Month: October 2022

Musso, Loana; Cincinelli, Raffaella; Zuco, Valentina; De Cesare, Michelandrea; Zunino, Franco; Fallacara, Anna Lucia; Botta, Maurizio; Dallavalle, Sabrina published the artcile< 3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is arylidene hydroxyoxindole synthesis antitumor p53 apoptosis; N-hydroxyoxindole; antiproliferative activity; antitumor agents; apoptosis; p53.

A series of compounds containing the N-hydroxyoxindole scaffold were synthesized and evaluated for antitumor activity. The compounds showed potent antiproliferative activity against the wild-type p53 IGROV-1 ovarian carcinoma cell line and considerably lower efficacy against the mutant IGROV-1/Pt1 subline that lacks p53 function. The differential response of ovarian carcinoma cells depending on p53 status was also reflected in the varied susceptibility to apoptosis of the treated cell lines. These results support a role for the p53 transcription factor as a determinant of cytotoxicity. The therapeutic potential of the most promising compound of the series was evaluated in the treatment of an IGROV-1 xenograft growing as ascitic tumor in mice. Using i.p. administration, daily treatment with the compound for four weeks produced a significant delay in the onset of ascites.

ChemMedChem published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Adesh Kumar; Kandasamy, Jeyakumar published the artcile< Palladium catalyzed stereocontrolled synthesis of C-aryl glycosides using glycals and arenediazonium salts at room temperature>, Reference of 4098-06-0, the main research area is palladium catalyzed stereoselective synthesis aryl glycoside glycal arenediazonium.

A stereocontrolled synthesis of aryl-C-glycosides was achieved using glycals and aryldiazonium salts in the presence of palladium acetate. A wide range of glycals including D-glucal, D-galactal, L-rhamnal, D-xylal and D-ribal underwent C-arylation at the anomeric carbon in the presence of different aryldiazonium tetrafluoroborates and gave synthetically useful 2,3-deoxy-3-keto-α-aryl-C-glycosides in good to excellent yields. Broad substrate scope, simple operation and room temperature reactions make this protocol very attractive in organic synthesis.

Organic & Biomolecular Chemistry published new progress about Arylation catalysts, stereoselective. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Reference of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Toshima, Hiroaki; Saito, Masatoshi; Yoshihara, Teruhiko published the artcile< Total synthesis of (+)-(2S,3R)-Piscidic acid via catalytic asymmetric dihydroxylation of a trisubstituted olefin>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is catalysis asym dihydroxylation trisubstituted olefin; piscidic acid total synthesis; asymmetric dihydroxylation; catalytic asymmetric synthesis; piscidic acid.

(+)-(2S,3R)-Piscidic acid was efficiently synthesized with high optical purity (90% e.e.) via Sharpless catalytic asym. dihydroxylation of a trisubstituted olefin in only 6 steps from com. available 4-hydroxyphenyl-pyruvic acid as the starting material. The reaction proceeded with high optical purity by using the chiral ligands, dihydroquinidine 2,5-diphenyl-4,6-pyrimidinediyl diether or dihydroquinidine 1,4-anthraquinonediyl diether.

Bioscience, Biotechnology, and Biochemistry published new progress about Dihydroxylation (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Di; Chang, Shiquan; Li, Xin; Shi, Huimei; Jing, Bei; Chen, Zhenni; Lin, Yi; Zheng, Yachun; Qian, Guoqiang; Pan, Yuwei; Zhao, Guoping published the artcile< Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis>, SDS of cas: 112-63-0, the main research area is mecobalamin neuroprotectant sciatic nerve chronic constriction injury; Schwann cells; TLR4/NF-kB; chronic constriction injury; chronic neuralgia; paeoniflorin; sciatica.

Therapeutic drugs of chronic neuralgia have a high risk of addiction, making it crucial to identify novel drugs for chronic neuralgia. This study aimed to explore the therapeutic effect of paeoniflorin on chronic sciatica via inhibiting Schwann cell apoptosis. 28 SD rats were randomly divided into four groups, including the sham operation group, chronic constriction injury (CCI) group, mecobalamin group, and paeoniflorin group. The therapeutic effect and mechanism of paeoniflorin were evaluated via rat and cell experiments Mech., hot, or cold hyperalgesia was induced in the rats after CCI operation, while paeoniflorin relieved chronic neuralgia. Besides, paeoniflorin decreased the levels of IL1, IL6, TNF-α, CRP, and LPS and increased the level of IL10 in serum. As for the sciatic nerve, the number of inflammatory cells was decreased, and Schwann cells were present after paeoniflorin treatment, and paeoniflorin promoted the recovery of nerve structure. In cell experiments, LPS induced Schwann cell apoptosis via the TLR4/NF-kB pathway. And paeoniflorin attenuated LPS-induced Schwann cell apoptosis by decreasing the levels of TLR4, p-NF-kB, caspase3, cleaved-caspase3, and cleaved-caspase7. Overall, these results suggest that paeoniflorin alleviates chronic sciatica by decreasing inflammatory factor levels and promotes the repair of damaged nerves by reducing Schwann cell apoptosis.

Phytotherapy Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rawal, Viresh H.; Cava, Michael P. published the artcile< Photocyclization of pyrrole analogs of stilbene: an expedient approach to antitumor agent CC-1065>, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is oxidation photochem cyclization pyrrolylethene; pyrroloindole; thienoindole; furoindole; benzindole.

Heterocycles were converted into pyrrole analogs of stilbene and subsequently cyclized to give the tricyclic ring structure necessary for CC-1065 and its analogs. Thus, Wittig reaction of the phosphonium salt I (R = Me) with the aldehydes II (X = NMe, S, O, R1 = H) and 4-MeOC6H4CHO gave 84-90% Wittig olefination products, which underwent oxidative photocyclization to give 38-80% tricyclic product III (X = NMe, S, O, R = Me, R1 = H) and IV. Analogously, Wittig reaction of I (R = CH2Ph) with II (X = NCH2Ph, R1 = CO2Et) gave, after oxidative cyclization, 78% III (X = NCH2Ph, R = CH2Ph, R1 = CO2Et), which on selective reduction of the more electron rich side gave the corresponding tricyclic phosphodiesterase type unit.

Journal of the Chemical Society, Chemical Communications published new progress about Oxidative cyclization. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Recommanded Product: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Wenjuan; Yu, Huizhu; Zhu, Xiaoquan; Li, Haoran published the artcile< A luminescence europium Metal-organic coordination polymer for Room-Temperature X-ray detection>, Quality Control of 112-63-0, the main research area is preparation europium pyrenetetrasulfonate coordination polymer xray detection luminescence scintillator.

A novel Eu ions-based metal-organic coordination polymer (MOCP) named Eu(1,3,6,8-PTS)(H2O)7·4H2OHbipy (1) (PTS = pyrenetetrasulfonic acid) was prepared, and its structure, stability, photoluminescence and scintillation properties were systematically investigated. Compound 1 gives a peculiar snake-shaped chain structure with the aid of π-π stacking effect of 4,4′-bipyridine auxiliary template. An efficient and stable light emission was detected under x-ray irradiation, which presents an excellent linear response to X-ray dose. Also, this compound demonstrates high radiation stability, illustrating its potential as a scintillator for x-ray detection. This work not only provides guidance for the design and fabrication of sulfonic ligand derived MOCPs with Eu (III) ions coordination, but also demonstrates the potential of MOCPs scintillators for x-ray detection technol.

Inorganic Chemistry Communications published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kierys, Agnieszka; Zaleski, Radoslaw; Grochowicz, Marta; Gorgol, Marek; Sienkiewicz, Andrzej published the artcile< Polymer-mesoporous silica composites for drug release systems>, Application In Synthesis of 3290-92-4, the main research area is polymer mesoporous silica composite drug.

The research describes systematic approach to the novel synthesis and formation of a potential organic-inorganic drug carriers. The poly(trimethylolpropane trimethacrylate) and polymer-silica composites based on SBA-3 or SBA-15 mesoporous silica were fabricated by the suspension-emulsion polymerization method in the form of small micrometric porous beads (sp. surface area approx. 500 m2/g). The type of organic templates filling silica pores has proved to be crucial in the synthesis of the composites. The introduction of diclofenac sodium via solvent diffusion method into the polymer and composites resulted in the solid drug dispersions. The composites have greater effectiveness in the drug desorption (90% of the release) in comparison with the pure polymer (20% of the release after 7 h). Both, however, suffer from the burst effect. This downside can be overcome by functionalization of the solid drug dispersions with (3-aminopropyl)triethoxysilane. The functionalized solid drug dispersions do not desorb the diclofenac sodium in an acidic medium (the desorption rate is less than 6% during 2 h contact), which makes them attractive for oral multiparticulate formulations of modified release. The presented solids were characterized with modern anal. methods and the relation between the material structure and desorption rate were discussed.

Microporous and Mesoporous Materials published new progress about Composites. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Application In Synthesis of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Yunxia; Chen, Hansen; Tsoi, Bun; Wang, Qi; Shen, Jiangang published the artcile< Danggui-Shaoyao-San (DSS) ameliorates cerebral ischemia-reperfusion injury via activating SIRT1 signaling and inhibiting NADPH oxidases>, Electric Literature of 112-63-0, the main research area is DSS cerebral ischemia reperfusion injury SIRT signaling NADPH oxidase; Danggui-Shaoyao-San; SIRT1; oxidative stress; peroxynitrite; stroke.

Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurol. health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Adult male Sprague-Dawley (S.D.) rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reperfusion. Both ethanol extract and aqueous extract of DSS (12 g/kg) were orally administrated into the rats at 30 min prior to MCAO ischemic onset. We found that 1 ethanol extract of DSS, instead of aqueous extract, reduced infarct sizes and improved neurol. deficit scores in the post-ischemic stroke rats; 2 Ethanol extract of DSS down-regulated the expression of the cleaved-caspase 3 and Bax, up-regulated bcl-2 and attenuated apoptotic cell death in the ischemic brains; 3 Ethanol extract of DSS decreased the production of superoxide and peroxynitrite; 4 Ethanol extract of DSS significantly down-regulated the expression of p67phox but has no effect on p47phox and iNOS statistically. 5 Ethanol extract of DSS significantly up-regulated the expression of SIRT1 in the cortex and striatum of the postischemic brains; 6 Co-treatment of EX527, a SIRT1 inhibitor, abolished the DSS’s neuroprotective effects. Taken together, DSS could attenuate oxidative/nitrosative stress and inhibit neuronal apoptosis against cerebral ischemic-reperfusion injury via SIRT1-dependent manner.

Frontiers in Pharmacology published new progress about Animal gene, Bcl-2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Akram, Muhammad; Mei, Zhipeng; Shi, Jiayan; Wen, Jiayue; Khalid, Hamad; Jiang, Jiapei; Tian, Yanhong; Tian, Yanqing published the artcile< Electrospun nanofibers and spin coated films prepared from side-chain copolymers with chemically bounded platinum (II) porphyrin moieties for oxygen sensing and pressure sensitive paints>, Synthetic Route of 71195-85-2, the main research area is electrospun nanofiber spin coated film side chain copolymer; Fluorinated polymers; Nanofibers; Oxygen responses; Oxygen sensing; Pressure sensitive paints.

Pressure sensitive paints (PSP) containing oxygen probes were primarily used to measure air pressure. In this perspective, a polymerizable methacrylate-derived tetraphenylporphinato platinum(II) (PtTPP-MA) monomer was copolymerized with acrylic/vinyl monomers to produce four different copolymers. Octafluoropentyl methacrylate (OCFPM) and pentafluorophenyl acrylate (PFPA) were used as fluorinated monomers. Me methacrylate (MMA) and styrene (S) were used as non-fluorinated monomers. The structures and phys. properties of the polymers were confirmed by 1H NMR, 19F NMR, GPC, and DSC. Exptl. conditions were optimized to get fine nanofibers. Pressure sensing electrospun membranes and spin coated films were fabricated. Nanofibers showed fast response and good sensitivity towards gaseous oxygen. The influence of types of substrate and polymer natures on response time, oxygen sensitivity, and pressure responses were deliberated. Among our synthesized copolymers, poly(PS-co-PFPA-co-OCFPM-co-PtTPPMA) (Polymer P3) showed fast response time and good pressure sensitivity both as spin coated films and nanofibers.

Talanta published new progress about Acrylic fibers, fluorine-containing Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PROC (Process), PREP (Preparation), USES (Uses). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Synthetic Route of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Di; Ma, Lixue; Wu, Mengna; Wang, Xiaoyu; Xu, Lei; Yu, Qiaoru; Wang, Changyuan published the artcile< Effect of microbial communities on the quality characteristics of northeast soybean paste: Correlation between microorganisms and metabolites>, Computed Properties of 112-63-0, the main research area is soybean paste microorganism metabolite microbial community.

To systematically explore the impact of microbial community composition on the quality characteristics of northeast soybean paste, the microbial community structure was determined by high-throughput sequencing technol. and the flavor substance, free amino acid (FAA) and biogenic amine (BA) contents were determined by HS-SPME-GC-MS and HPLC. Furthermore, the correlation between microorganisms and metabolites was investigated. The results indicated that the core bacteria mainly included Tetragenococcus, Bacillus and Lactobacillus; Candida_f__norank, Wickerhamomyces and Aspergillus were the dominant fungi. A total of 139 flavor compounds were detected in all samples, and decamethylcyclopentasiloxane, isoamyl phenylacetate and octamethylcyclotetrasiloxane accounted for the highest proportion. A total of 24 FAAs were detected in the soybean paste. Pantoea, Kroppenstedtia and Kocuria were significantly pos. correlated with most FAAs (p < 0.05). Addnl. 5 BAs were detected in the soybean paste, and the contents of BAs in Y4 were highest, which was affected by different microbes. This study provided relevant information for the microbial community composition and metabolites of northeast soybean paste, which was of great significance for understanding the characteristics and safety of soybean paste. LWT--Food Science and Technology published new progress about Acaulium. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics