Month: October 2022

Khan, Anowar H.; Cook, Jeffery K.; Wortmann, Wayne J. III; Kersker, Nathan D.; Rao, Asha; Pojman, John A.; Melvin, Adam T. published the artcile< Synthesis and characterization of thiol-acrylate hydrogels using a base-catalyzed Michael addition for 3D cell culture applications>, Reference of 112-63-0, the main research area is thiol acrylate hydrogel Michael addition 3D cell culture.

There is significant interest in developing new approaches for culturing mammalian cells in a three-dimensional (3D) environment due to the fact that it better recapitulates the in vivo environment. The goal of this work was to develop thiol-acrylate, biodegradable hydrogels that possess highly tunable properties to support in vitro 3D culture. Six different hydrogel formulations were synthesized using two readily available monomers, a trithiol (ETTMP 1300 [ethoxylated trimethylolpropane tri(3-mercaptopropionate) 1300]) and a diacrylate (PEGDA 700 [polyethylene glycol diacrylate 700]), polymerized by a base-catalyzed Michael addition reaction. The resultant hydrogels were homogeneous, hydrophilic, and biodegradable. Different mech. properties such as gelation time, storage modulus (or the elasticity G’), swelling ratio, and rate of degradation were tuned by varying the weight percentage of polymer, the molar ratio of thiol-to-acrylate groups, and the pH of the solution Cytocompatibility was assessed using two model breast cancer cell lines by both 2D and 3D cell culturing approaches. The hydrogel formulations with a thiol-to-acrylate molar ratio of 1.05 were found to be optimal for both 2D and 3D cultures with MDA-MB-231 cellular aggregates found to be viable after 17 days of 3D continuous culture. Finally, MCF7 cells were observed to form 3D spheroids up to 600μm in diameter as proof of principle for the thiol-acrylate hydrogel to function as a scaffold for in vitro 3D cell culture. A comparison of the different mech. properties of the six hydrogel formulations coupled with in vitro cell culture results and findings from previously published hydrogels conclude that the thiol-acrylate hydrogels have significant potential as a scaffold for 3D cell culture.

Journal of Biomedical Materials Research, Part B: Applied Biomaterials published new progress about Animal tissue culture. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ito, Kenji; Chuang, Jeffrey; Alvarez-Lorenzo, Carmen; Watanabe, Tsuyoshi; Ando, Nozomi; Grosberg, Alexander Yu. published the artcile< Multiple-contact adsorption of target molecules by heteropolymer gels>, Electric Literature of 112-63-0, the main research area is thermal sensitive isopropylacrylamide copolymer gel adsorption.

We examined adsorption of target mols. through a multiple-contact interaction in a thermo-sensitive heteropolymer gel which can undergo a volume transition at 34 °C in water. Multi-valent anionic target mols. were adsorbed electrostatically by monovalent cationic adsorbing sites in the gel. The overall affinity (SK) between the gel and the target mol. was calculated from the initial slope of the Langmuir adsorption isotherm: [Tads] = KS[Tsol]/(1 + K[Tsol]), where S, K, [Tsol] and [Tads] represent the number of adsorption sites per unit volume of the gel, the effective binding constant, the equilibrium target concentration in the external solution, and the target concentration adsorbed in the gel, resp. The affinity for the collapsed gel at 60° was studied in terms of the concentrations of three factors: the adsorber, the coexistent salt, and the cross-linker. We found that the relationship between the affinity and these factors can be summarized by an equation first suggested by T. Tanaka.

Macromolecular Symposia published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dai, Weimin; Wu, An; Li, Yunping; Yu, Guofeng; Yan, Xinjiang published the artcile< XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair.>, Application In Synthesis of 112-63-0, the main research area is XPA; glioblastoma; nucleotide excision repair; temozolomide.

Glioblastoma is the most frequent, as well as aggressive kind of high-grade malignant glioma. Chemoresistance is posing a significant clinical barrier to the efficacy of temozolomide-based glioblastoma treatment. By suppressing xeroderma pigmentosum group A (XPA), a pivotal DNA damage recognition protein implicated in nucleotide excision repair (NER), we devised a novel method to enhance glioblastoma therapy and alleviate temozolomide resistance. On the basis of preliminary assessment, we found that XPA dramatically increased in glioblastoma compared with normal cells and contributed to temozolomide resistance. By constructing XPA stably knockdown cells, we illustrate that XPA protects glioma cells from temozolomide-triggered reproductive cell death, apoptosis, as well as DNA repair. Besides, XPA silencing remarkably enhances temozolomide efficacy in vivo. This study revealed a crucial function of XPA-dependent NER in the resistance of glioma cells to temozolomide.

Cell transplantation published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdel Karim, M.; Sima, A.; Mekki, Mai published the artcile< Chemical constituents and antimicrobial activity of sudanese lagenaria siceraria standley (Cucurbitaceae) Oil>, Application In Synthesis of 112-63-0, the main research area is Cucurbitaceae oil sudanese lagenaria siceraria standley antimicrobial activity.

In this study, the constituents and antimicrobial activity of Lagenaria siceraria oil. have been investigated. Lagenaria sicerariaStandley is a common fruit vegetable in the family Cucurbitaceae. The fruit has many uses in ethnomedicine. Fruit is used as diuretic, immunosuppressant, cardio-protective and cardio-tonic. Lagenaria siceraria possesses antioxidant, hypolipidemic and hepatoprotective properties. GC- MS anal. of Lagenaria siceraria oil revealed the presence of three major constituents: linoleic acid Et ester (57.96%); 9,12-octadecenoic acid Me ester (19.56%) and hexdecanoic acid (10.15%%). The oil was screened for antimicrobial activity against five standard human pathogens by using the paper disk diffusion method. The oil showed moderate activity against Pseudomonas aeruginosa.

Pharmaceutical and Chemical Journal published new progress about Acetoxymethyl esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohanessian, Jacqueline; Caron, Michel published the artcile< A spectrophotometric study of the carbohydrate binding site of peanut lectin>, Application In Synthesis of 112-63-0, the main research area is peanut lectin carbohydrate binding; structure activity carbohydrate binding lectin.

The difference spectra spectrophotometric method (spectra recorded between 260 and 300 nm, determined at 10°) was used to determine the binding constants for specific binding of sugars (16 mono-and oligosaccharides) to peanut lectin. For C(6), an extracyclic chain is needed for lectin interaction, and orientation of the -OH group on C(6) is essential; substitution of the hydroxymethyl group decreases the strength of the association A free axial -OH on C(4) is needed for binding. A C(2) equatorial hydroxyl group is not essential for interaction, but the axial position of this group decreases the binding. Methylation of C(1) favors association; there seems to be a slight preference for the α-anomer configuration. For the glycosidic bonds, compounds with the β(1→4) linkage bind more strongly to the lectin than those with the α(1→6) linkage. Overall, these results show that the sequence C(4)-O(4), C(5), C(6)-O(6) of the galactopyranosyl ring is involved in the interactions in the carbohydrate binding site of peanut lectin as postulated previously (Lotan, R., et al, 1975), and that for di- and oligosaccharides, it appears that the configuration of C(1), the nature of the osidic bond and of the 2nd residue may influence the strength of the association

Lectins: Biology, Biochemistry, Clinical Biochemistry published new progress about Agglutinins and Lectins Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Tao; Ding, Yalan; Zhou, Lili; Xu, Haiyan; Loh, Teck-Peng; Wu, Xiaojin published the artcile< Palladium-Catalyzed anti-Michael Reductive Heck Reaction of α,β-Unsaturated Esters>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is palladium catalyzed anti Michael reductive Heck unsaturated ester.

A general intermol. anti-Michael reductive Heck reaction of α,β-unsaturated esters with organobromides has been developed. Most topical classes of aryl, heteroaryl, and vinyl bromides were found to efficiently react with a variety of internal conjugated alkenes. This protocol set up a platform toward diverse α-arylated 1,6-dicarbonyl frameworks found in natural products and drugs, which are still highly challenging targets in traditional α-arylation protocols because of competitive selectivity of enolation. A removable directing group, gram-scale reaction, and modification of complex mols. have addnl. demonstrated that the anti-Michael reductive Heck reaction is a powerful complementary strategy to the classical α-arylation approaches. Preliminary mechanistic studies are consistent with our proposed mechanistic design.

ACS Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hor, Papan Kumar; Goswami, Debabrata; Ghosh, Kuntal; Tako, Miklos; Halder, Suman Kumar; Mondal, Keshab Chandra published the artcile< Preparation of rice fermented food using root of Asparagus racemosus as herbal starter and assessment of its nutrient profile>, HPLC of Formula: 112-63-0, the main research area is rice fermented food Asparagus root herbal starter nutrient profile.

The popularity of traditional fermented food products is based on their healthiness. The addition of a starter brings consistent, desirable, and predictable food changes with improved nutritive, functional, and sensory qualities. The addition of a mixture of plant residues as a starter or source of microbes is an age-old practice to prepare traditional fermented food and beverages, and most of the reported data on traditional foods were based on the anal. of the final product. The contribution of an individual starter component (plant residue) is not exptl. substantiated for any traditional fermented food, but this data are very essential for the formulation of an effective starter. In this study, Asparagus racemosus, which used as a common ingredient of starter for preparation of rice fermented food in the Indian sub-continent, was used as a starter for the preparation of rice fermented food under laboratory scale, and its microbial and nutrient profile was evaluated. The fermented product was a good source of lactic acid bacteria, Bifidobacterium sp., yeast, etc. The food product was acidic and enriched with lactic acid and acetic acid with titratable acidity of 0.65%. The content of protein, fat, minerals, and vitamins (water-soluble) was considerably improved. Most notably, oligosaccharide (G3-matotriose), unsaturated fatty acids (ω3, ω6, ω7, and ω9), and a pool of essential and non-essential amino acids were enriched in the newly formulated food. Thus, the herbal starter-based rice fermented food would provide important macro- and micronutrients. They could also deliver large numbers of active microorganisms for the sustainability of health. Therefore, the selected plant part conferred its suitability as an effective starter for the preparation of healthier rice-based food products.

Systems Microbiology and Biomanufacturing published new progress about Batch fermentation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ignatiuk, Zaneta A.; Janicki, Mikolaj J.; Gora, Robert W.; Konieczny, Krzysztof; Kowalczyk, Rafal published the artcile< Applications of Thermal Activation, Ball-milling and Aqueous Medium in Stereoselective Michael Addition of Nitromethane to En-ynones Catalyzed by Chiral Squaramides>, HPLC of Formula: 112-63-0, the main research area is nitromethane enynone chiral squaramide enantioselective regioselective Michael addition; nitromethyl aryl phenyl pentynone.

Stereoselective addition of nitromethane to conjugated en-ynones was performed through the application of chiral squaramides. Three non-classical approaches to promote the addition reaction were tested, including activation of the nucleophile by inorganic base in a biphasic aqueous system, thermal activation, and ball-milling. Hydrogen-bonding catalysis was effective in all these methods, providing 1,4-addition products in high yields and stereoselectivities of up to 98% requiring 1-5 mol% of Cinchona alkaloid squaramide.

Advanced Synthesis & Catalysis published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Shaojian; Zhu, Jianhua; Wu, Bencheng; Ma, Rui; Li, Xiaohui published the artcile< Green synthesis of ester base oil with high viscosity - Part II: Reaction kinetics study>, Electric Literature of 112-63-0, the main research area is ester base oil high viscosity green synthesis reaction kinetics.

As an eco-friendly lubricant base oil, ester base oil is receiving increasing attention. However, studies on synthetic reaction kinetics of high viscosity complex ester have been rarely reported. In this work, based on the principle of equal reactivity of all functional groups and simplified kinetics models, synthetic reaction kinetics for high viscosity complex ester was investigated in two steps. As for the esterification of trimethylolpropane with glutaric acid, the activation energies of the first and second stage were 55.3 and 73.5 kJ/mol, resp. As for the esterification of the first step products with 2-ethylhexanoic acid, the activation energies of the first and second stage were 60.6 and 98.2 kJ/mol, resp. As for the esterification of the first step products with n-heptanoic acid, its activation energy was 68.9 kJ/mol. A mutation phenomenon on reaction order from zero to second order was discovered, which could be explained by the strong adsorption of organic acid on catalyst surface. The conversion rate of carboxyl of synthetic reaction for mixed acid ester was estimated by simulation, and average relative error was less than 3.0%. The synthetic process of high viscosity complex ester was considered to consist of a series of parallel-consecutive reactions with addition-elimination mechanism.

Chemical Engineering Research and Design published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Huiting; Li, Jiuyan; Liu, Di; Huang, Tingting; Li, Deli published the artcile< Effects of Electron Affinity and Steric Hindrance of the Trifluoromethyl Group on the π-Bridge in Designing Blue Thermally Activated Delayed Fluorescence Emitters>, Application of C19H34O2, the main research area is OLED TADF electron affinity steric hindrance; electron affinity steric hindrance trifluoromethyl pi Bridge; triazine acceptor carbazole tertbutylcarbazole donor; TADF; blue emission; electron affinity; fluorescence; steric hindrance.

To explore the correlation of the acceptor electron affinity and the mol. conformation to the thermally activated delayed fluorescence (TADF) feature, a series of D-π-A mols. were designed and synthesized with triazine (Trz) as the acceptor (A) and carbazole (Cz) or tert-butylcarbazole (BuCz) as the donor (D). On the phenylene bridge between D and A, Me or trifluoromethyl was incorporated close either to D or to A to tune the mol. conformation and the electron-withdrawing ability of acceptor. Both the twist angles and the singlet and triplet energy difference (ΔEST) were observed strongly dependent on the type and position of the substituent on the π-bridge. Only those mols. with trifluoromethyl locating close to the D side, namely TrzCz-CF3 and TrzBuCz-CF3, exhibit TADF feature, verifying that both sufficient electron affinity of the A unit and large dihedral angle between D and the π-bridge are necessary to ensure the occurrence of TADF. The blue organic light-emitting diodes OLED fabricated with TrzCz-CF3 and TrzBuCz-CF3 achieved external quantum efficiencies of 9.40% and 14.22% with CIE coordinates of (0.19, 0.23) and (0.18, 0.29) resp. This study provides practical design strategy for blue TADF materials particularly when planar and less crowded group is used as donor.

Chemistry – A European Journal published new progress about Blue-emitting electroluminescent devices. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics