Month: October 2022

Artyukhin, Alexander B.; Bakajin, Olgica; Stroeve, Pieter; Noy, Aleksandr published the artcile< Layer-by-Layer Electrostatic Self-Assembly of Polyelectrolyte Nanoshells on Individual Carbon Nanotube Templates>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon nanotube surface functionalization layer self assembly polyelectrolyte; polystyrene sulfonate sodium self assembly polydiallyldimethylammonium chloride nanotube.

A general procedure was implemented for modification of carbon nanotubes, based on polyelectrolyte layer-by-layer assembly. Multilayer structures were built around individual carbon nanotube bridges by first modifying the nanotube surface with a pyrene derivative followed by layer-by-layer deposition of polyelectrolyte macro-ions on the nanotube. Nanotubes were grown by the chem. vapor deposition (CVD) method using pyrolyzed ethylene as a carbon source. The polyelectrolytes used are poly(styrenesulfonate) sodium salt (PSS) and poly(diallyldimethylammonium chloride) (PDDA). The TEM and scanning confocal fluorescence microscopy images confirm the formation of nanometer-thick amorphous polymer nanoshells around the nanotubes. These multilayer polyelectrolyte shells on individual carbon nanotubes introduce nearly unlimited opportunities for the incorporation of various functionalities into nanotube devices, which, in turn, opens up the possibility of building more complex multicomponent structures.

Langmuir published new progress about Anionic polyelectrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sobhi, Rania; Farag, Nahla A.; Khalid, Haidy published the artcile< Lead discovery of new antiviral entities through the generation of 3D-QSAR pharmacophore hypothesis virtual screening and molecular docking study>, Application of C19H34O2, the main research area is QSAR pharmacophore hypothesis mol docking antiviral entity.

Sofosbuvir (Sovaldi) is the most successful clin. used antiviral agent targeted for the treatment of Hepatitis C. The study is aiming to discover new lead entities acting as specific inhibitors of the NS5B RNA-dependent RNA polymerase that is essential for viral replication. The recent approach of computer-aided drug design is a challenge nowadays in drug discovery. We generate a 3D-QSAR pharmacophore model from a training set of 17 nucleoside analog inhibitors including Sofosbuvir with congeneric structures and known (IC50) for each antiviral agent. A valid 3D- QSAR pharmacophore model has been successfully generated to identify the binding features responsible for the biol. activity using Discovery Studio software version The generated hypothesis is used for virtual screening of 3D databases which reveals 73 nucleoside analogs as coded compounds of expected nucleoside inhibitor antiviral activity. Followed by Mol. Docking of the compounds of highest fit values to the prepared HCV RNA dependent RNA polymerase NS5B enzyme which is downloaded from the protein data bank (4WTG) with its natural inhibitor SOFOSBUVIR DIPHOSPHATE GS-607596 to estimate the binding affinity and the geometrical orientation of the proposed compound in the HCV RNA dependent RNA polymerase NS5B binding site.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Moali, Catherine; Brollo, Maurice; Custot, Julien; Sari, Marie-Agnes; Boucher, Jean-Luc; Stuehr, Dennis J.; Mansuy, Daniel published the artcile< Recognition of α-Amino Acids Bearing Various C:NOH Functions by Nitric Oxide Synthase and Arginase Involves Very Different Structural Determinants>, Recommanded Product: (S)-tert-Butyl 3-amino-2-((tert-butoxycarbonyl)amino)propanoate, the main research area is hydroxyguanidine amino acid preparation arginase recognition; amidoxime amino acid preparation nitric oxide synthase recognition; amino acid recognition arginase nitric oxide synthase.

Several α-amino acids bearing a C:NOH function separated from the Cα carbon by two to five atoms have been synthesized and tested as substrates or inhibitors of recombinant nitric oxide synthases (NOS) I and II and as inhibitors of rat liver arginase (RLA). These include four N-hydroxyguanidines, Nω-hydroxy-L-arginine (NOHA) and its analogs homo-NOHA, nor-NOHA, and dinor-NOHA, two amidoximes bearing the -NH-C(CH3):NOH group, and two amidoximes bearing the -CH2-C(NH2):NOH group. Their behavior toward NOS and RLA was compared to that of the corresponding compounds bearing a C:NH function instead of the C:NOH function. The results obtained clearly show that efficient recognition of these α-amino acids by NOS and RLA involves very different structural determinants. NOS favors mols. bearing a -NH-C(R):NH motif separated from Cα by three or four CH2 groups – such as arginine itself – with the necessary presence of δ-NH and ω-NH groups and a more variable R substituent. The corresponding mols. with a C:NOH function exhibit a much lower affinity for NOS. On the contrary, RLA best recognizes mols. bearing a C:NOH function separated from Cα by three or four atoms, the highest affinity being observed in the case of three atoms. The presence of two ω-nitrogen atoms is important for efficient recognition, as in the two best RLA inhibitors, Nω-hydroxynorarginine and Nω-hydroxynorindospicine, which exhibit IC50 values at the micromolar level. However, contrary to what was observed in the case of NOS, the presence of a δ-NH group is not important. These different structural requirements of NOS and RLA may be directly linked to the position of crucial residues that have been identified from crystallog. data in the active sites of both enzymes. Thus, binding of arginine analogs to NOS particularly relies on strong interactions of their δ-NH and ω-NH2 groups with glutamate 371 (of NOS II), whereas binding of C:NOH mols. to RLA is mainly based on interactions of their terminal OH group with the binuclear Mn(II)···Mn(II) cluster of the enzyme and on possible addnl. bonds between their ω-NH2 group with histidine 141, glutamate 277, and one Mn(II) ion. The different modes of interaction displayed by both enzymes depend on their different catalytic functions and provide interesting opportunities to design useful mols. for selective regulation of NOS and arginase.

Biochemistry published new progress about Enzyme functional sites, active. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Recommanded Product: (S)-tert-Butyl 3-amino-2-((tert-butoxycarbonyl)amino)propanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zolla, Lello; Ceci, Marcello published the artcile< Plasma Metabolomics Profile of ′′Insulin Sensitive′′ Male Hypogonadism after Testosterone Replacement Therapy>, Product Details of C19H34O2, the main research area is insulin sensitive male hypogonadism plasma metabolomic testosterone replacement therapy; Cori cycle; hypogonadism; insulin sensitivity; testosterone therapy.

Male hypogonadism is a disorder characterized by low levels of testosterone, but patients can either show normal insulin (insulin-sensitive (IS)) or over time they can become insulin-resistant (IR). Since the two groups showed different altered metabolisms, testosterone replacement therapy (TRT) could achieve different results. In this paper, we analyzed plasma from 20 IS patients with low testosterone (<8 nmol/L) and HOMAi < 2.5. The samples, pre- and post-treatment with testosterone for 60 days, were analyzed by UHPLC and mass spectrometry. Glycolysis was significantly upregulated, suggesting an improved glucose utilization. Conversely, the pentose phosphate pathway was reduced, while the Krebs cycle was not used. Branched amino acids and carnosine metabolism were pos. influenced, while β-oxidation of fatty acids (FFA) was not activated. Cholesterol, HDL, and lipid metabolism did not show any improvements at 60 days but did so later in the exptl. period. Finally, both malate and glycerol shuttle were reduced. As a result, both NADH and ATP were significantly lower. Interestingly, a significant production of lactate was observed, which induced the activation of the Cori cycle between the liver and muscles, which became the main source of energy for these patients without involving alanine. Thus, the treatment must be integrated with chems. which are not restored in order to reactivate energy production International Journal of Molecular Sciences published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Verhoog, Stefan; Pfeifer, Lukas; Khotavivattana, Tanatorn; Calderwood, Samuel; Collier, Thomas Lee; Wheelhouse, Katherine; Tredwell, Matthew; Gouverneur, Veronique published the artcile< Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silver triflate mediated fluorine 18 labeling trifluoromethyl difluoromethyl arene.

We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.

Synlett published new progress about Radiochemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Roh, Tae Hoon; Lee, Ji-Hyun; Kim, Seo Jin; Shim, Jin-Kyoung; Park, Junseong; Yoon, Seon-Jin; Teo, Wan-Yee; Kim, Se Hoon; Chang, Jong Hee; Kang, Seok-Gu published the artcile< A novel biguanide (IM1761065) inhibits bioenergetics of glioblastoma tumorspheres>, Application In Synthesis of 112-63-0, the main research area is biguanide anticancer bioenergetics tumorsphere glioblastoma; Biguanide; Bioenergetics; Glioblastoma; IM1761065; Tumorsphere.

Glioblastoma (GBM) is a rapidly growing tumor in the central nervous system with altered metabolism Depleting the bioenergetics of tumors with biguanides have been suggested as an effective therapeutic approach for treating GBMs. The purpose of this study was to determine the effects of IM1761065, a novel biguanide with improved pharmacokinetics, on GBM-tumorspheres (TSs). The biol. activities of IM1761065 on GBM-TSs, including their effects on viability, ATP levels, cell cycle, stemness, invasive properties, and transcriptomes were examined The in vivo efficacy of IM1761065 was tested in a mouse orthotopic xenograft model. IM1761065 decreased the viability and ATP levels of GBM-TSs in a dose-dependent manner, and reduced basal and spare respiratory capacity in patient-derived GBM-TS, as measured by the oxygen consumption rate. Sphere formation, expression of stemness-related proteins, and invasive capacity of GBM-TSs were also significantly suppressed by IM1761065. A gene-ontol. comparison of IM1761065-treated groups showed that the expression levels of stemness-related, epithelial mesenchymal transition-related, and mitochondrial complex I genes were also significantly downregulated by IM1761065. An orthotopic xenograft mouse model showed decreased bioluminescence in IM1761065-treated cell-injected mice at 5 wk. IM1761065-treated group showed longer survival than the control group (P = 0.0289, log-rank test). IM1761065 is a potent inhibitor of oxidative phosphorylation. The inhibitory effect of IM1761065 on the bioenergetics of GBM-TS suggests that this novel compound could be used as a new drug for the treatment of GBM.

Journal of Neuro-Oncology published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balmaseda, Aitor; Rozes, Nicolas; Bordons, Albert; Reguant, Cristina published the artcile< Modulation of a defined community of Oenococcus oeni strains by Torulaspora delbrueckii and its impact on malolactic fermentation>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Torulaspora delbrueckii Oenococcus oeni malolactic fermentation winemaking.

Torulaspora delbrueckii is being used increasingly as a starter for alc. fermentation (AF) because of its chem. modulation of wine. Previous studies on this yeast in a natural must have shown a different Oenococcus oeni population by the end of MLF. In this study we aim to evaluate this aspect in a defined O. oeni strain consortium in a sterile grape must during winemaking. Before commencing AF with either S. cerevisiae or both T. delbrueckii and S. cerevisiae, the must was inoculated with a defined population of O. oeni strains. The use of T. delbrueckii determined the bacterial population at the end of MLF. Also, the inoculation of a selected strain after AF produced wines with different chem. composition to those fermented with the initial bacterial community. Different yeast inoculation strategies modulate the O. oeni population, and this has an impact on the chem. composition of the wines. Moreover, the inoculation of a small O. oeni population in must leads to a process similar to spontaneous MLF. Torulaspora delbrueckii can be used as a tool to modulate the O. oeni population and enhance the aromas related to MLF.

Australian Journal of Grape and Wine Research published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Weihua; Jiang, Zhigan; He, Haiying; Xiao, Fubiao; Lin, Fusen; Sun, Ya; Hou, Lijuan; Shen, Liang; Han, Lixia; Zeng, Minggao; Lai, Kunmin; Gu, Zhengxian; Chen, Xinsheng; Zhao, Tao; Guo, Li; Yang, Chun; Li, Jian; Chen, Shuhui published the artcile< Correction to ""The Discovery of 3,3′-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection"" [Erratum to document cited in CA168:169484]>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is spiro azetidine indoline fusion inhibitor respiratory syncytial virus erratum.

In the original publication, there are errors in two references and a typog. error within the table of contents; the corrections are provided here.

ACS Medicinal Chemistry Letters published new progress about Antiviral agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naidu, Mamta D.; Mason, James M.; Pica, Raymond V.; Fung, Hua; Pena, Louis A. published the artcile< Radiation resistance in glioma cells determined by DNA damage repair activity of Apel/Ref-1>, Application of C19H34O2, the main research area is X ray radiotherapy radioresistance Ape1 DNA damage repair glioma.

Since radiation therapy remains a primary treatment modality for gliomas, the radioresistance of glioma cells and targets to modify their radiation tolerance are of significant interest. Human apurinic endonuclease 1 (Ape1, Ref-1, APEX, HAP1, AP endo) is a multifunctional protein involved in base excision repair of DNA and a redox-dependent transcriptional co-activator. This study investigated whether there is a direct relationship between Ape1 and radioresistance in glioma cells, employing the human U87 and U251 cell lines. U87 is intrinsically more radioresistant than U251, which is partly attributable to more cycling U251 cells found in G2/M, the most radiosensitive cell stage, while more U87 cells are found in S and G1, the more radioresistant cell stages. But observed radioresistance is also related to Ape1 activity. U87 has higher levels of Ape1 than does U251, as assessed by Western blot and enzyme activity assays (∼1.5-2 fold higher in cycling cells, and ∼10 fold higher at G2/M). A direct relationship was seen in cells transfected with CMV-Ape1 constructs; there was a dose-dependent relationship between increasing Ape1 overexpression and increasing radioresistance. Conversely, knock down by siRNA or by pharmacol. down regulation of Ape1 resulted in decreased radioresistance. The inhibitors lucanthone and CRT004876 were employed, the former a thioxanthene previously under clin. evaluation as a radiosensitizer for brain tumors and the latter a more specific Ape1 inhibitor. These data suggest that Ape1 may be a useful target for modifying radiation tolerance.

Journal of Radiation Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Miao; Wang, Yi-Zhou; Yang, Yong; Lv, Meng-Wen; Li, Shan-Shan; Teixeira da Silva, Jaime A.; Wang, Liang-Sheng; Yu, Xiao-Nan published the artcile< Analysis of Chemical Components in the Roots of Eight Intersubgeneric Hybrids of Paeonia>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Paeonia root phenol paeonol intersubgeneric hybrid mass spectrometry; Paeonia; intersubgeneric hybrid; medicinal ingredient; paeoniflorin; tannins.

Paeonia cultivars are famous ornamental plants, and some of them are also traditional Chinese medicinal resources. Intersubgeneric hybrids of Paeonia (IHPs) are formed by the hybridization of herbaceous peony (Paeonia lactiflora) and tree peony (Paeonia×suffruticosa or lutea hybrid tree peony). The phenotypic characteristics of IHPs are similar to those of herbaceous peony, and their root systems are large and vigorous. However, their medicinal value has not been reported yet. In this study, the roots of eight IHP samples were analyzed by high performance liquid chromatog. quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS/MS). A total of 18 compounds were identified, including phenols, paeonols, monoterpene glycosides, and tannins. The contents of monoterpene glycosides and tannins in IHPs were higher than herbaceous peony and tree peony, exceeding 44.76 mg/g DW and 11.50 mg/g DW, resp. Three IHPs, ‘Prairie Charm’, ‘Garden Treasure’, and ‘Yellow Emperor’, with more types and a higher content of medicinal compounds, were screened out by cluster anal. These IHPs have considerable potential for the development of medicinal resources.

Chemistry & Biodiversity published new progress about High-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics