Month: October 2022

Palo-Nieto, Carlos; Sau, Abhijit; Williams, Ryan; Galan, M. Carmen published the artcile< Cooperative Bronsted Acid-Type Organocatalysis for the Stereoselective Synthesis of Deoxyglycosides>, Synthetic Route of 4098-06-0, the main research area is deoxyglycoside oligosaccharide stereoselective synthesis; Bronsted acid organocatalysis thiourea amplification glycal glycosylation.

A practical approach for the α-stereoselective synthesis of deoxyglycosides using cooperative Bronsted acid-type organocatalysis has been developed. The method is tolerant of a wide range of glycoside donors and acceptors, and its versatility is exempedilified in the one-pot synthesis of a trisaccharide. Mechanistic studies suggest that thiourea-induced acid amplification of the chiral acid via H-bonding is key for the enhancement in reaction rate and yield, while stereocontrol is dependent on the chirality of the acid. Thiourea-induced acid amplification.

Journal of Organic Chemistry published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sui, Meng; Chen, Yong; Li, Fashe; Wang, Hua published the artcile< Study on transition metal ion Fe3+ catalyzed biodiesel oxidation and inhibition mechanism>, Product Details of C19H34O2, the main research area is transition metal ion iron catalysis biodiesel oxidation inhibition mechanism.

Me linoleate is used as an alternative component of biodiesel. The catalytic oxidation of biodiesel is studied in the presence of iron acetate using Me linoleate as the alternative component. The composition of the products obtained from the oxidation process of Me linoleate is analyzed by GC-MS and liquid phase microextraction D. functional theory is used to calculate the electronic effects of the related reactants and products, and the related catalytic oxidation reaction paths are derived. The results show that during the process of catalytic oxidation of Me linoleate in biodiesel, mainly the catalytic cracking reaction of C-H and C-C bonds and Fenton-like reaction occur. The combination of two antioxidants, TEPA and [MI][C6H2(OH)3COO], can effectively inhibit the catalytic oxidation of Cu2+ and Fe3+ and interrupt the chain reaction of the oxidation process. The neg. value of the electrostatic potential of ferric acetate is relatively large, it is obviously alk., and has a certain ability to bind with H. The irregular structure of the iron acetate unit cell makes the O-Fe bond in the mol. easy to break, which is beneficial for the catalytic oxidation process.

Fuel published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deb, Barnali; Chakraborty, Ankita; Hossain, Jewel; Majumdar, Swapan published the artcile< A Task-Specific Ionic-Liquid-Mediated Solvent-Free Protocol for Direct Access to Dimethyl Acetal Protected Benzimidazole 2-Carboxaldehydes>, Product Details of C7H12O5, the main research area is dimethyl acetal benzimidazole carboxaldehyde preparation; amino aniline methyl dimethoxyoxobutanoate cyclization imidazolium ionic liquid catalyst.

A robust and straightforward protocol has been developed for the synthesis of a diverse array of di-Me acetal protected benzimidazole-2-carboxaldehydes I (R = H, 6-Me, 5,6-di-Me, 6-Cl, carboxyl; R1 = H, Bn, prop-2-en-1-yl, etc.) by reacting various 2-amino aniline derivatives II with Me 4,4-dimethoxy-3-oxobutanoate using the task-specific imidazolium ionic liquid (HBIm·TFA) as a promoter for N-C/C-N annulation processes. The present protocol offers several advantages over existing protocols, such as single-step process, short reaction times, very mild reaction conditions, high yields, ease of purification, recovery and reusability of the catalyst, and scale-up of the reaction.

SynOpen published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Product Details of C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Klotz-Berendes, Bruno; Schaefer, Hans J.; Grehl, Matthias; Froehlich, Roland published the artcile< Electroorganic syntheses. 60. Diastereoselective coupling of anodically generated radicals bearing chiral amide groups>, SDS of cas: 112-63-0, the main research area is diastereoselective coupling radical Kolbe electrolysis; crystallog chiral amide.

Diastereoselective radical coupling by means of Kolbe electrolysis with formation of a stereogenic center is reported. This was achieved by electrolyzing 2-substituted malonic acid amides , which have a chiral auxiliary linked through the amide function, in the presence of carboxylic acids. Crystal structure data for some products (e.g. I) were reported.

Angewandte Chemie, International Edition in English published new progress about Configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Xiao-Jing; Abdiaj, Irini; Sambiagio, Carlo; Li, Chenfei; Zysman-Colman, Eli; Alcazar, Jesus; Noel, Timothy published the artcile< Visible-Light-Promoted Iron-Catalyzed C(sp2)-C(sp3) Kumada Cross-Coupling in Flow>, Product Details of C19H34O2, the main research area is Kumada cross coupling aryl chloride Grignard reagent iron catalyst; visible light Kumada cross coupling iron catalyst mechanism flow; Kumada coupling; cross-coupling; flow chemistry; iron catalysis; photocatalysis.

A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes’ residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application. The mechanism was studied using radical clock experiments, kinetic measurements, DFT and other techniques.

Angewandte Chemie, International Edition published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hatami, Behnam; Ebrahimi, Aliasghar; Ehrampoush, Mohammad Hassan; Salmani, Mohammad Hossein; Dalvand, Arash; Pirmoradi, Neda; Angelidaki, Irini; Fotidis, Ioannis A.; Mokhtari, Mehdi published the artcile< Recovery of intermittent cycle extended aeration system sludge through conversion into biodiesel by in-situ transesterification>, COA of Formula: C19H34O2, the main research area is fatty acid methyl ester sludge transesterification biodiesel synthesis.

The feasibility of using intermittent cycle extended aeration system (ICEAS) sludge as a lipid feedstock for biodiesel production was investigated. The main effects of in situ transesterification parameters, reaction temperature (30-70°C), reaction time (4-24 h), catalyst concentration (1-5% volume/volume), and proportion of methanol to dry sludge (5-25 mL/g) at five-levels as well as their simultaneous interactions were evaluated to develop an empirical model. Optimized conditions were obtained at 60°C, 4.65% (volume/volume) H2SO4, 17.84 h reaction time, and 5:1 methanol to dry sludge proportion (ml/g), leading to a maximum of 18.58% (weight/weight) biodiesel yield with 94.23% fatty acid Me ester content. This result was higher in comparison with yields derived from conventional activated sludge, membrane bioreactor and anaerobic-anoxic-oxic processes. The ICEAS technol. advantages are owned to its different configurations leading to production of one blended sludge, shorter hydraulic retention time and higher COD to nitrogen ratios. The predominance of fatty acid Me esters such as palmitic, oleic, palmitoleic, stearic, linoleic and myristic acid Me ester, in the obtained biodiesel, indicated suitability of ICEAS sludge as feedstock for biodiesel production

Renewable Energy published new progress about Aeration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kolekar, Yuvraj A.; Bhanage, Bhalchandra M. published the artcile< Pd-Catalyzed Oxidative Aminocarbonylation of Arylboronic Acids with Unreactive Tertiary Amines via C-N Bond Activation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is amine tertiary arylboronic acid palladium catalyst aminocarbonylation bond activation; tertiary amide preparation.

An efficient synthesis of tertiary amides from aryl boronic acids and inert tertiary amines through the oxidative carbonylation via C(sp3)-N bond activation is presented. This protocol significantly restricts the homocoupling biarylketone product. It involves the use of a homogeneous PdCl2/CuI catalyst and a heterogeneous Pd/C based catalyst, which promotes C(sp3)-N bond activation of tertiary amines with aryl boronic acids. This process represents a ligand-free, base-free, and recyclable catalyst along with an ideal oxidant like mol. oxygen.

Journal of Organic Chemistry published new progress about Amides, tertiary Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Frelek, Jadwiga; Geiger, Marcela; Voelter, Wolfgang published the artcile< Absolute configurational assignment of α-hydroxy acids and α-hydroxy esters from their Cupra A circular dichroism spectra>, Formula: C6H10O5, the main research area is chiral alpha hydroxy acid absolute configuration Cotton effect; CD spectra Cupra A hydroxy acid chiral complex.

The in situ formed complexes of cuprammonium solution (Cupra A) with optically active α-hydroxy acids and α-hydroxy esters show CD spectra suitable for determination of the absolute configuration of both groups of compounds In the long wavelength spectral region, compounds of R configuration at the α carbon atom display a pos. Cotton effect of around 600 nm and a neg. one at ca. 720 nm, whereas (S)-α-hydroxy acids and esters exhibit neg. and pos. Cotton effects, resp., in the same spectral range.

Tetrahedron: Asymmetry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beltzig, Lea; Christmann, Markus; Kaina, Bernd published the artcile< Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics>, Application In Synthesis of 112-63-0, the main research area is apoptosis; artesunate; cell death; cellular senescence; chloroquine; curcumin; fisetin; glioma; senolytics; temozolomide.

A first-line therapeutic for high-grade glioma, notably glioblastoma (GBM), is the DNA methylating drug temozolomide (TMZ). Previously, we showed that TMZ induces not only apoptosis and autophagy, but also cellular senescence (CSEN). We presented the hypothesis that GBM cells may escape from CSEN, giving rise to recurrent tumors. Furthermore, the inflammatory phenotype associated with CSEN may attenuate chemotherapy and drive tumor progression. Therefore, treatments that specifically target senescent cells, i.e., senolytic drugs, may lead to a better outcome of GBM therapy by preventing recurrences and tumor inflammation. Here, we tested Bcl-2 targeting drugs including ABT-737, ABT-263 (navitoclax), several natural substances such as artesunate, fisetin and curcumin as well as lomustine (CCNU) and ionizing radiation (IR) for their senolytic capacity in GBM cells. Addnl., several proteins involved in the DNA damage response (DDR), ATM, ATR, Chk1/2, p53, p21, NF-kB, Rad51, PARP, IAPs and autophagy, a pathway involved in CSEN induction, were tested for their impact in maintaining CSEN. Treatment of GBM cells with a low dose of TMZ for 8-10 days resulted in >80% CSEN, confirming CSEN to be the major trait induced by TMZ. To identify senolytics, we treated the senescent population with the compounds of interest and found that ABT-737, navitoclax, chloroquine, ATMi, ATRi, BV-6, PX-866 and the natural compounds fisetin and artesunate exhibit senolytic activity, inducing death in senescent cells more efficiently than in proliferating cells. Curcumin showed the opposite effect. No specific effect on CSEN cells was observed by inhibition of Chk1/Chk2, p21, NF-kB, Rad51 and PARP. We conclude that these factors neither play a critical role in maintaining TMZ-induced CSEN nor can their inhibitors be considered as senolytics. Since IR and CCNU did not exhibit senolytic activity, radio- and chemotherapy with alkylating drugs is not designed to eliminate TMZ-induced senescent cancer cells.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karunakaran, K.; Elango, K. P. published the artcile< Kinetics and mechanism of oxidation of (arylthio)acetic acids by pyridinium hydrobromide perbromide>, Synthetic Route of 112-63-0, the main research area is kinetics pyridinium hydrobromide perbromide arylthioacetic acid; oxidation pyridinium hydrobromide perbromide arylthioacetic acid; mechanism pyridinium hydrobromide perbromide arylthioacetic acid.

Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid. The reaction is first order with respect to PHPB. Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid. The effect of solvent composition indicates that the transition state is more polar than the reactants. The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett’s substituent constants The p value is -1:60 at 35°C. The rates of oxidation of ortho substituted compounds are correlated with Charton’s triparametric equation. A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulfonium ion which hydrolyses in a subsequent fast step to the sulfoxide is proposed.

Journal of Physical Organic Chemistry published new progress about Formation constant. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics