Month: October 2022

Sghaier, Randa; Nury, Thomas; Leoni, Valerio; Caccia, Claudio; Pais De Barros, Jean-Paul; Cherif, Ameur; Vejux, Anne; Moreau, Thibault; Limem, Khalifa; Samadi, Mohammad; Mackrill, John J.; Masmoudi, Ahmed Slaheddine; Lizard, Gerard; Zarrouk, Amira published the artcile< Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol>, Category: esters-buliding-blocks, the main research area is oligodendrocyte oxiapoptophagy dimethyl monomethyl fumarate oxidative stress mitochondrial dysfunction; 158N cells; 7β-hydroxycholesterol; Apoptosis; Autophagy; Dimethyl fumarate; Lipid profile; Mitochondria; Monomethyl fumarate; Oxiapoptophagy; Oxidative stress; Peroxisome.

The cytoprotective effects of dimethylfumarate, used in the treatment of relapsing remitting multiple sclerosis and of MMF, its main metabolite, were evaluated on murine oligodendrocytes 158 N exposed to 7β-OHC (50μM, 24 h) with or without DMF or MMF (25μM). The activity of 7β-OHC in the presence or absence DMF or MMF was evaluated on several parameters: cell adhesion; plasma membrane integrity measured with PI, trypan blue and FDA assays; LDH activity; antioxidant enzyme activities ; generation of lipid peroxidation products (MDA, CDs) and CPs; ROS overproduction conducted with DHE and DHR123. Apoptosis and autophagy were characterized by staining with Hoechst 33,342, Giemsa and acridine orange, and with antibodies raised against caspase-3 and LC3. DMF and MMF attenuate 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction (decrease of succinate dehydrogenase activity, loss of ΔΨm, increase of mitochondrial O·-2 production, alteration of the TCA cycle, and cardiolipins content); oxidative stress induction; changes in fatty acid and cholesterol metabolism; and cell death induction (caspase-3 cleavage, activation of LC3-I in LC3-II). Ultrastructural alterations of mitochondria and peroxisomes were prevented. These results demonstrate that DMF and MMF prevent major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Lan-xiang; Zhang, Bao-hua; Zhang, Xing-chen published the artcile< Synthesis of 4-bromo-N,N-dimethylaniline>, Quality Control of 112-63-0, the main research area is bromo dimethylaniline preparation pyridinium tribromide.

A method for the synthesis of the title compound is reported here. In presence of pyridine, 4-bromo-N,N-dimethylaniline was synthesized by a substitution reaction starting from N,N-dimethylaniline and bromine. In this reaction, the easy-to-handle bromination agent pyridinium tribromide was formed and the regioselectivity of the substitution reaction was enhanced. The optimal molar ratio was n(C8H11N):n(Br2):n(C5H5N) = 1:1.1:1.1, the reaction was at 10-15° for 6 h (product yield 68%).

Hebei Shifan Daxue Xuebao, Ziran Kexueban published new progress about Bromination, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seo, Chang-Seob; Lee, Mee-Young published the artcile< Simultaneous Determination of Fourteen Marker Compounds in the Traditional Herbal Prescription, Geumgwesingihwan, Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry>, Formula: C19H34O2, the main research area is geumgwesingihwan traditional herbal prescription UPLCMS; Geumgwesingihwan; UPLC–MS/MS; simultaneous determination; traditional herbal prescription.

Geumgwesingihwan (GSH) is a traditional herbal prescription composed of eight medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Dioscorea japonica Thunb., Cornus officinalis Siebold and Zucc., Poria cocos Wolf, Paeonia suffruticosa Andrews, Alisma plantago-aquatica subsp. orientale (Sam.) Sam., Achyranthes bidentate Blume, and Plantago asiatica L. This study developed and validated an ultra-performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) method in the multiple reaction monitoring (MRM) mode for simultaneous determination of 14 compounds (allantoin, gallic acid, 5-(hydroxymethyl)furfural, geniposidic acid, oxypaeoniflorin, loganin, geniposide, paeoniflorin, ecdysterone, verbascoside, cornuside, benzoylpaeoniflorin, paeonol, and alisol B acetate) in GSH. The chromatog. separation of all marker analytes was carried out on an Acquity UPLC BEH C18 column (100 mm × 2.1 mm, 1.7μm) using gradient elution of a mobile phase of distilled water-acetonitrile containing 0.1% acetic acid. The newly established UPLC-MS/MS MRM method was validated by evaluating the linearity, the limits of detection and quantification, recovery, and precision. All markers were detected at concentrations of 6.94-4126.28 mg/kg. In addition, the recovery was 76.65-119.49% and the relative standard deviation value of the precision was 0.19-9.91%. The newly developed and validated UPLC-MS/MS assay will provide useful information for quality assessment of GSH.

Molecules published new progress about Achyranthes bidentata. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Roztocki, Kornel; Formalik, Filip; Bon, Volodymyr; Krawczuk, Anna; Goszczycki, Piotr; Kuchta, Bogdan; Kaskel, Stefan; Matoga, Dariusz published the artcile< Tuning Adsorption-Induced Responsiveness of a Flexible Metal-Organic Framework JUK-8 by Linker Halogenation>, Reference of 112-63-0, the main research area is pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF preparation crystal structure; gas adsorption responsiveness flexible zinc metal organic framework; crystal mol structure pyridyl benzenedicarbohalohydrazide zinc oxydibenzoic carboxylate MOF.

Flexible stimuli-responsive metal-organic frameworks have become promising candidates for numerous applications in gas-related technologies; however, the methods of fine tuning their responses are still limited and sought after. In this work, authors demonstrate control over the adsorption properties of a flexible platform by incorporating halogen substituents (X = F, Cl, Br, I) into an eightfold interpenetrated isoreticular series [Zn(oba)(X-pip)]n (JUK-8X; X-pip = 4-pyridyl-functionalized benzene-1,3-dicarbo-5-halogenohydrazide; oba2- = 4,4′-oxydibenzoic carboxylate). The introduced halogen atoms allow for precise tuning of CO2 gate-opening pressures from p/p0 = 0.08 for the parental JUK-8 to 0.78 for the chlorine-functionalized JUK-8Cl. The presence of fluorine or chlorine substituent in the X-pip linker practically does not influence the maximum molar CO2 uptake as compared to JUK-8, whereas larger bromine or iodine atoms increase this uptake by 59 and 48%, resp. Utilizing in situ powder x-ray diffraction (PXRD) during CO2 adsorption for a model JUK-8F, they propose a detailed mechanism of phase transitions including positions of the adsorbed gas mols. for the two loaded phases. D. functional theory calculations supported by in situ PXRD measurements at a saturation pressure shed light on the unusual CO2 adsorption properties of JUK-8Br and JUK-8I. Overall, their report demonstrates the use of halogen interactions for the control of a gas-responsive system and provides insightful guidance for the further development of flexible, adaptable materials.

Chemistry of Materials published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cote, Adrien P.; El-Kaderi, Hani M.; Furukawa, Hiroyasu; Hunt, Joseph R.; Yaghi, Omar M. published the artcile< Reticular Synthesis of Microporous and Mesoporous 2D Covalent Organic Frameworks>, HPLC of Formula: 112-63-0, the main research area is boronic acid derivative condensation triphenylene; covalent organic framework microporous organoborane preparation gas adsorption isotherm.

Three new crystalline microporous and mesoporous 2-dimensional covalent organic frameworks termed COF-6, -8, and -10 from boronic acid building blocks and 2,3,6,7,10,11-hexahydroxytriphenylene were synthesized and structurally characterized. These materials constructed of C2O2B rings form eclipsed layered structures with pore sizes ranging from 6.4 to 34.1 Å and have high thermal stability, low d., and high porosity as indicated by the surface areas of 980, 1400, and 2080 m2 g-1 for COF-6, -8, and -10, resp. The control of pore size and structure demonstrates the effectiveness of reticular chem. methods toward materials design.

Journal of the American Chemical Society published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kazmierski, Wieslaw M.; McDermed, John published the artcile< Synthesis of the carbonic acid benzotriazol-1-yl-ester-(2-biotinylamino)-9H-fluoren-9-ylmethyl ester: a convenient transient-biotinylation reagent for use in affinity chromatography>, HPLC of Formula: 112-63-0, the main research area is biotinylaminofluorenylmethoxycarbonyl peptide protective group preparation; affinity chromatog biotinylated fluorenylmethoxycarbonyl peptide.

Stepwise synthesis of hydrophobic peptides frequently yields deletion products, which often require extensive purification and identification. A new transient-biotinylation reagent I was prepared, which was conveniently used in affinity chromatog. of crude products to afford pure peptides. Unlike conventional affinity chromatog., reagent I leads to free N-terminal peptides, which are thus amenable to further chem. manipulations.

Tetrahedron Letters published new progress about Affinity chromatography. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Sun; Wang, Lei; Chauhan, Pankaj; Peuronen, Anssi; Rissanen, Kari; Enders, Dieter published the artcile< Asymmetric Synthesis of Five-Membered Spiropyrazolones via N-Heterocyclic Carbene (NHC)-Catalyzed [3+2] Annulations>, Quality Control of 112-63-0, the main research area is spiropyrazolone preparation enantioselective diastereoselective; enal unsaturated pyrazolone annulation heterocyclic carbene catalyst.

A new synthetic strategy for the asym. synthesis of five-membered spiropyrazolones via N-heterocyclic carbene-catalyzed [3+2] annulations employing enals and unsaturated pyrazolones as substrates has been developed. The new protocol allows the flexible variation of all four substituents of the pharmaceutically important spiropyrazolones in moderate to very good yields and in most cases with excellent diastereoselectivities and good to excellent enantioselectivities.

Synthesis published new progress about Cyclization ([3+2]). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, C. X.; Braendle, A.; Menyo, M. S.; Pester, C. W.; Perl, E. E.; Arias, I.; Hawker, C. J.; Klinger, D. published the artcile< Catechol-based layer-by-layer assembly of composite coatings: a versatile platform to hierarchical nano-materials>, Reference of 71195-85-2, the main research area is silica titanium dioxide catechol based polymer composite dip coating; layer by layer assembly refractive index.

Inspired by the marine mussel’s ability to adhere to surfaces underwater, an aqueous catechol-based dip coating platform was developed. Using a catechol-functionalized polyacrylamide binder in combination with inorganic nanoparticles enables the facile fabrication of robust composite coatings via a layer-by-layer process. This modular assembly of well-defined building blocks provides a versatile alternative to electrostatic driven approaches with layer thickness and refractive indexes being readily tunable. The platform nature of this approach enables the fabrication of hierarchically ordered nano-materials such as Bragg stacks.

Soft Matter published new progress about Coating materials. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Reference of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pan, Zhaoqun; Huang, Bingsheng; Zhu, Liqiang; Zeng, Kelin published the artcile< Synthesis of a boron-containing adhesion promoter for improving the adhesion of addition-cure silicone rubber to PPA>, Reference of 112-63-0, the main research area is polyphthalamide silicone rubber adhesion promoter optical property.

In this study, a boron-containing adhesion promoter PhBSiO with a high refractive index and MeBSiO with a low refractive index were synthesized by a non-hydrolytic sol-gel reaction. The chem. structures of the synthesized adhesion promoters were firstly characterized by IR spectroscopy (FT-IR) and gel permeation chromatog. (GPC). Then, the effects of adhesion promoters on the bonding properties of the cured silicone rubber were analyzed and the compatibility of the adhesion promoters to the silicon rubber was further studied through light transmittance detection. The boron-containing silicone adhesion promoters significantly enhanced the bonding strength of the cured silicone rubber to poly-phthalamide (PPA). When the addition amounts of PhBSiO and MeBSiO was 3.0 phr, the shear strength between silicone rubber and PPA resp. reached 0.761 MPa and 0.809 MPa, which were 145% and 161% higher than that of silicone rubber without adhesion promoter. In addition, the adhesion mechanism of the boron-containing adhesion promoter was investigated. The microscopic morphol. of the fractured surface of the cured silicone rubber further demonstrated that boron atoms in the adhesion promoters significantly improved the adhesion strength between silicone rubber and PPA.

Journal of Adhesion Science and Technology published new progress about Adhesion promoters. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schulz, Julia A.; Rodgers, Louis T.; Kryscio, Richard J.; Hartz, Anika M. S.; Bauer, Bjorn published the artcile< Characterization and comparison of human glioblastoma models>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ABC transporters; Glioblastoma; Invasiveness; U251-RedFLuc; U87-luc2.

Abstract: Glioblastoma (GBM) is one of the deadliest cancers. Treatment options are limited, and median patient survival is only several months. Translation of new therapies is hindered by a lack of GBM models that fully recapitulate disease heterogeneity. Here, we characterize two human GBM models (U87-luc2, U251-RedFLuc). In vitro, both cell lines express similar levels of luciferase and show comparable sensitivity to temozolomide and lapatinib exposure. In vivo, however, the two GBM models recapitulate different aspects of the disease. U87-luc2 cells quickly grow into large, well-demarcated tumors; U251-RedFLuc cells form small, highly invasive tumors. Using a new method to assess GBM invasiveness based on detecting tumor-specific anti-luciferase staining in brain slices, we found that U251-RedFLuc cells are more invasive than U87-luc2 cells. Lastly, we determined expression levels of ABC transporters in both models. Our findings indicate that U87-luc2 and U251-RedFLuc GBM models recapitulate different aspects of GBM heterogeneity that need to be considered in preclin. research.

BMC Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics