Month: October 2022

Alamgir, Md.; Nayak, G. C.; Mallick, Ashis; Sahoo, Sumanta published the artcile< Effects of TiO2 and GO nanoparticles on the thermomechanical properties of bioactive poly-HEMA nanocomposites>, Computed Properties of 3290-92-4, the main research area is HEMA titanium dioxide graphene oxide nanoparticle thermomech property.

Abstract: Bioactive polymeric nanocomposites are indispensable materials and have received great attention owing to their diverse applications in human body. In this study, a poly(hydroxyethyl methacrylate) (pHEMA) complex was prepared using hydroxyethyl methacrylate (HEMA) as a base material and trimethylolpropane trimethacrylate (TMPTA) and benzoyl peroxide (BPO) as crosslinking agents. The pHEMA nanocomposites were prepared by melt processing technique. In this process, a twin screw extruder machine was used. Twin screw extrusion is used extensively for mixing, compounding, or reacting polymeric materials. The flexibility of twin screw extrusion equipment allows this operation to be designed specifically for the formulation being processed. The nanocomposites of pHEMA/TiO2 and pHEMA/TiO2/GO were synthesized using pHEMA as a matrix with the addition of a small amounts of titanium oxide nanoparticles (TiO2 1 wt) and graphene oxide (GO 0.1 wt) as reinforcement materials. The thermomech. study of pHEMA/TiO2 and pHEMA/TiO2/GO nanocomposites was carried out via thermogravimetric (TGA), differential scanning calorimetry (DSC), micro-indentation, micro-scratch, and FTIR analyses, and compression testing. The microstructural characterization of the nanocomposites was studied by FESEM and XRD anal. Significant changes in microstructural behavior with improved thermomech. properties were observed in pHEMA/TiO2 and pHEMA/TiO2/GO nanocomposites as compared to pure pHEMA. In this work, pure pHEMA and pHEMA/TiO2 and pHEMA/TiO2/GO nanocomposites were studied for dental applications.

Iranian Polymer Journal published new progress about Nanocomposites. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Computed Properties of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fu, Kun; Liu, Chenxu; Wang, Lemeng; Huang, Xiayu; Fu, Dong published the artcile< Performance and mechanism of CO2 absorption in 2-ethylhexan-1-amine + glyme non-aqueous solutions>, SDS of cas: 112-63-0, the main research area is carbon dioxide glyme ethylhexan amine absorption.

In this work, novel non-aqueous absorbents composed of 2-ethylhexan-1-amine (EHA) and glyme were proposed for CO2 capture. The absorption performance of CO2 in EHA + diglyme, EHA + triglyme and EHA + tetraglyme non-aqueous solutions was investigated and the viscosities (η) of the CO2-saturated absorbents were measured. Besides the experiments, kinetic models were applied to correlate the CO2 absorption. The activation energy (Ea) was obtained from Arrhenius equation, and the absorption mechanism was deduced. The results showed that both Lagergren model and Avrami model can accurately correlate and predict the time-dependent absorption amount, thus an optimized composition under which excellent absorption performance and relatively low η and Ea can be simultaneously achieved was determined Compared to water-based absorbents like MEA, the optimized non-aqueous absorbents take the advantages of better absorption performance and lower activation energy. Moreover, the glyme solvents have about 50% lower sp. heat capacities and much higher b.ps. (≥435 K) than water, which is expected to greatly reduce the sensible heat and the latent heat of the solvent during regeneration. Therefore, the proposed novel absorbents have promising industrial application potential in the CO2 capture process.

Energy (Oxford, United Kingdom) published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tchani, G.; Baziard-Mouysset, G.; Younes, S.; Bellan, J.; Payard, M.; Stigliani, J. L.; Grassy, G.; Bonnafous, R.; Tisne-Versailles, J. published the artcile< Evaluation of calcium inhibitory activity of a series of diethyl benzylphosphonates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is calcium antagonist benzylphosphonate; structure activity relationship calcium channel blocking; cardiodepressive benzylphosphonate.

Thirty-nine di-Et benzylphosphonates (12 newly prepared) related to Fostedil were evaluated as calcium antagonists, using the inhibition test on aortic contraction in the rabbit, which was more selective than the neg. inotropic activity test on guinea-pig left atrial muscle. Six compounds had weak activity compared with Fostedil. Structure-activity relationships indicated a certain lipophilic influence; no correlation was found with electronic parameters. The prerequisite structure to obtain active products seems to require two conjugated aromatic rings separated by an optimal distance.

European Journal of Medicinal Chemistry published new progress about Calcium channel blockers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Zhonghe; Mi, Xing; Yu, Yanan; Shi, Wencheng; Feng, Anchao; Moad, Graeme; Thang, San H. published the artcile< ""All-PVC"" Flexible Poly(vinyl Chloride): Nonmigratory Star-Poly(vinyl Chloride) as Plasticizers for PVC by RAFT Polymerization>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is PVC flexible polyvinyl chloride polyvinyl plasticizer RAFT polymerization.

Xanthate-mediated RAFT polymerization has been used to prepare 3-star and 4-star-poly(vinyl chloride) (star-PVC) with a number average molar mass (Mn) in the range of 1 to 7 kg mol-1. The Tg of star-PVC reduces with molar mass and with the number of arms. The star-PVC have substantially lower glass-transition temperatures (Tg) than that of linear PVC of similar Mn, with the Tg of low-molar mass 4-star-PVC being -7.4°C. The star-PVC are effective in lowering the Tg of blends with com. PVC when added at 10-30 weight % PVC. When added even at 10 weight %, they are effective in improving the ductility of PVC with an elongation at break (EB) of ~350% (4-star-PVC) and ~300% (3-star-PVC) relative to com. PVC, which is substantially higher than that for PVC conventionally plasticized with 30 weight % dioctyl phthalate under similar conditions (EB ~160%). Importantly, the star-PVC, despite their low molar mass, do not migrate from the PVC blends when tested under standard conditions. The performance of the star-PVC as non-migratory plasticizers for PVC demonstrates the potential for an “”all-PVC”” flexible PVC.

Macromolecules (Washington, DC, United States) published new progress about Ductility. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoelzel, Conner A.; Hu, Hang; Wolstenholme, Charles H.; Karim, Basel A.; Munson, Kyle T.; Jung, Kwan Ho; Zhang, Han; Liu, Yu; Yennawar, Hemant P.; Asbury, John B.; Li, Xiaosong; Zhang, Xin published the artcile< A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents>, Safety of Dimethyl 2,2′-azanediyldiacetate hydrochloride, the main research area is triazole donor acceptor mol substituent; amines; charge transfer; donor-acceptor systems; fluorescence; solvent effects.

While organic donor-acceptor (D-A) mols. are widely employed in multiple areas, the application of more D-A mols. could be limited because of an inherent polarity sensitivity that inhibits photochem. processes. Presented here is a facile chem. modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and exptl. analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophys. properties of commonly used D-A fluorophores and their enhanced performance in biol. imaging are shown.

Angewandte Chemie, International Edition published new progress about Absorption. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Safety of Dimethyl 2,2′-azanediyldiacetate hydrochloride.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Watanabe, Hitoshi; Ishida, Kyoji; Yamamoto, Masanori; Horiguchi, Masakuni; Isobe, Yoshiaki published the artcile< Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor>, Quality Control of 112-63-0, the main research area is dibenzo diazepine preparation dopamine schizophrenia agranulocytosis antipsychotic; Agranulocytosis; Antipsychotics; Clozapine; Dopamine; Reactive metabolites; Treatment resistant schizophrenia.

Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered I as Clozapine-like dopamine D2/D1 receptor selectivity and improved reactive metabolites formation profile by the modification of piperazine moiety in Clozapine. The optimization of I gave compound II to be best compound (approx. 10-fold stronger affinity for D2/D1 receptor and similar D2/D1 selectivity ratio with Clozapine). Clozapine-like D2/D1 receptor occupancy profile was proved by in vivo evaluation. In addition, the reactive metabolites derived agranulocytosis risk of compound II was considered to be lower than Clozapine. The pharmacol. detail of compound II is being investigated to develop it for TRS treatment.

Bioorganic & Medicinal Chemistry Letters published new progress about Agranulocytosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Asahara, Haruyasu; Kikuchi, Shuhei; Unno, Yuto; Yokoyama, Soichi; Yoshioka, Kotaro; Tani, Shinki; Umezu, Kazuto; Nishiwaki, Nagatoshi published the artcile< A Facile Synthesis of Oxiranes Possessing Three or Four Carbonyl Groups>, Quality Control of 94-02-0, the main research area is carbonylated oxirane preparation; diethyl mesoxalate bromoketone condensation.

Tri-carbonylated oxiranes I [R = H; Ar = Ph, 4-MeC6H4, 4-BrC6H4, etc.] were efficiently synthesized via condensation of vicinal tricarbonyl compound with α-bromoketones in the presence of a base. This protocol was applicable to α-bromo-β-keto esters to give tetra-carbonylated oxiranes I [R = CO2Et] from which trifunctionalized bromoalkene was competitively formed. The ratio of compounds I was influenced by the solvent and reaction temperature Synthesis of 2,3-bis-organochalcogenyl-benzo[b]chalcogenophenes promoted by oxone.

Current Organic Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Quality Control of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Musser, J. H.; Hudec, T. T.; Bailey, K. published the artcile< A simple one-step synthesis of alkyl benzazol-2-carboxylates>, COA of Formula: C19H34O2, the main research area is benzoxazolecarboxylate ester; cyclocondensation aminophenol trialkoxyacetate; oxalate ortho ester cyclocondensation aminophenol.

Benzoxazoles, benzothiazole derivative, and benzimidazoles I (Z = CH, N; Z1 = O, S, NH, NPh; R = Me, Et; R1 = H and R2 = H, Cl, OMe, or R1R2 = benzo) were prepared from the resp. II and (RO)3CCO2R. Thus, 2-H2NC6H4OH was treated with (MeO)3CCO2Me to give I (R = Me, Z = CH, Z1 = O, R1 = R2 = H).

Synthetic Communications published new progress about Cyclocondensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuen, Carlen A.; Barbaro, Marissa; Haggiagi, Aya published the artcile< Newly Diagnosed Glioblastoma in Elderly Patients>, Category: esters-buliding-blocks, the main research area is review glioblastoma o6 methylguanine dna methyltransferase; Bevacizumab; Elderly; Glioblastoma; Hypofractionated radiation therapy; Temozolomide; Tumor-treating fields.

A review. A Review. Abstract: Purpose of Review: Elderly patients with newly diagnosed glioblastoma (eGBM) carry a worse prognosis compared with their younger counterparts. eGBM garners special attention due to the unique challenges, including increased treatment-associated toxicity, less relative benefit from aggressive therapy, medical comorbidities, and immunosuppression. The pivotal GBM trials excluded patients > 70 years old and the optimal treatment approach remains unsettled for eGBM. In this review, we analyze the historical evidence-based data for treating eGBM and discuss the future direction for managing this vulnerable population. Recent Findings: Treatment for eGBM continues to evolve. Therapy choice is guided by performance status and presence of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation. For eGBM with good performance status, combinatorial hypofractionated radiation therapy (hRT) and temozolomide should be recommended. For those with poor performance status, further stratification based on MGMT promoter methylation test result is recommended. Single-agent temozolomide is a viable treatment option for MGMT methylated tumors (mMGMT); in particular, those classified with receptor tyrosine kinase II methylation. hRT alone can be considered in MGMT unmethylated (uMGMT) eGBM patients. As precision oncol. continues to advance, effective targeted and immunotherapy may emerge as new treatment options for eGBM. Summary: Management of elderly patients with newly diagnosed GBM carries a unique set of challenges. Progress has been made in defining the optimal therapeutic approach for these patients, but many questions remain to be answered.

Current Oncology Reports published new progress about Comorbidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zeng, Jiuseng; Ji, Yafei; Luan, Fei; Hu, Jingwen; Rui, Yixing; Liu, Yao; Rao, Zhili; Liu, Rong; Zeng, Nan published the artcile< Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rβ/PI3K/Akt signaling pathway>, HPLC of Formula: 112-63-0, the main research area is xiaoyaosan antidepressant IGF1R beta PI3K Akt depression; Apoptosis; CUMS; IGF-1/IGF-1Rβ; Neurogenesis; PI3K/Akt pathway; Xiaoyaosan ethyl acetate fraction.

Xiaoyaosan (XYS), a representative and classic traditional Chinese medicine (TCM) prescription with function of dispersing stagnated liver and strengthening spleen, has been used for thousands of years to treat depression. XYS anti-depression effect has been demonstrated both clin. and expremental; however, the material basis for this effect has yet to be elucidated. To evaluate the impact and underlying action mechanism of XYS antidepressant active component (Xiaoyaosan Et acetate fraction, XYSEF) against chronic unpredictable mild stress (CUMS)-induced depression-like behavior in mice. First, we established a behavioral despair depression mouse model to preliminarily determine the effective antidepressant dose of XYSEF. Then, we created a CUMS mouse model and used various classic behavioral tests, including SPT, ST, NFST, and TST, to assess XYSEFs antidepressant properties. IGF-1 levels in mouse serum and hippocampus were quantified using ELISA. The average optical d. of Nissl bodies in the mouse hippocampal CA3 region was determined utilizing toluidine blue staining. Brdu and DCX expression in the hippocampal dentate gyrus (DG) was assayed using the immunofluorescence method. IGF-1Rβ, PI3K, p-PI3K, Akt, p-Akt, Caspase-3, and cleaved Caspase-3 protein levels in the hippocampus were determined with Western blot. The behavioral despair mouse model findings showed that 9.1 and 40 g/kg of XYSEF both significantly shortened the immobility time of mice, suggesting that the ED range was 9.1-40 g/kg. Compared to the CUMS mouse model, XYSEF at 20 and 40 g/kg markedly increased the sucrose preference percentage in the SPT and grooming time in the ST, shortened the immobility time in the TST and the feeding latency in the NSFT, and reversed the downregulated IGF-1 content in mouse serum and hippocampus. In addition, XYSEF amplified the average optical d. of Nissl bodies in the hippocampal CA3 region, promoted Brdu and DCX expression in DG, and diminished IGF-1Rβ, p-PI3K/PI3K, p-Akt/Akt, and cleaved Caspase-3/Caspase-3 protein levels in the hippocampi of CUMS mice. XYSEF acted as an antidepressant in mice exhibiting CUMS-induced depression-like behaviors, possibly by promoting hippocampal neurogenesis, reducing neuronal apoptosis, and inhibiting the over-activation of the IGF-1Rβ/PI3K/Akt pathway.

Journal of Ethnopharmacology published new progress about Antidepressants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics