Month: October 2022

In 2007,Portilla, Jaime; Mata, Ernesto G.; Cobo, Justo; Low, John N.; Glidewell, Christopher published 《Two isomeric reaction products: hydrogen-bonded sheets in methyl 4-(5-amino-3-phenyl-1H-pyrazol-1-yl)-3-nitrobenzoate and hydrogen-bonded chains of edge-fused rings in methyl 3-nitro-4-[(5-phenyl-1H-pyrazol-3-yl)amino]benzoate》.Acta Crystallographica, Section C: Crystal Structure Communications published the findings.Recommanded Product: 329-59-9 The information in the text is summarized as follows:

In Me 4-(5-amino-3-phenyl-1H-pyrazol-1-yl)-3-nitrobenzoate, C17H14N4O4, the mols. are linked into complex sheets by a combination of N-H···N, N-H···O, and C-H···O hydrogen bonds. In the isomeric Me 3-nitro-4-[(5-phenyl-1H-pyrazol-3-yl)amino]benzoate, mols. exhibit a polarized mol.-electronic structure and are linked into chains of edge-fused rings by a combination of N-H···O and C-H···O hydrogen bonds. The results came from multiple reactions, including the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: 329-59-9)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2007,Portilla, Jaime; Mata, Ernesto G.; Nogueras, Manuel; Cobo, Justo; Low, John N.; Glidewell, Christopher published 《Hydrogen-bonded chains of rings in methyl 4-[(5-methyl-1H-pyrazol-3-yl)amino]-3-nitrobenzoate and hydrogen-bonded sheets in methyl 1-(5-methyl-1H-pyrazol-3-yl)-1H-benzimidazole-5-carboxylate》.Acta Crystallographica, Section C: Crystal Structure Communications published the findings.COA of Formula: C8H6FNO4 The information in the text is summarized as follows:

Mols. of Me 4-[(5-Me-1H-pyrazol-3-yl)amino]-3-nitrobenzoate, C12H12N4O4, (I), exhibit a polarized (charge-separated) structure in the nitroaniline portion. The mols. are linked into chains of edge-fused R22(16) and R22(22) rings by a combination of N-H···O(carbonyl) and C-H···O(nitro) H bonds. Me 1-(5-Me-1H-pyrazol-3-yl)-1H-benzimidazole-5-carboxylate, C13H12N4O2, (II), which is readily formed from (I) by reduction followed by ring formation, crystallizes with Z’ = 2 in the space group P1̅. Each of the 2 independent mol. types is linked into sheets of R44(28) rings by a combination of N-H···N and C-H···O(carbonyl) H bonds. After reading the article, we found that the author used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9COA of Formula: C8H6FNO4)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.COA of Formula: C8H6FNO4Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Suppressing lithium dendrite growth by a synergetic effect of uniform nucleation and inhibition》 was written by Wu, Li-Na; Peng, Jun; Han, Fa-Ming; Sun, Ya-Ke; Sheng, Tian; Li, Yang-Yang; Zhou, Yao; Huang, Ling; Li, Jun-Tao; Sun, Shi-Gang. Related Products of 872-36-6 And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2020. The article conveys some information:

The lithium dendrites issue presents a major challenge limiting the commercialization of Li metal anodes for high-energy-d. batteries. Herein, an AgPF6-LiNO3 hybrid electrolyte additive was introduced into a carbonate electrolyte, which was found to induce the formation of a homogeneous dense layer of Ag-Li alloy seeds with small sizes on the Li metal surface. The formation mechanism of such fine Ag-Li alloy seeds on the Li metal substrate was evaluated, which revealed an interesting synergistic effect between AgPF6 and LiNO3. The occurrence of such a dense layer of Ag-Li alloy seeds was found to play a significant pos. role in homogeneous nucleation and growth of Li dendrites, and LiNO3 could inhibit the growth of Li and act as a grain refiner during a repetitive plating/stripping process, thus enabling profoundly improved structural stability and excellent long-term cycle performance for the Li anode during the cycling process. With the co-presence of AgPF6-LiNO3 in the electrolyte, the relevant sym. cells could work steadily for 3000 h with slight polarization at a d. of 0.5 mA cm-2; and the Li-graphite battery can exhibit good cycle performances and deliver a specific energy d. of 374 W h kg-1 at a power d. of 747 W kg-1. The experimental process involved the reaction of Vinylene carbonate(cas: 872-36-6Related Products of 872-36-6)

Vinylene carbonate(cas: 872-36-6) belongs to esters. Alkyl carbonates find applications as solvents for lithium ion battery electrolytes and the use of high quality battery grade electrolytes having extremely low water (<10 ppm) and acid (<10 ppm) contents are critical for achieving high electrochemical performance.Related Products of 872-36-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Materials Science & Engineering, C: Materials for Biological Applications included an article by Li, Heran; Wu, Xueqian; Yang, Baixue; Li, Jing; Xu, Lu; Liu, Hongzhuo; Li, Sanming; Xu, Jinghua; Yang, Mingshi; Wei, Minjie. Product Details of 7524-52-9. The article was titled 《Evaluation of biomimetically synthesized mesoporous silica nanoparticles as drug carriers: Structure, wettability, degradation, biocompatibility and brain distribution》. The information in the text is summarized as follows:

Herein, three kinds of mesoporous silica nanoparticles (BMSs) were biomimetically synthesized by using heterocyclic amino acid derivatives as template and their the basic capacity in being drug carriers that covered structure, wettability, degradation, brain uptake, hemocompatibility and toxicity were systematically evaluated. The results indicated that BMSs were kinds of spherical nanoparticles with good biocompatibility. Their in vitro and in vivo behaviors, including degradation, biodistribution and biocompatibility were mainly governed by the wettability which was closely related to the structure and pore diameter of mesoporous silica nanoparticles. BMSs can degrade completely under simulated physiol. environments through a time period of 2-13 wk. They showed the tendency of brain distribution, and the distribution amount peaked at 4 h post administration. Particularly, Trp-BMS (BMS templated by C16-L-tryptophan) with the largest amount of -OH groups on the surface exhibited highest wettability, fastest degradation rate and the lowest brain distribution ability. Besides, His-BMS (BMS templated by C16-L-histidine) and Pro-BMS (BMS templated by C16-L-poline) were silica materials with good biocompatibility. Both in vitro and in vivo studies uncovered no significantly toxicity for BMSs and they were proved to be safe when they circulated into the blood. However, Trp-BMS might induce severe hemolysis and cell cycle arrest due to the high wettability. It is believed that appropriate wettability is required for the in vivo application of nanomaterials and the in vivo evaluation of mesoporous silica nanoparticles will provide useful information for understanding the underlining toxicity of biomaterials and bring new insights on designing efficient drug delivery systems.H-Trp-OMe.HCl(cas: 7524-52-9Product Details of 7524-52-9) was used in this study.

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Product Details of 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Polyacrylonitrile fiber with strongly acidic electrostatic microenvironment: Highly efficient and recyclable heterogeneous catalyst for the synthesis of heterocyclic compounds》 were Xiao, Jian; Xu, Gang; Wang, Lu; Li, Pengyu; Zhang, Wenqin; Ma, Ning; Tao, Minli. And the article was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2019. Synthetic Route of C7H12O3 The author mentioned the following in the article:

Four categories of sulfonic acid functionalized fiber catalysts with different surface microenvironments were synthesized by covalent grafting using polyacrylonitrile fiber (PANF) as the support. After the effect of acid structure on catalytic activity was investigated by Friedlander reaction, PANEOSF was chosen for the synthesis of quinolines and coumarin derivatives with high yields and extensive substrate scope (51 examples) in ethanol or water. The effect of electrostatic microenvironment and solvent was discussed and a “”release-catch-release-catch”” catalytic pattern was proposed accordingly. PANEOSF can be easily recycled for 20 times without any decrease of catalytic activity. In the experimental materials used by the author, we found Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)

Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Regio- and stereoselective synthesis of (Z)-(2,3-dihydro-1,4-thiaselenin-2-yl) vinyl sulfides from 2-bromomethyl-1,3-thiaselenole under phase-transfer catalysis conditions》 was published in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. These research results belong to Filippov, Andrey S.; Amosova, Svetlana V.; Potapov, Vladimir A.. Application In Synthesis of Ethyl propiolate The article mentions the following:

A one-pot regio- and stereoselective method for the synthesis of previously unknown (Z)-(2,3-dihydro-1,4-thiaselenin-2-yl) vinyl sulfides I (R = OMe, OEt, Ph; R1 = H, COOMe, COOEt) based on 2-bromomethyl-1,3-thiaselenole and activated acetylenes R1CCC(O)R at room temperature under phase-transfer catalysis conditions in 90-96% yields has been developed.Ethyl propiolate(cas: 623-47-2Application In Synthesis of Ethyl propiolate) was used in this study.

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Application In Synthesis of Ethyl propiolate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of N-methyl-1H-indole and adamantane fragment containing derivatives via UGI-4CR》 was published in Research Journal of Pharmaceutical, Biological and Chemical Sciences in 2019. These research results belong to Bukia, Tinatin; Tevzadze, Tekle; Maisuradze, Jimsher; Samsonyia, Shota. Formula: C10H14ClNO2 The article mentions the following:

An efficient synthesis of N-Methyl-1H-indole and adamantane containing dipeptides obtained via Ugi-four component reaction (U4-CR) by the interaction of an amine, aldehyde, N-methyl-1H-indole-2-carboxylic acid and adamantyl-1-isonitrile was described. U4-CR involved a one-pot condensation of an amine, a carbonyl compound, a carboxylic acid, and an isocyanide to provide a substituted peptide-like product. For N-methyl-1H-indole and adamantane containing dipeptides were established the feasibility of the strategy and was optimized the reaction conditions including temperature, solvents and the influence of bases. The results came from multiple reactions, including the reaction of H-Phg-OEt.HCl(cas: 59410-82-1Formula: C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Formula: C10H14ClNO2 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Matrix assisted antibacterial activity of polymer conjugates with pendant antibiotics, and bioactive and biopassive moieties》 were Mukherjee, Ishita; Ghosh, Anwesha; Bhadury, Punyasloke; De, Priyadarsi. And the article was published in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2019. Electric Literature of C5H11NO2 The author mentioned the following in the article:

Antibacterial activity against a series of potentially pathogenic bacterial strains was evaluated in both liquid and solid matrixes using ciprofloxacin (a well-known fluoroquinolone antibiotic) based polymeric systems with pendant cationic charge and zwitterionic units. The ciprofloxacin containing polymeric architecture was designed to incorporate bioactive killing properties of cationic moieties, whereas biopassive activity was regulated by the bacterial cell repelling capacity of the zwitterionic group. tert-Bu carbamate (Boc)-leucine hydroxyethylmethacrylate (Boc-Leu-HEMA), Boc-ciprofloxacin hydroxyethylmethacrylate (Boc-Cipro-HEMA) and zwitterionic sulphabetaine methacrylate (SBMA) are copolymerized, followed by deprotection of Boc groups from the copolymer under acidic conditions. Boc deprotection resulted in water soluble polymers with cationic charge from the leucine moiety and retained the antibiotics in their active original form. The antibacterial activity of the polymeric system was evaluated against several bacterial species, namely, Escherichia coli (E. coli), Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), Vibrio alginolyticus (V. alginolyticus), and Vibrio chemaguriensis Iso1 (V. chemaguriensis), in both liquid and solid matrixes. The copolymer displayed significant bactericidal efficacy against non-biofilm forming E. coli and B. subtilis in both liquid and solid matrixes. However, the antibacterial effect on biofilm forming V. chemaguriensis was comparatively less prominent in the liquid matrix. Optical microscope images of Gram staining revealed an enhanced surface area of individual cells and chain formation in cells of V. chemaguriensis. The non-cytotoxic profile of the polymer towards mammalian red blood cells (RBCs) and enhanced bactericidal effect in the physiol. to basic pH (7.0-9.5) range against potentially pathogenic V. chemaguriensis using a multitude of microscopic techniques hinted toward the need to develop new antibiotics to combat possible clin. infections in the near future.tert-Butyl carbamate(cas: 4248-19-5Electric Literature of C5H11NO2) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Electric Literature of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Development, characterization and pharmacological evaluation of amino acid prodrugs of (+)-Ibuprofen》 was written by Nija, B.; Rasheed, Arun; Kottaimuthu, A.. Computed Properties of C12H15ClN2O2 And the article was included in International Journal of Research in Pharmaceutical Sciences (Madurai, India) in 2020. The article conveys some information:

The current research work investigate the neuronal pathway associated with NSAIDs that lead to the reduction in the initiation and progression of neurodegenerative diseases such as Alzheimer’s disease, Parkinsonism, etc. This research was developed amino acid prodrugs of the active enantiomer of ibuprofen, (+)-IBN and checks the pharmacol. effects, neuroprotective effect, anti inflammatory effect and anti-ulcerogenic effect. The treatment using (+)-IBN reduced the action of micoglia and the release of cytokine especially TNFα that are mainly involved in the neurodegenerative process. (+)- IBN reduced the deposition of soluble beta amyloid plaque by inhibiting the amyloid precursor protein, beta-secretase 1 and also enhancing the degradation process of beta amyloid via induction of insulin degrading enzyme. (+)-IBN also showed the property that the reduction in the TAU misfolding process. Therefore, the synthesized (+)-IBN amino acid prodrugs treatment effectively produce neuroprotective action, both restoring memory realed risk factors and reversing multiple brain neuropathol. hallmarks. The current research study developed the three amino acid prodrugs of (+)-ibuprofen by conjugating with L-Ph alanine, L-tryptophan and L-tyrosine also the physico-chem. characterization and spectral characterization was done. This study modify the carboxylic acid functional group present in the NSAIDs that lead to the formation of prodrugs with enhanced anti-inflammatory activity, reduced side effects and protective effect against neurodegenerative processes. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Computed Properties of C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Computed Properties of C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Computed Properties of C6H10O3On November 30, 2021 ,《Synthesis and permethylation of methyl 5-(2-chloropyridin-3-yl)pentanoates》 appeared in Chemistry of Heterocyclic Compounds (New York, NY, United States). The author of the article were Bendrath, Franziska; Langer, Peter. The article conveys some information:

Two Me 5-(2-chloropyridin-3-yl)pentanoates were prepared by condensation of 1,3-bis(silyloxy)-1,3-butadienes with 2-chloropyridine-3-carboxylic acid chloride. The permethylation of the products resulted in two completely different products, depending on the substitution pattern of the 1,3,5-tricarbonyl moiety. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Computed Properties of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Computed Properties of C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics