Month: October 2022

Modrocka, Viktoria; Veverkova, Eva; Baran, Rastislav; Sebesta, Radovan published the artcile< Enantioselective Synthesis of 2,3-Dihydrofurocoumarins by Squaramide-Catalyzed Michael Addition/Cyclization of 4-Hydroxycoumarins with β-Nitrostyrenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hydroxycoumarin nitrostyrene squaramide organocatalyst enantioselective diastereoselective Michael addition heterocyclization; hydroxyimino phenyl furochromenone preparation.

The enantioselective synthesis of chiral 2,3-dihydrofurocoumarins by squaramide-catalyzed Michael addition of 4-hydroxycoumarins to β-nitrostyrenes, followed by a cyclization reaction was described. A coumarin moiety was present in many chiral bioactive compounds, but the organocatalysis has still not reached its full potential in the synthesis of chiral coumarins. Squaramide catalysts comprising two chiral units, (S)-phenylethylamine and cyclohexane-1,2-diamine was used. These catalysts showed high reactivity and enantioselectivity in this transformation. Following this procedure, a series of 2,3-dihydrofurocoumarin derivatives in 47-93% yields and enantiomeric purities in the range of 78-94% ee were prepared Polystyrene-immobilized squaramide catalyst performed well for the initial two reaction cycles but then slowly degraded. The absolute configuration of 2,3-dihydrofurocoumarin products was determined by the comparison of the exptl. and d. functional theory-calculated electronic CD spectra.

ChemistrySelect published new progress about Circular dichroism. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mutlu, Tutku; Demir-Cakan, Rezan published the artcile< Carbonate or ether based electrolyte for Li-Se batteries: An in-situ study of intermediate polyselenide formation>, Application In Synthesis of 112-63-0, the main research area is carbonate ether electrolyte lithium selenium battery intermediate polyselenide formation.

Li-Se batteries have recently been considered as one of the most promising battery systems to satisfy the future energy storage needs. However, to further improve the electrochem. cell performances, understanding of the Li-Se cell working mechanism, especially focusing on the formation of dissolved Li polyselenides, is essential. An in-situ study of intermediate polyselenide formation based on the 4-electrode cycling voltammetry (CV) and 3-electrode electrochem. impedance spectroscopy (EIS) were used to detect the existence of polyselenides in carbonate and ether-based electrolytes. CV measurements reveal dissolved polyselenide intermediate formations in ether-based solvent while no signatures are observed in carbonate-based electrolytes. Similar findings are also observed by EIS measurements as well as studying the self-discharge behavior. Therefore, these two electrochem. characterizations can be easily implemented as prompt and cost-effective techniques to study the impact of the electrolyte solvents. Contrary to the Li-S counterparts, the outcome of the work suggests that carbonate-based electrolytes can be simply employed in the field of Li-Se batteries.

Electrochimica Acta published new progress about Battery electrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nogales-Delgado, Sergio; Encinar Martin, Jose Maria; Sanchez Ocana, Mercedes published the artcile< Use of mild reaction conditions to improve quality parameters and sustainability during biolubricant production>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is safflower oil biolubricant production oxidative stability biodegradability sustainability viscosity.

The use of alternative sources to produce less pollutant biofuels and biomaterials, replacing petroleum-derived products, is becoming an important issue for international organizations, governments, and society. Thus, biodiesel and biolubricant production has been increasingly researched, offering promising results. These products present some advantages such as sustainability or biodegradability, among others. However, some of their quality parameters can be altered during storage, mainly due to their low oxidative stability. Consequently, auto-oxidation processes can take place, increasing viscosity or acid number, which can compromise their marketability. To avoid these inconveniences, some alternatives have been presented, such as the use of antioxidants, vegetable oil selection or the promotion of mild chem. conditions during production The aim of this work was to assess the use of vacuum during biolubricant production from high-oleic safflower oil through double transesterification with methanol and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol to obtain mild chem. conditions. Under these circumstances (working pressure at 210 mmHg) and compared to previous studies, temperature and catalyst addition could be reduced from 140 to 100°C and from 0.5 to 0.3%, resp., increasing the reaction yield from 92.9 to 94.69% and improving the quality of the biolubricant, with 30% increase in viscosity index.

Biomass and Bioenergy published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bollini, Mariela; Domaoal, Robert A.; Thakur, Vinay V.; Gallardo-Macias, Ricardo; Spasov, Krasimir A.; Anderson, Karen S.; Jorgensen, William L. published the artcile< Computationally-Guided Optimization of a Docking Hit to Yield Catechol Diethers as Potent Anti-HIV Agents>, Quality Control of 112-63-0, the main research area is catechol ether anti HIV reverse transcriptase inhibitor computational optimization.

A 5-μM docking hit has been optimized to an extraordinarily potent (55 pM) non-nucleoside inhibitor of HIV reverse transcriptase. Use of free energy perturbation (FEP) calculations to predict relative free energies of binding aided the optimizations by identifying optimal substitution patterns for Ph rings and a linker. The most potent resultant catechol diethers feature terminal uracil and cyanovinylphenyl groups. A halogen bond with Pro95 likely contributes to the extreme potency of compound 42 (I). In addition, several examples are provided illustrating failures of attempted grafting of a substructure from a very active compound onto a seemingly related scaffold to improve its activity.

Journal of Medicinal Chemistry published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nunez-Briones, A. G.; Benavides, R.; Mendoza-Mendoza, E.; Martinez-Pardo, M. E.; Carrasco-Abrego, H.; Kotzian, C.; Saucedo-Zendejo, F. R.; Garcia-Cerda, L. A. published the artcile< Preparation of PVC/Bi2O3 composites and their evaluation as low energy X-Ray radiation shielding>, Formula: C18H26O6, the main research area is polyvinyl chloride bismuth oxide composite radiation shielding.

Plasticized and gamma crosslinked PVC composites were prepared by adding different amounts of Bi2O3 particles to evaluate their low energy X-ray radiation shielding properties. Composites were gamma-irradiated in an industrial irradiator (60Co source) at the corresponding times to obtain a dose of 75 kGy to enhance mech. properties through crosslinking. The shielding properties of composites were obtained by X-ray transmission measurements at low energies (X-ray tube voltages range 20-61 kV) by using a mammog. unit and an X-ray hospital equipment. A small influence in the dehydroclorination reaction of PVC was observed during decomposition in TGA experiments due to Bi2O3 nanoparticle content, but DMA results show improved viscoelastic properties for the crosslinked composites. The X-ray transmission values decrease as a function of nanoparticle content, observing an increase in the transmission values (low attenuation) at higher energies. The composite with 50wt.% of Bi2O3 showed the lowest transmission values, at X-ray tube voltages 20-30 kV, the transmittance was almost nil, and then it increases ∼27% at 61 kV.

Radiation Physics and Chemistry published new progress about Complex modulus, tan δ. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Formula: C18H26O6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kikalishvili, T. J.; Kereselidze, J. A. published the artcile< Trimeric mechanism of proton transfer in imidazole>, Formula: C19H34O2, the main research area is imidazole derivative proton transfer trimeric mechanism AM1 MO.

The energy, electronic, and structural characteristics of the tautomeric transformation of imidazole were calculated by the quantum-chem. semiempirical AM1 method. It was concluded on the basis of the calculated data that proton transfer in the tautomeric transformation 1H-imidazole ⇄ 3H-imidazole can take place by a trimeric mechanism.

Chemistry of Heterocyclic Compounds (New York, NY, United States)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Potential energy surface (proton transfer). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Numao, Naganori; Hamada, Tatsuo; Yonemitsu, Osamu published the artcile< A mechanistic study of the photoreaction of dimethylaniline and methyl chloroacetate. Role of acid-base properties in both the ground state and the excited state>, Product Details of C9H9NO4, the main research area is fluorescence quenching alkylation dimethylaniline; methoxycarbonylmethylation aniline photochem mechanism; exciplex dimethylaniline photochem methoxycarbonylmethylation; kinetics photochem methoxycarbonylmethylation methylaniline.

Quantum yields for fluorescence quenching and disappearance of PhNMe2 (I) were determined for the photochem. alkylation of I with ClCH2CO2Me, in both acidic and basic solutions, to give o- and p-MeO2CCH2C6H4NMe2. Under acidic conditions the reaction occurs via an exciplex, and under basic conditions an exciplex and a charge-transfer complex are involved.

Tetrahedron published new progress about 30095-98-8. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jang, Keun Sam; Shin, Dong Seok; Srisook, Ekaruth; Song, Ho-Chun; Chi, Dae Yoon published the artcile< Versatile functionalization of electron rich-fused heterocyclic arenes via electrophilic aromatic addition reaction and their applications>, SDS of cas: 112-63-0, the main research area is methoxyquinaldine regioselective bromomethoxylation; bromo alkoxyquinaldine preparation; dibromo dimethoxydihydroquinaldine amine regioselective nucleophilic substitution reaction; amino bromo methoxyyquinaldine preparation.

Divergent functionalized 8-methoxyquinaldines were synthesized via regioselective debromination, 1,3-bromine shift process, aromatization with treatment of a strong base, nucleophilic substitution reaction at the C7 position using amines and cyanide as a nucleophile in the absence of a metal source and a catalyst from an unusual electrophilic aromatic addition (AdEAr) reaction products. In addition, quinaldine-7,8-dione was prepared by presence of CAN (ceric ammonium nitrate) in AcOH and H2O for 10 min at room temperature from N-(alkylamino)-8-methoxyquinalidines. During the AdEAr reaction, new stereoselective dearomatized addition products were generated via discriminative reaction routes depending on the methoxy and bromine occupancy position. The AdEAr reaction not only allowed for the functionalization of electron rich-fused heterocyclic arenes, but also provided a new synthetic route to an alternative mechanism for electrophilic aromatic substitution reactions.

Tetrahedron published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nishikawa, Toshio; Urabe, Daisuke; Yoshida, Kazumasa; Iwabuchi, Tomoko; Asai, Masanori; Isobe, Minoru published the artcile< Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analogue of Puffer Fish Toxin>, SDS of cas: 112-63-0, the main research area is asym synthesis deoxytetrodotoxin analog Puffer fish toxin synthon.

8,11-Dideoxytetrodotoxin, an unnatural tetrodotoxin analog, was synthesized in a highly stereoselective manner from a common intermediate in our synthetic studies on tetrodotoxin. The synthesis features neighboring group participation of trichloroacetamide for stereoselective hydroxylation, protection of ortho ester, and guanidine installation with Boc-protected isothiourea.

Organic Letters published new progress about Hydroxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Henrot, Serge; Larcheveque, Marc; Petit, Yves published the artcile< Amino acids as chiral synthons: preparation of enantiomerically pure (R)- and (S)-malic acids and its application to the synthesis of 3-hydroxy-4-butanolide>, Related Products of 617-55-0, the main research area is aspartic acid deamination nitrous acid; malic acid conversion hydroxybutanolide; enantiomeric purity hydroxybutanolide malic acid; amino acid chiral synthon.

Nitrous acid deamination of (S)-aspartic acid gave (S)-malic acid, which dissolved in AcCl to give anhydride I. Reaction of I with MeOH gave the half ester which was chemoselectively reduced by borohydride to hydroxybutanolide II of high optical purity.

Synthetic Communications published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics