Month: October 2022

Delso, Ignacio; Marca, Eduardo; Mannucci, Vanni; Tejero, Tomas; Goti, Andrea; Merino, Pedro published the artcile< Tunable Diastereoselection of Biased Rigid Systems by Lewis Acid Induced Conformational Effects: A Rationalization of the Vinylation of Cyclic Nitrones En Route to Polyhydroxylated Pyrrolidines>, Application In Synthesis of 617-55-0, the main research area is tunable diastereoselective vinylation cyclic nitrone Lewis acid conformational effect; pyrrolidine polyhydroxylated diastereoselective preparation.

The diastereofacial selection in addition reactions to biased rigid systems can be modulated by the action of Lewis acids. As an example, the stereoselectivity of the nucleophilic addition of vinylmagnesium bromide (VMB) to cyclic nitrones in the presence of diethylaluminum chloride (DEAC) shows a strong dependence on the temperature and the carbon substituent adjacent at the reaction center; it is remarkable that whereas a high selectivity is obtained at higher temperatures, in the presence of DEAC, a trend to invert the stereochem. course of the reaction is observed at lower temperatures, provided the substituent at C3 of the pyrrolidine ring allows delivery of the vinyl moiety. This behavior and difference in selectivity is to be attributed to the high conformational barriers of the intermediate nitrone-DEAC-VMB complex. A clear inversion of the selectivity is observed at -78 °C for the reaction of the nitrone protected as an O-Me derivative The present study provides a rationalization for the stereocontrolled addition of nucleophiles to rigid systems (cyclic nitrones).

Chemistry – A European Journal published new progress about Conformational barrier (of nitrone-Grignard-Al complex). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jochum, Florian D.; Theato, Patrick published the artcile< Temperature and light sensitive copolymers containing azobenzene moieties prepared via a polymer analogous reaction>, Computed Properties of 71195-85-2, the main research area is azobenzene temperature light sensitive copolymer.

Four different series of polyacrylamides containing different amounts of azobenzene moieties have been synthesized via a polymer analogous reaction of poly(pentafluorophenylacrylate) (PPFPA). All copolymers were designed to exhibit a lower critical solution temperature (LCST) in aqueous solution, which was dependent on (i) the amount of incorporated chromophoric azobenzene groups and (ii) the isomerization state of the resp. azobenzene group. Higher LCST values were measured for UV-irradiated solutions of the copolymers in comparison to the non-irradiated copolymer solutions A maximum difference in the LCST of up to 7 °C was found for the copolymer poly(N,N-dimethylacrylamide) containing 8.5 mol% of azobenzene groups. Within this temperature range, a reversible solubility change of the copolymer could be induced by irradiation with light.

Polymer published new progress about Fluoropolymers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janeeshma, Edappayil; Puthur, Jos T.; Wrobel, Jacek; Kalaji, Hazem M. published the artcile< Metabolic alterations elicited by Cd and Zn toxicity in Zea mays with the association of Claroideoglomus claroideum>, HPLC of Formula: 112-63-0, the main research area is Claroideoglomus claroideum Cadmium Zinc toxicity metabolic alterations Zea mays; Arbuscular Mycorrhiza – AM; Cadmium; GC-MS; Mycorrhiza; Phytochemistry; Zinc.

The concentrations of cadmium (Cd) and zinc (Zn) in arable lands exceed the maximum permissible levels due to the excessive use of phosphorus fertilizers and fungicides by farmers. The increasing issues related to the application of agrochems. have lead to the demand for the implementation of sustainable agricultural approaches. Association of arbuscular mycorrhizae with crop plants is an appropriate strategy due to the potential of these microorganisms to augment the metals tolerance of plants through the immobilization of Cd and Zn in an eco-friendly manner. In the present study, 45 d old Zea mays (var. CoHM6) plants inoculated with AM fungi (Claroideoglomus claroideum) were exposed to 1.95 g Zn Kg-1 soil and 0.45 g Cd Kg-1 soil. The major objective of this study was to determine the metabolic alterations in the leaves and roots of mycorrhizal and non-mycorrhizal plants exposed to CdCl2 and ZnSO4. Both non AM and AM plants exhibited alterations in the quantity of primary and secondary metabolites on exposure to Zn and Cd toxicity. Moreover, Zn and Cd-induced accumulation of gamma-sitosterol reduced the quantity of neophytadiene (a well-known terpenoid) and aided the production of 3-beta-acetoxystigmasta-4,6,22-triene in maize leaves. Mycorrhization and heavy metal toxicity induced significant metabolic changes in the roots by producing 4,22-stigmastadiene-3-one, eicosane, 9,19-cyclolanost-24-en-3-ol, pentacosane, oxalic acid, heptadecyl hexyl ester, l-norvaline, and n-(2-methoxyethoxycarbonyl). In addition, the metal-induced variations in leaf and root lignin composition were characterized with the aid of the FTIR technique. Mycorrhization improved the tolerance of maize plants to Cd and Zn toxicity by stabilizing these metal ions in the soil and/or limiting their uptake into the plants, thus ensuring normal metabolic functions of their roots and shoots.

Ecotoxicology published new progress about Claroideoglomus claroideum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lv, Hongyang; Zhang, Xiaorui; Ren, Yuanyuan; Zeng, Yijia; Fang, Qian; Fu, Qinwen; He, Dongmei; Yan, Zhuyun published the artcile< Title The Use of GC-MS and Network Pharmacology to Analyze the Material Basis and Mechanism of Ligusticum chuanxiong Hort. in Treating Chronic Cerebral Circulation Insufficiency>, Product Details of C19H34O2, the main research area is GCMS network pharmacol Ligusticum chuanxiong chronic cerebral circulation insufficiency.

Use Gas chromatog.-mass spectrometry technol. (GC-MS) to identify volatile chem. components in Ligusticum chuanxiong Hort. (LCH). The TCMSP and Swiss Target Prediction online platform were used to screen and predict the potential targets of the chem. components of LCH, and GeneCards, CTD, OMIM, DisGeNET, GEO databases were used to collect the potential targets of chronic cerebral circulation insufficiency (CCCI). A total of 50 volatile chem. components in LCH were analyzed and identified, and 126 potential targets for LCH treatment of CCCI were screened on this basis. Through further network topol. anal., 33 core components and 36 potential core targets were screened out. GO and KEGG enrichment anal. revealed that LCH played a therapeutic role through signaling pathways such as Neuroactive ligand-receptor interaction, Alzheimer disease, Pathways of neurodegeneration-multiple diseases, Proteoglycans in cancer, and Chem. carcinogenesis-receptor activation. The mol. docking results showed the top 4 active ingredients, Ligustilide, Terpineol, 3-Butylidenephthalide, and Linalool, and the top 5 core targets CREBBP, HSP90AA1, ESR1, VEGFA, and NR3 C1 all have good binding activity. The free energy is less than ≤-5 kcal/mol, and the mol. docking conformation is stable. LCH may improve the symptoms of CCCI by acting on inhibiting inflammatory factors, protecting nerve cells, and promoting angiogenesis pathways.

ChemistrySelect published new progress about Aliphatic compounds Role: ANT (Analyte), PKT (Pharmacokinetics), PUR (Purification or Recovery), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Basova, Liana; Lindsey, Alexander; McGovern, Anne Marie; Ellis, Ronald J.; Marcondes, Maria Cecilia Garibaldi published the artcile< Detection of H3K4me3 identifies neurohiv signatures, genomic effects of methamphetamine and addiction pathways in postmortem HIV+ brain specimens that are not amenable to transcriptome analysis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is histone detection chromatin gene expression transcriptional profiling; H3K4me3; HIV; brain; methamphetamine; postmortem interval.

Human postmortem specimens are extremely valuable resources for investigating translational hypotheses. Tissue repositories collect clin. assessed specimens from people with and without HIV, including age, viral load, treatments, substance use patterns and cognitive functions. One challenge is the limited number of specimens suitable for transcriptional studies, mainly due to poor RNA quality resulting from long postmortem intervals. We hypothesized that epigenomic signatures would be more stable than RNA for assessing global changes associated with outcomes of interest. We found that H3K27Ac or RNA Polymerase (Pol) were not consistently detected by Chromatin Immunoprecipitation (ChIP), while the enhancer H3K4me3 histone modification was abundant and stable up to the 72 h postmortem. We tested our ability to use H3K4me3 in human prefrontal cortex from HIV+ individuals meeting criteria for methamphetamine use disorder or not (Meth +/-) which exhibited poor RNA quality and were not suitable for transcriptional profiling. Systems strategies that are typically used in transcriptional metadata were applied to H3K4me3 peaks revealing consistent genomic activity differences in regions where addiction and neuronal synapses pathway genes are represented, including genes of the dopaminergic system, as well as inflammatory pathways. The resulting comparisons mirrored previously observed effects of Meth on suppressing gene expression and provided insights on neurol. processes affected by Meth. The results suggested that H3K4me3 detection in chromatin may reflect transcriptional patterns, thus providing opportunities for anal. of larger numbers of specimens from cases with substance use and neurol. deficits. In conclusion, the detection of H3K4me3 in isolated chromatin can be an alternative to transcriptome strategies to increase the power of association using specimens with long postmortem intervals and low RNA quality.

Viruses published new progress about Activating transcription factor 2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lan, X-Y; Li, D; Li, S; Zhong, L-Z; Zhao, H; Xi, Y-L; Sun, Z-W published the artcile< Impact of angiogenic inhibition in the treatment of newly diagnosed and recurrent glioblastoma: a meta-analysis based on randomized controlled trials.>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

OBJECTIVE: Glioblastoma (GBM) is the most common and aggressive primary malignant tumor of the central nervous system in adults with high recurrence and mortality rates. Although radiotherapy and temozolomide have become the standard therapeutic regimen for GBM as adjuvant chemoradiotherapy after surgical resection, clinical outcomes remain suboptimal. In recent years, targeted antiangiogenic therapy has attracted considerable attention, but its therapeutic efficacy and safety are still controversial. MATERIALS AND METHODS: Randomized controlled trials (RCTs) of chemoradiotherapy with or without bevacizumab for the treatment of glioblastoma were collected by searching on the Pubmed, Embase, Cochrane, Ovid, Scopus, Web of Science, and Google Scholar databases from the date of database establishment to February 2022. Meta-analysis was performed using RevMan 5.3 software after two investigators independently screened the literature, extracted data, and assessed the risk bias of included studies. RESULTS: A total of 7 RCTs were included. The meta-analysis showed that bevacizumab in combination with chemoradiotherapy was superior to chemoradiotherapy alone in terms of progression-free survival (PFS), with a statistically significant difference. Interestingly, bevacizumab in combination with chemoradiotherapy improved PFS more significantly in recurrent glioblastoma than in newly diagnosed glioblastoma. However, for overall survival (OS), the combination of bevacizumab with chemoradiotherapy was similar to chemoradiotherapy alone, which was not significantly different. With regard to safety, the incidence of most adverse events was higher in the combination of bevacizumab and chemoradiotherapy than in chemoradiotherapy alone, especially in terms of hematologic adverse events. CONCLUSIONS: Current evidence suggests that angiogenesis inhibitor-containing chemoradiotherapy regimens are preferentially recommended for patients with recurrent glioblastoma to prolong their progression-free survival, provided that safety is acceptable, but this does not confer a significant benefit on overall patient survival.

European review for medical and pharmacological sciences published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Subramanian, K.; Somachandran, R. S. published the artcile< Synthesis of castor oil based pristine and silver nanoparticle embedded polyurethanes and their characterization by thermal and antibacterial activity analysis for biomedical applications>, Formula: C19H34O2, the main research area is Bacillus castor oil silver nanoparticle polyurethane antibacterial thermal stability.

Ecofriendly and sustainable pristine and silver nanoparticle embedded polyurethanes (PUs)/polyureas were synthesized by using the renewable castor oil as the main component, 1,6-hexane diol, poly(propylene glycol) and poly(propylene glycol)-bis-2-amino Pr ether as chain extenders, trimethylolpropane/or glycerol as cross linkers and toluene diisocyanate and dibutyltindilaurate as curator and catalyst, resp. The prepared PUs were characterized for their thermal degradation by simultaneous TGA/DTA, structural features by FT-IR and antibacterial activity against Bacillus subtilis and E. coli. The onset degradation temperature (265-269°C) of the PUs was much lower than the onset weight loss temperature of castor oil. In air, the thermal degradation was exothermic at temperatures beyond 300°C. Unlike the pristine PUs, AgNPs embedded PUs displayed antibacterial activity and comparatively lower degradation temperature due to the catalytic effect of silver nanoparticles (AgNPs). These PUs may be used for various biomedical applications such as antibacterial foam, antibacterial scaffold, body implant, food packaging, wound dressing, etc.

Asian Journal of Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Del Pozo, Vanessa; Robles, Andrew J.; Fontaine, Shaun D.; Liu, Qianqian; Michalek, Joel E.; Houghton, Peter J.; Kurmasheva, Raushan T. published the artcile< PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is PEGylated talazoparib temozolomide Ewing sarcoma; Molecular medicine; Oncology; Pharmacology.

Current therapy is ineffective for relapsed and metastatic Ewing sarcoma (EwS) owing to development of drug resistance. Macromol. prodrugs potentially lead to lower drug exposure in normal tissues and reduced toxicity. We evaluated the efficacy of PEGylated talazoparib (PEG∼TLZ), a PARP1 inhibitor, alone or in combination with the DNA-alkylating agent temozolomide (TMZ) in EwS and other pediatric tumors using conventional testing or single-mouse trial (SMT). A single dose of PEG∼TLZ (10 μmol/kg on day 0) combined with 5 daily doses of TMZ (40 mg/kg starting on day 3/4) produced minimal toxicity, and the combination achieved maintained complete response in EwS and glioblastoma models. The SMT trial with the 3-day interval between PEG∼TLZ and TMZ resulted in objective responses in EwS and other xenografts. Thus, PEG∼TLZ + TMZ demonstrated a broad range of activity in pediatric solid tumor models. Furthermore, the therapeutic window of PEG∼TLZ + TMZ was enhanced compared with the free-TLZ combination.

iScience published new progress about Alkylating agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Levin, Yevgenia; Hamza, Khalil; Abu-Reziq, Raed; Blum, Jochanan published the artcile< Sol-gel entrapped pyridinium hydrobromide perbromide as a recyclable bromination agent: its application to a one-pot bromination and dehydrobromination process>, Electric Literature of 112-63-0, the main research area is bromination solgel entrapped pyridinium hydrobromide perbromide.

Silica sol-gel encaged pyridinium hydrobromide perbromide can be used for clean, odorless bromination of a variety of substrates, including alkenes, ketones, and arenes. The used heterogenized bromination reagent can be recharged with bromine and recycled. In the presence of sol-gel entrapped 1,5,7-triazabicyclo[4.4.0]dec-5-ene, dibromides are dehydrobrominated to give vinyl monobromides and/or alkynes. Encapsulation of the pyridinium derivative and the guanidine base within sep. sol-gel matrixes enables the use of both opposing reagents in one-pot reactions without their mutual destroying each other.

European Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El Ouar, Mohamed; Knouzi, Nousedine; Hamelin, Jack published the artcile< Reaction of Ethyl 7-Aminoindole-2-carboxylate with β-Diketone and β-Oxo Ester Compounds>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pyrroloquinoline preparation; aminoindolecarboxylate reaction diketone oxo ester; indolecarboxylate amino reaction diketone oxo ester.

Reaction of Et 7-aminoindole-2-carboxylate has been investigated: 1H-pyrrolo[3,2-h]quinoline and 6-hydroxy-1H-pyrrolo[3,2-h]quinoline derivatives are obtained with β-diketones and β-oxo esters, resp.

Journal of Chemical Research, Synopses published new progress about Diketones, 1,3-diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics