Month: October 2022

Skupinska, Krystyna A.; McEachern, Ernest J.; Skerlj, Renato T.; Bridger, Gary J. published the artcile< Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines>, Reference of 112-63-0, the main research area is aminotetrahydroquinoline aminotetrahydroisoquinoline preparation; hydrogenation acetamidoquinoline acetamidoisoquinoline; hydrolysis acetamidotetrahydroquinoline; regioselective reduction quinoline derivative.

A method to prepare amino-substituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of the corresponding acetamido-substituted quinolines and isoquinolines followed by acetamide hydrolysis is described. The yields of the products are good when the acetamido substituent is present on the pyridine ring and moderate with the acetamido substituent on the benzene ring. This method has also been applied to the regioselective reduction of quinoline substrates bearing other substituents (R = OMe, CO2Me, Ph).

Journal of Organic Chemistry published new progress about Hydrogenation, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rice, Scott; Cox, Daniel J.; Marsden, Stephen P.; Nelson, Adam published the artcile< Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating 'stitching' annulation approach>, Synthetic Route of 61367-16-6, the main research area is polycyclic compound preparation regioselective diastereoselective; amine arylation cyclization.

Regioselective and stereospecific directed C-H arylation of simple amine substrates e.g., exo-2-aminonorbornane, and cyclisation, delivered three-dimensional scaffolds e.g., (1R,3aR,4R,10bS)-2,3,3a,4,5,10b-hexahydro-1,4-methanobenzo[c]cyclopenta[e]azepin-6(1H)-one. The unified approach significantly expanded the range of bridged ring systems that contain both a nitrogen atom and an aromatic ring.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 61367-16-6 belongs to class esters-buliding-blocks, and the molecular formula is C8H16ClNO2, Synthetic Route of 61367-16-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewinski, Piotr; Kaluzynski, Krzysztof; Pretula, Julia; Mielniczak, Grazyna; Penczek, Stanislaw published the artcile< Catalysis in polymerization of cyclic esters. Catalyst and initiator in one molecule. Polymerization of lactide>, Related Products of 112-63-0, the main research area is lactide ring opening polymerization catalyst.

Poly(L-lactide) (PLA) was synthesized with initiator and catalyst in one mol. (CINICAT): 5-ethyl-2-hydroxy-5-hydroxymethyl-1,3,2-dioxaphosphorinane-2-oxide (GM). Polymerizations were conducted at the relatively high temperature (170-190°C) because of the low basicity of LA. Nevertheless, the studied processes were found to be living/controlled, no side reactions were determined and only PLA with fragments of GM as the end-groups were detected. PLA with Mn up to ∼40·103 g/mol. Kinetic studies indicated second order dependence of the rate of polymerization on the initial concentration of the CINICAT. This result is suggesting activation of the monomer and propagation with two independent macromols.

Journal of Catalysis published new progress about Cationic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babichev, F. S.; Patratii, V. K.; Kovtunenko, V. A.; Prodanchuk, N. G.; Sinchenko, V. G.; Kisel, V. M. published the artcile< Synthesis and antimicrobial activity of 2-aryl-1,4-dihydroisoquinoline-3-imines>, Formula: C19H34O2, the main research area is bactericide aryldihydroisoquinoline imine derivative; fungicide aryldihydroisoquinoline imine derivative; antimicrobial aryldihydroisoquinoline imine derivative.

Reaction of o-(bromomethyl)phenylacetonitrile with aromatic amines gave rise to a number of hydrobromides of 2-aryl-1,4-dihydroisoquinoline-3-imines that were tested for their antimicrobial activity. The structure-activity relationship of the synthesized compounds is discussed.

Khimiko-Farmatsevticheskii Zhurnal published new progress about Fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Xiaohui; Kim, Yong-Jae; Lai, SuJen; Chen, Xi; Lizarzaburu, Mike; Turcotte, Simon; Fu, Zice; Liu, Qingxiang; Zhang, Ying; Motani, Alykhan; Oda, Kozo; Okuyama, Ryo; Nara, Futoshi; Murakoshi, Michiko; Fu, Angela; Reagan, Jeff D.; Fan, Peter; Xiong, Yumei; Shen, Wang; Li, Leping; Houze, Jonathan; Medina, Julio C. published the artcile< Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phenylalanine derivative preparation GPR142 agonists NIDDM diabetes.

GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells. GPR142 agonists potentiate glucose-dependent insulin secretion, and therefore can reduce the risk of hypoglycemia. Optimization of our lead pyridinone-phenylalanine series led to a proof-of-concept compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

zur Borg, Lisa; Schuell, Christoph; Frey, Holger; Zentel, Rudolf published the artcile< Directing the Self-Assembly of Semiconducting Copolymers: The Consequences of Grafting Linear or Hyperbranched Polyether Side Chains>, HPLC of Formula: 71195-85-2, the main research area is self assembly semiconducting copolymer grafting linear hyperbranched polyether chain; Block copolymers; hyperbranched polyglycerols; micelles; poly(para-phenylene vinylene); semiconducting materials.

The synthesis and self-assembly of novel semiconducting rod-coil type graft block copolymers based on poly(para-phenylene vinylene) (PPV) copolymers is presented, focusing on the ordering effect of linear vs. hyperbranched side chains. Using an addnl. reactive ester block, highly polar, linear poly(ethylene glycol), and hyperbranched polyglycerol side chains are attached in a grafting-to approach. Remarkably, the resulting novel semiconducting graft copolymers with polyether side chains show different solubility and side-chain directed self-assembly behavior in various solvents, e.g., cylindrical or spherical superstructures in the size range of 10 to 120 nm, as shown by TEM. By adjusting the mol. weight and the topol. of the polyether segments, self-assembly into defined superstructures can be achieved, which is important for the efficient charge transport in potential electronic applications.

Macromolecular Rapid Communications published new progress about Branched polymers, hyperbranched dendritic polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (polyether-polyphenylenevinylenes, diblock, graft). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Potikha, L. M.; Kovtunenko, V. O. published the artcile< Rearrangement of benzyl derivatives of condensed 3-aminoisoquinolinones>, Application of C19H34O2, the main research area is benzophenathridine preparation; isoquinoIinenone isoquinazolinone phenylacetonitrile rearrangement.

A new method for contructing the benzo[b]phenathridine system is proposed. Melting of benzimidazo[1,2-b]isoquinoline-11(5H)-one or 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one with [2-(bromomethyl)phenyl]acetonitrile leads to the formation of C-benzylation products, which is accompanied by intramol. acylation over the β-Carbon of the enamine fragment of the mols. Heating the fusion product in the presence of an acid provokes splitting of the isoquinoline ring and rearrangement to the 12,12a-dihydrobenzo[b]phenanthridine-5(6H)-one derivatives The features of the spatial structure of reaction products and their chem. behavior are considered.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about Phenanthridines Role: SPN (Synthetic Preparation), PREP (Preparation) (benzo). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ayoola, A. A.; Alagbe, E. E.; Agboola, O.; Ayeni, O. A.; Adeyemi, G. A.; Nnabuko, D.; Niakinwa, T. A. published the artcile< A simplified design for biodiesel production>, Product Details of C19H34O2, the main research area is biodiesel design esterification production.

In this research work, a simple design for the production of 1kg biodiesel involving two stage esterification-transesterification process, with the use of waste soybean oil (WSO) and NaOH catalyst was considered. CHEMCAD 7.1.2 software was used for the design operation which revealed that four (4) pumps, four (4) heaters, two (2) mixers, one (1) drying equipment and two (2) reactors were involved. Also, the production process design revealed that 0.05 13kg/h of methanol and 0.1 800kg/h of 0.1M H2SO4 were required during the esterification process. While 0.6921kg/h of methanol, 0.9870kg/h of WSO as well as 0.1934kg/h of NaOH catalyst were needed for the transesterification process. The simplicity of the design and high purity level of the biodiesel produced adjudged the design operation good.

IOP Conference Series: Materials Science and Engineering published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Dezhong; Li, Zhi; Li, Xiang; Chen, Xin; Li, Zhen; Yuan, Lixia; Huang, Yunhui published the artcile< Stable Room-Temperature Sodium-Sulfur Batteries in Ether-Based Electrolytes Enabled by the Fluoroethylene Carbonate Additive>, Synthetic Route of 112-63-0, the main research area is stable room temperature sodium sulfur battery ether electrolytes enabled; cathode−electrolyte interphase; electrolyte additive; room-temperature sodium−sulfur batteries; sulfurized polyacrylonitrile cathode; “solid−solid” conversion.

Because of its high energy d. and low cost, the room-temperature sodium-sulfur (RT Na-S) battery is a promising candidate to power the next-generation large-scale energy storage system. However, its practical utilization is hampered by the short life span owing to the severe shuttle effect, which originates from the “”solid-liquid-solid”” reaction mechanism of the sulfur cathode. In this work, fluoroethylene carbonate is proposed as an additive, and tetraethylene glycol di-Me ether is used as the base solvent. For the sulfurized polyacrylonitrile cathode, a robust F-containing cathode-electrolyte interphase (CEI) forms on the cathode surface during the initial discharging. The CEI prohibits the dissolution and diffusion of the soluble intermediate products, realizing a “”solid-solid”” reaction process. The RT Na-S cell exhibits a stable cycling performance: a capacity of 587 mA h g-1 is retained after 200 cycles at 0.2 A g-1 with nearly 100% Coulombic efficiency.

ACS Applied Materials & Interfaces published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Buchi, J.; Enezian, O.; Eichenberger, H.; Lieberherr, R. published the artcile< Synthesis and pharmacological action of some dialkylmalonic acid derivatives. Dialkylaminoethyl amides and esters of dialkylaminoethanols>, Quality Control of 112-63-0, the main research area is .

Heating 1 mol RR’C(CO2Et)2 in 150 mL. EtOH with 70 g. KOH in 150 mL. EtOH 2 h., evaporating the EtOH, ice-cooling, extracting with ether, HCl addition, and distillation give EtOCOCRR’CO2H (I) [R,R’, b.p., and yields (%)]: Me, Me, b0.5 93-5°, 87.5%; Et, Et, b0.4 92°, 50; Et, Pr, b0.15 118°, 72; Et, Bu, b2 133°, 96; and Pr, iso-Pr, b0.45 107°, 42.I and SOCl2 give EtOCOCRR’COCl(II): Me, Me, b1666°, 96; Et, Et, b20 93-5°, 96; Et, Pr, b15 107°, 93; Et, Bu, b20 123°, 86; and Pr, iso-Pr, b16 112°, 70. II (1 mol) in C6H6, 0.5 mol Na2CO3, and 1 mol R”R”’NCH2CH2NH2 give after heating and filtering RR’C(CO2Et)CONH(CH2)2 NR”R”’-(R, R’, R”, R”’, b.p., yield (%), and m.p. of HCl salt): Et, Et, Me, Me, b0.3 102-3°, 40, 105.5°; Me, Me, Et, Et, b0.35 108°, 80, 76-7°; Et, Et, Et, Et, b0.5 119°, 80, 104-5°; Et, Pr, Et, Et, b0.6 124°, 94, 39°; Et, Bu, Et, Et, b0.6 130°, 70; -; iso-Pr, Pr, Et, Et, b0.5 134°, 77, -. R”R”’NCH2CH2OH and II give RR’C(CO2Et)CO2(CH2)2NR”R”’: Et, Et, Me, Me, b0.2 112-14°, 49, 90.5°, Et, Et, Et, Et, b0.7 113.5°, 78-80, 105°; Et, Bu, Et, Et, b0.45 120°, 80, 93°; Et, Et, Bu, Bu, b0.4 130°, 83, -. The following Et2C(COR)2 derivatives are given (R, b.p., m.p., yield (%), and m.p. of di-HCl salt); NH(CH2)2NMe2, b0.2 159°, 32°, 48, 154°; NH(CH2)2NEt2, b0.7 174°, 47°, 88, 155°; O(CH2)2NEt2, b0.3 142°, -, 55, 162°. Pharmacol. data of these compounds are presented.

Helvetica Chimica Acta published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics