Month: October 2022

Sharif, Mariam; Anjum, Irfan; Shabbir, Arham; Mushtaq, Muhammad Naveed published the artcile< Anti-asthmatic effect of Juglans regia Linn. in mice>, Application of C19H34O2, the main research area is Juglans allergic asthma antiasthmatic phytochems.

Plants are considered as an essential source to treat different diseases. In traditional system of medicine, Juglans regia (J. regia) has been used in curing sinusitis and cough. The aim of the present study was to evaluate the anti-asthmatic activity of J. regia in ovalbumin-induced allergic asthmatic BALB/c mice. The mice were sensitized i.p. and subsequently challenged with ovalbumin (intranasal) to induce allergic asthma. Mice were treated with methanolic, n-hexane and Et acetate extracts of J. regia and methylprednisolone for 7 consecutive days, along with intranasal challenge. The total and differential leukocyte counts in blood, bronchoalveolar lavage fluid (balf) and lung wet/dry ratio were determined GC-MS anal. was also performed. The results showed that Et acetate extract of J. regia significantly reduced inflammatory cells count in both blood and balf more significantly. Lung wet/dry weight ratio was reduced in asthmatic mice treated with the different extracts of J. regia. Serum IgE antibodies level was also significantly decreased in extracts treated groups. GC-MS anal. of all three extracts of J. regia showed the presence of various phytochems. responsible for its anti-inflammatory and anti-asthmatic activity. The results of the present study validated the traditional use of J. regia in respiratory disorders like asthma and sinusitis.

Pakistan Journal of Pharmaceutical Sciences published new progress about Allergic asthma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diaz-Sanchez, Blanca R.; Iglesias-Arteaga, Martin A.; Melgar-Fernandez, Roberto; Juaristi, Eusebio published the artcile< Synthesis of 2-Substituted-5-halo-2,3-dihydro-4(H)-pyrimidin-4-ones and Their Derivatization Utilizing the Sonogashira Coupling Reaction in the Enantioselective Synthesis of α-Substituted β-Amino Acids>, Formula: C19H34O2, the main research area is pyrimidinone dihydro derivative preparation enantioselective conversion beta amino acid; crystal structure dihydropyrimidinone; mol structure dihydropyrimidinone.

A convenient, one-pot procedure for the synthesis of 1-benzoyl-2(S)-substituted-5-iodo-2,3-dihydropyrimidin-4(1H)-ones by tandem decarboxylation/β-iodination of the corresponding 6-carboxy-perhydropyrimidin-4-ones was developed. Several 1-benzoyl-2(S)-substituted-5-bromo-2,3-dihydropyrimidin-4(1H)-ones were readily prepared by bromination of 1-benzoyl-2(S)-substituted-2,3-dihydropyrimidin-4(1H)-ones. Subsequently, Sonogashira coupling of the halogenated heterocyclic enones with various terminal alkynes produced 1-benzoyl-2(S)-isopropyl-5-alkynyl-2,3-dihydropyrimidin-4(1H)-ones in good yields. Hydrogenation of the unsaturated C-C moieties in a Sonogashira product followed by acid hydrolysis afforded a highly enantioenriched α-substituted β-amino acid (S)-2-(aminomethyl)-4-phenylbutanoic acid. The crystal and mol. structures of 1-benzoyl-2(S)-phenyl-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-bromo-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-phenylethynyl-2,3-dihydropyrimidin-4(1H)-one were determined by x-ray crystallog.

Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zou, Ying; Fahmi, Nour Eddine; Vialas, Corine; Miller, Guy M.; Hecht, Sidney M. published the artcile< Total Synthesis of Deamido Bleomycin A2, the Major Catabolite of the Antitumor Agent Bleomycin>, Formula: C12H24N2O4, the main research area is deamido bleomycin A2 total synthesis; demethyl deamido bleomycin A2 total synthesis; aglycon deamido bleomycin A2 total synthesis; DNA relaxation cleavage deamido bleomycin A2.

This work describes the synthesis of deamido-demethyl-bleomycin A2, I (R = SMe) and deamido-bleomycin A2, I (R = SMe2), as well as their resp. aglycons. Amino ester II was the key intermediate for I. Synthetic deamido-bleomycin A2 was shown to be identical to the product formed by treatment of bleomycin A2 (BLM-A2) with bleomycin hydrolase, as judged by reversed-phase HPLC anal. and 1H NMR spectroscopy. Deamido-bleomycin A2 was found to retain significant DNA cleavage activity in DNA plasmid relaxation assays and had the same sequence selectivity of DNA cleavage as bleomycin A2. The most significant alteration of function noted in this study was a reduction in the ability of deamido-bleomycin A2 to mediate double-strand DNA cleavage, relative to that produced by BLM-A2.

Journal of the American Chemical Society published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Formula: C12H24N2O4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Jianqiang; Gu, Wenjing; Ma, Ning; Fan, Xiaoye; Ci, Xinxin published the artcile< Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway>, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is leonurine cisplatin ferroptosis acute kidney injury Nrf signalling pathway; Nrf2; cisplatin-induced acute kidney injury; ferroptosis; leonurine.

Evidence indicates that ferroptosis plays a key role in acute kidney injury induced by cisplatin. The Nrf2/NRF2 pathway regulates oxidative stress, lipid peroxidation and pos. regulates cisplatin-induced acute kidney injury, but its effect along with the alkaloid leonurine, found in motherwort, on ferroptosis after such acute kidney injury remains unclear. The anti-ferroptotic effects of Nrf2 and leonurine were assessed in a mouse model of cisplatin-induced acute kidney injury. In vitro, the effects of leonurine on erastin- and RSL3-induced HK-2 human PTEC ferroptosis were examined Nrf2 deletion induced ferroptosis-related protein expression and iron accumulation in vivo, aggravating cisplatin-induced acute kidney injury. Leonurine activated Nrf2 and prevented iron accumulation, lipid peroxidation and ferroptosis in vitro, being abolished in siNrf2-treated cells. Moreover, leonurine potently inhibited cisplatin-induced renal damage, as assessed by of serum creatinine, blood urea nitrogen, kidney injury mol.-1 and NGAL. Importantly, leonurine activated the Nrf2 antioxidative pathway and preventing changes in ferroptosis-related morphol. and biochem. indicators, malondialdehyde level, SOD and GSH depletion, and GPX4 and xCT down-regulation, in cisplatin-induced acute kidney injury. Nrf2 KO mice were more susceptible to ferroptosis after cisplatin-induced acute kidney injury than control mice. The protective effects of leonurine on acute kidney injury and ferroptosis were largely abolished in Nrf2 KO mice. These data suggest that renal protective effects of Nrf2 activation on cisplatin-induced acute kidney injury are achieved, at least partially, by inhibiting lipid peroxide-mediated ferroptosis, highlighting the potential of leonurine in acute kidney injury treatment.

British Journal of Pharmacology published new progress about Acute kidney injury. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Recommanded Product: Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Xiaoliang; Yan, Dayun; Lin, Li; Sherman, Jonathan H.; Peters, Katherine B.; Keir, Stephen T.; Keidar, Michael published the artcile< Cold Plasma Discharge Tube Enhances Antitumoral Efficacy of Temozolomide>, Computed Properties of 112-63-0, the main research area is temozolomide plasma discharge tube antitumor glioblastoma drug sensitization; Temozolomide; antitumor; drug-sensitization; glioblastoma; plasma discharge tube.

Glioblastoma (GBM) is a fatal human brain tumor with a low survival rate. Temozolomide (TMZ) has been widely used in GBM therapy with noticeable side effects. Cold plasma is an ionized gas that is generated near room temperature Here, we demonstrated the enhancement therapeutic efficacy of TMZ via using a cold plasma source based on nonequilibrium plasma in a sealed glass tube, named a radial cold plasma discharge tube (PDT). The PDT affected glioblastoma cells’ function just by its electromagnetic (EM) emission rather than any chem. factors in the plasma. The PDT selectively increased the cytotoxicity of TMZ on two typical glioblastoma cell lines, U87MG and A172, compared with normal astrocyte cell line hTERT/E6/E7 to some extent. Furthermore, on the basis of a patient-derived xenograft model, our preliminary in vivo studies demonstrated the drastically improved mean survival days of the tumor-barrier mice by more than 100% compared to control. The PDT is not only independent of continuous helium supply but is also capable of resisting the interference of environmental changes. Thus, the PDT was a stable and low-cost cold atm. plasma source. In short, this study is the first to demonstrate the promising application of PDTs in GBM therapy as a noninvasive and portable modality.

ACS Applied Bio Materials published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weng, Wei-Zhao; Gao, Yin-He; Zhang, Xue; Liu, Yan-Hua; Shen, Ying-Jie; Zhu, Yan-Ping; Sun, Yuan-Yuan; Meng, Qing-Guo; Wu, An-Xin published the artcile< Oxidative C(sp3)-H functionalization of methyl-azaheteroarenes: a facile route to 1,2,4-triazolo[4,3-a]pyridines>, Electric Literature of 112-63-0, the main research area is triazolopyridine quinoline preparation; quinoline hydrazinyl pyridine oxidative cyclization.

An oxidative [4 + 1] annulation used to prepare 1,2,4-triazolo[4,3-a]pyridines e.g., I in the presence of I2-DMSO were described. This protocol enables synthesis of triazolo[4,3-a]pyridine-quinoline linked diheterocycles I via a direct oxidative functionalization of sp3 C-H bonds of 2-methyl-azaheteroarenes e.g., 2-methylquinoline. The reaction shows a wide substrate scope and good functional group tolerance.

Organic & Biomolecular Chemistry published new progress about C-H bond activation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joshi, Balawant S.; Viswanathan, Narayanan; Gawad, Dilip H.; Von Philipsborn, Wolfgang published the artcile< Carbon-13 NMR spectroscopy. 7. Piperaceae alkaloids. I. Structure of piperstachine. Carbon-13 and proton NMR studies>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Piper alkaloid piperstachine; NMR piperstachine; piperstachine structure; hexahydropiperstachine.

The structure of piperstachine (I), a new alkaloid from the stem of Piper trichostachyon C. DC, was determined based on its spectral data and the synthesis of hexahydropiperstachine (II).

Helvetica Chimica Acta published new progress about Alkaloids Role: PRP (Properties). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dutta, A. K.; Ryan, W.; Thomas, B. F.; Singer, M.; Compton, D. R.; Martin, B. R.; Razdan, R. K. published the artcile< Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)>, COA of Formula: C19H34O2, the main research area is alkyloxy indole derivative preparation cannabimimetic structure.

Several novel 4-alkyloxy-aminoalkyl indole derivatives I (R = H, alkyl or alkylnaphthyl) were synthesized from 4-benzyloxyindole. Alkylation of 4-benzyloxyindole with 4-(2-chloroethyl)morpholine (NaH/HMPA) formed 4-benzyloxy-1-[2-(4-morpholinyl)ethyl]-1H-indole. Deprotection using palladium hydroxide on carbon/hydrogen followed by alkylation with the appropriate alkyl bromide gave the target compounds In the synthesis of two of the derivatives, the appropriate alkyl bromides were prepared from the com. available 1-naphthylethyl bromide using the chain lengthening sequences. In receptor binding assay and in vivo testing, the long chain alkoxy compounds (Ki = 127 nM) showed affinity for the CB1 receptor which was approx. 16-35-fold less than that of WIN 55,225. However, the pharmacol. profile of one of the derivatives mimics that of WIN 55,212. An examination of the SAR of these analogs shows that translocating the naphthyl group in AAIs from the C-3 position to C-4 via an oxygen (ether linkage) decreases activity which is in contrast to previous findings that a naphthylcarbonyl at C-4 retains activity. The present work points to the importance of the role of a keto group in the interaction with the receptor. Mol. modeling work suggests that, although reasonable superposition of key structural features between Δ9-THC and AAIs can be made, the overlay is not straightforward. The present study also illustrates the difficulty in accommodating AAIs into the cannabinoid pharmacophore and it seems likely that a unique pharmacophore will need to be developed. Only then will the similarities to and differences from the classical cannabinoid pharmacophore be clearly delineated.

Bioorganic & Medicinal Chemistry published new progress about Cannabinoid receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Miao; Luo, Zhao-Xiang; Li, Tian; Xiong, De-Cai; Ye, Xin-Shan published the artcile< Electrochemical Trifluoromethylation of Glycals>, Name: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is protective group fluoromethylation glycal catalyst electrochem redox.

Carbohydrates play essential roles in various physiol. and pathol. processes. Trifluoromethylated compounds have wide applications in the field of medicinal chem. Herein, we report a practical and efficient trifluoromethylation of glycals by an electrochem. approach using CF3SO2Na as the trifluoromethyl source and MnBr2 as the redox mediator. A variety of trifluoromethylated glycals bearing different protective groups are obtained in 60-90% yields with high regioselectivity. The successful capture of a CF3 radical indicates that a radical mechanism is involved in this reaction.

Journal of Organic Chemistry published new progress about Glycals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Name: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crosby, John; Moilliet, Jock; Parratt, Julian S.; Turner, Nicholas J. published the artcile< Regioselective hydrolysis of aromatic dinitriles using a whole cell catalyst>, HPLC of Formula: 112-63-0, the main research area is regioselective hydrolysis aromatic dinitrile biochem catalyst; whole cell catalyst hydrolysis aromatic dinitrile.

A series of aromatic dinitriles have been examined as substrates for an immobilized whole cell Rhodococcus sp. that catalyzes the hydrolysis of nitriles to amides and/or carboxylic acids. The fluorinated aromatic dinitriles were regioselectivity hydrolyzed to the corresponding cyano amides whereas the non-fluorinated analogs were converted to cyano acids but with poorer regioselectivity.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Brevibacterium Role: CAT (Catalyst Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics