Month: October 2022

Rai, Vishal; Mobin, Shaikh M.; Namboothiri, Irishi N. N. published the artcile< Cinchonine catalyzed diastereo- and enantioselective Michael addition of α-lithiated phosphonates to nitroalkenes>, Quality Control of 112-63-0, the main research area is cinchonine catalyst stereoselective Michael addition phosphonate lithiated nitroalkene; phosphonate stereoselective preparation; crystal mol structure phosphonate chlorophenylnitrophenylpropyl preparation.

Conjugate addition of α-lithiated benzyl- and alkylphosphonates to a variety of aromatic and heteroaromatic nitroalkenes in the presence of 50 mol % of cinchonine-Li catalyst system proceeded in high yields, diastereo- and enantioselectivities in most cases.

Tetrahedron: Asymmetry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent) (nitroalkenes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Xiao-Chen; Tremblay, Pier-Luc; Xue, Miao; Song, Xinyi; Zhang, Tian published the artcile< Fumarate disproportionation by Geobacter sulfurreducens and its involvement in biocorrosion and interspecies electron transfer>, SDS of cas: 112-63-0, the main research area is Geobacter fumarate disproportionation biocorrosion electron transfer; Biocorrosion; C4-dicarboxylate; Geobacter; Interspecies electron transfer; Metabolic disproportionation; iron-rich sediment.

The model electroactive bacterium Geobacter sulfurreducens can acquire electrons directly from solid donors including metals and other species. Reports on this physiol. concluding that solid donors are the only electron sources were conducted with fumarate believed to serve exclusively as the terminal electron acceptor (TEA). Here, G. sulfurreducens was repeatedly transferred for adaptation within a growth medium containing only fumarate and no other solid or soluble substrate. The resulting evolved strain grew efficiently with either the C4-dicarboxylate fumarate or malate acting simultaneously as electron donor, carbon source, and electron acceptor via disproportionation. Whole-genome sequencing identified 38 mutations including one in the regulator PilR known to repress the expression of the C4-dicarboxylate antiporter DcuB essential to G. sulfurreducens when growing with fumarate. Futhermore, the PilR mutation was identical to the sole mutation previously reported in an evolved G. sulfurreducens grown in a co-culture assumed to derive energy solely from direct interspecies electron transfer, but cultivated with fumarate as the TEA. When cultivating the fumarate-adapted strain in the presence of stainless steel and fumarate, biocorrosion was observed and bacterial growth was accelerated 2.3 times. These results suggest that G. sulfurreducens can conserve energy concomitantly from C4-dicarboxylate disproportionation and the oxidation of a solid electron donor. This co-metabolic capacity confers an advantage to Geobacter for survival and colonization and explains in part why these microbes are omnipresent in different anaerobic ecosystems.

Science of the Total Environment published new progress about Biocorrosion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bertus, Philippe; Zhang, Jing-Heng; Sir, Geoffroy; Weibel, Jean-Marc; Pale, Patrick published the artcile< Asymmetric synthesis of the cyclopentanones related to NCS and N1999A2 antitumor antibiotics>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxylated cyclopentanone Bestmann cyclization preparation; NCS N1999A2 hydroxylated cyclopentanone core preparation.

Optically pure protected mono- or dihydroxylated cyclopentanones, precursors for the core of the antitumor antibiotics NCS and N1999A2 were obtained in six to eight steps via a key Bestmann cyclization with excellent overall yields (up to 52%).

Tetrahedron Letters published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mphahlele, Malose J.; Moekwa, Thwanthwadi B. published the artcile< Iodo- and bromo-enolcyclization of 2-(2-propenyl)cyclohexanediones and 2-(2-propenyl)cyclohexenone derivatives using iodine in methanol and pyridinium hydrobromide perbromide in dichloromethane>, Related Products of 112-63-0, the main research area is iodo bromo enolcyclization propenylcyclohexanedione propenylcyclohexenone; iodomethyltetrahydrobenzofuranone preparation aromatization; tetrahydrobenzofuranone iodomethyl preparation aromatization; tetrahydrobenzopyranone bromomethyl preparation aromatization.

α-Allylcyclohexane-1,3-diones undergo one-pot iodine-methanol promoted iodocyclization and oxidative aromatization to afford variously substituted 2-iodomethyltetrahydrobenzofuran-4-ones (minor) and 2-iodomethyl-4-methoxydihydrobenzofuran derivatives (major). On the other hand, the α-allyl-1,3-cyclohexanediones react with pyridinium hydrobromide perbromide in dichloromethane to afford mixtures of 2-bromomethyltetrahydrobenzofuran-4-ones (major) and 3-bromomethyltetrahydrobenzopyran-5-ones (minor). The prepared products and their derivatives were characterized using a combination of NMR, FT-IR and mass spectroscopic techniques.

Organic & Biomolecular Chemistry published new progress about Aromatization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regano, Celia; Alla, Abdellilah; De Ilarduya, Antxon Martinez; Munoz-Guerra, Sebastian published the artcile< Linear polyamides from L-malic acid and alkanediamines>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is malic acid linear polyamide synthesis optical thermal mech property.

A series of linear polyamides (PnMLM) derived from O-methyl-protected L-malic acid and 1,n-alkanediamines with even n values ranging from 4 to 12 were prepared and fully characterized. L-Malic acid entered in the chain with a random orientation rendering essentially aregic polymers. PnMLM displayed optical rotation consistent with the content of the polymer in malic units, and they all were crystalline with m.ps. ranging from 158 to 188 °C and glass-transition temperatures varying from 37 to 70 °C. PnMLM appeared to be fairly stable to heat with thermal decomposition starting close to 300 °C. Hydrolytic degradation of PnMLM at 37 °C was slow, but the process was significantly faster at 70 °C. Thermal degradation took place with the formation of cyclic malimides in the residual polymer and released the 1,n-alkanediamine. However, hydrolytic degradation took place in a first stage with the formation of open chains of carboxylic- and amine-ended oligomers.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about Hydrolytic polymer degradation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prestes, Alessandro de Souza; dos Santos, Matheus Mulling; Kamdem, Jean Paul; Mancini, Gianni; Schuler da Silva, Luana Caroline; de Bem, Andreza Fabro; Barbosa, Nilda Vargas published the artcile< Methylglyoxal disrupts the functionality of rat liver mitochondria>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is liver mitochondria superoxide phosphorylation bioenergetics methylglyoxal; High-resolution respirometry; Methylglyoxal; Mitochondria; Oxidative stress.

Methylglyoxal (MG) is a reactive metabolite derived from different physiol. pathways. Its production can be harmful to cells via glycation reactions of lipids, DNA, and proteins. But, the effects of MG on mitochondrial functioning and bioenergetic responses are still elusive. Then, the effects of MG on key parameters of mitochondrial functionality were examined here. Isolated rat liver mitochondria were exposed to 0.1-10 mM of MG to determine its toxicity in the mitochondrial viability, membrane potential (Δψm), swelling and the superoxide (O·-2) production Besides, mitochondrial oxidative phosphorylation parameters were analyzed by high-resolution respiratory (HRR) assay. In this set of experiments, routine state, PM state (pyruvate/malate), oxidative phosphorylation (OXPHOS), LEAK respiration, electron transport system (ETS) and oxygen residual (ROX) states were evaluated. HRR showed that PM state, OXPHOS CI-Linked, LEAK respiration, ETS CI/CII-Linked and ETS CII-Linked/ROX were significantly inhibited by MG exposure. MG also inhibited the complex II activity, and decreased Δψm and the viability of mitochondria. Taken together, our data indicates that MG is an inductor of mitochondrial dysfunctions and impairs important steps of respiratory chain, effects that can alter bioenergetics responses.

Chemico-Biological Interactions published new progress about Cell viability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Anli; Gong, Yingjie; Pei, Zhixin; Jiang, Ling; Xia, Lingling; Wu, Yonggui published the artcile< Paeoniflorin ameliorates diabetic liver injury by targeting the TXNIP-mediated NLRP3 inflammasome in db/db mice>, Product Details of C19H34O2, the main research area is paeoniflorin NLRP TXNIP diabetic liver injury inflammasome steatosis inflammation; Diabetic liver injury; Inflammation; Paeoniflorin; T2DM; TXNIP/NLRP3.

Diabetic liver injury (DLI) is a complication that damages the quality of life in diabetes patients. While paeoniflorin (PF) exhibits anti-inflammatory and antioxidant effects, no data are available on whether PF protects against DLI. Therefore, we evaluated the effects of PF on hepatic steatosis and inflammation in db/db mice, a type 2 diabetes model. In this study, we investigated the effects of PF on DLI using diabetic mice model (db/db mice) and high glucose (HG)-induced mouse AML12 cells. The effects of PF on TXNIP-mediated NLRP3 inflammasome in vivo and in vitro were evaluated by Western bloting, RT-PCR, immunohistochem. (IHC) and immunofluorescence (IF) anal. Through mol. docking experiments and cellular thermal shift assay (CETSA), we studied the binding ability of PF to thioredoxin-interacting protein (TXNIP). We use TXNIP siRNA to knock down TXNIP in AML12 cells. We found that PF reversed abnormal liver function and liver steatosis in db/db mice, while blocking the release of inflammatory cytokines. These effects are associated with PF inhibition of the TXNIP/NLRP3 signaling pathway. Mol. docking experiments and CETSA also demonstrated that TXNIP is a likely target of PF. In HG-treated AML12 cells, TXNIP knockdown eliminated the beneficial effects of PF. Using a combination of animal and in vitro experiments, this study demonstrated for the first time that PF ameliorates DLI through targeting the TXNIP-activated NLRP3 inflammasome. Thus, PF may be a potential therapeutic agent against DLI.

International Immunopharmacology published new progress about Adhesion G protein-coupled receptor E1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lohse, Jonas; Swier, Lotteke J. Y. M.; Oudshoorn, Ruben C.; Medard, Guillaume; Kuster, Bernhard; Slotboom, Dirk-Jan; Witte, Martin D. published the artcile< Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides>, Category: esters-buliding-blocks, the main research area is diazotransfer reagent protein azide label.

In chem. biol., azides are used to chem. manipulate target structures in a bioorthogonal manner for a plethora of applications ranging from target identification to the synthesis of homogeneously modified protein conjugates. While a variety of methods have been established to introduce the azido group into recombinant proteins, a method that directly converts specific amino groups in endogenous proteins is lacking. Here, the authors report the first biotin-tethered diazotransfer reagent DtBio and demonstrate that it selectively modifies the model proteins streptavidin and avidin and the membrane protein BioY on cell surface. The reagent converts amines in the proximity of the binding pocket to azides and leaves the remaining amino groups in streptavidin untouched. Reagents of this novel class will find use in target identification as well as the selective functionalization and bioorthogonal protection of proteins.

Bioconjugate Chemistry published new progress about Avidins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rajeswari, Doodigama; Anil, Kumar V. published the artcile< Method development and validation for the simultaneous estimation of lamivudine and stavudine by RP-HPLC>, Electric Literature of 112-63-0, the main research area is lamivudine stavudine reversed phase high performance liquid chromatog.

The proposed method was found to be simple, sensitive, rapid and economical for the determination of Lamivudine and Stavudine in combined tablet formulation. The developed method was checked for the performance characteristics and has also been validated. The method was found to be linear (r>0.999), precise (RSD: 0.41 for Lamivudine, 0.10 for Stavudine) and accuracy (mean percentage recovery fields 98.7% for Lamivudine, 99.1% for Stavudine). The proposed HPLC method was simple, precise because of commonly used buffer and shorter run time. The mean percentage recovery above 95% indicates the reproducibility and accuracy of new developed method compared. The result of study include the proposed method is highly accurate, simple, precise and specific. The sample recoveries in all formulations were in good agreement with their resp. label claims and they suggest non-interference of formulation excipients in the estimation After validating proposed method as per ICH guidelines and correlating obtained values with the standard values, satisfactory results were obtained. Hence the method can easily and conveniently adopted for the estimation of combined dosage form of Lamivudine and Stavudine.

International Journal of Science and Research Methodology published new progress about Agrochemical tablets. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RajanBabu, T. V.; Reddy, G. S.; Fukunaga, Tadamichi published the artcile< Nucleophilic addition of silyl enol ethers to aromatic nitro compounds: scope and mechanism of reaction>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is organosilicon alkylation nitro compound; silicon organic nitro alkylation; aromatic nitro organosilicon alkylation; heteroaromatic nitro organosilicon alkylation; benzene nitro organosilicon alkylation; anthracene nitro organosilicon alkylation; naphthalene nitro organosilicon alkylation; isoquinoline nitro organosilicon alkylation; benzothiadiazole nitro organosilicon alkylation.

In contrast to alkali metal enolates, silyl enol ethers and ketene silyl acetals added to aromatic nitro compounds in the presence of a fluoride ion source to give intermediate dihydroarom. nitronates, which could be observed by NMR. In situ oxidation of the intermediate with Br or DDQ gave α-nitroaryl carbonyl compounds in moderate to high yields. The reaction was applicable to alkyl-, alkoxy-, and halogen-substituted nitrobenzenes as well as to heterocyclic and condensed nitroarom. compounds While substitution ortho to the nitro group predominated with sterically undemanding silyl reagents, para-substitution products were exclusively obtained with bulky reagents. However, by blocking the para position with an appropriate group such as chlorine, the addition could be directed to the ortho position. Halogen atoms of halogenated nitro aromatics and p-nitrocumenyl chloride were not displaced in the reaction, suggesting the absence of radical ion intermediates. Dihydroarom. nitro derivatives could be isolated in some cases, such as anthracene and naphthalene systems, which are less prone to rearomatize.

Journal of the American Chemical Society published new progress about Alkylation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics