Month: October 2022

Huang, Peng-Yang; Huang, Chen-Yang; Li, Jia-Wun; Shen, Sheng-Yen; Cheng, Chih-Chia; Chiu, Chih-Wei; Jeng, Ru-Jong; Lin, Jiang-Jen published the artcile< Immobilization of Air-Stable Copper Nanoparticles on Graphene Oxide Flexible Hybrid Films for Smart Clothes>, Application of C19H34O2, the main research area is graphene oxide copper film nanoparticle immobilization anti oxidation property; copper nanoparticles; electrical conductivity; electrocardiogram; graphene oxide; nanohybrids; polymeric dispersant; smart clothes.

Through the use of organic/inorganic hybrid dispersants-which are composed of polymeric dispersant and two-dimension nanomaterial graphene oxide (GO)-copper nanoparticles (CuNPs) were found to exhibit nano stability, air-stable characteristics, as well as long-term conductive stability. The polymeric dispersant consists of branched poly(oxyethylene)-segmented esters of trimellitic anhydride adduct (polyethylene glycol-trimethylolpropane-trimellitic anhydride, designated as PTT). PTT acts as a stabilizer for CuNPs, which are synthesized via in situ polymerization and redox reaction of the precursor Cu(CH3COO)2 within an aqueous system, and use graphene oxide to avoid the reduction reaction of CuNPs. The results show that after 30 days of storage the CuNPs/PTT/GO composite film maintains a highly conductive network (9.06 x 10-1 Ω/sq). These results indicate that organic/inorganic PTT/GO hybrid dispersants can effectively maintain the conductivity stability of CuNPs and address the problem of CuNP oxidation Finally, the new CuNPs/PTT/GO composite film was applied to the ECG (ECG) smart clothes. This way, a stable and antioxidant-sensing electrode can be produced, which is expected to serve as a long-term ECG monitoring device.

Polymers (Basel, Switzerland) published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Fei; Chen, Xiang-Yu; Ye, Song published the artcile< [3 + 4] Annulation of Bromoenals and 1,2-Benzenedithiol: Base-Promoted [2 + 4] Reaction and N-Heterocyclic Carbene-Catalyzed Ring-Expansion>, Quality Control of 112-63-0, the main research area is benzo dithiepinone preparation bromoenal benzenedithiol heterocyclic carbene catalyzed annulation; benzodithiine preparation bromoenal benzenedithiol ring expansion.

The [3 + 4] and [2 + 4] annulations of bromoenals and 1,2-benzenedithiol were developed in the presence or absence of N-heterocyclic carbene, resp. Control experiment and kinetic investigation revealed the [3 + 4] annulation involves the base-promoted [2 + 4] annulation and the following carbene-catalyzed ring-expansion.

Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction (catalysts). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dolby, Jorgen; Dahlbom, Richard; Hasselgren, Karl H.; Nilsson, J. L. G. published the artcile< Bicyclic enamines. I. Rearrangement of a quaternary quinuclidine-3-carboxylic acid ester and total synthesis of gentianadine>, COA of Formula: C8H9NO2, the main research area is quinuclidinecarboxylic rearrangement; gentianadine alkaloid preparation; nicotinic lactone; enamines bicyclic.

Me 2,3-didehydroquinuclidine-3-carboxylate methiodide loses MeI and is rearranged to 4-(2-hydroxyethyl)-1-methyl-1,4,5,6-tetrahydronicotinic acid lactone when heated without solvent to its m.p. The structure of the lactone was confirmed by an independent synthesis which also involved the total synthesis of the alkaloid gentianadine.

Acta Chemica Scandinavica (1947-1973) published new progress about Rearrangement. 33402-75-4 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO2, COA of Formula: C8H9NO2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cheng, Yunlei; Cao, Youming published the artcile< Synthesis of imine carboxylic acid chelating resin>, COA of Formula: C19H34O2, the main research area is bromostyrene divinylbenzene copolymer diethyl iminodiacetate reaction chelating resin synthesis.

An imine carboxylic acid chelating resin was synthesized via suspension polymerization with 1, 2-divinyl benzene (o-DVB) and iminodiacetic acid di-Et ester as feedstock, polyethylene glycol as emulsifier, NaCl water solution as dispersed phase, and toluene as oil phase solvent. The functional group and morphol. of the product were characterized, and the impact of bromide time, initiator, mole ratio of feedstock on yield of brominated polystyrene were observed as well. The yield of brominated polystyrene increases and then decreases with the increasing of bromide time, and the optimal bromide time is 45 min; it also surges then drops slightly with the initiator increasing and reaches the peak of 72% when the initiator is 0.18 g; the yield of the product follows the increasing of the mole ratio of o-DVB and brominated DVB, while the destiny of functional group is decreased. There the more the initiator are, the smaller the particle of brominated polystyrene becomes, and the greater granulation rate achieves.

Hecheng Shuzhi Ji Suliao published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Paulo, Pedro M. R.; Laia, Cesar A. T.; Costa, Silvia M. B. published the artcile< Clusters in Polymer-Surfactant AOT Microemulsions Probed by Excited State Quenching Kinetics>, Formula: C19H34O2, the main research area is dynamics PEG bisethylhexyl sulfosuccinate surfactant cluster microemulsion quenching kinetics; fluorescence quenching laser flash photolysis dynamics polymer surfactant microemulsion.

Excited-state quenching kinetics were applied to sodium 1,4-bis(2-ethylhexyl)sulfosuccinate (AOT) reversed micelles with poly(oxy)ethylene (POE) of mol. weight 35 000 Da where clusters were previously detected [Laia, C. A. T., et al, 2000]. The data obtained in AOT reversed micelles, with a fixed value of the molar ratio of water to surfactant (w0 = [H2O]/[AOT]) w0 = 20, were compared in the absence and presence of the polymer. Two reaction time scales were studied with different probes: 1,3,6,8-pyrenetetrasulfonic acid (PTSA) in the nanosecond range and Cr(bpy)33+ in the microsecond range, using, resp., time-resolved fluorescence with picosecond resolution and laser flash photolysis techniques. The exptl. decays were analyzed assuming two components, one due to polymer-free micelles described by a Poisson distribution model kinetics and another associated with the polymer-induced micelle clusters, analyzed according to a model based on the concept of random walks in regular compact lattices. A step frequency, kw = 107 s-1, was extracted from the nanosecond results for the quencher’s random walk within the cluster. By contrast, the triplet absorption quenching studies did not distinguish between free micelles and clusters and afforded an aggregation number for the former in the range 260 ± 40, in good agreement with literature data. Decay simulations confirm the validity of the data treatment used in the nanosecond range, but the short time behavior predicted in the microsecond range was not observed within the equipment time resolution

Journal of Physical Chemistry B published new progress about Anionic surfactants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jablonowski, Jill A.; Grice, Cheryl A.; Chai, Wenying; Dvorak, Curt A.; Venable, Jennifer D.; Kwok, Annette K.; Ly, Kiev S.; Wei, Jianmei; Baker, Sherry M.; Desai, Pragyna J.; Jiang, Wen; Wilson, Sandy J.; Thurmond, Robin L.; Karlsson, Lars; Edwards, James P.; Lovenberg, Timothy W.; Carruthers, Nicholas I. published the artcile< The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists>, Quality Control of 112-63-0, the main research area is indole derivative preparation histamine H4 receptor antagonist structure activity.

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified a potential lead compound Investigation of the structure-activity relationship (SAR) resulted in the discovery of novel compounds, which are the first potent and selective histamine H4 receptor antagonists to be described.

Journal of Medicinal Chemistry published new progress about Antihistamines. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kelly, Martha J.; Pietranico-Cole, Sherrie; Larigan, J. Douglas; Haynes, Nancy-Ellen; Reynolds, Charles H.; Scott, Nathan; Vermeulen, John; Dvorozniak, Mark; Conde-Knape, Karin; Huang, Kuo-Sen; So, Sung-Sau; Thakkar, Kshitij; Qian, Yimin; Banner, Bruce; Mennona, Frank; Danzi, Sara; Klein, Irwin; Taub, Rebecca; Tilley, Jefferson published the artcile< Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tetrahydrotriazinecarbonitrile derivative MGL3196 thyroid hormone receptor agonist dyslipidemia treatment.

The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogs. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclin. model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 wk.

Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kakoee, Alireza; Gharehghani, Ayat; Mostafei, Mohsen published the artcile< Development of a reduced chemical kinetic mechanism for biodiesel/natural gas mixture>, Electric Literature of 112-63-0, the main research area is methyl palmitate heptane chem kinetics one dimensional model.

Biodiesel as an alternative fuel for diesel in compression ignition engines cab be used directly to this type of engine without any significant changes in geometry. Some neg. points of biodiesel in compression ignition (CI) engines such as high viscosity, injector carbonize and high NOx emissions cause to use this fuel with other fuels such as alc. fuels and natural gas based on desired properties of second fuel. Numerical study of fuels such as biodiesel needs to have a chem. kinetic mechanism that can predict combustion characteristics and output emissions. In this study, a reduced detailed mechanism of biodiesel introduced by Zhang et al. is chosen to merged with natural gas GRI-Mech 3.0 mechanism to obtain a chem. kinetic mechanism of biodiesel/natural gas. Direct relation graph with error propagation (DRGP) method and consequently sensitivity anal. was employed to 525 reactions and 126 species that modified with highly sensitive reactions. At first, reduced mechanism of biodiesel/natural gas compared with merged mechanism of these fuels’ mixture with 0-Dimension simulation of ignition delay and 1-Dimension simulation of flame speed. Obtained results show error less than 1% for all intake temperatures and equivalence ratios. In the following, the reduced mechanism with zero percent of natural gas compared with original biodiesel mechanism. Yet again, results show errors almost near zero in lower equivalence ratio and acceptable error, in maximum condition about 10%, in moderate and high equivalence ratios (ERs) during predicting ignition delay with 0-Dimension simulation. Also, flame speed in this evaluation shows less than 2% error in 1-Dimension simulation.

Fuel published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondo, Hiroki; Uno, Shingo; Moriuchi, Fumio; Sunamoto, Junzo; Ogushi, Susumu; Tsuru, Daisuke published the artcile< Synthesis and enzymatic carboxylation of a biotin-containing peptide representing the coenzyme binding site of E. coli acetyl-CoA carboxylase>, Electric Literature of 112-63-0, the main research area is acetyl CoA carboxylase biotin binding site; peptide biotin acetyl CoA carboxylase.

A biotin-containing pentapeptide, Boc-Glu-Ala-Met-Bct-Met (I) (where Boc = tert-butoxycarbonyl and Bct = N’-biotinyl-L-lysine), that corresponds to the coenzyme-binding site of Escherichia coli acetyl-CoA carboxylase (II) was prepared I, as well as free biotin, served as substrate for the carboxylation reaction catalyzed by the biotin carboxylase subunit dimer of E. coli II. The Km and Vmax values for I were 18 mM and 2.8 μM min-1, resp. The corresponding values for biotin were 214 mM and 28 μM min-1. Thus, the overall reactivity (Vmax/Km) of I exceeded that of biotin by 20%.

Bulletin of the Chemical Society of Japan published new progress about Escherichia coli. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lahner, Harald; Mathew, Annie; Klocker, Anna Lisa; Unger, Nicole; Theysohn, Jens; Rekowski, Jan; Joeckel, Karl-Heinz; Theurer, Sarah; Schmid, Kurt Werner; Herrmann, Ken; Fuehrer, Dagmar published the artcile< Streptozocin/5-fluorouracil chemotherapy of pancreatic neuroendocrine tumours in the era of targeted therapy>, Related Products of 112-63-0, the main research area is pancreatic neuroendocrine tumor streptozocin fluorouracil chemotherapy; 5-fluorouracil; Objective response; Pancreatic neuroendocrine tumor; Streptozocin; Survival.

The role of streptozocin-based chemotherapy (STZ CTx) in advanced, well-differentiated pancreatic neuroendocrine tumors (PanNET) and the best sequence of treatments in advanced PanNET are unclear. We examined the outcomes after STZ CTx in patients who had been selected according to the current therapeutic guidelines. Data from 50 PanNET patients consecutively treated with STZ CTx between 2010 and 2018 were analyzed. The endpoints of the study were the objective-response rate (ORR), progression-free survival (PFS), and overall survival (OS). STZ CTx was the first-line treatment in 54% of patients. The PanNET grades were as follows: 6% G1, 88% G2, and 6% well-differentiated G3. The ORR was 38%. Stable disease was the best response in 38% of patients and 24% showed progressive disease. Treatment was discontinued because of toxicity in one patient. Median PFS and OS were 12 (95% confidence interval (CI), 8.5-15.5) and 38 mo (95% CI, 20.4-55.6), resp. In the Kaplan-Meier anal., the median OS was 89 mo (95% CI, 34.9-143.1) for STZ CTx as first-line therapy compared with 22 mo (95% CI, 19.3-24.7; p = 0.001, log-rank test) for subsequent lines. Bone metastases neg. impacted survival (HR, 2.71, p = 0.009, univariate anal., HR, 2.64, p = 0.015, multivariate anal., and Cox regression). In patients selected according to current guidelines, PFS, and OS after STZ CTx were lower than previously reported, whereas ORR was unchanged. First-line treatment was pos. associated with OS and the presence of bone metastases was neg. associated with OS. Pre-treatment with targeted or peptide-receptor radionuclide therapy did not alter ORR, PFS, or OS.

Endocrine published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics