Month: October 2022

Khan, Ali; Pervaiz, Aini; Ansari, Bushra; Ullah, Riaz; Shah, Syed Muhammad Mukarram; Khan, Haroon; Saeed Jan, Muhammad; Hussain, Fida; Ijaz Khan, Mohammad; Albadrani, Ghadeer M.; Altyar, Ahmed E.; Abdel-Daim, Mohamed M. published the artcile< Phytochemical Profiling, Anti-Inflammatory, Anti-Oxidant and In-Silico Approach of Cornus macrophylla Bioss (Bark)>, Quality Control of 112-63-0, the main research area is Cornus macrophylla antiinflammatory antioxidant phytochem profiling; Cornus macrophylla; GC-MS; anti-inflammatory; antioxidant.

The objective of the current study was to evaluate the phytochem. and pharmacol. potential of the Cornus macrophylla. C. macrophylla belongs to the family Cornaceae. It is locally known as khadang and is used for the treatment of different diseases such as analgesic, tonic, diuretic, malaria, inflammation, allergy, infections, cancer, diabetes, and lipid peroxidative. The crude extract and different fractions of C. macrophyll were evaluated by gas chromatog. and mass spectroscopy (GC-MS), which identified the most potent bioactive phytochems. The antioxidant ability of C. macrophylla was studied by 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS) and 1,1 diphenyl-2-picryl-hydrazyl (DPPH) methods. The crude and subsequent fractions of the C. macrophylla were also tested against anti-inflammatory enzymes using COX-2 (Cyclooxygenase-2) and 5-LOX (5-lipoxygenase) assays. The mol. docking was carried out using mol. operating environment (MOE) software. The GC-MS study of C. macrophylla confirmed forty-eight compounds in Et acetate (Et.AC) fraction and revealed that the Et.AC fraction was the most active fraction. The antioxidant ability of the Et.AC fraction showed an IC50 values of 09.54μg/mL and 7.8μg/mL against ABTS and DPPH assay resp. Among all the fractions of C. macrophylla, Et.AC showed excellent activity against COX-2 and 5-LOX enzyme. The observed IC50 values were 93.35μg/mL against COX-2 and 75.64μg/mL for 5-LOX resp. Mol. docking studies supported these in vitro results and confirmed the anti-inflammatory potential of C. macrophylla. C. macrophylla has promising potential as a source for the development of new drugs against inflammation in the future.

Molecules published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rohrbacher, Florian; Zwicky, Andre; Bode, Jeffrey W. published the artcile< Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid-hydroxylamine (KAHA) ligation>, COA of Formula: C9H9NO4, the main research area is alphaketoacid hydroxylamine ligation antibacterial protein homoserine mutant.

An antibacterial cyclic AS-48 protein was chem. synthesized by α-ketoacid-hydroxylamine (KAHA) ligation. Initial challenges associated with the exceptionally hydrophobic segments arising from the amphiphilic nature of the protein were resolved by the development of bespoke reaction conditions for hydrophobic segments, using hexafluoroisopropanol (HFIP) as a co-solvent. The synthetic protein displays similar biol. activity and properties to those of the native protein. To support the current understanding of its antibacterial mode of action, we demonstrate the ability of AS-48 to be incorporated into synthetic multilamellar vesicles (MLVs).

Chemical Science published new progress about Antibacterial agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Biao; Chen, Wenjun; Zhao, Qiongli; Yu, Wenquan; Chang, Junbiao published the artcile< Synthesis of Functionalized Imidazolium Salts via Iodine-Mediated Annulations of Enamines>, SDS of cas: 94-02-0, the main research area is imidazolium salt preparation; enamine preparation annulation iodine.

A novel annulation reaction of two enamine mols. with iodine under basic conditions to form 4-functionalized imidazolium salts has been established. In this reaction, iodine acts as both an iodinating reagent and a Lewis acid catalyst. Features of this synthetic method include facilitative preparation of substrates, no use of transition metals, mild reaction conditions, simplicity of operation, and gram scale synthesis.

Organic Letters published new progress about Cyclization. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, SDS of cas: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Ning; Nagai, Atsushi; Jiang, Donglin published the artcile< Anthracene-based covalent organic frameworks and layer locking-and-unlocking driven by external stimuli>, Computed Properties of 112-63-0, the main research area is anthracene covalent organic framework locking driven stimuli.

Covalent organic frameworks (COFs) are an intriguing class of crystalline porous polymers, which allow the covalent integration of organic units into periodicity. Because of their high surface area, excellent thermal stability, and low densities, COFs have emerged as a new media for gas adsorption. We have synthesized various COFs with π electronic building blocks and developed light-emitting, semiconducting, photoconducting, and charge separating properties.

PMSE Preprints published new progress about Absorption spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohno, Osamu; Ye, Mao; Koyama, Tomoyuki; Yazawa, Kazunaga; Mura, Emi; Matsumoto, Hiroshi; Ichino, Takao; Yamada, Kaoru; Nakamura, Kazuhiko; Ohno, Tomohiro; Yamaguchi, Kohji; Ishida, Junji; Fukamizu, Akiyoshi; Uemura, Daisuke published the artcile< Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension>, SDS of cas: 112-63-0, the main research area is benzyl benzoate cinnamate derivative isolation preparation hypertension.

Hypertension is a lifestyle-related disease which often leads to serious conditions such as heart disease and cerebral hemorrhage. Angiotensin II (Ang II) plays an important role in regulating cardiovascular homeostasis. Consequently, antagonists that block the interaction of Ang II with its receptors are thought to be effective in the suppression of hypertension. In this study, we searched for plant compounds that had antagonist-like activity toward Ang II receptors. From among 435 plant samples, we found that EtOH extract from the resin of sweet gum Liquidambar styraciflua strongly inhibited Ang II signaling. We isolated benzyl benzoate and benzyl cinnamate from this extract and found that those compounds inhibited the function of Ang II in a dose-dependent manner without cytotoxicity. An in vivo study showed that benzyl benzoate significantly suppressed Ang II-induced hypertension in mice. In addition, we synthesized more than 40 derivatives of benzyl benzoate and found that the meta-Me and 3-methylbenzyl 2′-nitrobenzoate derivatives showed about 10-fold higher activity than benzyl benzoate itself. Thus, benzyl benzoate, its derivatives, and benzyl cinnamate may be useful for reducing hypertension.

Bioorganic & Medicinal Chemistry published new progress about Angiotensin AT1 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Baobei; Pan, Xueshan; Wang, Fang; Liu, Lulu; Jia, Jing published the artcile< Photoprotective carbon redistribution in mixotrophic Haematococcus pluvialis under high light stress>, HPLC of Formula: 112-63-0, the main research area is Haematococcus high light stress photoprotective carbon redistribution; Astaxanthin biosynthesis; Differential proteomics; Photorespiration; Photosynthetic apparatus; Regulatory mechanisms.

Mixotrophy of Haematococcus pluvialis is a potential strategy for producing astaxanthin. However, this strategy has not been extensively commercialized because the mixotrophic mechanisms by which H. pluvialis overcomes high light stress are unclear. This study analyzed the biochem. compositions and differential proteomics of mixotrophic H. pluvialis under different light conditions. High light exposure substantially increased astaxanthin, carbohydrate, and fatty acid contents. A total of 119 and 81 proteins were significantly up- and down-regulated after two days of high light exposure. These proteins mainly enriched pathways for photosynthetic metabolism, glyoxylate cycle, and biosynthesis of secondary metabolites. This study proposed a regulatory model through which mixotrophic H. pluvialis copes with high light stress. The model includes pathways for modulating photosynthetic apparatus, increasing astaxanthin accumulation by enhancing photorespiration, pentose phosphate and Embden-Meyerhof-Parna pathways, while thickening the cell wall by malate-oxaloacetate shuttle.

Bioresource Technology published new progress about Antioxidant enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tom, Martin C; Milano, Michael T; Chao, Samuel T; Soltys, Scott G; Knisely, Jonathan P S; Sahgal, Arjun; Nagpal, Seema; Lo, Simon S; Jabbari, Siavash; Wang, Tony J C; Ahluwalia, Manmeet S; Simonson, Marian; Palmer, Joshua D; Gephart, Melanie Hayden; Halasz, Lia M; Garg, Amit K; Chiang, Veronica L S; Chang, Eric L published the artcile< Executive summary of American Radium Society's appropriate use criteria for the postoperative management of lower grade gliomas.>, SDS of cas: 112-63-0, the main research area is Anaplastic glioma; Grade 2 glioma; Grade 3 glioma; Guidelines; Low grade glioma; Lower grade glioma.

Postoperative management of lower grade gliomas (grade 2 and 3) is heterogeneous. The American Radium Society’s brain malignancies panel systematically reviewed and evaluated the literature to develop consensus guidelines addressing timing of postoperative therapy, monotherapy versus combined modality therapy, type of chemotherapy used with radiotherapy, and radiotherapy dose. Thirty-six studies were included. Using consensus methodology (modified Delphi), the panel voted upon representative case variants using a 9-point appropriateness scale to address key questions. Voting results were collated to develop summarized recommendations. Following gross-total surgical resection, close surveillance is appropriate for well-selected grade 2, IDH-mutant oligodendrogliomas or astrocytomas with low-risk features. For grade 2 gliomas with high-risk features or any grade 3 glioma, immediate adjuvant therapy is recommended. When postoperative therapy is administered, radiation and planned chemotherapy is strongly recommended over monotherapy. For grade 2 and 3 IDH-mutant oligodendrogliomas and astrocytomas, either adjunctive PCV (procarbazine, lomustine, vincristine) or temozolomide is appropriate. For grade 3 IDH-mutant astrocytomas, radiotherapy followed by temozolomide is strongly recommended. The recommended radiotherapy dose for grade 2 gliomas is 45-54 Gy/1.8-2.0 Gy, and for grade 3 gliomas is 59.4-60 Gy/1.8-2.0 Gy. While multiple appropriate treatment options exist, these consensus recommendations provide an evidence-based framework to approach postoperative management of lower grade gliomas.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xingmei; Dang, Limin; Yang, Hai; Huang, Xianwei; Yu, Xinliang published the artcile< Machine learning-based prediction of toxicity of organic compounds towards fathead minnow>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is SAR Pimephales promelas organic compound toxicity machine learning.

Predicting the acute toxicity of a large dataset of diverse chems. against fathead minnows (Pimephales promelas) is challenging. In this paper, 963 organic compounds with acute toxicity towards fathead minnows were split into a training set (482 compounds) and a test set (481 compounds) with an approx. ratio of 1 : 1. Only six mol. descriptors were used to establish the quant. structure-activity/toxicity relationship (QSAR/QSTR) model for 96 h pLC50 through a support vector machine (SVM) along with genetic algorithm. The optimal SVM model (R2 = 0.756) was verified using both internal (leave-one-out cross-validation) and external validations. The validation results (qint2 = 0.699 and qext2 = 0.744) were satisfactory in predicting acute toxicity in fathead minnows compared with other models reported in the literature, although our SVM model has only six mol. descriptors and a large data set for the test set consisting of 481 compounds

RSC Advances published new progress about Genetic algorithm. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baltina, Lidia; Sapozhnikova, Tatyana; Makara, Nina; Gabdrakhmanova, Svetlana; Baltina, Lia; Kondratenko, Rimma published the artcile< Paeoniflorin benzoates: synthesis and influence on learning and memory of aged rats in the passive avoidance task>, Application In Synthesis of 112-63-0, the main research area is paeoniflorin benzoate preparation learning memory age Alzheimer’s; Paeoniflorin; benzoates; passive avoidance task; rats.

Paeoniflorin per-O-benzoates with the preserved pinane structure and rearranged aglycon , containing C4 = O function, were obtained and their influence on learning and memory of aged rats was studied in the passive avoidance task. It was found that the chem. modification of paeoniflorin affected the cognitive functions of aged rats. The introduction of C4 = O function into the pinane part of benzoate led to the improvement in learning process and preservation of the memory trace in aged rats as compared to the natural glycoside. This compound can be considered as the promising for further studies on in vivo models of disorders characteristic for Alzheimer’s disease.

Natural Product Research published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koenig, W. A. published the artcile< Collection of enantiomeric separation factors obtained by capillary gas chromatography on chiral stationary phases>, Category: esters-buliding-blocks, the main research area is capillary gas chromatog enantiomer separation factor; cyclodextrin chiral derivative gas chromatog resolution.

Capillary gas chromatog. enantiomeric separation factors, column length, and temperature are tabulated for 295 racemates on the chiral stationary phase octakis(3-O-butyryl-2,6-di-O-pentyl)-γ-cyclodextrin (Lipodex E). The major classes of compounds included: alcs., ketones, carboxylic acids, lactones, hydroxy carboxylic acids, amino acids, and sulfoxides. The racemates were chromatographed either in underivatized form, trifluoroacetates or acetates (many alcs.), Me or Et esters (many carboxylic acids), N-trifluoroacetyl derivatives (amino acids), N-alkoxycarbonyl derivatives (histidine), or containing a combination of these derivatizing groups.

Journal of High Resolution Chromatography published new progress about Alcohols Role: PUR (Purification or Recovery), RCT (Reactant), PREP (Preparation), RACT (Reactant or Reagent). 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics