Month: October 2022

Sui, Meng; Chen, Yong; Li, Fashe; Wang, Wenchao; Shen, Jiaxu published the artcile< Study on the mechanism of auto-oxidation of Jatropha biodiesel and the oxidative cleavage of C-C bond>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biodiesel methyl linoleate hexanal oxidation Jatropha.

Jatropha biodiesel was obtained according to the continuous preparation process which included vapor esterification – transesterification – methanol steam distillation Accelerated oxidation of small Jatropha biodiesel was obtained by the Rancimat method. GC-MS and liquid phase micro-extraction were used to study and analyze the components in the oxidation process of Jatropha curcas biodiesel. The electronic effects of the related reactants and products were calculated by d. functional theory, followed by the deduction of the related chem. reaction paths. Exptl. investigation shows that Me linoleate is the main factor affecting the oxidation stability of the Jatropha biodiesel. The main volatile products at the initial stages of the oxidation of Me linoleate are hexanal, Me octanoate, styrene, and 2-heptenal. The cis/trans-3-octyl-oxiranyl octanoic acid Me ester (18.03% yield) is produced by the reaction of peroxy acid and Me oleate during the oxidation of Me oleate. The hydrogen extraction reaction is difficult to occur, and the oxidation reaction energy barrier is relatively high due to the relatively large bond energy of the C-H bond in the Me stearate mol. In this manuscript, the auto-oxidation mechanism of the biodiesel fatty acid Me esters at the initial stage of oxidation, the path of oxidative cleavage of the C-C bond of Jatropha biodiesel and the formation process of ethylene oxide structure are obtained through DFT calculation and anal. of the oxidation products.

Fuel published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Jun; Zhu, Shengqing; Wang, Fang; Qing, Feng-Ling; Chu, Lingling published the artcile< Silver-Enabled General Radical Difluoromethylation Reaction with TMSCF2H>, Computed Properties of 151259-38-0, the main research area is silver mediated oxidative difluoromethylation styrene vinyl trifluoroborate TMSCF2H; regioselective synthesis; alkenes; difluoromethylation; heteroarenes; radical fluoroalkylation; silver.

A silver-mediated oxidative difluoromethylation of styrenes and vinyl trifluoroborates with TMSCF2H is reported for the first time. This method enables direct and facile access to CF2H-alkenes from abundant alkenes with excellent functional-group compatibility. Moreover, this Ag/TMSCF2H protocol could further enable a series of radical difluoromethylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CF2H bonds.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151259-38-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H19NO2, Computed Properties of 151259-38-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xiaoqin; Zhu, Derong; He, Minghua published the artcile< Study on synthesis of drug intermediates (S)-3-hydroxytetrahydrofuran>, Computed Properties of 617-55-0, the main research area is hydroxytetrahydrofuran synthesis malic acid drug intermediate esterification reduction cyclization.

(S)-3-hydroxytetrahydrofuran was synthesized from L-malic acid by esterification, reduction, and cyclization. The chem. structure of the target compound was identified by element anal., IR, NMR and MS spectra. The total yield and the purity of the product were 41% and 99.2%, and the optical purity was 95.8%. This optimal synthetic procedure with lower cost and mild reaction conditions is worthy to have a further pilot manufacture

Huaxue Yanjiu Yu Yingyong published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Computed Properties of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Lyu; Chen, Yanlu; Lin, Leyu; Schlarb, Alois K.; Li, Yue; Shi, Xinyan published the artcile< Architecture of covalent bonds between filament layers to enhance performance of 3D printing biodegradable polymer blends>, Synthetic Route of 112-63-0, the main research area is biodegradable polymer blend three dimensional printing covalent bond filament.

Generally, the filament layer adhesion in articles 3D printed by Fused Deposition Modeling (FDM, one of 3D printing method) is completely provided by the diffusion and entanglement of mol. chains between adjacent layers. However, the poor layer adhesion and strong anisotropy in FDM due to the difficult movement of polymer chains and the complex thermal history during 3D printing have turned to be the main factors restricting the development of FDM. In this paper, poly (lactic acid)/poly (butylene adipate terephthalate)/poly (lactic acid) grafted glycidyl methacrylate biodegradable blend (PLA/PBAT/PLA-g-GMA, PLA-g-GMA was a self-made compatibilizer) was used as the matrix. A low mol. weight three-armed PLA (noted as U-PLA) was synthesized by ring opening polymerization of lactide which was initiated by trimethylolpropane (TMP) and end capping with double bonds. Then, U-PLA and phenylbis (2,4,6-trimethylbenzoyl) phosphine oxide (XBPO) was added in the matrix. The rheol. results found that U-PLA acted as a low mol. weight plasticizer to promote the fluidity of the matrix during 3D printing process. On the other hand, compared with polymer chains in matrix, U-PLA was more prone to cross interlayer motion, resulting in stronger phys. entanglements. With UV irradiation, XBPO was triggered to release free radicals and initiated crosslinking at terminal double bonds of U-PLA which rich concentrated between adjacent layers. Mol. dynamics and exptl. results showed that with increase of U-PLA, the interlayer bonding strength of FDM specimens increased significantly. The maximum tensile strength of 3D printing specimens increased by 82.5% (printing direction at 90°). This work clearly showed that with UV irradiation covalent bonds were successfully architected between filament layers of FDM specimens.

Polymer Testing published new progress about Biodegradable plastics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Tengteng; Lv, Shujie; Zhang, Wei; Tang, Yanan; Chang, Hong; Hu, Zihan; Fang, Liang; Du, Jiaojiao; Wu, Sifan; Yang, Xinli; Guo, Yangfu; Guo, Ruihan; Ge, Zongrui; Wang, Lei; Zhang, Caiyun; Wang, Rulin; Chen, Weidong published the artcile< PF-PLC micelles ameliorate cholestatic liver injury via regulating TLR4/MyD88/NF-κB and PXR/CAR/UGT1A1 signaling pathways in EE-induced rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is 17α-ethynylestradiol; CAR; Cholestasis liver injury; MyD88; NF-κB pathway; PF-PLC micelles; PXR; TLR4; UGT1A1.

Paeoniflorin (PF) has a certain therapeutic effect on cholestasis liver injury. To further improve the bioavailability of PF and play its pharmacol. role in liver protection, PF-phospholipid complex micelles (PF-PLC micelles) were prepared based on our previous research on PF-PLC. The protective effects of PF and PF-PLC micelles on cholestasis liver injury induced by 17α-ethynylestradiol (EE) were compared, and the possible mechanisms were further explored. Herein, we showed that PF-PLC micelles effectively improved liver function, alleviated liver pathol. damage, and localized infiltration of inflammatory cells. Mechanism studies indicated that PF-PLC micelles treatment could suppress the TLR4/MyD88/NF-κB pathway, and further reduce the levels of pro-inflammatory factors. Meanwhile, our exptl. results demonstrated that the beneficial effect of PF-PLC micelles on EE-induced cholestasis may be achieved by the upregulation of nuclear receptors and metabolic enzymes (PXR/CAR/UGT1A1). All these results indicate that PF-PLC micelles have great potential in the treatment of cholestatic liver disease.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kubisch, Christin; Ochsenreither, Katrin published the artcile< Valorization of a Pyrolytic Aqueous Condensate and Its Main Components for L-Malic Acid Production with Aspergillus oryzae DSM 1863>, Application In Synthesis of 112-63-0, the main research area is Aspergillus malic acid valorization pyrolytic aqueous condensate.

Pyrolytic aqueous condensate (PAC) might serve as a cost-effective substrate for microbial malic acid production, as it is an unused side stream of the fast pyrolysis of lignocellulosic biomass that contains acetol and acetate as potential carbon sources. In the present study, shake flask cultures were performed to evaluate the suitability of acetol and its combination with acetate as substrates for growth and L-malate production with the filamentous fungus Aspergillus oryzae. Acetol concentrations of up to 40 g/L were shown to be utilized for fungal growth. In combination with acetate, co-metabolization of both substrates for biomass and malate formation was observed, although the maximum tolerated acetol concentration decreased to 20 g/L. Furthermore, malate production on PAC detoxified by a combination of rotary evaporation, overliming and activated carbon treatment was studied. In shake flasks, cultivation using 100% PAC resulted in the production of 3.37 ± 0.61 g/L malate, which was considerably improved by pH adjustment up to 9.77 ± 0.55 g/L. A successful scale-up to 0.5-L bioreactors was conducted, achieving comparable yields and productivities to the shake flask cultures. Accordingly, fungal malate production using PAC was successfully demonstrated, paving the way for a bio-based production of the acid.

Fermentation published new progress about Aspergillus oryzae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Ning; Ding, Xuesong; Kim, Jangbae; Ihee, Hyotcherl; Jiang, Donglin published the artcile< A Photoresponsive Smart Covalent Organic Framework>, Related Products of 112-63-0, the main research area is anthracene covalent organic framework photoinduced cycloaddition reaction; anthracene; covalent organic frameworks; photoresponsive materials; porous polymer; smart materials.

Ordered π-columnar structures found in covalent organic frameworks (COFs) render them attractive as smart materials. However, external-stimuli-responsive COFs have not been explored. Here we report the design and synthesis of a photoresponsive COF with anthracene units as the photoresponsive π-building blocks. The COF is switchable upon photoirradiation to yield a concavo-convex polygon skeleton through the interlayer [4π+4π] cycloaddition of anthracene units stacked in the π-columns. This cycloaddition reaction is thermally reversible; heating resets the anthracene layers and regenerates the COF. These external-stimuli-induced structural transformations are accompanied by profound changes in properties, including gas adsorption, π-electronic function, and luminescence. The results suggest that COFs are useful for designing smart porous materials with properties that are controllable by external stimuli.

Angewandte Chemie, International Edition published new progress about Covalent organic frameworks. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Kenji; Takaishi, Hideo published the artcile< Synthetic microbial chemistry. XXII. Synthesis of monocerin, an antifungal, insecticidal and phytotoxic heptaketide metabolite of Exserohilum monoceras>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is monocerin total synthesis.

Both the naturally occurring enantiomer I and the racemate of monocerin were synthesized for the first time.

Tetrahedron published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Le Marechal, Jean-Francois published the artcile< Bromination of alkenes: between chemical and pedagogical improvements>, Electric Literature of 112-63-0, the main research area is bromination alkene pedagogical.

The bromination of stilbene is used to illustrate some chem. concepts that are difficult for student comprehension. The mechanism of trans-stilbene bromination by pyridinium tribromide is compared to that by bromine. The solvent effect on the reaction stereochem. is also discussed. The use of binary phase diagrams is used to discuss the racemate of the reaction products.

BUP published new progress about Alkenes Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Minghe; Li, Lin; Huang, Ming; Tan, Yao; Shang, Ye; Meng, Xianghui; Pang, Yafen; Xu, Hong; Zhao, Xin; Lei, Wei; Chang, Yanxu; Wang, Yi; Zhang, Deqin; Zhang, Boli; Li, Yuhong published the artcile< Sanye tablet ameliorates insulin resistance and dysregulated lipid metabolism in high-fat diet-induced obese mice>, Application In Synthesis of 112-63-0, the main research area is Sanye tablet insulin lipid metabolism lipidomics proteomics; HFD; SYT; insulin resistance; lipidomics; proteomics.

Sanye Tablet (SYT) is a patent prescription widely used in treating T2D and pre-diabetes, especially T2D comorbid with hypertriglyceridemia, for many years in China. However, the underlying mechanism that accounts for the anti-diabetic potential of SYT by regulating lipid-related intermediates remains to be elucidated. This study aimed to investigate the mechanism of SYT on lipid metabolism and insulin sensitivity in high-fat diet (HFD)-induced obese mice by means of combining lipidomics and proteomics. The obese mice models were developed via HFD feeding for 20 consecutive weeks. Mice in the treatment group were given metformin and SYT resp., and the effects of SYT on body weight, blood glucose, insulin sensitivity, fat accumulation in the organs, and pathol. changes in the liver were monitored. Lipid metabolism was examined by lipidomics. Further determination of signaling pathways was detected by proteomics. The biol. contributions of the compounds detected in SYT′s chem. fingerprint were predicted by network pharmacol. SYT treatment reduced body weight, inhibited viscera and hepatic steatosis lipid accumulation, and prevented insulin resistance. Furthermore, it was found that circulatory inflammatory cytokines were reduced by SYT treatment. In addition, lipidomics anal. indicated that SYT targets lipid intermediates, including diacylglycerol (DAG) and Ceramide (Cer). Mechanistically, SYT pos. affected these lipid intermediates by suppressing liver lipogenesis via downregulation of SREBP1/ACC and the JAK/STAT signaling pathway. Our results predicted that astragalin and rosmarinic acid might regulate the JAK-STAT pathway by targeting PIM2 and STAT1, resp., while paeoniflorin and rosmarinic acid were likely to regulate inflammatory responses by targeting TNFα, IL-6, and IL-4 during T2D. Overall, our study provides supportive evidence for the mechanism of SYT′s therapeutic effect on dysregulated lipid metabolism in diabesity.

Frontiers in Pharmacology published new progress about Antiinflammatory cytokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics