Month: October 2022

Kamoshita, Shione; Matsui, Saho; Suto, Nanako; Sakurai, Kaori published the artcile< Reactivity Analysis of New Multivalent Electrophilic Probes for Affinity Labeling of Carbohydrate Binding Proteins>, SDS of cas: 112-63-0, the main research area is electrophilic probe reactivity analysis affinity labeling carbohydrate binding protein; affinity labeling; carbohydrates; chemical probes; electrophiles; gold-nanoparticles; multivalency.

We have designed and synthesized six different multivalent electrophiles as carbohydrate affinity labeling probes. Evaluation of the reactivity of the electrophiles against peanut agglutinin (PNA) and Ricinus communis agglutinin (RCA) showed that p- and m-aryl sulfonyl fluoride are effective protein reactive groups that label carbohydrate binding lectins in a ligand-dependent fashion at a nanomolar probe concentration Anal. of the selectivity of affinity labeling in the presence of excess BSA as a nonspecific protein indicated that m-arylsulfonyl fluoride is a more selective protein-reactive group, albeit with attenuated reactivity. Further anal. showed that the labeling efficiency of the multivalent electrophilic probes can be improved by employing reaction conditions involving 25 °C instead of typically employed 4 °C. Both isomers of arylsulfonyl fluoride groups together represent promising affinity labels for target identification studies that could serve as more efficient alternatives to photoreactive groups.

ChemBioChem published new progress about Affinity labeling. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chu, Kevin L.; Koley, Somnath; Jenkins, Lauren M.; Bailey, Sally R.; Kambhampati, Shrikaar; Foley, Kevin; Arp, Jennifer J.; Morley, Stewart A.; Czymmek, Kirk J.; Bates, Philip D.; Allen, Doug K. published the artcile< Metabolic flux analysis of the non-transitory starch tradeoff for lipid production in mature tobacco leaves>, Electric Literature of 112-63-0, the main research area is nontransitory starch lipid production tobacco leaf triacylglycerol; (13)C isotope Labeling; Acyl-ACPs; Carbon partitioning; Metabolic flux analysis; Nicotiana tabacum (tobacco); Starch-triacylglycerol tradeoff.

The metabolic plasticity of tobacco leaves has been demonstrated via the generation of transgenic plants that can accumulate over 30% dry weight as triacylglycerols. In investigating the changes in carbon partitioning in these high lipid-producing (HLP) leaves, foliar lipids accumulated stepwise over development. Interestingly, non-transient starch was observed to accumulate with plant age in WT but not HLP leaves, with a drop in foliar starch concurrent with an increase in lipid content. The metabolic carbon tradeoff between starch and lipid was studied using 13CO2-labeling experiments and isotopically nonstationary metabolic flux anal., not previously applied to the mature leaves of a crop. Fatty acid synthesis was investigated through assessment of acyl-acyl carrier proteins using a recently derived quantification method that was extended to accommodate isotopic labeling. Anal. of labeling patterns and flux modeling indicated the continued production of unlabeled starch, sucrose cycling, and a significant contribution of NADP-malic enzyme to plastidic pyruvate production for the production of lipids in HLP leaves, with the latter verified by enzyme activity assays. The results suggest an inherent capacity for a developmentally regulated carbon sink in tobacco leaves and may in part explain the uniquely successful leaf lipid engineering efforts in this crop.

Metabolic Engineering published new progress about Chloroplast. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Isilar, Ozer; Bulut, Adnan; Sahin Yaglioglu, Ayse; Demirtas, Ibrahim; Arat, Esra; Turk, Mustafa published the artcile< Synthesis and biological evaluation of novel urea, thiourea and squaramide diastereomers possessing sugar backbone>, Reference of 112-63-0, the main research area is antiproliferative antitumor aminoglycoside disaccharide preparation; aminoglycoside disaccharide preparation urea thiourea squaramide human; Antiproliferative activity; Cytotoxicity; Squaramide; Sugar; Thiourea; Urea.

A series of novel chiral 14 urea, thiourea and squaramide stereoisomers possessing carbohydrate backbones as well as amide functional groups was synthesized and characterized by their, 1H NMR, 13C NMR, FT-IR, HRMS, optical rotation, and m.ps. Their antiproliferative activities were investigated against HeLa and PC3 cell lines. Aminoglycosides I (X = S, O) showed better activities at 25μM against PC3 cell line with respect to the standard 5-fluorouracil (5-FU). Especially, the compounds 9 and 11 showed higher activities than the standard 5-FU even at low concentration (5μM) against HeLa cell line. IC50 results also confirm these activities. The compounds I (X = S, O) have the IC50 values of 1.10μM and 1.02μM, resp. while 5-FU has 2.51μM.

Carbohydrate Research published new progress about Aminoglycosides Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luecking, Ulrich; Scholz, Arne; Lienau, Philip; Siemeister, Gerhard; Kosemund, Dirk; Bohlmann, Rolf; Briem, Hans; Terebesi, Ildiko; Meyer, Kirstin; Prelle, Katja; Denner, Karsten; Boemer, Ulf; Schaefer, Martina; Eis, Knut; Valencia, Ray; Ince, Stuart; von Nussbaum, Franz; Mumberg, Dominik; Ziegelbauer, Karl; Klebl, Bert; Choidas, Axel; Nussbaumer, Peter; Baumann, Matthias; Schultz-Fademrecht, Carsten; Ruehter, Gerd; Eickhoff, Jan; Brands, Michael published the artcile< Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer>, Related Products of 112-63-0, the main research area is atuveciclib BAY1143572 preparation PTEFb CDK9 inhibitor antitumor; CDK; PTEFb; antitumor agents; drug design; sulfoximines.

Selective inhibition of exclusively transcription-regulating PTEFb/CDK9 is a promising new approach in cancer therapy. Starting from lead compound BAY-958, lead optimization efforts strictly focusing on kinase selectivity, physicochem. and DMPK properties finally led to the identification of the orally available clin. candidate atuveciclib (BAY 1143572). Structurally characterized by an unusual benzyl sulfoximine group, BAY 1143572 exhibited the best overall profile in vitro and in vivo, including high efficacy and good tolerability in xenograft models in mice and rats. BAY 1143572 is the first potent and highly selective PTEFb/CDK9 inhibitor to enter clin. trials for the treatment of cancer.

ChemMedChem published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lombardi, Francesca; Augello, Francesca Rosaria; Artone, Serena; Gugu, Mitilda Karoli; Cifone, Maria Grazia; Cinque, Benedetta; Palumbo, Paola published the artcile< Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines>, Related Products of 112-63-0, the main research area is cyclooxygenase upregulation expression temozolomide human glioblastoma; COX-2; COX-2 inhibitor; MGMT; NS398; SOX-2; T98G; U251MG; glioblastoma; temozolomide; β-catenin.

TMZ-resistance remains a main limitation in glioblastoma (GBM) treatment. TMZ is an alkylating agent whose cytotoxicity is modulated by O6-methylguanine-DNA methyltransferase (MGMT), whose expression is determined by MGMT gene promoter methylation status. The inflammatory marker COX-2 has been implicated in GBM tumorigenesis, progression, and stemness. COX-2 inhibitors are considered a GBM add-on treatment due to their ability to increase TMZ-sensitivity. We investigated the effect of TMZ on COX-2 expression in GBM cell lines showing different COX-2 levels and TMZ sensitivity (T98G and U251MG). β-catenin, MGMT, and SOX-2 expression was analyzed. The effects of NS398, COX-2 inhibitor, alone or TMZ-combined, were studied evaluating cell proliferation by the IncuCyte system, cell cycle/apoptosis, and clonogenic potential. COX-2, β-catenin, MGMT, and SOX-2 expression was evaluated by RT-PCR, Western blotting, and immunofluorescence and PGE2 by ELISA. Our findings, sustaining the role of COX-2/PGE2 system in TMZ-resistance of GBM, show, for the first time, a relevant, dose-dependent up-regulation of COX-2 expression and activity in TMZ-treated T98G that, in turn, correlated with chemoresistance. Similarly, all the COX-2-dependent signaling pathways involved in TMZ-resistance also resulted in being up-modulated after treatment with TMZ. NS398+TMZ was able to reduce cell proliferation and induce cell cycle arrest and apoptosis. Moreover, NS398+TMZ counteracted the resistance in T98G preventing the TMZ-induced COX-2, β-catenin, MGMT, and SOX-2 up-regulation.

International Journal of Molecular Sciences published new progress about Antitumor agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santhana Kumar, V.; Das Sarkar, Soma; Das, Basanta Kumar; Sarkar, Dhruba Jyoti; Gogoi, Pranab; Maurye, Praveen; Mitra, Tandrima; Talukder, Anjon Kumar; Ganguly, Satabdi; Nag, Subir Kumar; Munilkumar, Sukham; Samanta, Srikanta published the artcile< Sustainable biodiesel production from microalgae Graesiella emersonii through valorization of garden wastes-based vermicompost>, Related Products of 112-63-0, the main research area is biodiesel Graesiella valorization garden waste vermicompost; Biodiesel; Culture media; Graesiella sp.; Microalgae; Vermicompost extract; Waste management.

Biodiesel production from microalgae has gained significant interest recently due to the growing energy demand and non-renewable nature of petroleum. However, high cost of production and environmental health related issues like excess use of inorganic fertilizers, eutrophication are the major constraints in com.-scale biodiesel production Besides this, solid wastes (garden-based) management is also a global concern. In the present study, to overcome these limitations vermicompost extract was tested as nutrient source to enhance growth performance and lipid production from a freshwater microalga (Graesiella emersonii MN877773). Garden wastes were first converted into vermicompost manure and its extract (aerobic and anaerobically digested) was prepared The efficacy of the extract was then tested in combination with BG11 medium. The mixotrophic cultivation of microalgae in anaerobically digested vermicompost extract at 50:50 combination with BG11 medium enhanced the cell biomass (0.64 g d. weight L-1) and lipid productivity (3.18 mg L-1 day-1) of microalgae by two times. Moreover, the combination also improved the saturated (Me palmitate) and monounsaturated fatty acids (oleic acid) content in the test algae. The quality of biodiesel also complies with all the properties of biodiesel standard provided by India, the USA, and Europe except the cold filter plugging property. The combination was also found to improve the cell biomass (0.041 g L-1) as compared to BG11 medium in mass-scale cultivation. Hence, the study proved that G. emersonii grown in media supplemented with garden waste-based vermicompost extract had significant potential for mass-scale biodiesel and bioproduct production

Science of the Total Environment published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J. published the artcile< Pyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands>, HPLC of Formula: 112-63-0, the main research area is pyrazolotriazine preparation corticotropin releasing factor receptor ligand.

The syntheses and rat CRF receptor binding affinities of retro-pyrazolotriazine’ corticotropin-releasing factor (CRF) ligands are reported. Some have high affinity for rat CRF receptors (Ki≤10 nM). The data provide addnl. support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the design of high-affinity CRF receptor ligands, provided the peripheral pharmacophore elements are maintained in the same three-dimensional array.

Bioorganic & Medicinal Chemistry published new progress about Corticotropin releasing factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagnieres, Olivier; Xu, Zhengren; Wang, Qian; Zhu, Jieping published the artcile< Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A>, Product Details of C9H9NO4, the main research area is stereoselective synthesis monoterpene indole alkaloid; goniomitine stereoselective synthesis; dehydroaspidospermidine stereoselective synthesis; aspidospermidine vincadifformine kopsihainanine stereoselective synthesis; decarboxylative vinylation palladium catalyst monoterpene indole alkaloid synthesis; oxidation reduction cyclization integrated stereoselective synthesis monoterpene indole alkaloid.

Total syntheses of (±)-goniomitine, (±)-1,2-dehydroaspidospermidine, (±)-aspidospermidine, (±)-vincadifformine, and (±)-kopsihainanine A were achieved featuring two common key steps: (1) a palladium-catalyzed decarboxylative vinylation that provides quick access to cyclopentene intermediates containing all of the carbons present in the natural products and (2) an integrated oxidation/reduction/cyclization (iORC) sequence for skeletal reorganization that converts the cyclopentenes to the pentacyclic structures of the natural products. By incorporation of a geometric constraint to iORC substrates, both the chemoselectivity (C7 vs. N1 cyclization) and the stereoselectivity (trans- vs. cis-fused ring system) of the cyclization process can be controlled.

Journal of the American Chemical Society published new progress about Cyclization. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Wenying; Lin, Yanjun; Kong, Xianggui; Zhang, Shitong; Jia, Yankun; Wei, Min; Evans, David G.; Duan, Xue published the artcile< Fabrication of pyrenetetrasulfonate/layered double hydroxide ultrathin films and their application in fluorescence chemosensors>, Application of C19H34O2, the main research area is fabrication pyrenetetrasulfonate layered hydroxide ultrathin film fluorescence chemosensor.

This paper reports the fabrication of fluorescence indicator/layered double hydroxide (LDH) ultrathin films (UTFs) by alternate assembly of 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt (PTS) and Zn-Al LDH nanosheets on quartz substrates using the layer-by-layer (LBL) deposition technique, and demonstrates their application as a fluorescence chemosensor for Cu2+. UV-visible absorption spectroscopy indicates a stepwise and regular growth of the PTS/LDH UTFs upon increasing deposition cycles. X-ray diffraction, at. force microscopy and SEM demonstrate that the UTFs possess a periodical layered structure perpendicular to the substrates with a thickness of 1.93-1.98 nm per bilayer. Also, the fluorescence chemosensor with film thickness of 48 nm (24 bilayers) exhibits a broad linear response range for Cu2+ solution (0.6-50 μM), good repeatability (relative standard deviation <5% in 20 consecutive measurements), high photostability and storage stability (∼93.2% of its initial fluorescence intensity remains after one month) as well as excellent selectivity. The study on mechanism of measurement-regeneration cycle of the fluorescence chemosensor shows that Cu2+ enters/departs from the PTS/LDH UTF with reversible change in chem. composition, surface morphol. and fluorescence anisotropy. Therefore, this work provides new opportunities for fabrication and application of chromophore/LDH UTFs which can be used as fluorescence chemosensors. Journal of Materials Chemistry published new progress about Fluorescence quenching. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brittain, Harry G. published the artcile< Optical activity in mixed-ligand terbium(III) complexes containing pyridine-2,6-dicarboxylic acid and chiral hydroxycarboxylic acids>, HPLC of Formula: 112-63-0, the main research area is optical activity terbium chiral hydroxycarboxylic.

The optical activity associated with the f-f emission bands of Tb(III) complexes which contain chiral hydroxycarboxylic acids was studied by means of circularly polarized luminescence (CPL) spectroscopy. Complexes having the general formulas Tb(DPA)(L) and Tb(DPA)2(L) were studied (where DPA signifies pyridine-2,6-dicarboxylate), with the chiral L ligand being L-lactic acid, L-α-hydroxyisocaproic acid, L-argininic acid, L-mandelic acid, L-phenyllactic acid, L-malic acid, L-hydroxyglutaric acid, and D-isocitric acid. The CPL spectra were sensitive to the mode of bonding existing between the metal and the chiral ligand and therefore enabled predictions to be made regarding how the hydroxycarboxylic acid ligands attach to the Tb(III) ion. In addition, the degree of optical activity varied systematically with the concentration of chiral ligand, and this dependence was used to calculate formation constants for the addition of a hydroxycarboxylic acid ligand to the Tb/DPA complexes. Finally, the line shapes and magnitudes of the CPL spectra provide information regarding the type of chirality experienced by the Tb(III) ion.

Inorganic Chemistry published new progress about Circularly polarized luminescence. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics