Month: October 2022

Sun, Qin; Law, Andy; Crowder, Michael W.; Geysen, H. Mario published the artcile< Homo-cysteinyl peptide inhibitors of the L1 metallo-β-lactamase, and SAR as determined by combinatorial library synthesis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is homocysteinyl peptide inhibitor metallo beta lactamase QSAR combinatorial library.

Homo-cysteinyl peptides were found to be more active than cysteinyl peptides toward L1 metallo-β-lactamase as reversible competitive inhibitors. A combinatorial library of more than 90 homo-cysteinyl peptides was synthesized and screened for their inhibitory activity toward the L1 enzyme. A systematic structure-activity relationship anal. has revealed the preferred interaction groups for L1 conserved binding sites of β-lactam substrates. The most active compound 95b, had a Ki of 2.1 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Combinatorial library. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guan, Yun; Pan, Mingyuan; Yang, Jun; Lu, Qiuxia; Han, Liangfu; Liu, Ying; Li, Jing; Zhu, Huaguang; Gong, Xiu; Mei, Guanghai; Liu, Xiaoxia; Pan, Li; Dai, Jiazhong; Wang, Yang; Wang, Enmin; Wang, Xin published the artcile< A phase II open label, single arm study of hypofractionated stereotactic radiotherapy with chemoradiotherapy using intensity-modulated radiotherapy for newly diagnosed glioblastoma after surgery: the HSCK-010 trial protocol>, HPLC of Formula: 112-63-0, the main research area is Adjuvant chemoradiotherapy; Hypofractionated stereotactic radiotherapy; Newly diagnosed glioblastoma.

Abstract: Background: The most frequently diagnosed primary brain tumor is glioblastoma (GBM). Nearly all patients experience tumor recurrence and up to 90% of which is local recurrence. Thus, increasing the therapeutic ratio of radiotherapy using hypofractionated stereotactic radiotherapy (HSRT) can reduce treatment time and may increase tumor control and improve survival. To evaluate the efficacy and toxicity of the combination of HSRT and intensity-modulated radiotherapy (IMRT) with temozolomide after surgery in GBM patients and provide evidence for further randomized controlled trials. Methods/design: HSCK-010 is an open-label, single-arm phase II trial (NCT04547621) which includes newly diagnosed GBM patients who underwent gross total resection. Patients will receive the combination of 30 Gy/5fx HSRT, and 20 Gy/10fx IMRT adjuvant therapy with concurrent temozolomide and adjuvant chemotherapy. The primary endpoint is overall survival (OS). Secondary outcomes include progression-free survival (PFS) rate, objective-response rate (ORR), quality of life (Qol) before and after the treatment, cognitive function before and after the treatment, and rate of treatment-related adverse events (AE). The combination of HSRT and IMRT with temozolomide can benefit the patients after surgery with good survival, acceptable toxicity, and reduced treatment time. Trial registration: NCT04547621. Registered on 14 Sept. 2020.

BMC Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kato, Kazuaki; Mizusawa, Tomoki; Ohara, Akihiro; Ito, Kohzo published the artcile< Direct enhancement of intercomponent interactions in polyrotaxane and its pronounced effects on glass state properties>, HPLC of Formula: 112-63-0, the main research area is enhancement intercomponent interaction polyrotaxane glass state polybutadiene cyclodextrin.

Strong interactions between the host cyclodextrin and the threading guest polymer were introduced by selective modifications to the polymer of a polybutadiene-based polyrotaxane. The changes in the intercomponent interactions influenced the mobility of the threading polymer that was confined in the glassy host framework, resulting in different mech. properties.

Chemical Communications (Cambridge, United Kingdom) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fang, Fang; Wen, Wei-Bo; Xie, Xue-Hua; Yang, Ling; Zhang, Xu; Zhao, Jie published the artcile< The Mechanism of Jian-Gan-Xiao-Zhi Decoction in Insulin Resistant Adipocytes and Its Component Analysis>, Quality Control of 112-63-0, the main research area is Jian Gan hepatoprotectant adipocyte non alc fatty liver disease.

Jian-Gan-Xiao-Zhi decoction (JGXZ) is a traditional Chinese medicine formula to treat patients with non-alc. fatty liver disease (NAFLD). The study aimed to analyze the mechanism of JGXZ in adipocytes and detect the main components of the drug in rat serum. 3T3-L1 preadipocytes were used to establish an insulin resistant (IR) adipocyte model. Lipid accumulation in adipocytes was detected by oil red O staining. After JGXZ treatment, glucose consumption, total cholesterol (TC), and triglyceride (TG) were analyzed using the corresponding kits. ROS levels were measured by flow cytometry. In addition, Western blot was used to assess LKB1/AMPK and JNK/IRS/PI3k/AKT expressions. The main components of JGXZ in rat serum samples were detected by LC-MS/MS using a Phenomenex Luna C18 column, a mobile phase of methanol and 0.1% formic acid solution, and ESI detection. JGXZ significantly decreased glucose levels and adipogenesis, accompanied by decreased IR (P < 0.01). Besides, JGXZ markedly affected ROS, LKB1/AMPK, and JNK/IRS/PI3k/AKT levels (P < 0.01). R1, Rg1, paeoniflorin, Rb1, astragaloside IV, and tanshinone could be significantly quantified. JGXZ decreased glucose and lipid synthesis, possibly via the ROS/AMPK/JNK pathway. R1, Rg1, paeoniflorin, Rb1, astragaloside IV, and tanshinone in JGXZ could play major roles in treating NAFLD, which could assist in the study of the mechanism of JGXZ in treating NAFLD. Natural Product Communications published new progress about Adipocyte. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bellucci, Maria Cristina; Sacchetti, Alessandro; Volonterio, Alessandro published the artcile< Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides>, Category: esters-buliding-blocks, the main research area is orotyl aminophenylalanine preparation combinatorial multicomponent reaction regioselective cyclization; dihydroorotic acid amide preparation combinatorial multicomponent reaction regioselective cyclization; carbodiimide; combinatorial chemistry; dihydroorotic acid; domino process; multicomponent reactions.

A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N’-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for the first time, a library of 29 derivatives, encompassing 19 Nα-substituted-N4-dihydroorotyl-4-aminophenylalanine derivatives, a key residue of gonadotropin-releasing hormone antagonist Degarelix. The corresponding products were prepared from easily accessible starting materials in good to excellent yields with broad substrate scope.

ACS Combinatorial Science published new progress about Combinatorial chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lukovits, Istvan; Linert, Wolfgang published the artcile< A Topological Account of Chirality>, Category: esters-buliding-blocks, the main research area is mol topol chirality.

Graph invariants may differentiate structural isomers but are inappropriate to account for stereoisomerism and to distinguish between chiral structures. This work is an attempt to address this problem. A chiral function F satisfying condition F(D) = -F(L), where D and L denote enantiomers of the same structure, was applied in combination with Randic index 1χv. The resulting index χc was used to explain the variance in thin-layer chromatog. retention indexes.1.

Journal of Chemical Information and Computer Sciences published new progress about Amino acids Role: PRP (Properties) (topol. index). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Feipeng; Hou, Zhen-Lin; Pramanick, Pranab K.; Yao, Bo published the artcile< Site-selective modification of α-amino acids and oligopeptides via native amine-directed γ-C(sp3)-H arylation>, Application of C8H18ClNO2, the main research area is amino acid functionalization arylation aryl iodide amine directed acylation; peptide coupling functionalization arylation aryl iodide amine solvent effect.

Site-selective modification of chem. and biol. valuable α-amino acids and peptides is of great importance for biochem. study and pharmaceutical development. Few methods based on remote C(sp3)-H functionalization of aliphatic side-chains of peptides has been disclosed in recent years. In this report, we developed a novel approach for γ-C(sp3)-H and γ-/δ-C(sp2)-H arylation of α-amino acids with α-hydrogen by native amine-directed C-H functionalization and further realized the γ-C(sp3)-H arylation of N-terminally unprotected peptides.

Organic Letters published new progress about Acylation. 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Application of C8H18ClNO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thi Ngo, Men; Han, Jae Woo; Van Nguyen, Minh; Le Dang, Quang; Kim, Hun; Choi, Gyung Ja published the artcile< Antifungal properties of natural products from Pterocarya tonkinensis against phytopathogenic fungi>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is Pterocarya antifungal phytopathogenic fungus.

The objectives of this article were (i) to isolate and identify the antifungal substances from the Pterocarya tonkinensis extract based on a bioassay-guided fractionation and (ii) to investigate their potential as a biocontrol agent with their antifungal activities in vitro and in vivo. Eighteen compounds were identified from methanol extract of Pterocarya tonkinensis, including two new natural products 1 and 2: 1, pterocaryalactone; 2, pterocaryafuranone; 3, (1S, 6R)-9-hydroxymegastigm-7-en-3-one; 4, (S)-di-Me malate; 5, α-linolenic acid; 6-8, α-tetralones; 9, (R)-methyl-2-hydroxyl-3-phenyl-propanoate; 10, (E)-4-hydroxycinnamic acid Me ester; 11-14, diarylheptanoids, and 15-18, pentacyclic triterpenoids. Based on results of in vitro antifungal assay, Magnaporthe oryzae and Phytophthora infestans were most sensitive to isolated compounds among tested phytopathogenic fungi. When ten active compounds were applied onto plants at concentration of 100 or 500 μg mL-1, compounds 1 and 8 effectively suppressed rice blast disease, and compounds 15 and 16 not only strongly reduced development of blast on rice but also effectively controlled the development of late blight on tomatoes. This is first report to evaluate the in vitro and in vivo antifungal activities of the isolated compounds from a methanol extract of Pterocarya tonkinensis against phytopathogenic fungi, and our results suggest that Pterocarya tonkinensis and its substances can be used as source to develop natural fungicides.

Pest Management Science published new progress about Alternaria brassicicola. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ouyang, Siming; Xie, Yuqing; Fu, Wangxing; Ding, Yongbo; Shen, Liang published the artcile< Preparation of autoxidative water-reducible alkyd resins from waste polyethylene terephthalate>, Related Products of 112-63-0, the main research area is autoxidative aqueous reducible alkyd resin waste polyethylene terephthalate; hardness; physical properties; waste polyethylene terephthalate; water resistance; water-borne alkyd resin.

In this paper, the waste polyethylene terephthalate (PET) was glycolyzed by trimethylolpropane with zinc acetate as catalyst. The effects of different content glycolysis product of waste PET on the appearance, viscosity, particle size and mol. weight of autoxidative water-reducible alkyd resins and the corresponding film adhesion, flexibility, impact resistance, gloss, hardness and chem. resistance were studied. Meanwhile, exptl. results were compared with com. water-reducible alkyd and water-reducible alkyd without the glycolysis product of waste PET. The results show that the maximum concentration of PET in autoxidative waterreducible alkyd resins can reach 8.5 weight%, and the mol. weight, particle size and viscosity of water-reducible alkyd resin do not change much with the increase of PET concentration The introduction of PET resulted in the viscosity of waterreducible alkyd resins being greater than that of water-reducible alkyd resin without PET; this is mainly because PET contains harder terephthalic acid monomer units. However, the particle size of water-reducible alkyd resins with waste PET is significantly lower than that of the water-reducible alkyd resin without PET; this is due to PET-free water-reducible alkyd resin containing more pentaerythritol with greater steric hindrance. In addition, the hardness of the water-reducible alkyd resin paint film (PET content is 8.5%) reaches 1H, which is higher than the hardness (HB) of the water-reducible alkyd resin paint film without PET and the com. alkyd resin paint film, while the phys. properties and chem. resistance of the former are comparable to those of the latter two kinds of paint films. Therefore, the use of waste PET in water-borne coatings systems not only reduces the cost of coatings, but also opens up a new market for recycled PET, which may contribute a promising method for management of waste PET.

Royal Society Open Science published new progress about Adhesion, physical. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Hua; Wang, Zheyuan; Wang, Zirui; Chu, Yunpeng; Wang, Shuncheng; Hui, Xin-Ping published the artcile< Visible-Light-Mediated Formal Carbene Insertion Reaction: Enantioselective Synthesis of 1,4-Dicarbonyl Compounds Containing All-Carbon Quaternary Stereocenter>, HPLC of Formula: 94-02-0, the main research area is dicarbonyl compound preparation enantioselective; diketone diazoester carbene insertion visible light.

Authors developed an efficient visible-light-mediated formal carbene insertion reaction of 1,3-diketones with diazoesters for the construction of enantioenriched 1,4-dicarbonyl compounds with a quaternary carbon center. Combining visible light and a Bronsted acid catalyst, chiral 1,4-dicarbonyl compounds were achieved in good yields with high enantioselectivities by a photochem. carbene transfer protocol.

ACS Catalysis published new progress about Diazo compounds, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, HPLC of Formula: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics