Month: October 2022

Chernov, Alexandr N.; Filatenkova, Tatiana A.; Glushakov, Ruslan I.; Buntovskaya, Alexandra S.; Alaverdian, Diana A.; Tsapieva, Anna N.; Kim, Alexandr V.; Fedorov, Evgeniy V.; Skliar, Sofia S.; Matsko, Marina V.; Galimova, Elvira S.; Shamova, Olga V. published the artcile< Anticancer Effect of Cathelicidin LL-37, Protegrin PG-1, Nerve Growth Factor NGF, and Temozolomide: Impact on the Mitochondrial Metabolism, Clonogenic Potential, and Migration of Human U251 Glioma Cells>, Category: esters-buliding-blocks, the main research area is ECAR; OCR; cathelicidin LL-37; clonogenicity; human glioma U251; metabolism of mitochondria; migration; nerve growth factor NGF; protegrin PG-1; temozolomide.

Glioblastoma (GBM) is one of the most aggressive and lethal malignancy of the central nervous system. Temozolomide is the standard of care for gliomas, frequently results in resistance to drug and tumor recurrence. Therefore, further research is required for the development of effective drugs in order to guarantee specific treatments to succeed. The aim of current study was to investigate the effects of nerve growth factor (NGF), human cathelicidin (LL-37), protegrin-1 (PG-1), and temozolomide on bioenergetic function of mitochondria, clonogenicity, and migration of human U251 glioma cells. Colony formation assay was used to test the ability of the glioma cells to form colonies in vitro. The U251 glioma cells migration was evaluated using wound-healing assay. To study the mitochondrial metabolism in glioma cells we measured oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) using a Seahorse XF cell Mito stress test kit and Seahorse XF cell Glycolysis stress kit, resp. We revealed that LL-37, NGF, and TMZ show strong anti-tumorigenic activity on GMB. LL-37 (4 μM), TMZ (155 μM), and NGF (7.55 x 10-3 μM) inhibited 43.9%-60.3%, 73.5%-81.3%, 66.2% the clonogenicity of glioma U251 cells for 1-2 days, resp. LL-37 (4 μM), and NGF (7.55 x 10-3 μM) inhibited the migration of U251 glioma cells on the third and fourth days. TMZ also inhibited the migration of human glioma U251 cells over 1-3 days. In contrast, PG-1 (16 μM) stimulated the migration of U251 glioma cells on the second, fourth, and sixth days. Anti-mitogenic and anti-migration activities of NGF, LL-37, and TMZ maybe are relation to their capacity to reduce the basal OCR, ATP-synthetase, and maximal respiration of mitochondria in human glioma U251 cells. Glycolysis, glycolytic capacity and glycolytic spare in glioma U251 cells haven’t been changed under the effect of NGF, LL-37, PG-1, and TMZ in regard to control level. Thus, LL-37 and NGF inhibit migration and clonogenicity of U251 glioma cells, which may indicate that these compounds have anti-mitogenic and anti-migration effects on human glioma cells. The study of the mechanisms of these effects may contribute in the future to the use of NGF and LL-37 as therapeutic agents for gliomas.

Molecules published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Redjeb, Youcef; Kaabeche-Djerafi, Khatima; Stoppato, Anna; Benato, Alberto published the artcile< The IRC-PD Tool: A Code to Design Steam and Organic Waste Heat Recovery Units>, Quality Control of 112-63-0, the main research area is steam organic waste Rankine cycle heat recovery design.

The Algerian economy and electricity generation sector are strongly dependent on fossil fuels. Over 93% of Algerian exports are hydrocarbons, and approx. 90% of the generated electricity comes from natural gas power plants. However, Algeria is also a country with huge potential in terms of both renewable energy sources and industrial processes waste heat recovery. For these reasons, the government launched an ambitious program to foster renewable energy sources and industrial energy efficiency. In this context, steam and organic Rankine cycles could play a crucial role; however, there is a need for reliable and time-efficient optimization tools that take into account tech., economic, environmental, and safety aspects. For this purpose, the authors built a math. tool able to optimize both steam and organic Rankine units. The tool, called Improved Rankine Cycle Plant Designer, was developed in MATLAB environment, uses the Genetic Algorithm toolbox, acquires the fluids thermophys. properties from CoolProp and REFPROP databases, while the safety information is derived from the ASHRAE database. The tool, designed to support the development of both RES and industrial processes waste heat recovery, could perform single or multi-objective optimizations of the steam Rankine cycle layout and of a multiple set of organic Rankine cycle configurations, including the ones which adopt a water or an oil thermal loop. In the case of the ORC unit, the working fluid is selected among more than 120 pure fluids and their mixtures The turbines’ design parameters and the adoption of a water- or an air-cooled condenser are also optimization results. To facilitate the plant layout and working fluid selection, the economic anal. is performed to better evaluate the plant economic feasibility after the thermodn. optimization of the cycle. Considering the willingness of moving from a fossil to a RES-based economy, there is a need for adopting plants using low environmental impact working fluids. However, because ORC fluids are subjected to environmental and safety issues, as well as phase out, the code also computes the Total Equivalent Warming Impact, provides safety information using the ASHRAE database, and displays an alert if the organic substance is phased out or is going to be banned. To show the tool’s potentialities and improve the knowledge on waste heat recovery in bio-gas plants, the authors selected an in-operation facility in which the waste heat is released by a 1 MWel internal combustion engine as the test case. The optimization outcomes reveal that the tech., economic, environmental, and safety performance can be achieved adopting the organic Rankine cycle recuperative configuration. The unit, which adopts Benzene as working fluid, needs to be decoupled from the heat source by means of an oil thermal loop. This optimized solution guarantees to boost the electricity production of the bio-gas facility up to 15%.

Energies (Basel, Switzerland) published new progress about Air. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramakrishna Pillai, Jayachithra; Wali, Adil Farooq; Menezes, Godfred Antony; Rehman, Muneeb U.; Wani, Tanveer A.; Arafah, Azher; Zargar, Seema; Mir, Tahir Maqbool published the artcile< Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit>, Related Products of 112-63-0, the main research area is Physalis leaf fruit phytochem antimicrobial antioxidant cytotoxicity; DLD-1; HeLa; MCF-7; Physalis angulata; Solanaceae; antioxidant activity; cytotoxic activity.

Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chem. composition and structure of bioactive chems. reported in extracts The anticancer activity results revealed a decrease in the percentage of anticancer cells′ viability in a concentration- and time-dependent way. We also noticed morphol. alterations in the cells, which we believe are related to Physalis angulata extracts Under light microscopy, we observed that as the concentration of ethanolic extract (fruit and leaves) treated HeLa cells increased, the number of cells began to decrease.

Molecules published new progress about Alkaloids Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wuensch, Bernhard; Nerding, Sven published the artcile< A facile and regioselective synthesis of donor-substituted 2-(2-halophenyl)acetaldehyde acetals>, HPLC of Formula: 112-63-0, the main research area is regioselective preparation donor substituted halophenylacetaldehyde acetal.

Starting from vanillin a facile and high yielding procedure for the preparation of the donor substituted (2-bromophenyl)- and (2-iodophenyl)-acetaldehyde acetals I [R = Br (II), I (III)] is described. Homologation of O-benzylvanillin to obtain the phenylacetaldehyde acetal I [R = H(IV)]succeeds by Wittig reaction with the Ph3P+CH2OMe Cl- and subsequent addition of methanol. IV is brominated with pyridinium bromide perbromide in methanol to yield the bromo acetal II in 65% yield from vanillin. Iodination of IV with iodine and iodic acid leads to the iodo acetal III.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Acetals Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zenouz, A. Moshtaghi; Allahverdi, S.; Raissossadat Q., M.; Sadeghi Sh., Q. published the artcile< Synthesis of the C-2 functionalized 1,4-dihydropyridines>, Application In Synthesis of 112-63-0, the main research area is methyl pyridine bromination; bromomethyl pyridine preparation reaction thiourea; isothiuronium salt pyridine preparation reaction methyl iodide; sulfide methyl pyridine preparation; dithiane reaction bromomethyl pyridine; dithio acetal preparation.

Unsym. 1,4-dihydropyridine esters were synthesized from the sym. precursor 2,6-dimethylpyridine derivative through the intermediacy of 2-bromomethyl derivative 2-bromomethyl-6-methylpyridine derivative Then reaction of isothiuronium salt of pyridine derivative with electrophilic specie, methyl-iodide, in the presence of base produced S-methylated pyridine derivative Reaction of the dibrominated pyridine derivative with lithium salt of 1,3-dithiane led to the formation of dithio acetal of pyridine derivative

Asian Journal of Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baldwin, Jack E.; Reiss, James A. published the artcile< Preference for 6-exo-trigonal closures of ω-hydroxy-αβ-unsaturated esters>, Formula: C7H12O3, the main research area is ester hydroxy unsaturated cyclization; valerate hydroxy methylene cyclization; lactonization hydroxmethylenevalerate.

Treatment of HO(CH2)3C(CO2Me):CH2 (I) with base, e.g. NaH, NaOMe, or KOCMe3, caused slow cyclization to give the lactone II. II is formed by a 6-Exo-Trig process which is a faster reaction than the alternative 6-Endo-Trig mode of ring closure. The slow reaction of I was due to its isomerization to the s-trans conformation in which the 6-Exo-Trig closure was sterically improbable.

Journal of the Chemical Society, Chemical Communications published new progress about Cyclization. 18729-20-9 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O3, Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saigal, Neil; Pichika, Rama; Easwaramoorthy, Balasubramaniam; Collins, Daphne; Christian, Bradley T.; Shi, Bingzhi; Narayanan, Tanjore K.; Potkin, Steven G.; Mukherjee, Jogeshwar published the artcile< Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate>, Reference of 112-63-0, the main research area is serotonin 5HT1A receptor fluorine 18 mefway PET.

Serotonin 5-HT1A receptors have been implicated in disorders of the central nervous system and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability of 5-HT1A agents currently in human use (11C-labeled N-(2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-(2-pyridinyl)cyclohexanecarboxamide [11C-WAY-100635]), 4-(2′-methoxyphenyl)-1-[2′-(N-2”-pyridinyl)-p-18F-fluorobenzamido]ethylpiperazine [18F-MPPF], and 18F-labeled trans-4-fluoro-N-(2-[4-(2-methoxyphenyl)piperazin-1-yl)ethyl]-N-(2-pyridyl)cyclohexanecarboxamide) [18F-FCWAY]. We have synthesized N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-18F-fluoromethylcyclohexane)carboxamide (18F-mefway), which contains a 18F on a primary carbon to make the compound more stable to defluorination. Methods: Radiosynthesis of 18F-mefway was performed in a single tosylate for 18F-fluoride exchange. In vitro binding studies on rat brain slices using 18F-mefway were read on a phosphor imager. Monkey PET studies were performed on a whole-body PET scanner. Results: Binding affinity (inhibitory concentration of 50% [IC50]) of mefway was 26 nmol/L and was comparable to that of WAY-100635, 23 nmol/L. Yields of 18F-mefway were 20%-30% in specific activities of 74-111 GBq/μmol at the end of synthesis. In vitro binding of 18F-mefway in the hippocampus (Hp), colliculus (Co), cortex (Ctx), and other brain regions-with limited binding in the cerebellum (Cer)-was observed, with ratios of Hp/Cer = 82.3, Co/Cer = 45.8, and Ctx/Cer = 40. Serotonin displaced 18F-mefway from various brain regions with IC50 values in the range of 169-243 nmol/L. PET studies in a rhesus monkey showed 18F-mefway binding in the fontal cortex (FC), temporal cortex (TC) including hippocampus, raphe (Rp), and other brain regions, with ratios of FC/Cer = 9.0, TC/Cer = 10, and Rp/Cer = 3.3. Plasma anal. indicated the presence of approx. 30% of 18F-mefway at 150-180 min after injection. Conclusion: The high ratios in specific brain regions such as the hippocampus suggest that 18F-mefway has potential as a PET agent for 5HT1A receptors.

Journal of Nuclear Medicine published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rodenko, Boris; Toebes, Mireille; Hadrup, Sine Reker; van Esch, Wim J. E.; Molenaar, Annemieke M.; Schumacher, Ton N. M.; Ovaa, Huib published the artcile< Generation of peptide-MHC class I complexes through UV-mediated ligand exchange>, Computed Properties of 30095-98-8, the main research area is peptide complex MHC class I UV exchange.

Major histocompatibility complex (MHC) class I mols. present peptide ligands on the cell surface for recognition by appropriate cytotoxic T cells. MHC-bound peptides are critical for the stability of the MHC complex, and standard strategies for the production of recombinant MHC complexes are based on in vitro refolding reactions with specific peptides. This strategy is not amenable to high-throughput production of vast collections of MHC mols. The authors have developed conditional MHC ligands that form stable complexes with MHC mols. but can be cleaved upon UV irradiation The resulting empty, peptide-receptive MHC mols. can be charged with epitopes of choice under native conditions. Here the authors describe in-depth procedures for the high-throughput production of peptide-MHC (pMHC) complexes by MHC exchange, the anal. of peptide exchange efficiency by ELISA and the parallel production of MHC tetramers for T-cell detection. The production of the conditional pMHC complex by an in vitro refolding reaction can be achieved within 2 wk, and the actual high-throughput MHC peptide exchange and subsequent MHC tetramer formation require less than a day.

Nature Protocols published new progress about CD8-positive T cell. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Computed Properties of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto published the artcile< C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is platinum carbene complex preparation catalyst borylation arene heteroarene; phenylboronic ester preparation.

Despite significant progress in the area of C-H bond functionalization of arenes, no general method is reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, the authors report the development of the 1st Pt-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Xin; Hu, Shaoqi; Yang, Qiao; Sang, Xianan; Tang, Dongxin; Cao, Gang published the artcile< Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: From oxidative stress to autophagy>, Category: esters-buliding-blocks, the main research area is paeoniflorin airway inflammation immune response asthma oxidative stress; Asthma; Immune; Inflammatory; Paeoniflorin; Pulmonary injury.

Asthma characterized by airway remodeling is a multiple pulmonary disease, which is associated with various physiol. processes including inflammation reaction, immune response, oxidative stress and autophagy. This study aimed to investigate whether these processes are modulated by the total glucosides of Paeonia lactiflora Pall (TGP), and its active compound paeoniflorin (PF) with anti-inflammatory and immune-regulatory effects could alleviate ovalbumin (OVA)-induced mouse asthma. In vivo, models of mouse asthma were established by i.p. with a mixture of OVA and aluminum hydroxide, plus a single nasal injected with OVA to female C57BL/6 mice. The results were observed with PET imaging, TEM, RT-PCR, western blotting. In vitro, CD4+ T cells were isolated and detected with flow cytometry. TGP, either in its crude or processed form, and PF effectively ameliorated lung injury in mice induced by OVA, regulated immune/inflammatory response by inhibiting the release of pro-inflammatory cytokines, thereby decreasing Th2 cell proportion, inhibited oxidative stress by recovering mitochondrial membrane potential and regulating metabolic activity in dose-dependent manner. Moreover, PF could inhibit autophagy by regulating mitochondrial function. In addition, the therapeutic effects of TGP and PF on pulmonary injury in asthmatic mice were not affected by processing. PF may be a valuable agent in ameliorating inflammation and immune response in asthmatic mice, and the possible mechanism involved in this response rang may from oxidative stress to autophagy.

Phytomedicine published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics