Month: October 2022

Kim, Moonsik; Yoo, Jihwan; Chang, Jong Hee; Kim, Se Hoon published the artcile< Association of MGMT gene promoter methylation with clinicopathological parameters in patients with wild-type IDH glioblastoma>, Application In Synthesis of 112-63-0, the main research area is isocitrate dehydrogenase MGMT gene promoter methylation clinicopathol glioblastoma human; ATRX loss; MGMT; glioblastoma; hypermethylation; low methylation; methylation status; temozolomide chemotherapy; wild-type IDH.

The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter plays a key role in response to temozolomide chemotherapy and disease prognosis in patients with wild-type isocitrate dehydrogenase (IDH) glioblastoma (GBM). The MGMT promoter methylation status and its association with clinicopathol. parameters were retrospectively analyzed in a cohort of 316 patients with GBM with wild-type IDH. MGMT methylation was significantly associated with ATRX chromatin remodeler (ATRX) loss and completion of the standard Stupp protocol. The median durations of overall and progression-free survival for the unmethylated, low-methylated (10-39%), and hypermethylated (≥40%) groups were 15, 23, and 30 mo and 11, 18, and 21 mo, resp. However, the improvement in the survival of the hypermethylated group was not statistically significant. We suggest a possible association between MGMT methylation status and ATRX mutations in GBM with wild-type IDH.

Anticancer Research published new progress about Age groups. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Robichaud, Joeel; Bayly, Christopher I.; Black, W. Cameron; Desmarais, Sylvie; Leger, Serge; Masse, Frederic; McKay, Daniel J.; Oballa, Renata M.; Paquet, Julie; Percival, M. David; Truchon, Jean-Francois; Wesolowski, Gregg; Crane, Sheldon N. published the artcile< β-Substituted cyclohexanecarboxamide cathepsin K inhibitors: Modification of the 1,2-disubstituted aromatic core>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyclohexanecarboxamide preparation cathepsin K inhibitor SAR.

Further SAR study around the central 1,2-disubstituted Ph of the previously disclosed Cat K inhibitor (-)-1 (I) has demonstrated that the solvent exposed P2-P3 linker can be replaced by various 5- or 6-membered heteroaromatic rings. While some potency loss was observed in the 6-membered heteroaromatic series (IC50 = 1 nM for pyridine-linked 4 vs 0.5 nM for phenyl-linked (±)-1), several inhibitors showed a significantly decreased shift in the bone resorption functional assay (10-fold for pyridine 4 vs 53-fold for (-)-1). Though this shift was not reduced in the 5-membered heteroaromatic series, potency against Cat K was significantly improved for thiazole 9 (IC50 = 0.2 nM) as was the pharmacokinetic profile of N-Me pyrazole 10 over our lead compound (-)-1.

Bioorganic & Medicinal Chemistry Letters published new progress about Bone resorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Skrastins, I.; Kastrons, V.; Duburs, G.; Mazeika, I.; Kadis, V. published the artcile< Preparation of furo- and difuro-1,4-dihydropyridines via bromination of 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-(o-nitrophenyl)-1,4-dihydropyridines>, Category: esters-buliding-blocks, the main research area is furopyridine dihydro; difuropyridine dihydro; pyridine furo difuro.

Furo- and difuro-1,4-dihydropyridines I and II were prepared by bromination of 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-nitrophenyl)-1,4-dihydropyridine with mild brominating agents, e.g., pyridine hydrogen tribromide, dioxane dibromide and NBS, followed by oxidation with 3N HNO3.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babushkina, T. A.; Robas, V. I.; Semin, G. K. published the artcile< Temperature dependences of the nuclear quadrupole resonance frequencies in molecular crystals>, Related Products of 112-63-0, the main research area is temperature nuclear quadrupole resonances; nuclear quadrupole resonances temperature; quadrupole resonances nuclear temperature; resonances nuclear quadrupole temperature; benzenes halo derivative; halobenzenes; nitrobenzenes.

About 90 temperature dependences of the nuclear quadrupole resonance frequencies (ω) of the nuclei 35Cl, 79Br, and 127I in mol. crystals of different aliphatic and C6H6 halogen derivatives were studied. The chief contribution to the temperature dependence of ω comes from torsional vibrations of the mols. in the crystal. In the temperature region 77-295°., ω is a linear function of temperature; hence, measurements at 3 temperatures (77, 195, and 295°K.) were sufficient. An exception was nitrohalogen derivatives of C6H6 (Br and I) and m-F2C6Br4 where the point of inflection of the temperature curve takes place on the side opposite that predicted by the Baeyer theory. Values of ω were measured for the compounds EtSiCl3 and CCl2(NO2)2 which had phase transformations. Although the relative changes in ω for CCl2(NO2)2 during phase transformations do not exceed 1.5%, T1 was equal to 130, 12, and 2.5 msec. for the α, β, and γ phases, resp., at 77°K. A statistical treatment of crystal shifts (∼600 splittings) showed that the most probable splitting values were in the range of 0.2-0.3% of the signal frequency.

Radiospektrosk. Tverd. Tela published new progress about Nuclear quadrupole resonance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yi-Yang; You, Jin-Hai; Zhang, Shao-Jian; Lin, Hua; Ren, Wen-Feng; Deng, Li; Pan, Si-Yu; Huang, Ling; Zhou, Yao; Li, Jun-Tao; Sun, Shi-Gang published the artcile< Li0.5PAA domains filled in porous sodium alginate skeleton: A 3D bicontinuous composite network binder to stabilize micro-silicon anode for high-performance lithium ion battery>, COA of Formula: C19H34O2, the main research area is lithium PAA domain filled porous sodium alginate skeleton; bicontinuous composite network binder silicon anode lithium battery.

An important strategy to improve energy d. of Li-ion batteries is to substitute the traditional graphite anode by Si-based anode which is endowed with ultra-high theor. specific capacity. However, the commercialization of Si anodes is hindered by its huge volume variation that results in electrode pulverization. In the current study, the authors fill up the pores of Na alginate (SA) network with lithiated polyacrylic acid (LixPAA) to form a cross-linked bicontinuous composite network binder (b-Li0.5PAA@SA), in which the pores of the SA skeleton are dominated with the Li0.5PAA domains; within such composite the SA and Li0.5PAA interlock tightly each other via extensive interfacial ester bonding. The resulting b-Li0.5PAA@SA network binder can effectively buffer the volume variation of Si microparticles (m-Si) during repeating cycling and prevent pulverization of the electrode, which is evidenced by a cycling capacity of 2762 mAh g-1 in the 1st cycle and a retention of 1584 mAh g-1 after 150 cycles. As a comparison, the m-Si electrode with only SA binder suffers from fatal capacity degradation after merely 20 cycles under the same conditions. Also, since the Li0.5PAA domains are ionic conductive and significantly reduce the porosity of the SA network, the b-Li0.5PAA@SA network binder could also enable a stable solid electrolyte interphase (SEI) film and fast electron/ion transfer, leading to an enhanced rate capability of the m-Si anodes.

Electrochimica Acta published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Douglas, James; Ling, Kenneth B.; Concellon, Carmen; Churchill, Gwydion; Slawin, Alexandra M. Z.; Smith, Andrew D. published the artcile< NHC-Mediated Chlorination of Unsymmetrical Ketenes: Catalysis and Asymmetry>, Related Products of 112-63-0, the main research area is chlorination asym unsaturated ketene nitrogen heterocyclic carbene catalyst.

NHCs promote the efficient chlorination of unsym. disubstituted ketenes with a range of chlorinating agents; chiral NHCs display promising levels of asym. induction in the chlorination process with up to 61 % ee observed using 2,3,4,5,6,6-hexachlorocyclohexa-2,4-dienone.

European Journal of Organic Chemistry published new progress about Chlorination catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Picado, Alfredo; Chaikuad, Apirat; Wells, Carrow I.; Shrestha, Safal; Zuercher, William J.; Pickett, Julie E.; Kwarcinski, Frank E.; Sinha, Parvathi; de Silva, Chandi S.; Zutshi, Reena; Liu, Shubin; Kannan, Natarajan; Knapp, Stefan; Drewry, David H.; Willson, Timothy M. published the artcile< A chemical probe for dark kinase STK17B derives its potency and high selectivity through a unique P-loop conformation>, Recommanded Product: Ethyl 2-hydroxyacetate, the main research area is human dark kinase STK17B probe selectivity P loop structure.

STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the role of STK17B in normal and disease pathol. is poorly defined. Here, we present the discovery of thieno[3,2-d] pyrimidine SGC-STK17B-1 (11s), a high-quality chem. probe for this understudied “”dark”” kinase. 11S is an ATP-competitive inhibitor that showed remarkable selectivity over other kinases including the closely related STK17A. X-ray crystallog. of 11s and related thieno[3,2-d]pyrimidines bound to STK17B revealed a unique P-loop conformation characterized by a salt bridge between R41 and the carboxylic acid of the inhibitor. Mol. dynamic simulations of STK17B revealed the flexibility of the P-loop and a wide range of R41 conformations available to the apo-protein. The isomeric thieno[2,3-d]pyrimidine SGC-STK17B-1N (19g) was identified as a neg. control compound The >100-fold lower activity of 19g on STK17B was attributed to the reduced basicity of its pyrimidine N1.

Journal of Medicinal Chemistry published new progress about Apoptosis. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Recommanded Product: Ethyl 2-hydroxyacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Papageorgiou, Christos; Benezra, Claude published the artcile< Synthesis of potentially allergenic chiral α-(hydroxyalkyl)acrylates>, Category: esters-buliding-blocks, the main research area is asym synthesis hydroxylalkylacrylate; acrylate hydroxyalkyl asym synthesis; sulfoxide optically active asym induction.

Treating (R)- or (S)-4-MeC6H4S(O)CHMeCO2CMe3 with Me3CMgBr and aldehydes RCH2CHO (R = Me, Bu, octyl), followed by thermal elimination, gave title compounds (R)- or (S)-Me3CO2CC(:CH2)CH(OH)CHR, resp., in 75% enantiomeric excess.

Tetrahedron Letters published new progress about Esters Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Guizhuan; Zhang, Shaohao; Zheng, Zhangbin; Wang, Chen; Wang, Shijie; Tao, Hongge published the artcile< Direct conversion of fructose to 5-ethoxymethylfurfural catalyzed by ultra stable Y zeolite>, Application of C19H34O2, the main research area is fructose ethoxymethylfurfural ultra stable Y zeolite catalyst.

5-Ethoxymethylfurfural (EMF) is a new type of biofuel with a high energy d. and excellent fuel properties. One-pot production of EMF from renewable carbohydrate catalyzed by heterogeneous catalysts has the potential to be an attractive reaction pathway. In this study, fructose was directly converted to EMF in ethanol medium catalyzed by ultra stable Y zeolite (USY). The effects of different reaction conditions on EMF yields were investigated, and an optimum reaction condition was obtained by utilizing response surface methodol. Under the optimum reaction conditions, which were a temperature of 132°C, substrate d. of 60 g/L, and catalyst dosage of 2.1 wt%, a maximum EMF yield of 73.8 mol% with the prediction error of 1.6% was achieved in 25 min. Moreover, the reusability of USY and characterization were evaluated. This study demonstrated a promising strategy for EMF production from fructose.

BioResources published new progress about Response surface methodology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamamizu, Takafumi; Akiyama, Minoru; Takeda, Kunihiko published the artcile< A new styrene derivative and its application to reactive polymer synthesis>, Quality Control of 112-63-0, the main research area is divinylbenzene selective bromination; bromoethylstyrene copolymer divinylbenzene styrene; pyridinium perbromide divinylbenzene selective bromination; chain transfer bromoethylstyrene.

One of the vinyl groups of 1,3-divinylbenzene (I) [108-57-6] was selectively brominated by pyridinium hydrobromide perbromide  [39416-48-3] to form 3-(1,2-dibromoethyl)styrene (II) [95386-00-8]. The high selectivity is apparently the result of an electron-inductive effect by the 1,2-dibromoethyl group and the relatively mild activity of the brominating agent. The resulting monomer exhibits Q = 1.26 and e = 0.06 in its copolymerization with styrene. The chain-transfer constant to II was also estimated From II-styrene copolymer [95386-12-2] or I-II copolymer [97126-69-7], polymers with pendant vinyl groups were synthesized.

Reactive Polymers, Ion Exchangers, Sorbents published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics