oxidation processes can take place, increasing viscosity or acid number, which can compromise their marketability. To avoid these inconveniences, some alternatives have been presented, such as the use of antioxidants, vegetable oil selection or the promotion of mild chem. conditions during production The aim of this work was to assess the use of vacuum during biolubricant production from high-oleic safflower oil through double transesterification with methanol and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol to obtain mild chem. conditions. Under these circumstances (working pressure at 210 mmHg) and compared to previous studies, temperature and catalyst addition could be reduced from 140 to 100°C and from 0.5 to 0.3%, resp., increasing the reaction yield from 92.9 to 94.69% and improving the quality of the biolubricant, with 30% increase in viscosity index.

Biomass and Bioenergy published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bollini, Mariela; Domaoal, Robert A.; Thakur, Vinay V.; Gallardo-Macias, Ricardo; Spasov, Krasimir A.; Anderson, Karen S.; Jorgensen, William L. published the artcile< Computationally-Guided Optimization of a Docking Hit to Yield Catechol Diethers as Potent Anti-HIV Agents>, Quality Control of 112-63-0, the main research area is catechol ether anti HIV reverse transcriptase inhibitor computational optimization.

A 5-μM docking hit has been optimized to an extraordinarily potent (55 pM) non-nucleoside inhibitor of HIV reverse transcriptase. Use of free energy perturbation (FEP) calculations to predict relative free energies of binding aided the optimizations by identifying optimal substitution patterns for Ph rings and a linker. The most potent resultant catechol diethers feature terminal uracil and cyanovinylphenyl groups. A halogen bond with Pro95 likely contributes to the extreme potency of compound 42 (I). In addition, several examples are provided illustrating failures of attempted grafting of a substructure from a very active compound onto a seemingly related scaffold to improve its activity.

Journal of Medicinal Chemistry published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics