Month: October 2022

Lou, Jiang; He, Yuan; Li, Yunlong; Yu, Zhengkun published the artcile< Transition-Metal-Promoted Direct C-H Cyanoalkylation and Cyanoalkoxylation of Internal Alkenes via Radical C-C Bond Cleavage of Cycloketone Oxime Esters>, SDS of cas: 112-63-0, the main research area is cyanoalkylated alkene preparation cyanoalkoxylation bond cleavage cycloketone oxime ester; cyanoalkoxylation internal alkene bond cleavage cycloketone oxime ester.

Transition-metal-catalyzed alkyl-Heck-type cross-coupling of olefinic C-H bonds has been a challenge in the C-H activation area. Herein, we report FeCl3-promoted efficient direct C-H cyanoalkylation of internal alkenes, i.e., ketene dithioacetals, with cycloketone oxime esters via radical C-C bond cleavage under the redox-neutral conditions. With CuCl2 as the catalyst under a dioxygen atm. direct C-H cyanoalkoxylation of the same internal alkenes was achieved. The cyanoalkylated tetrasubstituted alkene products could be diversely transformed to cyanoalkyl-functionalized N- and S-heterocyclic compounds The mechanistic studies have revealed that these C-H cyanoalkylation and cyanoalkoxylation reactions proceed through a radical pathway.

Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (internal). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thangavel, Vigneshwaran; Mastouri, Afef; Guery, Claude; Morcrette, Mathieu; Franco, Alejandro A. published the artcile< Understanding the Reaction Steps Involving Polysulfides in 1 M LiTFSI in TEGDME : DOL Using Cyclic Voltammetry Experiments and Modelling>, SDS of cas: 112-63-0, the main research area is lithium bistrifluoromethanesulfonylimide tetraethylene glycol dimethy ether dioxolane cyclic voltammetry.

The reaction mechanisms of polysulfides in the electrolytes of lithium sulfur (Li-S) batteries are known to be complex. These reaction mechanisms may also change with the electrolyte used. Understanding the reaction steps of the polysulfides in a Li-S battery electrolyte is important to assess the underlying phenomena behind the Li-S cell performance limitations. Here, we investigate the reaction steps of polysulfides in electrolyte solutions containing S8, Li2S8 and Li2S6 in 1 M LiTFSI in TEGDME : DOL (volume/volume 1 : 1) (one of the most interesting electrolytes for use in Li-S batteries), using exptl. cyclic voltammetry and a math. model. The math. model assists in understanding the reaction steps behind the characteristics changes of cyclic voltammograms (CVs) with the scan rate and polysulfides speciation. Our systematic study shows that the reaction steps conventionally used in Li-S battery models are not sufficient to simulate all the CV characteristics of the investigated electrolyte solutions

Batteries & Supercaps published new progress about Cyclic voltammetry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Halat, David M.; Fang, Chao; Hickson, Darby; Mistry, Aashutosh; Reimer, Jeffrey A.; Balsara, Nitash P.; Wang, Rui published the artcile< Electric-field-induced spatially dynamic heterogeneity of solvent motion and cation transference in electrolytes>, Reference of 112-63-0, the main research area is electrolytic solution elec field liquid electrolyte solvent motion.

While elec. fields primarily result in migration of charged species in electrolytic solutions, the solutions are dynamically heterogeneous. Solvent mols. within the solvation shells of the cation will be dragged by the field while free solvent mols. will not. We combine electrophoretic NMR measurements of ion and solvent velocities under applied elec. fields with mol. dynamics simulations to interrogate different solvation motifs in a model liquid electrolyte. Measured values of the cation transference number (t0+) agree quant. with simulation-based predictions over a range of electrolyte concentrations Solvent-cation interactions strongly influence the concentration-dependent behavior of t+0. We identify a critical concentration at whichmost of the solventmols. liewithin solvation shells of the cations. The dynamic heterogeneity of solvent mols. is minimized at this concentration where t+0 is approx. equal to zero.

Physical Review Letters published new progress about Concentration (process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Odashima, Tsugikatsu; Kikuchi, Takemitsu; Ohtani, Wataru; Ishii, Hajime published the artcile< Synthesis and chromogenic properties of water-soluble substituted 2-pyridyl-3'-sulfophenylmethanone 2-pyridylhydrazones and spectrophotometric and analog derivative spectrophotometric determination of trace amounts of cobalt with 2-pyridyl-3'-sulfophenylmethanone 2-(5-nitro)pyridylhydrazone>, Related Products of 112-63-0, the main research area is cobalt determination spectrophotometry; steel analysis cobalt spectrophotometry; pyridylsulfophenylmethanone nitropyridylhydrazone reagent cobalt determination; ionization pyridylsulfophenylmethanone pyridylhydrazone substituent effect.

Three water-soluble hydrazones, in which the 5-position of the pyridine ring in the hydrazine moiety of 2-pyridyl-3′-sulfophenylmethanone 2-pyridylhydrazone was substituted by a Me, chloro or nitro group, were synthesized and their chromogenic properties and reactivities with metal ions investigated. The acid dissociation constants (Ka) of the synthesized hydrazones were determined spectrophotometrically. These values obeyed Hammett’s law; the inductive effect of the substituents reflect the pKa values. Of the synthesized hydrazones, 2-pyridyl-3′-sulfophenylmethanone 2-(5-nitro)pyridylhydrazone (PSNPH) is the most sensitive for Co(II) determination It reacts with Co(II) complex to form a 1:2 (metal:ligand) complex. This complex is rapidly oxidized above pH 2 to give a stable Co(III) complex with an absorption maximum at 496 nm. Beer’s law is obeyed over the range 0.05-1.0 μg mL-1 of Co and the apparent molar absorptivity of the complex is 5.69 × 104 L mol-1cm-1 at 496 nm. A sensitive and practical spectrophotometric method for the determination of trace amounts of Co with PSNPH is proposed and was successfully applied to the determination of Co in steel samples. The method may be made more sensitive by employing an analog derivative spectrophotometric technique.

Analyst (Cambridge, United Kingdom) published new progress about Ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Perkin, W. H.; Smith, Alice E. published the artcile< The synthesis of ααγ-trimethylglutaric acid, of the cis- and trans-modifications of β-hydroxy-ααγ-trimethylglutaric acid, and of ααγ-trimethylglutaconic acid>, HPLC of Formula: 112-63-0, the main research area is .

A study on the synthesis of ααγ-trimethylglutaric acid, of the cis- and trans-modifications of β-hydroxy-ααγ-trimethylglutaric acid, and of ααγ-trimethylglutaconic acid was carried out. A mixture of ethyl dimethylmalonate and ethyl acetate was readily acted on by sodium, yielding the sodium compound of ethyl αα-dimethylacetonedicarboxylate. If this was treated with methyl iodide, a methyl group is introduced in the place of the metal and ethyl ααγ-trimethylacetonedicarboxylate is formed. When ethyl ααγ-trimethylacetonedicarboxylate was reduced with sodium amalgam, it yielded a mixture of two isomeric acids that melt at 115° and 155°, and were stereoisomeric modifications of β-hydroxy-ααγ-trimethylglutaric acid.

Journal of the Chemical Society, Transactions published new progress about Charcoal (animal). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Carboni, D.; Jiang, Y.; Malfatti, L.; Innocenzi, P. published the artcile< Selective detection of organophosphate through molecularly imprinted GERS-active hybrid organic-inorganic materials>, Electric Literature of 112-63-0, the main research area is organophosphate graphene mol imprinting hybrid organic inorganic material; graphene enhanced Raman scattering hybrid organic inorganic material.

A selective sensing platform for the organophosphate paraoxon, a highly toxic organic pollutant, has been designed and tested on water samples. A porous hybrid organic-inorganic film, synthesized using tetraethoxysilane, 1,8-bis(triethoxysilyl)octane and cetyltrimethylammonium bromide, has been molecularly imprinted with a structural analog of paraoxon, the diethyl(4-nitrobenzyl)phosphonate, to induce selective recognition. Exfoliated graphene has been incorporated into the porous matrix to provide enhancement of the Raman scattering signal. The Raman sensor has been tested on different concentrations of paraoxon in both ethanol and water/ethanol mixture The mol. selectivity has been assessed by comparing the Raman signal enhancement of paraoxon with a similar organophosphate, the bis-(4-nitrophenyl) phosphate. The molecularly imprinted film has shown a fourfold increase of the paraoxon signal, when compared with the corresponding not-imprinted. The evaluation of the d. of mol. cavities into the molecularly imprinted samples (4.50 * 10-10 μmol μm-3) has allowed assuming that each mol. cavity is capable of providing a remarkable signal enhancement of 1.47 * 1012 count * μmol-1 only when recognising paraoxon. The material design has allowed coupling the sensitivity of the graphene-mediated enhancement of Raman scattering with the selectivity of mol. imprinting into a single and potentially portable, anal. system. Copyright © 2017 John Wiley & Sons, Ltd.

Journal of Raman Spectroscopy published new progress about Density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aguilar-Morante, Diana; Gomez-Cabello, Daniel; Quek, Hazel; Liu, Tianqing; Hamerlik, Petra; Lim, Yi Chieh published the artcile< Therapeutic Opportunities of Disrupting Genome Integrity in Adult Diffuse Glioma>, Product Details of C19H34O2, the main research area is review glioma glioblastoma genome central nervous system therapeutics; CNS tumors; DNA damage response; DNA repair; glioma; molecular markers; pharmacotherapeutics; precision medicine; synthetic lethality; targeted therapy.

A review. Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present outcome is discouraging as most patients will succumb to this disease. The low cure rate is consistent with the failure of first-line therapy, radiation and temozolomide (TMZ). Even with their therapeutic mechanism of action to incur lethal DNA lesions, tumor growth remains undeterred. Delivering addnl. treatments only delays the inescapable development of therapeutic tolerance and disease recurrence. The urgency of establishing lifelong tumor control needs to be re-examined with a greater focus on eliminating resistance. Early genomic and transcriptome studies suggest each tumor subtype possesses a unique mol. network to safeguard genome integrity. Subsequent seminal work on post-therapy tumor progression sheds light on the involvement of DNA repair as the causative contributor for hypermutation and therapeutic failure. In this review, we will provide an overview of known mol. factors that influence the engagement of different DNA repair pathways, including targetable vulnerabilities, which can be exploited for clin. benefit with the use of specific inhibitors.

Biomedicines published new progress about Central nervous system. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Junnan; Zhao, Min; Zhang, Shuang; Liu, Jiaonan; Zhao, Chunjie; Wang, Miao published the artcile< Rapid characterization of the chemical constituents of Wangbi Capsule by UPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is capsule UPLC ion cyclotron resonance mass spectrometry.

Wangbi Capsule is a compound preparation composed of 17 traditional Chinese medicines, which is widely used in the treatment of rheumatoid arthritis. In our study, a rapid and straightforward anal. method was successfully established by using Ultra performance liquid chromatog. coupled with Fourier transform ion cyclotron resonance mass spectrometry technol. to quickly sep. and identify the chem. constituents of Wangbi Capsule. The chromatog. was performed on a Universal XB-C18 column (2.1 mm x 150 mm, 3μm) by the mobile phase containing acetonitrile (A)-0.1% formic acid and water (B) at the flow rate of 0.2 mL/min. The pos. and neg. ions of the samples were analyzed by extraction ion chromatog. Based on accurate mass spectrometry informations such as excimer ions and fragment ions, combined with the reference materials and the reference literature, 140 compounds in the Wangbi Capsule were identified or preliminarily characterized. The results of the study show that Wangbi Capsules mainly contain 3 types of nucleosides, 31 types of alkaloids, 12 types of organic acids, 29 types of flavonoids, 12 types of monoterpene glycosides, 30 types of coumarins, 10 types of chromones, 3 types of saponins, 6 kinds of phenylethanoid glycosides and other chem. components. The method established in this study can quickly and efficiently identify the chem. constituents in Wangbi Capsules. It is hoped that it will have a certain significance for the characterization of other Chinese medicine components and lay the foundation for pharmacol. research and subsequent in vivo studies of Wangbi Capsules.

Microchemical Journal published new progress about Capsules. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yunfei; Chen, Li; Zou, Canlin; He, Jiangtao; Feng, Luanqi; Wu, Jia-Qiang; Chen, Wen-Hua; Hu, Jinhui published the artcile< Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization>, Application In Synthesis of 19241-24-8, the main research area is hydrazinopyridine isothiocyanate tetrabutylammonium iodide catalyst desulfurative cyclization; amino triazolo pyridine electrochem preparation.

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity.

Organic Letters published new progress about Antitumor agents. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Jun; Yang, Min; Liu, Jin-Biao; He, Fu-Sheng; Wu, Jie published the artcile< A copper-catalyzed insertion of sulfur dioxide via radical coupling>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is beta sulfonyl enamine preparation stereoselective regioselective; ortho acyl oxime azirine DABCO sulfur dioxide insertion copper.

A copper-catalyzed three-component reaction of O-acyl oximes, DABCO.(SO2)2, and 2H-azirines under mild conditions has been achieved. This protocol provides an efficient route for the construction of various tetrasubstituted β-sulfonyl N-unprotected enamines in moderate to good yields with excellent stereoselectivity and regioselectivity. Notably, this method represents a rare example of 2H-azirines as useful synthons for β-functionalized N-unprotected enamines. Preliminary mechanistic studies indicate that the reaction proceeds through coupling of a sulfonyl radical and α-carbon radical via copper-catalyzed ring-opening C-C bond cleavage of O-acyl oxime and C-N bond cleavage of 2H-azirine with the insertion of sulfur dioxide.

Chemical Communications (Cambridge, United Kingdom) published new progress about Azirines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics