Month: October 2022

Walker, James A.; Vickerman, Kevin L.; Humke, Jenna N.; Stanley, Levi M. published the artcile< Ni-Catalyzed alkene carboacylation via amide C-N bond activation>, Reference of 112-63-0, the main research area is allylbenzamide carboacylation nickel; indanone preparation; nickel carboacylation catalyst.

A Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters is reported. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Jie; Han, Lin; Yang, Feng; Zhao, Mingliang; Zhou, Hong; Hu, Linwang published the artcile< SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy>, Reference of 112-63-0, the main research area is Bcl-2; Glioblastoma; SOCS5; autophagy; resistance; temozolomide.

Temozolomide (TMZ) is the primary chemotherapeutic drug for treating glioblastoma (GBM); however, the final clin. outcome is considerably limited by the poor response and resistance to TMZ. Although autophagy is thought to be associated with chemotherapy resistance and cancer cell survival, the precise mol. mechanisms underlying this process remain elusive. The suppressor of cytokine signaling (SOCS) family is widely distributed in vivo and exerts a range of effects on tumors; however, the expression pattern and role of SOCS in GBM remains unknown. In this study, we determined that high SOCS5 expression level was associated with poor prognosis and TMZ resistance in GBM. TMZ induced an increase in SOCS5 expression level and upregulated autophagy during the acquisition of drug resistance. The observed increase in the extent of autophagy was mediated by SOCS5. Mechanistically, SOCS5 enhances the transcription of Bcl-2. Knockdown of SOCS5 inhibited TMZ chemoresistance in GBM cells through the inhibition of Bcl-2 recruited autophagy; upregulation of Bcl-2 blocked this effect. In summary, our findings revealed the involvement and underlying mechanism of SOCS5 in TMZ resistance. SOCS5 plays a critical role in GBM chemoresistance and may serve as a novel prognostic marker and therapeutic target for chemotherapeutically treating drug-resistant GBM.

Bioengineered published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Fangdi; Grenert, James P; Tan, Lisa; Van Ziffle, Jessica; Joseph, Nancy M; Mulvey, Claire K; Bergsland, Emily published the artcile< Checkpoint Inhibitor Immunotherapy to Treat Temozolomide-Associated Hypermutation in Advanced Atypical Carcinoid Tumor of the Lung.>, Computed Properties of 112-63-0, the main research area is .

There is no abstract available for this document.

JCO precision oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karabanova, L. V.; Honcharova, L. A.; Shtompel, V. I. published the artcile< Structure and Properties of the POSS-Containing Nanocomposites Based on Polyurethane Matrix>, Category: esters-buliding-blocks, the main research area is polyurethane polyhedral oligomeric silsesquioxane nanocomposite structure property.

Nanocomposites based on Polyurethane (PU) matrix and 1,2-propanediolisobutyl-POSS (POSS) nanoparticles were prepared and investigated. POSS nanoparticles were incorporated into PU matrix in the process of PU synthesis. The structure peculiarities, the dynamic mech. and thermal properties, the morphol. of the nanocomposites have been investigated. Overall, it was found that POSS nanoparticles are capable to be incorporated into PU polymer chain by a chem. reaction between hydroxyl groups of POSS and diisocyanate groups of PU. The incorporation of the POSS nanoparticles into PU matrix leads to the formation of a more ordered structure, the POSS acts as a nanostructuring agent in the system. The introduction of the POSS nanoparticles into PU matrix significantly affects the thermal properties of the nanocomposites: the increasing in thermal stability was found. Investigation by WAXS/SAXS methods has shown that nanofiller POSS slightly affects the amorphous structure of PU. However, to a greater extent, the nanofiller POSS affects the microphase structure of PU. By dynamic mech. anal., it was detected that the storage moduli of PU/POSS nanocomposites exceeds the storage modulus of PU. But Mn/Mo changes non-monotonically with POSS content. The storage modulus of the nanocomposites increases in 1, 5 times compared to the native PU for the nanocomposites contained from 1 to 5 weight% of POSS. From the morphol. investigation, it is obvious that POSS introduced into PU matrix acts as nanostructuring agent. As a result, the nanocomposites with more ordered structure are formed thus leading to materials with improved thermal stability.

Springer Proceedings in Physics published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aimi, Takahiro; Meguro, Tomohiro; Kobayashi, Akihiro; Hosoya, Takamitsu; Yoshida, Suguru published the artcile< Nucleophilic transformations of azido-containing carbonyl compounds via protection of the azido group>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azido alc preparation; carbonyl compound azido nucleophile nucleophilic transformation.

Nucleophilic transformations of azido-containing carbonyl compounds, e.g., 4-(4-azidophenyl)benzaldehyde are discussed. The phosphazide formation from azides and di(tert-butyl)(4-(dimethylamino)phenyl)phosphine (Amphos) enabled transformations of carbonyl groups with nucleophiles such as lithium aluminum hydride and organometallic reagents RMgX (R = Et, Ph, 2-thienyl, etc.; X = Cl, Br). The good stability of the phosphazide moiety allowed to perform consecutive transformations of a diazide like 3-azido-5-(azidomethyl)benzaldehyde through triazole I formation and the Grignard reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Li; Cui, Jean; Liang, Congxin; Zhou, Yong; Nematalla, Asaad; Wang, Xueyan; Chen, Hui; Tang, Cho; Wei, James published the artcile< Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185erbB) tyrosine kinases>, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate, the main research area is dihydropyrimidine derivative preparation EGF receptor Her2 tyrosine kinase inhibitor; structure activity dihydropyrimidine derivative preparation EGFR Her2 tyrosine kinase.

A novel class of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones has been discovered as potent and selective inhibitors of the EGF-R tyrosine kinase family. These compounds selectively inhibit EGF-R kinase activity at low nanomolar concentration and tyrosine autophosphorylation in cells expressing EGF-R or Her2 (p185erbB). Structure-activity relationships (SARs) for this class of compounds are presented.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Name: Ethyl 5-formyl-1H-pyrrole-2-carboxylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Peng-Cheng; Wang, Sheng-Xin; Yan, Xiang-Li; He, Ying-Ying; Wang, Min-Chun; Zheng, Hao-Zhen; Shi, Xu-Guang; Tan, Yong-Heng; Wang, Li-Sheng published the artcile< Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway>, Electric Literature of 112-63-0, the main research area is HT22 cells; Ischaemia/reperfusion injury; OGD/R injury; neuroprotective effects; synergistic enhancement; synergistic interaction.

ContextPaeoniflorin (PF) and calycosin-7-glucoside (CG, Paeonia lactiflora Pall. extract) have demonstrated protective effects in ischemic stroke. ObjectiveTo investigate the synergistic effects of PF + CG on ischemia/reperfusion injury in vivo and in vitro. Materials and methodsMale Sprague-Dawley rats were subjected to the middle cerebral artery occlusion/reperfusion (MCAO/R). After MCAO/R for 24 h, rats were randomly subdivided into 5 groups: sham, model (MCAO/R), study treatment (PF + CG, 40 + 20 mg/kg), LY294002 (20 mg/kg), and study treatment + LY294002. Males were given via intragastric administration; the duration of the in vivo experiment was 8 days. Neurol. deficits, cerebral infarction, brain edoema, and protein levels were assessed in vivo. Hippocampal neurons (HT22) were refreshed with glucose-free DMEM and placed in an anaerobic chamber for 8 h. Subsequently, HT22 cells were reoxygenated in a 37 °C incubator with 5% CO2 for 6 h. SOD, MDA, ROS, LDH and protein levels were measured in vitro. ResultsPF + CG significantly reduced neurobehavioral outcomes (21%), cerebral infarct volume (44%), brain edoema (1.6%) compared with the MCAO/R group. Moreover, PF + CG increased p-PI3K/PI3K (4.69%, 7.4%), p-AKT/AKT (6.25%, 60.6%) and Bcl-2/BAX (33%, 49%) expression in vivo and in vitro, and reduced GSK-3β (10.5%, 9.6%) expression. In vitro, PF + CG suppressed apoptosis in HT22 cells and decreased ROS and MDA levels (20%, 50%, resp.). ConclusionsPF + CG showed a synergistic protective effect against ischemic brain injury, potentially being a future treatment for ischemic stroke.

Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Altarawneh, Ibrahem; Altarawneh, Mohammednoor; Rawadieh, Saleh published the artcile< Theoretical study on thermochemical parameters and IR spectra of chlorinated isomers of nitrobenzene>, HPLC of Formula: 112-63-0, the main research area is theor thermochem parameter IR spectra nitrobenzene chlorinated isomer.

Thermochem. and geometrical parameters and internal rotation barriers of all chlorinated nitrobenzene isomers were calculated with the G3MP2B3 composite method. Standard entropies, standard Gibbs free energies of formation, standard enthalpies of formation, and heat capacities were calculated and compared with their corresponding available exptl. data. Our calculated enthalpy values agree well with the corresponding exptl. data. The temperature dependence of entropy and heat capacity has been analyzed. All isomers with ortho-chlorine substituents were found to be less stable than other corresponding isomers. Rotational barriers and distortions of the benzene rings were incorporated in the calculations of values for entropy and heat capacity. The IR spectra were calculated and found to be in reasonable agreement with the exptl. spectra.

Canadian Journal of Chemistry published new progress about Bond angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomas, Eric J.; Williams, Andrew C. published the artcile< A stereoselective approach to the δ-lactone fragment of the lankacidin antibiotics>, Application In Synthesis of 617-55-0, the main research area is lankacidin lactone fragment stereoselective preparation.

The lactone fragment I of the lankacidins was prepared from dibenzyl aspartate via the azetidinones II (R = SiMe2CMe3, COEt, R1 = R2 = H, R3 = SiMe2CMe3, CH2OCH2Ph). II (R = R3= SiMe2CMe3, R1 = Me, R2 = OCH2OCH2Ph) was similarly prepared

Journal of the Chemical Society, Chemical Communications published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Xiao; Song, Xiaosheng; Guo, Zhijie; Bian, Tengfei; Zhang, Jin; Zhao, Yong published the artcile< Biphasic Electrolyte Inhibiting the Shuttle Effect of Redox Molecules in Lithium-Metal Batteries>, Product Details of C19H34O2, the main research area is lithium metal battery shuttle effect biphasic electrolyte; biphasic electrolytes; lithium redox flow batteries; lithium-oxygen batteries; redox mediators; shuttle effects.

Redox mols. (RMs) as electron carriers have been widely used in electrochem. energy-storage devices (ESDs), such as lithium redox flow batteries and lithium-O2 batteries. Unfortunately, migration of RMs to the lithium (Li) anode leads to side reactions, resulting in reduced coulombic efficiency and early cell death. Our proof-of-concept study utilizes a biphasic organic electrolyte to resolve this issue, in which nonafluoro-1,1,2,2-tetrahydrohexyl-trimethoxysilane (NFTOS) and ether (or sulfone) with lithium bis(trifluoromethane)sulfonimide (LiTFSI) can be separated to form the immiscible anolyte and catholyte. RMs are extracted to the catholyte due to the enormous solubility coefficients in the biphasic electrolytes with high and low polarity, resulting in inhibition of the shuttle effect. When coupled with a lithium anode, the Li-Li sym., Li redox flow and Li-O2 batteries can achieve considerably prolonged cycle life with biphasic electrolytes. This concept provides a promising strategy to suppress the shuttle effect of RMs in ESDs.

Angewandte Chemie, International Edition published new progress about Cell cycle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics