Month: October 2022

Lu, Yang; Liu, Yi; Dai, Ya-Zhong; Yang, Chi-Yuan; Un, Hio-Ieng; Liu, Si-Wei; Shi, Ke; Wang, Jie-Yu; Pei, Jian published the artcile< 5,5'-Diazaisoindigo: an Electron-Deficient Building Block for Donor-Acceptor Conjugated Polymers>, Computed Properties of 112-63-0, the main research area is isoindigo derivative donor acceptor conjugated polymer; conjugated polymers; diazaisoindigo; donor-acceptor systems; electron-deficient compounds.

A novel electron-deficient building block, 5,5′-diazaisoindigo (5DNIID), was synthesized through a facile method in good yield. As a derivative of isoindigo, 5DNIID shows an ultra-low LUMO level of -3.92 eV after incorporation of two electron-deficient nitrogen atoms into the para-position of the amine groups in the isoindigo π skeleton. Modified polymerization conditions were applied to efficiently afford the donor-acceptor (D-A) conjugated polymer 5DNIID-2T, which exhibited a p-type charge transport property.

Chemistry – An Asian Journal published new progress about Annealing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Meng-Meng; Yin, Deng-Ke; Rui, Xue-Lin; Shao, Fu-Ping; Li, Jia-Cheng; Xu, Li; Yang, Ye published the artcile< Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is colorectal cancer colitis Wnt signaling pathway; AOM-DSS; CAC; Gut microbiota; Pai-Nong-San; Wnt signaling pathway.

Pai-Nong-San (PNS), a prescription of traditional Chinese medicine, has been used for years to treat abscessation-induced diseases including colitis and colorectal cancer. This study was aimed to investigate the preventive effects and possible protective mechanism of PNS on a colitis-associated colorectal cancer (CAC) mouse model induced by azoxymethane (AOM)/dextran sodium sulfate (DSS). The macroscopic and histopathol. examinations of colon injury and DAI score were observed The inflammatory indicators of intestinal immunity were determined by immunohistochem. and immunofluorescence. The high throughput 16S rRNA sequence of gut microbiota in the feces of mice was performed. Western blot was used to investigate the protein expression of the Wnt signaling pathway in colon tissues. PNS improved colon injury, as manifested by the alleviation of hematochezia, decreased DAI score, increased colon length, and reversal of pathol. changes. PNS treatment protected against AOM/DSS-induced colon inflammation by regulating the expression of CD4+ and CD8+ T cells, inhibiting the production of HIF-α, IL-6, and TNF-α, and promoting the expression of IL-4 and IFN-γ in colon tissues. Meanwhile, PNS improved the components of gut microbiota, as measured by the adjusted levels of Firmicutes, Bacteroidetes, Proteobacteria, and Lactobacillus. PNS down-regulated the protein expression of p-GSK-3β, β-catenin, and c-Myc, while up-regulating the GSK-3β and p-β-catenin in colon tissues of CAC mice. In conclusion, our results suggested that PNS exhibits protective effect on AOM/DSS-induced colon injury and alleviates the development of CAC through suppressing inflammation, improving gut microbiota, and inhibiting the Wnt signaling pathway.

Chinese Journal of Natural Medicines (Amsterdam, Netherlands) published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gruber, Stefan; Ametamey, Simon M.; Schibli, Roger published the artcile< Unexpected reactivity of cyclic perfluorinated iodanes with electrophiles>, Related Products of 112-63-0, the main research area is perfluorinated compound preparation reactivity.

The cyclic perfluorinated iodanes react with electrophiles (E+ = Br, Cl, F, I) to afford perfluorinated E-RF compounds This reactivity is unexpected since cyclic perfluorinated iodanes are considered as electrophilic reagents that normally react with nucleophiles (e.g. Nu- = SR, OR) to afford Nu-RF products. The utility of this new transformation is demonstrated for a [18F]CF3CF2-containing compound which was prepared from [18F]XeF2 obtained from cyclotron produced [18F]fluoride.

Chemical Communications (Cambridge, United Kingdom) published new progress about Electrophiles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dahlgren, Anders; Johansson, Per-Ola; Kvarnstrom, Ingemar; Musil, Djordje; Nilsson, Ingemar; Samuelsson, Bertil published the artcile< Novel Morpholinone-Based D-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex>, Synthetic Route of 617-55-0, the main research area is morpholinone tripeptide analog preparation thrombin inhibitor MSBAR; reductive amination ring closure preparation morpholinone tripeptide thrombin inhibitor; crystal structure thrombin morpholinone tripeptide inhibitor.

A morpholinone structural motif derived from D(+)- and L(-)-malic acid has been used as a mimic of D-Phe-Pro in the thrombin inhibiting tripeptide D-Phe-Pro-Arg. In place of Arg the more rigid P1 truncated p-amidinobenzylamine (Pab) or 2-amino-5-aminomethyl-3-methyl-pyridine have been utilized. The synthetic strategy developed readily delivers these novel thrombin inhibitors used to probe the α-thrombin inhibitor binding site. The best candidate (I) in this series of thrombin inhibitors exhibits an in vitro IC50 of 720 nM.3. The X-ray crystal structure of I co-crystallized with α-thrombin is discussed.

Bioorganic & Medicinal Chemistry published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh Syali, Mohanjeet; Mishra, Kuldeep; Kanchan, D. K.; Kumar, Deepak published the artcile< Studies on a novel Na+ superionic conducting polymer gel cocktail electrolyte membrane immobilizing molecular liquid mixture of carbonates, tetraglyme and ionic liquid>, Quality Control of 112-63-0, the main research area is superionic conducting polymer gel carbonates tetraglyme ionic liquid.

Novel Na+ superionic conducting polymer gel cocktail electrolyte membranes immobilizing mol. liquid mixture of carbonates, tetraglyme and ionic liquid have been prepared by solution cast method. The optimized free standing electrolyte membrane offers ionic conductivity of 3.3 x 10-3 S cm-1 and sodium-ion transport number of 0.31 at ambient temperature The detailed ion-dynamics have been investigated with the help of frequency dependent dielec. and modulus studies. The possible interaction of these mol. liquids with sodium tetrafluoroborate salt and poly(vinylidiene fluoride-hexafluoropropylene) polymer host is investigated by FTIR studies. The DSC study confirms that the electrolyte system maintains the gel phase up to ∼ 120°C. The linear sweep voltammetry reveal the working voltage range offered by the electrolyte system to be 3.46 V. The Elec. double layer capacitor (EDLC) cell with optimized electrolyte membrane and electrodes of activated carbon demonstrate the specific discharge capacity of ∼ 60F g-1 and drops negligibly with cycle number The reported Na+ superionic conducting cocktail electrolyte system can be utilized as an electrolyte while fabricating electrochem. devices especially the EDLCs.

Journal of Molecular Liquids published new progress about Activated carbon fibers Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barton, John W.; Buhaenko, Michael; Moyle, Brian; Ratcliffe, Norman M. published the artcile< A promising material for nonlinear optics: observation of second harmonic generation from [N-(4-carboxypentyl)-N-methylamino]-4'-nitrostilbene-coated substrates>, Quality Control of 112-63-0, the main research area is nonlinear optic material; carboxypentylmethylaminonitrostilbene Langmuir Blodgett glass coating; second harmonic glass coating carboxypentylmethylaminonitrostilbene.

Glass coated with p-O2NC6H4CH:CHC6H4[NMe(CH2)4CO2H]-p (prepared in 4 steps from p-O2NC6H4Me) by the Langmuir-Blodgett technique gave a noncentrosym. material exhibiting 2nd harmonic generation, 1.06 to 0.53 μm.

Journal of the Chemical Society, Chemical Communications published new progress about Second-harmonic generation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wong, Thomas Y.; Zhang, Kevin S.; Gandhi, Ripal T.; Collins, Zachary S.; O’Hara, Ryan; Wang, Eric A.; Vaheesan, Kirubahara; Matsuoka, Lea; Sze, Daniel Y.; Kennedy, Andrew S.; Brown, Daniel B. published the artcile< Long-term outcomes following 90Y Radioembolization of neuroendocrine liver metastases: evaluation of the radiation-emitting SIR-spheres in non-resectable liver tumor (RESiN) registry>, Reference of 112-63-0, the main research area is yttrium90 radiation therapy prognosis neuroendocrine tumor hepatotoxicity liver metastasis; Liver cancer; Metastases; Neuroendocrine tumor.

The goal of this study was to evaluate efficacy and safety of 90Y radioembolization for neuroendocrine liver metastases (NELM) in a multicenter registry. One hundred-seventy patients with NELM were enrolled in the registry (NCT 02685631). Prior treatments included hepatic resection (n = 23, 14%), arterial therapy (n = 62, 36%), octreotide (n = 119, 83%), cytotoxic chemotherapy (n = 58, 41%), biol. therapy (n = 49, 33%) and immunotherapy (n = 10, 6%). Seventy-seven (45%) patients had extrahepatic disease. Seventy-eight (48%), 61 (37%), and 25 (15%) patients were Eastern Cooperative Oncol. Group (ECOG) performance status of 0, 1, or ≥ 2. Tumor grade was known in 81 (48%) patients: 57 (70%) were well-, 12 (15%) moderate-, and 12 (15%) poorly-differentiated. Kaplan-Meier anal. and log rank tests were performed to compare overall and progression-free survival (OS/PFS) by tumor location and grade. Toxicities were reported using Common Terminol. Criteria for Adverse Events v.5. Cox Proportional Hazards were calculated for pancreatic primary, performance status, extrahepatic disease at treatment, unilobar treatment, baseline ascites, and > 25% tumor burden. One, 2, and 3-yr OS rates were 75, 62 and 46%, resp. Median OS was 33 mo 95% CI: 25-not reached. The longest median OS was in patients with pancreatic (42 mo, 95% CI: 33-NR) and hindgut (41 mo, 95% CI: 12-NR) primaries. The shortest OS was in foregut primaries (26 mo; 95% CI: 23-NR; X2 = 7, p = 0.1). Median OS of well-differentiated tumors was 36 mo (95% CI: 10-NR), compared to 44 (95% CI: 7-NR) and 25 (95% CI: 3-NR) months for moderate and poorly differentiated tumors. Median progression-free survival (PFS) was 25 mo with 1, 2, and 3-yr PFS rates of 70, 54, and 35%, resp. Thirteen patients (7.6%) developed grade 3 hepatic toxicity, most commonly new ascites (n = 8, 5%) at a median of 5.5 mo. Performance status of ≥2 (HR 2.7, p = 0.01) and baseline ascites (HR 2.8, P = 0.049) predicted shorter OS. Discussion: In a population with a high incidence of extrahepatic disease, 90Y was effective and safe in treatment of NELM, with median OS of 41 mo for well differentiated tumors. Grade 3 or greater hepatic toxicity was developed in 7.6% of patients. Trial registration: NCT 02685631.

BMC Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Chao; Gu, Haiwei; Jin, Yan; Wurm, Daniel; Freidhof, Brian; Lu, Yingying; Chen, Qin M. published the artcile< Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols>, SDS of cas: 112-63-0, the main research area is Nrf2 NAD sugar alc oxidative stress metabolomic; Cardiomyocytes; NAD; Nrf2 knockout; Pentose phosphate pathway; Sugar alcohols.

Nrf2 encodes a transcription factor best known for regulating the expression of antioxidant and detoxification genes. Recent evidence suggested that Nrf2 mediates metabolic reprogramming in cancer cells. However, the role of Nrf2 in the biochem. metabolism of cardiac cells has not been studied. Using LC-MS/MS-based metabolomics, we addressed whether knocking out the Nrf2 gene in AC16 human cardiomyocytes affects metabolic reprogramming by oxidative stress. Profiling the basal level metabolites showed an elevated pentose phosphate pathway and increased levels of sugar alcs., sorbitol, L-arabitol, xylitol and xylonic acid, in Nrf2 KO cells. With sublethal levels of oxidative stress, depletion of NAD, an increase of GDP and elevation of sugar alcs., sorbitol and dulcitol, were detected in parent wild type (WT) cells. Knocking out Nrf2 did not affect these changes. Biochem. assays confirmed depletion of NAD in WT and Nrf2 KO cells due to H2O2 treatment. These data support that although Nrf2 deficiency caused baseline activation of the pentose phosphate pathway and sugar alc. synthesis, a brief exposure to none-LDs of H2O2 caused NAD depletion in an Nrf2 independent manner. Loss of NAD may contribute to oxidative stress associated cell degeneration as observed with aging, diabetes and heart failure.

Toxicology and Applied Pharmacology published new progress about Aging, animal. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shimizu, Junji; Murao, Atsushi; Nofi, Colleen; Wang, Ping; Aziz, Monowar published the artcile< Extracellular CIRP promotes GPX4-mediated ferroptosis in sepsis>, Reference of 347174-05-4, the main research area is ferroptosis eCIRP therapeutic target inflammation sepsis; GPX4; acute lung injury; eCIRP; ferroptosis; lung; macrophage; sepsis.

Sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated mol. pattern (DAMP) that promotes inflammation and induces cell death via apoptosis, NETosis, and/or pyroptosis. Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxide on cellular membranes. We hypothesize that eCIRP induces ferroptosis in macrophages and lung tissue during sepsis. RAW 264.7 cells stimulated with recombinant murine (rm) CIRP significantly decreased the expression of glutathione peroxidase 4 (GPX4), a neg. regulator of ferroptosis, and increased lipid reactive oxygen species (ROS) in a TLR4 dependent manner. In TLR4-/- peritoneal macrophages, depression of GPX4 expression and increase in lipid ROS levels were attenuated after rmCIRP-treatment compared to WT macrophages. rmCIRP also induced cell death in RAW 264.7 cells which was corrected by the ferroptosis inhibitor, ferrostatin-1 (Fer-1). I.p. injection of rmCIRP decreased GPX4 expression and increased lipid ROS in lung tissue, whereas the increase of lipid ROS was reduced by Fer-1 treatment. GPX4 expression was significantly decreased, while malondialdehyde (MDA), iron levels, and injury scores were significantly increased in lungs of WT mice after cecal ligation and puncture (CLP)-induced sepsis compared to CIRP-/- mice. Treatment with C23, a specific eCIRP inhibitor, in CLP mice alleviated the decrease in GPX4 and increase in MDA levels of lung tissue. These findings suggest that eCIRP induces ferroptosis in septic lungs by decreasing GPX4 and increasing lipid ROS. Therefore, regulation of ferroptosis by targeting eCIRP may provide a new therapeutic approach in sepsis and other inflammatory diseases.

Frontiers in Immunology published new progress about Apoptosis. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Reference of 347174-05-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pandey, Karuna Shanker; Shriprakash; Pandey, Mamta; Rao, Karumuru Mallikarjuna; Vaidyanathaswamy, Ramamoorthy published the artcile< Synthesis and resolution of tetrahydropyran carboxylic acids and the bioevaluation of their esters as cockroach attractants>, Name: Methyl tetrahydro-2H-pyran-3-carboxylate, the main research area is tetrahydropyrancarboxylate attractant cockroach.

Tetrahydropyran-2- and 3-carboxylic acids were resolved by using quinine. The enantiomeric purity of the corresponding Me esters (I and II) was determined by proton NMR, using a lanthanide chiral shift reagent [Eu(hfc)3] in the ratio 1:3 (substrate/shift reagent). The relative attractant activity of the racemic, and (+) and (-) isomers of these esters was evaluated against Blattella germanica (L.) and Supella longipalpa (F.). The results show that the activity order for I was (-) > (+) > racemic, and for II was (+) > (-) > racemic.

Bioscience, Biotechnology, and Biochemistry published new progress about Blattella germanica. 18729-20-9 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O3, Name: Methyl tetrahydro-2H-pyran-3-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics