Month: October 2022

Karunakaran, K.; Elango, K. P. published the artcile< Kinetics of oxidation of phenoxyacetic acids by pyridinium hydrobromide perbromide>, Category: esters-buliding-blocks, the main research area is kinetic mechanism oxidation phenoxyacetic acid; LFER oxidation phenoxyacetic acid; pyridinium hydrobromide perbromide oxidation phenoxyacetic acid; isotope effect oxidation phenoxyacetic acid.

The oxidation of several monosubstituted phenoxyacetic acids by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid. The reaction is first order with respect to PHPB. Michaelis-Menten-type kinetics are observed with respect to phenoxyacetic acids. The oxidation of [2,2-2H2]phenoxyacetic acid exhibits a substantial kinetic isotopic effect. The effect of solvent composition indicates that the transition state is more polar than the reactants. The formation constants of the intermediate phenoxyacetic acid-PHPB complexes and the rates of their decomposition were determined at different temperatures The rates of oxidation of para- and meta-substituted phenoxyacetic acids were correlated with Hammett’s substituent constants The ρ value is -2·59 at 35°. The rates of oxidation of ortho-substituted compounds are correlated with Charton’s triparametric equation. A mechanism involving transfer of a hydride ion from the substrate to the oxidant is proposed.

Journal of Physical Organic Chemistry published new progress about Carboxylic acids Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jorgensen, Mikkel; Krebs, Frederik C. published the artcile< Stepwise and Directional Synthesis of End-Functionalized Single-Oligomer OPVs and Their Application in Organic Solar Cells>, Electric Literature of 112-63-0, the main research area is stepwise oligomerization end functionalized oligomer phenylene vinylene solar cell.

A new stepwise directional synthetic route to single-oligomer p-phenylenevinylenes (OPVs) was developed. The 1st step in the reaction sequence is the condensation of a functionalized benzaldehyde with a novel monomer having a Me phosphonate ester group in one end and an acetal-protected aldehyde at the other end of a stilbene core. Oligomerization then proceeds stepwise by alternating reaction of the previous aldehyde-terminated OPV fragment with the monomer and deprotection of the acetal. Thus, OPVs with 3, 5, 7, 9, and 11 phenylene vinylene units were prepared that has an electron-donating methoxy group at one end and an electron-accepting aldehyde group at the other end. Some examples where a dimethylamino group replaced the methoxy group were also prepared The oligomer with seven phenylene vinylene units was then further derivatized at the aldehyde position to create OPVs with a range of substituents from strongly electron-accepting nitrophenyl to electron-donating methoxyphenyl. Photovoltaic cells were assembled with the synthesized OPVs as the photoactive layer. Illumination under simulated sunlight (AM1.5) gave short circuit currents (Isc) in the range 0.015-0.5 mA cm-2 and typical open circuit voltages (Voc) of 0.4-0.8 V. The maximum efficiency obtained was ∼0.1%.

Journal of Organic Chemistry published new progress about Acetals Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PUR (Purification or Recovery), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Shao, Yujie; Pan, Yue; Li, Yueqing; Wang, Yang; Wang, Liu; Wang, Xu; Shao, Kun; Wang, Shisheng; Liu, Naixuan; Zhang, Jingdong; Zhao, Weijie; Nakamura, Hiroyuki published the artcile< Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy>, Related Products of 39987-25-2, the main research area is hydroxyneolamellarin antitumor agent HIF alpha inhibitor; 7-Hydroxyneolamellarin A; Anti-tumor; HIF-1α inhibition; Total synthesis.

7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-Hydroxyneolamellarin A could attenuate the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibit vascular epidermal growth factor (VEGF) transcriptional activity, showing well inhibitory effect on HIF-1 signaling pathway. Meantime, 7-Hydroxyneolamellarin A had the well anti-tumor activities, such as inhibiting tumor angiogenesis, proliferation, migration and invasion. More importantly, 7-Hydroxyneolamellarin A exhibited profound anti-tumor effect in mice breast cancer model by suppressing the accumulation of HIF-1α in tumor tissue. Mechanism study demonstrated that 7-Hydroxyneolamellarin A might target the protein with the ability of stabilizing HIF-1α in hypoxia. Due to the excellent water solubility, superior anti-tumor activity and good biocompatibility, 7-OH-Neo A shows the promising potential for being exploited as an anti-tumor agent in near future.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Related Products of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Perrin, Charles L.; Arrhenius, Thomas published the artcile< Malonic anhydride>, Synthetic Route of 112-63-0, the main research area is malonic anhydride; ozonolysis enol ester; isopropenyl acetate ozonolysis; diketene ozonolysis; glutaric anhydride.

The ozonolysis of enol esters was used to prepare several anhydrides. Thus, CH2:CMeOAc yielded Ac2O and I is converted into glutaric anhydride. Ozonolysis of diketene or II in CH2Cl2 at -78°C produced monomeric malonic anhydrides (I; R = H, Me, resp.). The latter are unstable and undergo cycloreversion near 0° to CO2 and R2C:C:O.

Journal of the American Chemical Society published new progress about Anhydrides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Verschueren, Rik H.; Gilles, Philippe; Van Mileghem, Seger; De Borggraeve, Wim M. published the artcile< Solvent-free N-Boc deprotection by ex situ generation of hydrogen chloride gas>, Category: esters-buliding-blocks, the main research area is amine hydrochloride salt preparation green chem; tertbutyl carbamate deprotection.

An efficient, scalable and sustainable method for the quant. deprotection of the tert-Bu carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. The ex situ generation of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas were demonstrated. The solvent-free conditions allow deprotection of a wide variety of N-Boc derivatives e.g., N-Boc benzylamine to obtain the hydrochloride salts in e.g., benzylamine hydrochloride quant. yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.

Organic & Biomolecular Chemistry published new progress about Amines, salts Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yoshioka, Hiromasa; Kawamura, Tatsuro; Muroi, Makoto; Kondoh, Yasumitsu; Honda, Kaori; Kawatani, Makoto; Aono, Harumi; Waldmann, Herbert; Watanabe, Nobumoto; Osada, Hiroyuki published the artcile< Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)>, Product Details of C15H22N2O2, the main research area is anticancer GPX4 FSP1 inhibitor NPD4928 synergistic effects ferroptosis enhancer.

Glutathione peroxidase 4 (GPX4) is an intracellular enzyme that oxidizes glutathione while reducing lipid peroxides, and is a promising target for cancer therapy. Till date, several GPX4 inhibitors have been reported to exhibit cytotoxicity against cancer cells. However, some cancer cells are less sensitive to the known GPX4 inhibitors. This study aimed to explore compounds showing synergistic effects with GPX4 inhibitors. We screened a chem. library and identified a compound named NPD4928 (I), whose cytotoxicity was enhanced in the presence of a GPX4 inhibitor. Furthermore, we identified ferroptosis suppressor protein 1 (FSP1) as its target protein. The results indicate that NPD4928 enhanced the sensitivity of various cancer cells to GPX4 inhibitors, suggesting the combination to possibly have therapeutic potential via the induction of ferroptosis.

ACS Chemical Biology published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vaz, Paula; Buck, W. Chris; Bhatt, Nilesh; Bila, Dulce; Auld, Andrew; Houston, James; Cossa, Loide; Alfredo, Charity; Jobarteh, Kebba; Sabatier, Jennifer; Macassa, Eugenia; Sousa, Amina; De Vos, Josh; Jani, Ilesh; Yang, Chunfu published the artcile< Compromise of second-line antiretroviral therapy due to high rates of human immunodeficiency virus drug resistance in Mozambican treatment-experienced children with virologic failure>, Product Details of C19H34O2, the main research area is HIV; drug resistance; pediatric; virologic failure.

Background. Virol. failure (VF) is highly prevalent in sub-Saharan African children on antiretroviral therapy (ART) and is often associated with human immunodeficiency virus drug resistance (DR). Most children still lack access to routine viral load (VL) monitoring for early identification of treatment failure, with implications for the efficacy of second-line ART. Methods. Children aged 1 to 14 years on ART for ≥12 mo at 6 public facilities in Maputo, Mozambique were consecutively enrolled after informed consent. Chart review and caregiver interviews were conducted. VL testing was performed, and specimens with ≥1000 copies/mL were genotyped. Results. Of the 715 children included, the mean age was 103 mo, 85.8% had no immunosuppression, 73.1% were taking stavudine/lamivudine/nevirapine, and 20.1% had a history prevention of mother-to-child transmission exposure. The mean time on ART was 60.0 mo. VF was present in 259 patients (36.3%); 248 (95.8%) specimens were genotyped, and DR mutations were found in 238 (96.0%). Severe immunosuppression and nutritional decline were associated with DR. M184V and Y181C were the most common mutations. In the 238 patients with DR, standard second-line ART would have 0, 1, 2, and 3 effective antiretrovirals in 1 (0.4%), 74 (31.1%), 150 (63.0%), and 13 (5.5%) patients, resp. Conclusion. This cohort had high rates of VF and DR with frequent compromise of second-line ART. There is urgent need to scale-up VL monitoring and heat-stable protease inhibitor formulations or integrase inhibitorsfor a more a durable first-line regimen that can feasibly be implemented in developing settings.

Journal of the Pediatric Infectious Diseases Society published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bielecka-Wajdman, Anna M; Ludyga, Tomasz; Smyk, Daria; Smyk, Wojciech; Mularska, Magdalena; Świderek, Patrycja; Majewski, Wojciech; Mullins, Christina Susanne; Linnebacher, Michael; Obuchowicz, Ewa published the artcile< Glucose Influences the Response of Glioblastoma Cells to Temozolomide and Dexamethasone.>, Computed Properties of 112-63-0, the main research area is adjuvant treatment in brain cancer; brain tumor; chemotherapy in brain cancer; glioblastoma; glucose in cancer.

OBJECTIVE: Current research indicates that weakness of glucose metabolism plays an important role in silencing of invasiveness and growth of hypoxic tumors such as GBM. Moreover, there are indications that DXM, frequently used in treatment, may support GBM energy metabolism and provoke its recurrence. METHODS: We carried out in vitro experiments on the commercial T98G cell line and two primary GBM lines (HROG02, HROG17) treated with TMZ and/or DXM in physiological oxygen conditions for GBM (2.5% oxygen) and for comparison, in standard laboratory conditions (20% oxygen). The influence of different glucose levels on selected malignancy features of GBM cells-cellular viability and division, dynamic of cell culture changes, colony formation and concentration of InsR have been elevated. RESULTS: Under 2.5% oxygen and high glucose concentration, an attenuated cytotoxic effect of TMZ and intensification of malignancy features in all glioblastoma cell lines exposed to DXM was seen. Furthermore, preliminary retrospective analysis to assess the correlation between serum glucose levels and Ki-67 expression in surgical specimens derived from patients with GBM (IV) treated with radio-chemotherapy and prophylactic DXM therapy was performed. CONCLUSION: The data suggest a link between the in vitro study results and clinical data. High glucose can influence on GBM progression through the promotion of the following parameters: cell viability, dispersal, InsR expression and cell proliferation (Ki-67). However, this problem needs more studies and explain the mechanism of action studied drugs.

Cancer control : journal of the Moffitt Cancer Center published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gon, Masayuki; Wakabayashi, Junko; Nakamura, Masashi; Tanaka, Kazuo; Chujo, Yoshiki published the artcile< Controlling Energy Gaps of π-Conjugated Polymers by Multi-Fluorinated Boron-Fused Azobenzene Acceptors for Highly Efficient Near-Infrared Emission>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is energy gap conjugated polymer fluorinated boron fused azobenzene acceptor; NIR; azobenzene; boron; conjugated polymer; solid-state emission.

We demonstrate that multi-fluorinated boron-fused azobenzene (BAz) complexes can work as a strong electron acceptor in electron donor-acceptor (D-A) type π-conjugated polymers. Position-dependent substitution effects were revealed, and the energy level of the LUMO was critically decreased by fluorination. As a result, the obtained polymers showed near-IR (NIR) emission (λPL=758-847 nm) with high absolute photoluminescence quantum yield (FPL=7-23%) originating from low-lying LUMO energy levels of the BAz moieties (-3.94 to -4.25 eV). Owing to inherent solid-state emissive properties of the BAz units, deeper NIR emission (λPL=852980 nm) was detected in film state. Clear solvent effects prove that the NIR emission is from a charge transfer state originating from a strong D-A interaction. The effects of fluorination on the frontier orbitals are well understandable and predictable by theor. calculation with d. functional theory. This study demonstrates the effectiveness of fluorination to the BAz units for producing a strong electron-accepting unit through fine-tuning of energy gaps, which can be the promising strategy for designing NIR absorptive and emissive materials.

Chemistry – An Asian Journal published new progress about Charge transfer state. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Berthelot, J.; Guette, C.; Lange, C. published the artcile< Mass spectra of bromine, bromides and tribromides under negative-ion chemical-ionization conditions>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is mass spectra tribromide bromide bromine.

Neg.-ion chem.-ionization (NICI) mass spectra of Bu4N+ X- [X = Br, Br3 (I)], pyridinium tribromide, Me3CBr, Br2 and PhNMe3+ Br3- were measured. I was the most efficient brominating reagent in the gas phase in a mass spectrometer under NICI conditions.

Organic Mass Spectrometry published new progress about Negative ion chemical ionization mass spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics