Month: October 2022

Ahad, Abdul; Shakeel, Faiyaz; Raish, Mohammad; Ahmad, Ajaz; Bin Jardan, Yousef A.; Al-Jenoobi, Fahad I.; Al-Mohizea, Abdullah M. published the artcile< Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents>, Quality Control of 112-63-0, the main research area is temozolomide polyethylene glycol 400 thermodn solubility temperature; Apelblat and Van’t Hoff models; solubility; solution thermodynamics; temozolomide.

The solubility parameters, and solution thermodn. of temozolomide (TMZ) in 10 frequently used solvents were examined at five different temperatures The maximum mole fraction solubility of TMZ was ascertained in DMSO (1.35 x 10-2), followed by that in polyethylene glycol-400 (3.32 x 10-3) > Transcutol (2.89 x 10-3) > ethylene glycol (1.64 x 10-3) > propylene glycol (1.47 x 10-3) > H2O (7.70 x 10-4) > Et acetate (5.44 x 10-4) > ethanol (1.80 x 10-4) > iso-Pr alc. (1.32 x 10-4) > 1-butanol (1.07 x 10-4) at 323.2 K. An analogous pattern was also observed for the other investigated temperatures The quantitated TMZ solubility values were regressed using Apelblat and Van’t Hoff models and showed overall deviances of 0.96% and 1.33%, resp. Apparent thermodn. anal. indicated endothermic, spontaneous, and entropy-driven dissolution of TMZ in all solvents. TMZ solubility data may help to formulate dosage forms, recrystallize, purify, and extract/sep. TMZ.

Molecules published new progress about Dissolution. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yiliu; Turunen, Petri; de Waal, Bas F. M.; Blank, Kerstin G.; Rowan, Alan E.; Palmans, Anja R. A.; Meijer, E. W. published the artcile< Catalytic single-chain polymeric nanoparticles at work: from ensemble towards single-particle kinetics>, Computed Properties of 71195-85-2, the main research area is catalytic single chain polymeric nanoparticle design preparation.

Folding a single polymer chain around catalytically active sites to construct catalytic single chain polymeric nanoparticles (SCPNs) is a novel approach to mimic the activity and selectivity of enzymes. In order to relate the efficiency of SCPNs to their three-dimensional structure, a better understanding of their catalytic activity at an individual level, rather than at an ensemble level, is highly desirable. In this work, we present the design and preparation of catalytic SCPNs and a family of fluorogenic substrates, their characterization at the ensemble level as well as our progress toward analyzing individual SCPNs with single-mol. fluorescence microscopy. Firstly, organocopper-based SCPNs together with rhodamine-based fluorogenic substrates were designed and synthesized. The SCPNs catalyze the carbamate cleavage reaction of mono-protected rhodamines, with the dimethylpropargyloxycarbonyl protecting group being cleaved most efficiently. A systematic study focusing on the conditions during catalysis revealed that the ligand acceleration effect as well as the accumulation of substrates and catalytically active sites in SCPNs significantly promote their catalytic performance. Secondly, a streptavidin-biotin based strategy was developed to immobilize the catalytic SCPNs on the surface of glass coverslips. Fluorescence correlation spectroscopy experiments confirmed that the SCPNs remained catalytically active after surface immobilization. Finally, single-SCPN activity measurements were performed. The results qual. indicated that fluorescent product mols. were formed as a result of the catalytic reaction and that individual fluorescent product mols. could be detected. So far, no evidence for strongly different behaviors has been observed when comparing individual SCPNs.

Molecular Systems Design & Engineering published new progress about Catalysts. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Canella Vieira, Bruno; Sousa Alves, Guilherme; Vukoja, Barbara; Velho, Vinicius; Zaric, Milos; Houston, Trenton W.; Fritz, Bradley K.; Kruger, Greg R. published the artcile< Spray drift potential of dicamba plus S-metolachlor formulations>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is S metolachlor Amaranthus formulation spray drift potential; capsule suspension; crop injury; emulsifiable concentrate; off-target movement; premix; tankmix.

Early-postemergence herbicide applications in the USA often include residual herbicides such as S-metolachlor to suppress late late-emerging Amaranthus spp. Although this practice benefits weed control, herbicide tankmixes can influence spray droplet size and drift potential during applications. The addition of S-metolachlor products to dicamba spray solutions generally decreases spray droplet size and increases spray drift potential. Advances in formulation technol. fostered the development of products with reduced spray drift potential, especially for herbicide premixes containing multiple active ingredients. The objective of this study was to compare the drift potential of a novel dicamba plus S-metolachlor premix formulation (capsule suspension) against a tankmix containing dicamba (soluble liquid) and S-metolachlor (emulsifiable concentrate) using different venturi nozzles. The MUG nozzle had greater DV0.5 (1128.6μm) compared to the ULDM (930.3μm), TDXL-D (872.9μm), and TTI nozzles (854.8μm). The premix formulation had greater DV0.5 (971.0μm) compared to the tankmix (922.3μm). Nozzle influenced spray drift deposition (P < 0.0001) and soybean biomass reduction (P = 0.0465). Herbicide formulation influenced spray drift deposition (P < 0.0001), and biomass reduction of soybean (P < 0.0001) and cotton (P = 0.0479). The novel capsule suspension formulation (premix) of dicamba plus S-metolachlor had reduced area under the drift curve (AUDC) (577.6) compared to the tankmix (913.7). Applications using the MUG nozzle reduced AUDC (459.9) compared to the other venturi nozzles (ranging from 677.4 to 1141.7). Study results evidence that advances in pesticide formulation can improve pesticide drift mitigation. Pest Management Science published new progress about Amaranthus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joehnck, Matthias; Kalveram, Stefan; Lehmacher, Stefan; Pompe, Guido; Rudolph, Stefan; Neyer, Andreas; Hofstraat, Johannes W. published the artcile< Characterization of passive polymer optical waveguides>, Product Details of C9H3F5O2, the main research area is polymer optical waveguide tetrachloroethylacrylate tetrachloroethylmethacrylate POPCORN technol; pentafluorophenylacrylatete pentafluorophenylmethacrylate polymer optical waveguide.

The characterization of monomode passive polymer optical devices fabricated according to the POPCORN technol. by methods originated from electron, ion and optical spectroscopy is summarized. Impacts of observed waveguide perturbations on the optical characteristics of the waveguide are evaluated. In the POPCORN approach optical components for telecommunication applications are fabricated by photo-curing of liquid halogenated (meth)acrylates which were applied on molded thermoplastic substrates. For tuning of waveguide material refractive indexes with respect to the substrate refractive index frequently comonomer mixtures are used. The polymerization characteristics, especially the polymerization kinetics of individual monomers, determine the formation of copolymers. Therefore the unsaturation as function of UV-illumination time in the formation of halogenated homo- and copolymers was examined From different suitable copolymer system, after characterization of their glass transition temperatures, their curing behavior and their refractive indexes as function of the monomer ratios, monomode waveguides applying PMMA substrates were fabricated. To examine the materials composition also in the 6 X 6 μm2 waveguides they were visualized by TEM. With this method, e.g., segregation phenomena could be observed in the waveguide cross section characterization as well. The optical losses in monomode waveguides caused by segregation and other materials induce defects like micro bubbles formed as a result of shrinkage were quantized by return loss measurements. Defects causing scattering could be observed by confocal laser scanning microscopy and by conventional light microscopy.

Proceedings of SPIE-The International Society for Optical Engineering published new progress about Optical waveguides. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Product Details of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Lingling; Wu, Haiting; Liang, Yunshi; Deng, Huiying; He, Yiting; Xu, Qin; Zhang, Jing published the artcile< Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry>, SDS of cas: 19241-24-8, the main research area is methylenethiazoline amino preparation chemoselective; propargylamine isothiocyanate addition cyclization silver catalyst tandem reaction.

An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis.

Organic & Biomolecular Chemistry published new progress about Addition reaction. 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, SDS of cas: 19241-24-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reinhardt, Luiza Steffens; Moras, Ana Moira; Henn, Jeferson Gustavo; Arantes, Pablo Ricardo; Ferro, Matheus Bernardes; Braganhol, Elizandra; de Souza, Priscila Oliveira; de Oliveira Merib, Josias; Borges, Gabriela Ramos; Dalanhol, Carolina Silveira; de Barros Dias, Mabilly Cox Holanda; Nugent, Michael; Moura, Dinara Jaqueline published the artcile< Nek1-inhibitor and temozolomide-loaded microfibers as a co-therapy strategy for glioblastoma treatment>, Reference of 112-63-0, the main research area is Drug delivery systems; Electrospinning; Glioblastoma; Microfibers; NIMA-related kinase 1; Polyvinyl alcohol; Temozolomide.

Malignant glioblastoma (GB) is the predominant primary brain tumor in adults, but despite the efforts towards novel therapies, the median survival of GB patients has not significantly improved in the last decades. Therefore, localised approaches that treat GB straight into the tumor site provide an alternative to enhance chemotherapy bioavailability and efficacy, reducing systemic toxicity. Likewise, the discovery of protein targets, such as the NIMA-related kinase 1 (Nek1), which was previously shown to be associated with temozolomide (TMZ) resistance in GB, has stimulated the clin. development of target therapy approaches to treat GB patients. In this study, we report an electrospun polyvinyl alc. (PVA) microfiber (MF) brain-implant prepared for the controlled release of Nek1 protein inhibitor (iNek1) and TMZ or TMZ-loaded nanoparticles. The formulations revealed adequate stability and drug loading, which prolonged the drugs′ release allowing a sustained exposure of the GB cells to the treatment and enhancing the drugs′ therapeutic effects. TMZ-loaded MF provided the highest concentration of TMZ within the brain of tumor-bearing rats, and it was statistically significant when compared to TMZ via i.p. (IP). All animals treated with either co-therapy formulation (TMZ + iNek1 MF or TMZ nanoparticles + iNek1 MF) survived until the endpoint (60 days), whereas the Blank MF (drug-unloaded), TMZ MF and TMZ IP-treated rats′ median survival was found to be 16, 31 and 25 days, resp. The tumor/brain area ratio of the rats implanted with either MF co-therapy was found to be reduced by 5-fold when compared to Blank MF-implanted rats. Taken together, our results strongly suggest that Nek1 is an important GB oncotarget and the inhibition of Nek1′s activity significantly decreases GB cells′ viability and tumor size when combined with TMZ treatment.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Li; Jiao, Lei published the artcile< Visible-Light-Induced Organocatalytic Borylation of Aryl Chlorides>, Application of C19H34O2, the main research area is visible light catalyst organocatalytic borylation aryl chloride mechanism photoactivation; aryl boronate preparation.

The preparation of arylboronates from unactivated aryl chlorides in a transition-metal-free manner is rather challenging. There are only few examples to achieve this goal by using UV irradiation Based on the mechanistic understanding of the diboron/methoxide/pyridine reaction system, we achieved photoactivation of the in situ generated super electron donor and developed a visible-light-induced organocatalytic method for efficient borylation of unactivated aryl chlorides.

Journal of the American Chemical Society published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kantzanou, Maria; Karalexi, Maria A.; Zivinaki, Anduela; Riza, Elena; Papachristou, Helen; Vasilakis, Alexis; Kontogiorgis, Christos; Linos, Athina published the artcile< Concordance of genotypic resistance interpretation algorithms in HIV-1 infected patients: An exploratory analysis in Greece>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Atazanavir Kaletra Saquinavir Tripranav antiHIV agent HIV1 infection; Antiretroviral drug; Genotypic resistance; HIV; Inter-algorithm interpretation discordances; Protease inhibitors.

Genotypic resistance-related mutations in HIV-1 disease are often difficult to interpret. Different algorithms have been developed to provide meaningful application into clin. context. We aimed to compare, for the first time in Greece, the results of genotypic resistance derived from three interpretation algorithms. The sequences of 120 HIV 1-infected patients were tested for genotypic resistance to 19 antiretroviral (ARV) drugs (n = 2280 sequences). The interpretation results of Rega, ANRS and ViroSeq algorithms were compared. Complete concordance was found for 2/19 ARV drugs, namely lamivudine and emptricitabine. Concordance was high for nucleoside reverse transcriptase inhibitors (NRTIs) and low for protease inhibitors (PIs). In inter-algorithm pairs, agreement was high between Rega and ViroSeq (kappa = 0.701), especially by ARV class, namely NRTIs (k = 0.869) and NNRTIs (k = 0.562). The only exception was noted for rilpivirine, where agreement was higher between ANRS and Rega (k = 0.410) compared to other inter-algorithm pairs (k = 0.018-0.055). By contrast, for PIs all comparisons yielded concordance equivalent to chance (k = 0.000). Our exploratory anal. provided evidence of significant inter-algorithm discordances, especially for PIs and NNRTIs highlighting the importance of matching the results of different algorithms to achieve optimized risk stratification. Ongoing research could assist clin. physicians in interpreting complex genotypic resistance patterns.

Journal of Clinical Virology published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Demont, Emmanuel H.; Bamborough, Paul; Chung, Chun-wa; Craggs, Peter D.; Fallon, David; Gordon, Laurie J.; Grandi, Paola; Hobbs, Clare I.; Hussain, Jameed; Jones, Emma J.; Le Gall, Armelle; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Roberts, Andy D.; Sheppard, Robert J.; Watson, Robert J. published the artcile< 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is benzimidazolone preparation bromodomain inhibitor; crystal structure; BRD1; BRPF1; BRPF2; BRPF3; bromodomain; chemical probe; epigenetics; fragment; inhibitor.

The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, the authors report the discovery, binding mode, and structure-activity relationship (SAR) of the first potent, selective series of inhibitors of the BRPF1 bromodomain.

ACS Medicinal Chemistry Letters published new progress about Bromodomain-containing proteins Role: BSU (Biological Study, Unclassified), PRP (Properties), RCT (Reactant), BIOL (Biological Study), RACT (Reactant or Reagent) (crystal structure, complexes with di-Me benzimidazolones). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dinakaran, Paul M.; Bhagavannarayana, G.; Kalainathan, S. published the artcile< Synthesis, growth, structural, optical, spectral, thermal and mechanical studies of 4-methoxy 4-nitrostilbene (MONS): A new organic nonlinear optical single crystal>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is methoxy nitrostilbene optical nonlinear crystal synthesis; luminescence methoxy nitrostilbene optical nonlinear crystal synthesis; DTA methoxy nitrostilbene optical nonlinear crystal synthesis; thermogravimetry methoxy nitrostilbene optical nonlinear crystal synthesis; thermal analysis methoxy nitrostilbene optical nonlinear crystal synthesis; NMR methoxy nitrostilbene optical nonlinear crystal synthesis; UV visible spectra methoxy nitrostilbene optical nonlinear crystal synthesis; near IR spectra methoxy nitrostilbene optical nonlinear crystal synthesis; mid IR spectra methoxy nitrostilbene optical nonlinear crystal synthesis; XRD methoxy nitrostilbene optical nonlinear crystal synthesis; microhardness methoxy nitrostilbene optical nonlinear crystal synthesis; lattice parameter methoxy nitrostilbene optical nonlinear crystal synthesis; structure crystal methoxy nitrostilbene optical nonlinear synthesis; second harmonic generation nitrostilbene optical nonlinear crystal synthesis.

4-Methoxy 4-nitrostilbene (MONS), a new organic nonlinear optical material was synthesized. Based on the solubility data good quality single crystal with dimensions up to 38 × 11 × 3 mm3 was grown by slow evaporation method using Et Me ketone (MEK) as a solvent. Powder XRD confirms the crystalline property and also the diffraction planes were indexed. The lattice parameters for the grown MONS crystals were determined by using single crystal x-ray diffraction anal. and it reveals that the crystal lattice system is triclinic. The crystalline perfection of the grown crystals was analyzed by high resolution x-ray diffraction (HRXRD) rocking curve measurements. FTIR spectrum for powd. MONS sample confirms the functional groups present in the grown crystal. The UV-visible absorption spectrum was recorded at 190-1100 nm and the cut off wavelength 499 nm was determined The optical constants of MONS were determined through UV-visible-NIR spectroscopy. The MONS crystals were further subjected to other characterizations. i.e., 1H NMR, TG/DTA, photoluminescence and microhardness test. The Kurtz and Perry powder technique confirms the NLO property of the grown crystal and the SHG efficiency of MONS is 1.55× greater than that of KDP crystal.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Absorptivity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics