Month: October 2022

Ennis, B. C.; Holan, George; Samuel, Eva L. published the artcile< 2-Trihalomethylbenzazoles. III. Reactions of 2-(trichloromethyl)benzimidazole with nucleophiles>, Electric Literature of 112-63-0, the main research area is BENZAZOLES; BENZIMIDAZOLES; IMIDAZOLES BENZ.

Nucleophilic displacements of Cl from 2-(trichloromethyl)benzimidazole (I) by water, alcs., phenols, and their S analogs are described. The special reactivity of the trichloromethyl group in this compound is compared with that of the trichloromethyl group in non-activated positions. The Friedel-Crafts reaction of 2-(trichloromethyl)benzimidazole with benzene is reported.

Journal of the Chemical Society [Section] C: Organic published new progress about Nucleophiles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sau, Abhijit; Williams, Ryan; Palo-Nieto, Carlos; Franconetti, Antonio; Medina, Sandra; Galan, M. Carmen published the artcile< Palladium-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals>, Safety of (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is palladium catalyzed stereoselective glycosylation glycoside preparation disaccharide; acetals; asymmetric catalysis; deoxyglycosides; glycosylation; palladium.

Palladium(II) in combination with a monodentate phosphine ligand enables the unprecedented direct and α-stereoselective catalytic synthesis of deoxyglycosides from glycals. Initial mechanistic studies suggest that in the presence of N-phenyl-2-(di-tert-butylphosphino)pyrrole as the ligand, the reaction proceeds via an alkoxy palladium intermediate that increases the proton acidity and oxygen nucleophilicity of the alc. The method is demonstrated with a wide range of glycal donors and acceptors, including substrates bearing alkene functionalities.

Angewandte Chemie, International Edition published new progress about Disaccharides Role: SPN (Synthetic Preparation), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Safety of (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Hai-Jun; Chen, Longrui; Oderinde, Martins S.; Edwards, Jacob T.; Kawamata, Yu; Baran, Phil S. published the artcile< Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols>, COA of Formula: C19H34O2, the main research area is ether preparation chemoselective; alc aryl bromide arylation nickel electrocatalyst; O-Arylation; chemoselectivity; coupling; electrochemistry; nickel catalysis.

Herein a Ni-catalyzed electrochem. driven protocol to afford aryl-alkyl ether bonds through O-arylation of alcs. was depicted. This electrochem. method did not require strong base, exogenous expensive transition metal catalysts (e.g., Ir, Ru), and could easily be scaled up in either a batch or flow setting. Interestingly, e-etherification exhibited an enhanced substrate scope over the mechanistically related photochem. variant as it tolerated tertiary amine functional groups in the alc. nucleophile. with a broad substrate scope in an operationally simple way.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Rui; Liu, Tingting; Chen, Jiayu; Zhang, Dianbao published the artcile< Paradol Induces Cell Cycle Arrest and Apoptosis in Glioblastoma Cells>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is paradol anticancer agent cell cycle arrest apoptosis.

Despite being the most common primary malignant tumor of the central nervous system, the prognosis of glioblastoma (GBM) is still remarkably poor. Paradol is a flavor phenolic constituent found in pepper and ginger, with anti-tumor, anti-inflammatory, and antioxidant activities. However, the effects of paradol on GBM cells remain unknown. In this study, we investigated the cytotoxicity of paradol on U-87 and U-251 GBM cells. Cell viability and Transwell assays revealed that paradol treatment markedly inhibited the viability and migration of GBM cells. Flow cytometry anal. showed G0/G1 cell cycle arrest, which was verified by the downregulation of CCNA and CCNB expression using western blotting. Paradol-induced cell apoptosis was confirmed by annexin V-FITC/PI staining and nuclear morphol. Furthermore, the phosphorylation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) was determined by western blotting. Collectively, our data revealed that paradol inhibited cell viability and migration of GBM cells by inducing G0/G1 phase arrest and apoptosis, and activating ERK and p38 MAPK signaling.

Nutrition and Cancer published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jain, R.; Sundram, A.; Lopez, S.; Neckermann, G.; Wu, C.; Hackbarth, C.; Chen, D.; Wang, W.; Ryder, N. S.; Weidmann, B.; Patel, D.; Trias, J.; White, R.; Yuan, Z. published the artcile< α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents. [Erratum to document cited in CA140:128630]>, Synthetic Route of 617-55-0, the main research area is erratum hydroxamic acid preparation bacterial deformylase inhibitor antibacterial agent; proline hydroxamic preparation bacterial deformylase inhibitor antibacterial agent erratum.

The corrected version of Table 2 is given.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wada, Kojiro; Ishida, Tatsuyoshi published the artcile< A steroid hydroxylase inhibitor, diplodialide A, and related metabolites from Diplodia pinea>, Electric Literature of 617-55-0, the main research area is diplodialide Diplodia lactone structure; steroid hydroxylase inhibition diplodialide.

The structures of diplodialide A (I; RR1 = O), B (I; R = OH, R1 = H), C (II), and D (III) from Diplodia pinea were determined from chem. and spectral data.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Diplodia pinea. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Electric Literature of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Landwehr, Katherine R.; Hillas, Jessica; Mead-Hunter, Ryan; Brooks, Peter; King, Andrew; O’Leary, Rebecca A.; Kicic, Anthony; Mullins, Benjamin J.; Larcombe, Alexander N. published the artcile< Fuel feedstock determines biodiesel exhaust toxicity in a human airway epithelial cell exposure model>, HPLC of Formula: 112-63-0, the main research area is biodiesel fuel feedstock exhaust toxicity airway epithelial cell; Biodiesel; Exhaust exposure; Health; In vitro exposure model; Vehicle emissions.

Biodiesel is promoted as a sustainable replacement for com. diesel. Biodiesel fuel and exhaust properties change depending on the base feedstock oil/fat used during creation. The aims of this study were, for the first time, to compare the exhaust exposure health impacts of a wide range of biodiesels made from different feedstocks and relate these effects with the corresponding exhaust characteristics. Primary airway epithelial cells were exposed to diluted exhaust from an engine running on conventional diesel and biodiesel made from Soy, Canola, Waste Cooking Oil, Tallow, Palm and Cottonseed. Exhaust properties and cellular viability and mediator release were analyzed post exposure. The exhaust physico-chem. of Tallow biodiesel was the most different to diesel as well as the most toxic, with exposure resulting in significantly decreased cellular viability (95.8 ± 6.5%) and increased release of several immune mediators including IL-6 (+223.11 ± 368.83 pg/mL) and IL-8 (+1516.17 ± 2908.79 pg/mL) above Air controls. In contrast Canola biodiesel was the least toxic with exposure only increasing TNF-α (4.91 ± 8.61). This study, which investigated the toxic effects for the largest range of biodiesels, shows that exposure to different exhausts results in a spectrum of toxic effects in vitro when combusted under identical conditions.

Journal of Hazardous Materials published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russell, Glen A.; Rhee, Jong Uk; Baik, Woonphil published the artcile< Electron transfer processes. Part 63. Reactions of p-nitrobenzyl halides with dialkyl phosphite anions in dimethyl sulfoxide>, COA of Formula: C19H34O2, the main research area is nitrobenzyl halide reaction dialkyl phosphite anion; solvent effect nitrobenzyl halide dialkyl phosphite.

The reactions of p-O2NC6H4CH2Cl with (RO)2PO- in Me2SO with R = Me, Et, Pr, Bu, CF3CH2, i-Pr, Ph involve the formation of p-O2NC6H4CH2P(O)(OR)2 by SN2 substitution followed by a further SRN1 p-nitro-benzylation of p-O2NC6H4CH[P(O)(OR)2]- and p-O2NC6H4C(CH2C6H4NO2-p)[P(O)(OR)2]-. With p-O2NC6H4CH2Br, the reactions proceed mainly to form p-O2NC6H4CH-2, which undergoes reaction with p-O2NC6H4CH2Br to form p-O2NC6H4CH2CH2C6H4NO2-p. Halophilic reaction of (RO)2PO- with p-O2NC6H4CH(CH3)X (X = Cl, Br) leading to the bibenzyl is the preferred reaction course. Reactions of (RO)2PO- or p-O2NC6H4CH[P(O)(OR)2]- with p-O2NC6H4CH2X in Me2SO do not form significant amounts of p-O2NC6H4CHX- that would yield p-O2NC6H4CH:CHC6H4NO2-p. However, p-Cl-C6H4CH[P(O)(OEt)]- readily abstracts the benzylic proton from p-O2NC6H4CH2X to form the stilbene, although p-O2NC6H4CH2Br reacts with p-O2NC6H4CH[P(O)(OR)2]- to form p-O2NC6H4CH(CH2C6H4No2-p)P(O)(OR)2 in a reaction mixture not inhibited by (t-Bu)2NO•.

Heteroatom Chemistry published new progress about Solvent effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Huihua; Morshedi, Mahbod; Kodikara, Mahesh S.; Moxey, Graeme J.; Wang, Genmiao; Wang, Huan; Quintana, Cristobal; Stranger, Rob; Zhang, Chi; Cifuentes, Marie P.; Humphrey, Mark G. published the artcile< Synthesis, Optical, Electrochemical, and Theoretical Studies of Dipolar Ruthenium Alkynyl Complexes with Oligo(phenylenevinylene) Bridges>, Quality Control of 112-63-0, the main research area is dipolar ruthenium alkynyl oligophenylenevinylene bridged preparation crystal mol structure; electrochem redox quadratic nonlinear optical property alkynyl ruthenium oligophenylenevinylene; mol structure calculation alkynyl ruthenium oligophenylenevinylene bridged; computational chemistry; electrochemistry; nonlinear optics; organometallic chemistry; transition metals.

The syntheses of oligo(p-phenylenevinylene)s (OPVs) end-functionalized with a ligated ruthenium alkynyl unit as a donor and a nitro as acceptor, namely trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru4), trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru6), and trans-[Ru{CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-Et2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(2-ethyl-n-hexyl)2-4-(E)-CH:CH-1-C6H2-2,5-(2-ethyl-n-hexyl)2-4-(E)-CH:CH-1-C6H4-4-NO2}Cl(dppe)2] (Ru8), are reported, together with those of precursor alkynes. Their electrochem. properties were assessed by cyclic voltammetry (CV), their linear optical and quadratic nonlinear optical (NLO) properties assayed by UV/Vis-NIR spectroscopy and hyper-Rayleigh scattering studies at 1064 nm, resp., and their linear optical properties in the formally RuIII state examined by UV/Vis-NIR spectroelectrochem. Computational studies employing time-dependent d. functional theory were undertaken on model complexes to rationalize the optical observations.

ChemPlusChem published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Sung-Bae; Lee, Jin-Seok; Moon, Sung-Ok; Lee, Hwa-Dong; Yoon, Yoo-Sik; Son, Chang-Gue published the artcile< A standardized herbal combination of Astragalus membranaceus and Paeonia japonica, protects against muscle atrophy in a C26 colon cancer cachexia mouse model>, HPLC of Formula: 112-63-0, the main research area is albiflorin paeoniflorin formononetin Astragalus antiinflammatory agent muscle atrophy; Astragalus membranaceus; Cancer cachexia; Muscle atrophy; Paeonia japonica.

Astragalus membranaceus (Fisch.) and Bunge and Paeonia japonica (Makino)Miyabe & H. Takeda have been traditionally used to improve the poor quality of life such as weakness, lack of appetite, fatigue, and malaise which is considered with cachexia condition. We investigated anti-cachectic effects of a herbal formula composed of Astragalus membranaceus and Paeonia japonica (APX) and the mol. mechanisms of APX in C26 cancer-induced cachexia mice and TNF-a-treated C2C12 myotubes. Addnl. synergistic anti-cachectic effects of APX were compared to those of individual herbal extracts and megestrol acetate. The forty-two BALB/c mice were randomly divided into 6 groups: normal (nontreatment), control (C26 injection), AM (C26 injection with Astragalus membranaceus), PJ (C26 injection with Paeonia japonica), APX C26 injection with combination of Astragalus membranaceus and Paeonia japonica and MA (C26 injection with megestrol acetate). All mice were orally administered DW (normal and control groups) or 100 mg/kg AM, PJ, APX or MA for 10 days. In the animal model, several tissues were weighed, and muscle tissue and blood were used to measure pro-inflammatory cytokines. C2C12 myotubes were exposed to 100 ng/mL TNF- α with or without 10μg/mL of AM, PJ, APX or MA for 48 h. The cells were used to immunofluorescence staining and western blot analyses. C26 injection induced notable body and muscle weight loss while APX administration significantly attenuated these alterations and the decrease of muscle weights and strength. APX also significantly attenuated the abnormal elevations in the concentration of three muscle atrophy-inducible cytokines; serum and muscle TNF-α,muscle TWEAK and IL-6 in C26 tumor-bearing mice. In the TNF-α-treated C2C12 myotube model, TNF-α treatment notably decreased MyH but activated atrophic proteins (MuRF and Fbx32) along with p38 and NFκB while these mol. alterations were significantly ameliorated by APX treatment. These pharmacol. actions of APX were supported by the results of immunofluorescence staining to MyH expression and the translocation of NFκB into the nucleus in C2C12 myotubes. Our data indicate the potential of an herbal formula, APX as an anti-cachexia agent; the effect of APX was superior to that of megestrol acetate overall especially for muscle atrophy. The underlying mechanisms of this herbal formula may involve the modulation of muscle atrophy-promoting mols. including p38, NFκB, TNF-α and TWEAK.

Journal of Ethnopharmacology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics