Month: October 2022

Ziemczonek, Piotr; Gosecka, Monika; Gosecki, Mateusz; Marcinkowska, Monika; Janaszewska, Anna; Klajnert-Maculewicz, Barbara published the artcile< Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies>, HPLC of Formula: 112-63-0, the main research area is PFGE block PGGE hydrogel nifuratel solubility gynaecol therapy; Trichomonas infections; candidiasis; drug delivery system; hydrophobic drug; nifuratel; poly(furfuryl glycidyl ether); poly(glyceryl glycerol ether); unimolecular copolymer micelle; vulvovaginitis.

In this paper, we present novel well-defined unimol. micelles constructed a on poly(furfuryl glycidyl ether) core and highly hydrophilic poly(glyceryl glycerol ether) shell, PFGE-b-PGGE. The copolymer was synthesized via anionic ring-opening polymerization of furfuryl glycidyl ether and (1,2-isopropylidene glyceryl) glycidyl ether, resp. MTT assay revealed that the copolymer is non-cytotoxic against human cervical cancer endothelial (HeLa) cells. The copolymer thanks to furan moieties in its core is capable of encapsulation of nifuratel, a hydrophobic nitrofuran derivative, which is a drug applied in the gynaecol. therapies that shows a broad antimicroorganism spectrum. The study shows high loading capacity of the copolymer, i.e., 146 mg of nifuratel per 1 g of copolymer. The load unimol. micelles were characterized using DLS and TEM microscopy and compared with the reference glyceryl glycerol ether homopolymer sample. The presence of numerous 1,2-diol moieties in the shell of PFGE-b-PGG macromols. enabled the formation of reversible crosslinks with 2-acrylamidephenylboronic acid-based polyacrylamide. The obtained hydrogels were both injectable and self-healable, which was confirmed with a rheol. study.

International Journal of Molecular Sciences published new progress about Anionic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Ying; Zhang, Ling; Yang, Chao; Han, Jinsong; Wang, Chongqing; Zheng, Canhui; Zhou, Youjun; Lv, Jiaguo; Song, Yunlong; Zhu, Ju published the artcile< Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma>, Product Details of C19H34O2, the main research area is benzene sulfonamide derivative preparation dual PI3K mTOR inhibitor hepatoma; Antitumor; Benzenesulfonamide derivatives; Dual inhibitors; Hepatocellular carcinoma; Mammalian target of rapamycin (mTOR); Phosphoinositide 3-kinase (PI3K).

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway is related to cellular activities. Abnormalities of this signaling pathway were discovered in various cancers, including hepatocellular carcinoma (HCC). The PI3K/mTOR dual inhibitors were proposed to have enhanced antitumor efficacies by targeting multiple points of the signaling pathway. We synthesized a series of propynyl-substituted benzenesulfonamide derivatives as PI3K/mTOR dual inhibitors. Compound 7k (NSC781406) was identified as a highly potent dual inhibitor, which exhibited potent tumor growth inhibition in the hepatocellular carcinoma BEL-7404 xenograft model. Compound 7k may be a potential therapeutic drug candidate for HCC.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Chunying; Ishige, Ryohei; Yasumatsu, Ryou; Kang, Sungmin; Tokita, Masatoshi; Watanabe, Junji published the artcile< Regular undulation and polarization modulation on the film surface of a planarly aligned SmC* polymer>, Product Details of C6H10O5, the main research area is smectic C polymer regular undulation polarization modulation planarly aligned.

Chiral smectic C (SmC*) in a main-chain type of polymer exhibits undulations on its glassy film surface; these undulations are produced by the helical assembly of polymer conforming to the helical field of SmC*. In this study, we have found a polarization modulation superimposed on the undulation from the combined observations of Kelvin force microscopy (KFM) and at. force microscopy (AFM) images. This modulation is caused by the spontaneous polarization of each smectic layer; its direction is parallel to the layer and perpendicular to the tilt direction of mols. within a layer, and rotates around the helical axis. The polarization modulation length corresponds perfectly to the undulation length, i.e., helical pitch of SmC*. By clarifying the relative direction of the spontaneous polarization to the tilt direction of mesogens, we described how the polymers are accommodated to produce such a regular undulation and polarization modulation.

Soft Matter published new progress about Electrooptical switches. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Product Details of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guggisberg, Yves; Faigl, Ferenc; Schlosser, Manfred published the artcile< Optional ortho or alpha hydroxymethylation of alkylarenes>, Synthetic Route of 112-63-0, the main research area is regioselective hydroxymethylation alkylarene; alkanol aryl; benzyl alc alkyl.

Treatment of arenes carrying Me or primary alkyl groups, e.g., EtPh, in THF with potassium tert-butoxide activated butyllithium followed by reaction with formaldehyde gives 2-arylalkanols, e.g., PhCHMeCH2OH. In contrast, if prior to the addition of the electrophile a stoichiometric amount of magnesium dibromide is added then the regioisomeric 2-alkylbenzyl alcs., e.g., 2-EtC6H4CH2OH, are formed.

Journal of Organometallic Chemistry published new progress about Regiochemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sudta, Pichit; Kirk, Nicholas; Bezos, Anna; Gurlica, Anthony; Mitchell, Rhys; Weber, Thomas; Willis, Anthony C.; Prabpai, Samran; Kongsaeree, Palangpon; Parish, Christopher R.; Suksamrarn, Sunit; Kelso, Michael J. published the artcile< Synthesis, Structural Characterisation, and Preliminary Evaluation of Non-Indolin-2-one-based Angiogenesis Inhibitors Related to Sunitinib (Sutent)>, Electric Literature of 30095-98-8, the main research area is sunitinib analog preparation angiogenesis inhibitor SAR.

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent) and predecessor angiogenesis inhibitors that have undergone anticancer clin. trials (e.g. semaxanib, SU5416). In pursuit of novel anti-angiogenic scaffolds, we were interested in identifying whether the indolin-2-one group in these structures could be modified without losing activity. This paper describes novel condensation chem. used to prepare a test series of (E)- and (Z)-alkenes related to SU5416 that retain the 2,4-dimethylpyrrole unit while incorporating ring-opened indolin-2-ones. Unique structural characteristics were identified in the compounds, such as intramol. hydrogen bonds in the (Z)-alkenes, and several examples were shown to possess significant anti-angiogenic activity in a rat aorta in vitro model of angiogenesis. The work demonstrates that the indolin-2-one moiety is not an absolute requirement for angiogenesis inhibition in the sunitinib/SU5416 class.

Australian Journal of Chemistry published new progress about Antiangiogenic agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phukan, Prodeep published the artcile< Iodine as an extremely powerful catalyst for the acetylation of alcohols under solvent-free conditions>, Application of C6H10O5, the main research area is alc acetylation acetic anhydride solvent free; acetate preparation.

Iodine was found to promote quant. acetylation of alcs. in a very short time with an equimolar amount of acetic anhydride under solvent-free conditions at room temperature

Tetrahedron Letters published new progress about Acetylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Foroozan, Ali; Behboodi, Tahereh; Jahani, Yousef published the artcile< Influence of branching on the rheology and morphology of melt state long-chain branched polypropylene/polybuten-1 blends>, Related Products of 3290-92-4, the main research area is polybutene polypropylene blend branching viscosity.

In this study, the compatibility of polypropylene (PP)/polybutene-1 (PB-1) homopolymer blends before and after a long-chain branching process was studied. The blends were prepared and long-chain branched directly via a reactive extrusion process in the presence of a free radical initiator and trimethylolpropane trimethacrylate (TMPTMA) poly functional monomer. The optimum percentage of TMPTMA and PB-1 resin was determined by measuring the grafting efficiency and by studying the rheol. behavior in steady state shear and transient extensional mode and the morphol. of samples was investigated by SEM. The morphol. observations, which were also approved by rheol. data, demonstrated an enhanced compatibility for the blend branched with 1.5wt% of TMPTMA and 10wt% of PB-1 resin. The highest grafting efficiency of 37% and branch index of 5.2 were achieved for this blend composition The zero-shear viscosity (η0) of PP increased from 4500 Pa.s to 6800 Pa.s after branching process, and further enhanced to 2400 Pa.s by using 10 wt% PB-1 resin. The long-chain branched structure of blend resulted in a prominent higher zero-shear viscosity, a longer relaxation time and a pronounced strain-hardening behaviors. The branch index of blend samples were determined, and their branching behavior was quantified using extensional viscosity data.

Polyolefins Journal published new progress about Branched polymer chains. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Related Products of 3290-92-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Gang; Liu, Richard Y.; Yang, Yang; Fang, Cheng; Lambrecht, Daniel S.; Buchwald, Stephen L.; Liu, Peng published the artcile< Ligand-Substrate Dispersion Facilitates the Copper-Catalyzed Hydroamination of Unactivated Olefins>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is unactivated olefin copper catalyzed hydroamination ligand substrate dispersion interaction.

The current understanding of ligand effects in transition metal catalysis is mostly based on the anal. of catalyst-substrate through-bond and through-space interactions, with the latter commonly considered to be repulsive in nature. The dispersion interaction between the ligand and the substrate, a ubiquitous type of attractive noncovalent interaction, is seldom accounted for in the context of transition-metal-catalyzed transformations. Herein we report a computational model to quant. analyze the effects of different types of catalyst-substrate interactions on reactivity. Using this model, we show that in the copper(I) hydride (CuH)-catalyzed hydroamination of unactivated olefins, the substantially enhanced reactivity of copper catalysts based on bulky bidentate phosphine ligands originates from the attractive ligand-substrate dispersion interaction. These computational findings are validated by kinetic studies across a range of hydroamination reactions using structurally diverse phosphine ligands, revealing the critical role of bulky P-aryl groups in facilitating this process.

Journal of the American Chemical Society published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kost, A. N.; Minkin, V. I.; Sagitullin, R. S.; Gorbunov, V. I.; Sadekov, I. D. published the artcile< Transfer of substituent effects across the indole ring>, Reference of 112-63-0, the main research area is charge transfer indoles; indoles charge transfer.

The pK values and σ constants (Taft, Hammett, Webster, and Dewar constants) were determined for substituted indole-2-carboxylic acids (I). The transfer of the elec. charges in this ring system is weaker than in carbocyclic systems. The electron-donating groups have very little effect. The relation of structure with the pK of I is best expressed in terms of the Dewar theory.

Zhurnal Organicheskoi Khimii published new progress about Ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sojak, L.; Perjessy, A.; Kubinec, R.; Giumanini, A. G. published the artcile< CGC-FTIR characterization of mononitro and dinitro isomers from nitration mixtures of methyl arylacetates>, HPLC of Formula: 30095-98-8, the main research area is GC FTIR nitration mixture methyl arylacetate; gas chromatog FTIR arylacetate nitration mixture.

Twenty-one isomeric compounds from nitration of Me phenyl-, diphenyl-, and (hydroxy)diphenylacetates and the parent compounds were separated by capillary gas chromatog. with apolar stationary phase HP-5 and detected by FID and FTIRD. The measured retention indexes and IR spectral data of C=O and NO2 groups were correlated with mol. structure of analytes. The regularities in GC retention as well as in the FTIR data of isomeric aromatic nitro compounds were formulated. The obtained results can be useful for GC-FTIR identification of ring positional isomers of nitration products of other Me arylacetates.

Chemical Papers published new progress about Capillary gas chromatography. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics