Month: October 2022

Majidi, Leily; Ahmadiparidari, Alireza; Shan, Nannan; Kumar Singh, Sachin; Zhang, Chengji; Huang, Zhehao; Rastegar, Sina; Kumar, Khagesh; Hemmat, Zahra; Ngo, Anh T.; Zapol, Peter; Cabana, Jordi; Subramanian, Arunkumar; Curtiss, Larry A.; Salehi-Khojin, Amin published the artcile< Nanostructured Conductive Metal Organic Frameworks for Sustainable Low Charge Overpotentials in Li-Air Batteries>, HPLC of Formula: 112-63-0, the main research area is lithium oxide metal organic framework overpotential; Li-O 2 batteries; electrocatalysis; metal organic frameworks.

Lithium-oxygen batteries are among the most attractive alternatives for future electrified transportation. However, their practical application is hindered by many obstacles. Due to the insulating nature of Li2O2 product and the slow kinetics of reactions, attaining sustainable low charge overpotentials at high rates becomes a challenge resulting in the battery′s early failure and low round trip efficiency. Herein, outstanding characteristics are discovered of a conductive metal organic framework (c-MOF) that promotes the growth of nanocrystalline Li2O2 with amorphous regions. This provides a platform for the continuous growth of Li2O2 units away from framework, enabling a fast discharge at high current rates. Moreover, the Li2O2 structure works in synergy with the redox mediator (RM). The conductivity of the amorphous regions of the Li2O2 allows the RM to act directly on the Li2O2 surface instead of catalyst edges and then transport through the electrolyte to the Li2O2 surface. This direct charge transfer enables a small charge potential of <3.7 V under high current densities (1-2 A g-1) sustained for a long cycle life (100-300 cycles) for large capacities (1000-2000 mAh g-1). These results open a new direction for utilizing c-MOFs towards advanced energy storage systems. Small published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhuang, Jiaming; Jiwpanich, Siriporn; Deepak, V. D.; Thayumanavan, S. published the artcile< Facile Preparation of Nanogels Using Activated Ester Containing Polymers>, Application of C9H3F5O2, the main research area is pentafluorophenyl acrylate polyethylene glycol methacrylate diamine crosslinker nanogel; Activated ester; Amphiphilic polymer assembly; Nanogel synthesis; Surface modification.

A facile methodol. to prepare water-dispersible nanogels based on pentafluorophenyl acrylate and polyethylene glycol methacrylate random copolymer and diamine cross-linkers has been developed. The crosslinking reaction was characterized by FTIR and 19F NMR. We show that those nanogels are (i) water-dispersible; (ii) can conveniently encapsulate lipophilic guest mols.; (iii) can be prepared with different nanosizes; and (iv) are engineered to allow for surface decoration with addnl. functional groups.

ACS Macro Letters published new progress about Encapsulants. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application of C9H3F5O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Ying; Sendzik, Martin; Zhang, Jeff; Gao, Zhenting; Sun, Yongfeng; Wang, Long; Gu, Justin; Zhao, Kehao; Yu, Zhengtian; Zhang, Lijun; Zhang, Qiong; Blanz, Joachim; Chen, Zijun; Dubost, Valerie; Fang, Douglas; Feng, Lijian; Fu, Xingnian; Kiffe, Michael; Li, Ling; Luo, Fangjun; Luo, Xiao; Mi, Yuan; Mistry, Prakash; Pearson, David; Piaia, Alessandro; Scheufler, Clemens; Terranova, Remi; Weiss, Andreas; Zeng, Jue; Zhang, Hailong; Zhang, Jiangwei; Zhao, Mengxi; Dillon, Michael P.; Jeay, Sebastien; Qi, Wei; Moggs, Jonathan; Pissot-Soldermann, Carole; Li, En; Atadja, Peter; Lingel, Andreas; Oyang, Counde published the artcile< Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies>, HPLC of Formula: 112-63-0, the main research area is EED226 MAK683 dihydrobenzofuran triazolopyridine synthesis anticancer pharmacokinetics toxicity PRC2.

Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On a mol. level, PRC2 catalyzes methylation of histone H3 lysine 27 (H3K27), resulting in mono-, di-, or trimethylated forms of H3K27, of which the trimethylated form H3K27me3 leads to transcriptional repression of polycomb target genes. Previously, we have shown that binding of the low-mol.-weight compound EED226 to the H3K27me3 binding pocket of the regulatory subunit EED can effectively inhibit PRC2 activity in cells and reduce tumor growth in mouse xenograft models. Here, we report the stepwise optimization of the tool compound EED226 toward the potent and selective EED inhibitor MAK683 (compound 22) and its subsequent preclin. characterization. Based on a balanced PK/PD profile, efficacy, and mitigated risk of forming reactive metabolites, MAK683 has been selected for clin. development.

Journal of Medicinal Chemistry published new progress about Adrenal gland. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joshi, Nikita; Chauhan, Komal published the artcile< Nutritional properties of pumpkin seeds: emerging seed for a therapeutic benefits>, Category: esters-buliding-blocks, the main research area is therapeutic benefit pumpkin seeds emerging seed nutritional property.

In recent time, seeds and nuts of plants got tremendous attention due to its various health benefits. Pumpkin seeds are thrown out by most of the industries, as agricultural waste. Pumpkin seeds are commonly known as “”pepitas””. Pumpkin seeds are loaded with variety of nutrients and particularly they are rich in Proteins, Vitamins and Minerals.However, assuming that being traditional food, people are not aware about the nutritional benefits of that and still it is unexploited. The objective of this study is to evaluate the proximate composition, fatty acid profile, Antioxidant activity and Micronutrients (Vitamins and Minerals) of pumpkin seeds (Cucurbita Moschata). Proximate composition and mineral composition of pumpkin seeds was carried by using AOAC methods, Fatty acid profile by Gas Chromatog., Vitamins by HPLC methods and FRAP method was used for the assessment of antioxidant activity. As per the results obtained, pumpkin seeds are rich in protein, Selenium, Zinc and Unsaturated fatty acids therefore, pumpkin seeds can be used for a therapeutic management of Diabetes, Hyperlipidemia, Cancer prevention and enhancement of immunity. Therefore, modification of these waste agricultural product into valuable element will be a huge step towards food sustainability.

World Journal of Pharmaceutical Research published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Solmonson, Ashley; Faubert, Brandon; Gu, Wen; Rao, Aparna; Cowdin, Mitzy A.; Menendez-Montes, Ivan; Kelekar, Sherwin; Rogers, Thomas J.; Pan, Chunxiao; Guevara, Gerardo; Tarangelo, Amy; Zacharias, Lauren G.; Martin-Sandoval, Misty S.; Do, Duyen; Pachnis, Panayotis; Dumesnil, Dennis; Mathews, Thomas P.; Tasdogan, Alpaslan; Pham, An; Cai, Ling; Zhao, Zhiyu; Ni, Min; Cleaver, Ondine; Sadek, Hesham A.; Morrison, Sean J.; DeBerardinis, Ralph J. published the artcile< Compartmentalized metabolism supports midgestation mammalian development>, Category: esters-buliding-blocks, the main research area is midgestation mammalian embryogenesis metabolome LIPT1.

Mammalian embryogenesis requires rapid growth and proper metabolic regulation. Midgestation features increasing oxygen and nutrient availability concomitant with fetal organ development. Understanding how metabolism supports development requires approaches to observe metabolism directly in model organisms in utero. Here we used isotope tracing and metabolomics to identify evolving metabolic programs in the placenta and embryo during midgestation in mice. These tissues differ metabolically throughout midgestation, but we pinpointed gestational days (GD) 10.5-11.5 as a transition period for both placenta and embryo. Isotope tracing revealed differences in carbohydrate metabolism between the tissues and rapid glucose-dependent purine synthesis, especially in the embryo. Glucoses contribution to the tricarboxylic acid (TCA) cycle rises throughout midgestation in the embryo but not in the placenta. By GD12.5, compartmentalized metabolic programs are apparent within the embryo, including different nutrient contributions to the TCA cycle in different organs. To contextualize developmental anomalies associated with Mendelian metabolic defects, we analyzed mice deficient in LIPT1, the enzyme that activates 2-ketoacid dehydrogenases related to the TCA cycle. LIPT1 deficiency suppresses TCA cycle metabolism during the GD10.5-GD11.5 transition, perturbs brain, heart and erythrocyte development and leads to embryonic demise by GD11.5. These data document individualized metabolic programs in developing organs in utero.

Nature (London, United Kingdom) published new progress about Anemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Zilu; Zhang, Min; Teuscher, Kevin B.; Ji, Haitao published the artcile< Discovery of 1-Benzoyl 4-Phenoxypiperidines as Small-Molecule Inhibitors of the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction>, Application In Synthesis of 112-63-0, the main research area is benzoyl phenoxypiperidine derivative preparation catenin BCL9 protein interaction cancer.

Structure-based design and optimization were performed to develop small-mol. β-catenin/B-cell lymphoma 9 (BCL9) inhibitors and improve their inhibitory activities. Compound ZL3138 with a novel 1-benzoyl 4-phenoxypiperidine scaffold was discovered to disrupt the β-catenin/BCL9 protein-protein interaction (PPI) with a Ki of 0.96μM in AlphaScreen competitive inhibition assays and displayed good selectivity for β-catenin/BCL9 over β-catenin/E-cadherin PPIs. The binding mode of new inhibitors was characterized by structure-activity relationship and site-directed mutagenesis studies. Protein pull-down assays indicate that this series of compounds directly binds with β-catenin. Cellular target engagement and co-immunoprecipitation experiments demonstrate that ZL3138 binds with β-catenin and disrupts the β-catenin/BCL9 interaction without affecting the β-catenin/E-cadherin interaction in living cells. Further cell-based studies show that ZL3138 selectively suppresses transactivation of Wnt/β-catenin signaling, regulates transcription and expression of Wnt target genes, and inhibits the growth of Wnt/β-catenin-dependent cancer cells.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Danta, Chhanda Charan published the artcile< CNS Penetration Ability: A Critical Factor for Drugs in the Treatment of SARS-CoV-2 Brain Infection>, Category: esters-buliding-blocks, the main research area is drug treatment SARS CoV 2; CNS infection; CNS penetration; COVID19; SARS-CoV-2; drug treatment; log P.

Now, it has been evidenced that Covid19 (SARS-CoV-2) infects the brain tissues. Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. Targeting the treatment of brain infection, it has also been a challenge that the clin. drug should have good CNS penetration ability to cross the blood-brain barrier.

ACS Chemical Neuroscience published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Zhong-Yuan; Sun, Wei-Feng; Zhao, Hong published the artcile< Significantly improved electrical properties of photo-initiated auxiliary crosslinking EPDM used for cable termination>, Product Details of C18H26O6, the main research area is photoinitiated auxiliary crosslinking EPDM cable termination elec property; crosslinking reaction; electrical conductance; finite element simulation; first-principles calculation; ultraviolet irradiation.

In order to achieve high quality elec. materials for cable terminations, the crosslinked ethylene-propylene-diene monomer (EPDM) materials, with adequate breakdown strength, appropriately increased conductivity and are developed by employing auxiliary crosslinker and UV photoinitiated crosslinking technique. The characteristic cyclic anhydrides with coupled carbonyl groups are utilized as auxiliary crosslinkers to promote crosslinking efficiency and provide polar-groups to EPDM mols. in UV-initiated crosslinking processes, which can be effectively fulfilled in industrial cable production The results of IR spectroscopy show that the auxiliary crosslinkers have been successfully grated to EPDM mols. through UV initiation process. The conductivity of EPDM increases after individually utilizing three auxiliary crosslinkers to EPDM at various temperatures of cable operations, by which the highest conductivity has been acquired by grafting N.N-m-phenylene dimaleimide. The first-principles calculations demonstrate that some occupied local electronic-states have been introduced in the band-gap of the EPDM crosslinked by N.N-m-phenylene dimaleimide (EPDM-HAV2), which can be thermally excited from valence band to conduction band at lower temperature or in higher d., leading to augmentation in elec. conductivity

Polymers (Basel, Switzerland) published new progress about Band gap. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Product Details of C18H26O6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Miranda, Renata Rank; Oliveira, Anny Carolline Silva; Skytte, Lilian; Rasmussen, Kaare Lund; Kjeldsen, Frank published the artcile< Proteome-wide analysis reveals molecular pathways affected by AgNP in a ROS-dependent manner>, Application In Synthesis of 112-63-0, the main research area is proteome ROS bend3 NRF2 cytotoxicity; N-Acetyl L-cysteine; Silver nanoparticles; metal uptake; oxidative stress; proteomics.

The use of mass spectrometry-based proteomics has been increasingly applied in nanomaterials risk assessments as it provides a proteome-wide overview of the mol. disturbances induced by its exposure. Here, we used this technique to gain detailed mol. insights into the role of ROS as an effector of AgNP toxicity, by incubating Bend3 cells with AgNP in the absence or presence of an antioxidant N-acetyl L-cystein (NAC). ROS generation is a key player in AgNP-induced toxicity, as cellular homeostasis was kept in the presence of NAC. By integrating MS/MS data with bioinformatics tools, in the absence of NAC, we were able to pinpoint precisely which biol. pathways were affected by AgNP. Cells respond to AgNP-induced ROS generation by increasing their antioxidant pool, via NRF2 pathway activation. Addnl., cell proliferation-related pathways were strongly inhibited in a ROS-dependent manner. These findings reveal important aspects of the AgNP mechanism of action at the protein level.

Nanotoxicology published new progress about BEN domain-containing protein 3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cioffi, Christopher L.; Racz, Boglarka; Varadi, Andras; Freeman, Emily E.; Conlon, Michael P.; Chen, Ping; Zhu, Lei; Kitchen, Douglas B.; Barnes, Keith D.; Martin, William H.; Pearson, Paul G.; Johnson, Graham; Blaner, William S.; Petrukhin, Konstantin published the artcile< Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis>, Application of C19H34O2, the main research area is RBP4 antagonist preparation hepatic steatosis.

Retinol-binding protein 4 (RBP4) serves as a transporter for all-trans-retinol (1) in the blood, and it has been proposed to act as an adipokine. Elevated plasma levels of the protein have been linked to diabetes, obesity, cardiovascular diseases, and nonalcoholic fatty liver disease (NAFLD). Recently, adipocyte-specific overexpression of RBP4 was reported to cause hepatic steatosis in mice. We previously identified an orally bioavailable RBP4 antagonist that significantly lowered RBP4 serum levels in Abca4-/- knockout mice with concomitant normalization of complement system protein expression and reduction of bisretinoid formation within the retinal pigment epithelium. We describe herein the discovery of novel RBP4 antagonists 48 and 59, which reduce serum RBP4 levels by >80% in mice upon acute oral dosing. Furthermore, 59 demonstrated efficacy in the transgenic adi-hRBP4 murine model of hepatic steatosis, suggesting that RBP4 antagonists may also have therapeutic utility for the treatment of NAFLD.

Journal of Medicinal Chemistry published new progress about Complement Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics