Month: October 2022

Suzuki, Hitomi; Takeuchi, Toyomi; Mori, Tadashi published the artcile< Ozone-Mediated Nitration of Phenylalkyl Ethers, Phenylacetic Esters, and Related Compounds with Nitrogen Dioxide. The Highest Ortho Substitution Observed in the Electrophilic Nitration of Arenes>, Quality Control of 30095-98-8, the main research area is ozone nitration phenylalkyl ether phenylacetate; aryl ether nitration Kyodai regiochem; regioselective substitution Kyodi nitration phenyl ether; Kyodai nitration phenylalkyl ether benzeneacetate; electrophilic nitration nitrogen dioxide.

By the combined action of ozonized oxygen and nitrogen dioxide (the Kyodai nitration), the title compounds were smoothly nitrated in dichloromethane at subzero degrees with high ortho positional selectivity. Although the conventional nitration of phenylacetic acid and esters mainly produces m- and p-nitro derivatives, the present nitration offers a simple high-yield synthesis of o-nitro derivatives which are important as precursor in organic synthesis. The proportions of the ortho isomer in the nitration products from Me 2-phenylethyl ether and Me phenylacetate were 71 and 88%, resp., the latter value being the highest ortho isomer proportion so far observed in the electrophilic aromatic nitration. The observed high ortho selectivity has been rationalized in terms of radical cation intermediate and six-membered cyclic transition state.

Journal of Organic Chemistry published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Quality Control of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruan, Yonglan; Ling, Jinying; Ye, Fan; Cheng, Nuo; Wu, Fei; Tang, Zongxiang; Cheng, Xiaolan; Liu, Hongquan published the artcile< Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway>, Product Details of C19H34O2, the main research area is paeoniflorin SUCNR TRPV HIF NLRP CFA inflammatory pain signaling; Inflammatory pain; NLPR3; Paeoniflorin; SUCNR1; Succinate; TRPV1.

Treatment of chronic inflammatory pain remains a major goal in the clinic. It is thus of prime importance to characterize inherent pathophysiol. pathways to design new therapeutic strategies and analgesics for pain management. Paeoniflorin (PF), a monoterpenoid glycoside from Paeonia lactiflora Pallas plants, possesses promising anti-nociceptive property. However, therapeutic effect and underlying mechanism of action of PF on inflammatory pain have not yet been fully elucidated. In this study, we aim to investigate the analgesic effect further and clarify its mechanism of action of PF on complete freund’s adjuvant (CFA)-evoked inflammatory pain. Twenty-four male mice were divided into 3 groups: sham, CFA, and CFA + PF groups (n = 8/group). Mice were treated with normal saline or PF (30 mg/kg) for 11 days. Footpad swelling (n = 8/group), mech. (n = 8/group) and thermal hypersensitivity (n = 8/group) were measured to evaluate the analgesic effect of PF on CFA-injected mice. At the end of the animal experiment, blood and L4-L6 dorsal root ganglion neurons were collected to assess the therapeutic effect of PF on CFA-induced inflammatory pain. Next, hematoxylin and eosin, quant. realtime PCR, ELISA, capsaicin and di-Me succinate induced pain test (n = 8/group), motor coordination test (n = 8/group), tail flicking test (n = 8/group), pyruvate and succinate dehydrogenase assay (n = 6/group), immunohistochem. staining, were performed to clarify the action mechanism of PF on CFA-evoked inflammatory pain. Besides, the effect of PF on TRPV1 was evaluated by whole-cell patch clamp recording on primary neurons (n = 7). Finally, mol. docking further performed to evaluate the binding ability of PF to TRPV1. PF significantly relieved inflammatory pain (P < 0.001) and paw edema (P < 0.001) on a complete Freund adjuvant (CFA)-induced peripheral inflammatory pain model. Furthermore, PF inhibited neutrophil infiltration (P < 0.01), IL-1β increase (P< 0.01), and pain-related peptide substance P release (P < 0.001). Intriguingly, CFA-induced succinate aggregation was notably reversed by PF via modulating pyruvate and SDH activity (P < 0.01). In addition, PF dampened the high expression of subsequent succinate receptor SUCNR1 (P < 0.01), HIF-1α(P < 0.05), as well as the activation of NLRP3 inflammasome (P < 0.05) and TRPV1 (P < 0.05). More importantly, both capsaicin and di-Me succinate supplementation obviously counteracted the pain-relieving effect of PF and TRPV1 (P < 0.01 or P < 0.001). Our findings suggest that PF can significantly relieve CFA-induced paw swelling, as well as mech. and thermal hyperalgesia. PF alleviated inflammatory pain partly through inhibiting the activation of TRPV1 and succinate/SUCNR1-HIF-1α/NLRP3 pathway. Furthermore, we found that PF exerted its analgesic effect without affecting motor coordination and pain-related cold ion-channels. In summary, this study may provide valuable evidence for the potential application of PF as therapeutic strategy for inflammatory pain treatment. International Immunopharmacology published new progress about Analgesia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Kyungae; Campbell, Jennifer; Swoboda, Jonathan G.; Cuny, Gregory D.; Walker, Suzanne published the artcile< Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antibacterial Staphylococcus wall teichoate biosynthesis inhibitor preparation structure activity.

A small mol. (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure-activity relationships and leading to the identification of targocil, a potent antibiotic.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Dan; Dai, Yitong; Chen, Xuejiao; Zhang, Xuena; Yue, Danwei; Wang, Jingying; Guo, Yongsheng published the artcile< Stability and catalytic activity of hyperbranched polyglycerol stabilized gold nanofluids>, Quality Control of 112-63-0, the main research area is polyglycerol stabilized gold nanofluid stability catalytic activity.

A gold nanofluid with good suspension stability was prepared using hyperbranched polyglycerol (HPG) as a stabilizer because of the functional hydroxyl groups at the end of every branch in its structure. The effects of reaction-medium pH and temperature on the preparation of the HPG-gold nanofluids were discussed. The influences of pH on the stability of HPG-gold nanofluids after preparation were investigated. The HPG-gold nanofluid was employed as catalyst for the reduction of 4-nitrophenol. The results showed that HPG-Au nanofluid stabilized at high pH range (pH = 10). The nanofluid exhibited high activity in the catalytic hydrogenation of 4-nitrophenol. The HPG-gold nanofluid was promising for applications of quasi-homogeneous catalysis.

Journal of Molecular Liquids published new progress about Catalysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhaoqiang; Kang, Chengjun; Peh, Shing Bo; Shi, Dongchen; Yang, Fengxia; Liu, Qixing; Zhao, Dan published the artcile< Efficient Adsorption of Acetylene over CO2 in Bioinspired Covalent Organic Frameworks>, Formula: C19H34O2, the main research area is adsorption acetylene CO2 bioinspired covalent organic framework.

Rational design of covalent organic frameworks (COFs) to broaden their diversity is highly desirable but challenging due to the limited, expensive, and complex building blocks, especially compared with other easily available porous materials. In this work, we fabricated two novel bioinspired COFs, namely, NUS-71 and NUS-72, using reticular chem. with ellagic acid and triboronic acid-based building blocks. Both COFs with AB stacking mode exhibit high acetylene (C2H2) adsorption capacity and excellent separation performance for C2H2/CO2 mixtures, which is significant but rarely explored using COFs. The impressive affinities for C2H2 appear to be related to the sandwich structure formed by C2H2 and the host framework via multiple host-guest interactions. This work not only represents a new avenue for the construction of low-cost COFs but also expands the variety of the COF family using natural biochems. as building blocks for broad application.

Journal of the American Chemical Society published new progress about Adsorbents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bruvers, Z.; Zuika, I. published the artcile< SCF MO calculations of quinoline and its derivatives. 3. Energy of protonation and basic properties>, Computed Properties of 112-63-0, the main research area is protonation quinoline substituent effect MO; electron configuration quinoline derivative; bond energy protonated quinoline derivative.

The protonation energy (E), N charge, N-H bond energy, and pKNH+ were calculated for quinoline and its NH2, MeO, MeS, and other derivatives by the CNDO/2 method. In quinolines substituted at the 3-, 4-, 5-, 6-, and 7-positions, E and pKNH+ were determined mainly by the interaction of the substituent with the heterocyclic system. 2-Substituted quinolines exhibited steric effects, and 8-substituted quinolines showed H-bonding effects.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Basicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zampella, Angela; Bassarello, Carla; Bifulco, Giuseppe; Gomez-Paloma, Luigi; D’Auria, Maria Valeria published the artcile< Stereochemistry of sphinxolides and reidispongiolides. Asymmetric synthesis of the C17-C22 fragment of reidispongiolide A>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is reidispongiolide absolute stereochem fragment preparation ozonolysis; asym synthesis hexanetetraol derivative.

Five fragments, [I (R = α, β-OH), II, III (R = α, β-OH)] embedding all the stereogenic centers of reidispongiolide A (IV), have been prepared by a controlled ozonolysis of the IV. The absolute stereochem. of the asym. centers of II, corresponding to the C17-C22 portion of IV, was determined by enantioselective synthesis and application of the advanced Mosher method.

European Journal of Organic Chemistry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Zhi; Qiao, Jing; Nagy, Tamas; Xiong, May P. published the artcile< ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo>, Reference of 71195-85-2, the main research area is ROS responsive polymeric deferoxamine nanogel iron chelation therapy; Chelation therapy; Deferoxamine (DFO); Iron overload (IO); Nanogel; Reactive oxygen species (ROS).

Iron-mediated generation of highly toxic Reactive Oxygen Species (ROS) plays a major role in the process leading to iron overload-related diseases. The long-term s.c. administration of Deferoxamine (DFO) is currently clin.-approved to improve patient symptoms and survival. However, non-specific toxicity and short circulation times of the drug in humans often leads to poor patient compliance. Herein, thioketal-based ROS-responsive polymeric nanogels containing DFO moieties (rNG-DFO) were designed to chelate iron and to degrade under oxidative stimuli into fragments <10 nm to enhance excretion of iron-bound chelates. Serum ferritin levels and iron concentrations in major organs of IO mice decreased following treatment with rNG-DFO, and fecal elimination of iron-bound chelates increased compared to free DFO. Furthermore, rNG-DFO decreased iron mediated oxidative stress levels in vitro and reduced iron-mediated inflammation in the liver of IO mice. The study confirms that ROS-responsive nanogels may serve as a promising alternative to DFO for safer and more efficient iron chelation therapy. Journal of Controlled Release published new progress about Chelation. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shuai, Shu-Yuan; Liu, Shan-Shan; Liu, Xiao-Jin; Zhang, Guo-Song; Zheng, Qin; Yue, Peng-Fei; Yang, Ming; Hu, Peng-Yi published the artcile< Essential oil of Ligusticum chuanxiong Hort. Regulated P-gp protein and tight junction protein to change pharmacokinetic parameters of temozolomide in blood, brain and tumor.>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Essential oil of Ligusticum chuanxiong Hort.; Glioma; P-gp; Pharmacokinetics; Temozolomide; Tight junction.

ETHNOPHARMACOLOGICAL RELEVANCE: The existence of the blood-brain barrier/blood tumor barrier (BBB/BTB) severely restricts the effectiveness of anti-tumor drugs, thus glioma is still an incurable disease with a high fatality rate. Chuanxiong (Ligusticum chuanxiong Hort., Umbelliferae) was used as a messenger drug to increase the distribution of drugs in brain tissue, and its application in Chinese herbal formula for treating glioma was also the highest. AIM OF THE STUDY: Our previous researches showed that essential oil (EO) of chuanxiong could promote temozolomide (TMZ) entry into glioma cells in vitro and enhance TMZ-induced anticancer efficiency in vivo, and therefore, the aim of this study was to investigate whether EO could increase the concentration accumulation of TMZ in brain or tumor of C6 glioma rats and the related mechanisms. MATERIALS AND METHODS: The pharmacokinetics were conducted in C6 glioma rats by administering either TMZ alone or combined with EO through oral routes. TMZ concentration in blood, brain and tumor was detected using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and then pharmacokinetic parameters were calculated. The changed expressions of P-gp protein, tight junction occludin, claudin-5 and zonula occludens-1 (ZO-1) in brain of glioma rats were studied by Western blot to clarify the mechanism. Finally, the chemical composition of EO was analyzed by gas chromatography-massspectrometry (GC-MS). RESULTS: The results showed that EO significantly affected the pharmacokinetic parameters such as Tmax, Cmax and CL (p < 0.01), but did not significantly change the AUC(0→∞) of TMZ in blood (p > 0.05). However, EO markedly improved the AUC(0→∞)of TMZ in brain and tumor (p < 0.01). The calculate drug targeting index was greater than 1, indicating that EO could promote the distribution of TMZ to the brain and tumor. Western blot analysis showed that EO significantly inhibited the expression of P-gp, tight junction protein claudin-5, occludin and ZO-1. And meanwhile, the expressions of P-gp, claudin-5 and occludin also markedly down-regulated in EO-TMZ co-administration treatment. GC-MS analysis of the TIC component of EO was (E)-Ligustilide (36.93%), Terpinolene (7.245%), gamma-terpinene (7.225%) etc. CONCLUSION: EO could promote the distribution of TMZ in the brain and tumor of C6 glioma rats, which may attribute to down-regulate the expression of P-gp, claudin-5 and occludin. Journal of ethnopharmacology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Bin; Meng, Xiang; Ma, Yanfang; Li, Huizhen; Liu, Yuqi; Shi, Nannan; Chen, Yaolong; Wang, Yanping; Lu, Cheng published the artcile< Clinical safety of total glucosides of paeony adjuvant therapy for rheumatoid arthritis treatment: a systematic review and meta-analysis>, Electric Literature of 112-63-0, the main research area is meta analysis methotrexate antiinflammatory rheumatoid arthritis; Adjuvant therapy; Clinical safety; Meta-analysis; Rheumatoid arthritis; Systematic review; Total glucosides of paeony.

Total glucosides of paeony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pallas, has been increasingly used as the adjunctive therapy for rheumatoid arthritis (RA) patients. Though TGP could mitigate the unanticipated adverse effects during the conventional treatment of RA, high-quality evidence-based meta-anal. data on this subject are still insufficient. The objective of this study is to evaluate the clin. safety of TGP adjuvant therapy in the RA treatment. PubMed, EMBASE, Web of Science, China Network Knowledge Infrastructure (CNKI), SinoMed and WanFang Data were retrieved for randomized controlled trials (RCTs) and cohort study about TGP adjuvant therapy in patients with RA up to 28 Jan. 2021. Literatures with eligibility criteria and information were screened and extracted by two researchers independently. The RevMan5.3 software was used for data anal. with effect estimates as risk ratio (RR) with 95% confidence interval (CI). A total of 39 studies involving 3680 RA participants were included. There were 8 comparisons: TGP plus methotrexate (MTX) therapy vs. MTX therapy, TGP plus leflunomide (LEF) therapy vs. LEF therapy, TGP plus MTX and LEF therapy vs. MTX plus LEF therapy, TGP plus tripterygium glycosides (TG) therapy vs. TG therapy, TGP plus meloxicam (MLX) therapy vs. MLX therapy and TGP plus sulfasalazine (SSZ) therapy vs. SSZ therapy, TGP plus iguratimod (IGU) therapy vs. IGU therapy, TGP plus prednisone acetate tablets (PAT) therapy vs. PAT therapy. The meta-anal. results showed that the occurrence of hepatic adverse effect (RR = 0.31, 95% CI = 0.23-0.41, P < 0.00001) and leukopenia (RR = 0.41, 95% CI = 0.26-0.66, P = 0.0002) in TGP adjuvant therapy was significant decreased compared with non-TGP therapy. However, only TGP plus LEF therapy (RR = 0.22, 95% CI = 0.08-0.60, P = 0.003) and TGP plus MTX and LEF therapy (RR = 0.31, 95% CI = 0.22-0.42, P < 0.00001) had statistical difference in the subgroups of hepatic adverse effect. In leukopenia, TGP plus MTX and LEF therapy (RR = 0.47, 95% CI = 0.25-0.87, P = 0.02) had statistical difference. This meta-anal. indicated that TGP adjuvant therapy might alleviate the incidence of hepatic adverse effect and leukopenia for the RA treatment compared to non-TGP therapy. The clin. safety of TGP adjuvant therapy warrant further investigation in exptl. studies. BMC Complementary Medicine and Therapies published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics