Month: October 2022

Sandeep, Anjamkudy; Praveen, Vakayil K.; Shankar Rao, D. S.; Krishna Prasad, S.; Ajayaghosh, Ayyappanpillai published the artcile< Transforming a C3-Symmetrical Liquid Crystal to a π-Gelator by Alkoxy Chain Variation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is self assembly columnar liquid crystal gelation.

Rational understanding of the structural features involving different noncovalent interactions is necessary to design a liquid crystal (LC) or an organogelator. Herein, we report the effect of the number and positions of alkoxy chains on the self-assembly induced phys. properties of a few π-conjugated mols. For this purpose, we designed and synthesized three C3-sym. mols. based on oligo(p-phenylenevinylene), C3OPV1-3. The self-assembly properties of these mols. are studied in the solid and solution states. All of the three mols. follow the isodesmic self-assembly pathway. Upon cooling from isotropic melt, C3OPV1 having nine alkoxy chains (-OC12H25) formed a columnar phase with two-dimensional rectangular lattice and retained the LC phase even at room temperature Interestingly, when one of the -OC12H25 groups from each of the end benzene rings is knocked out, the resultant mol., C3OPV2 lost the LC property, however, transformed as a gelator in toluene and n-decane. Surprisingly, when the -OC12H25 group from the middle position is removed, the resultant mol. C3OPV3 failed to form either the LC or the gel phases.

ACS Omega published new progress about Fluorescence. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuo, Elizabeth A.; Hambleton, Philip T.; Kay, David P.; Evans, Phillip L.; Matharu, Saroop S.; Little, Edward; McDowall, Neil; Jones, C. Beth; Hedgecock, Charles J. R. published the artcile< Synthesis, Structure-Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy- N-[3'-methyl-4'-(trifluoromethyl)phenyl]propenamide and Related Compounds>, Application of C19H34O2, the main research area is immunosuppressant leflunomide metabolite analog preparation activity; dihydroorotate dehydrogenase inhibition leflunomide metabolite analog; arthritis inhibition leflunomide metabolite analog structure.

The active, ring-opened metabolite of the novel immunosuppressive agent leflunomide has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogs of the leflunomide metabolite have been synthesized. Their in vivo biol. activity determined in rat and mouse delayed type hypersensitivity has been found to correlate well with their in vitro DHODH potency. The most promising compound has shown activity in rat and mouse collagen (II)-induced arthritis models (ED50 = 2 and 31 mg/kg, resp.) and has shown a shorter half-life in man when compared with leflunomide. Clin. studies in rheumatoid arthritis are in progress.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

La Rosa, Francesca; Zoia, Chiara Paola; Bazzini, Chiara; Bolognini, Alessandra; Saresella, Marina; Conti, Elisa; Ferrarese, Carlo; Piancone, Federica; Marventano, Ivana; Galimberti, Daniela; Fenoglio, Chiara; Scarpini, Elio; Clerici, Mario published the artcile< Modulation of MAPK- and PI3/AKT-Dependent Autophagy Signaling by Stavudine (D4T) in PBMC of Alzheimer's Disease Patients>, Application of C19H34O2, the main research area is ERK; NLRP3-inflammasome; amyloid-β; caspase-3 and Bcl2; neuroinflammation; p38; p70S6K and CREB phosphorylation.

Background: Aβ42 deposition plays a pivotal role in AD pathogenesis by inducing the activation of microglial cells and neuroinflammation. This process is antagonized by microglia-mediated clearance of Aβ plaques. Activation of the NLRP3 inflammasome is involved in neuroinflammation and in the impairments of Aβ-plaque clearance. On the other hand, stavudine (D4T) downregulates the NLRP3 inflammasome and stimulates autophagy-mediated Aβ-clearing in a THP-1-derived macrophages. Methods: We explored the effect of D4T on Aβ autophagy in PBMC from AD patients that were primed with LPS and stimulated with Aβ oligomers in the absence/presence of D4T. We analyzed the NLRP3 activity by measuring NLRP3-ASC complex formation by AMNIS FlowSight and pro-inflammatory cytokine (IL-1β, IL-18 and Caspase-1) production by ELISA. The phosphorylation status of p38, ERK, AKT, p70, and the protein expression of CREB, LAMP2A, beclin-1, Caspase-3 and Bcl2 were analyzed by Western blot. Results: Data showed that D4T: (1) downregulates NLRP3 inflammasome activation and the production of down-stream pro-inflammatory cytokines in PBMC; (2) stimulates the phosphorylation of AKT, ERK and p70 as well as LAMP2A, beclin-1 and Bcl2 expression and reduces Caspase-3 expression, suggesting an effect of this compound on autophagy; (3) increases phospho-CREB, which is a downstream target of p-ERK and p-AKT, inducing anti-inflammatory cytokine production and resulting in a possible decrease of Aβ-mediated cytotoxicity; and (4) reduces the phosphorylation of p38, a protein involved in the production of pro-inflammatory cytokines and tau hyperphosphorylation. Conclusions: D4T reduces the activation of the NLRP3 inflammasome, and it might stimulate autophagy as well as the mol. mechanism that modulates Aβ cytotoxicity, and D4T might reduce inflammation in the cells of AD patients. It could be very interesting to check the possible beneficial effects of D4T in the clin. scenario.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Jin; Hua, Wei; Zhao, Xinyuan; Yang, Fan; Guo, Ting; Zhang, Jianhua; Zheng, Xuerong; Liang, Wanqi published the artcile< Paeoniflorin alleviates endothelial dysfunction caused by overexpression of soluble fms-like tyrosine kinase 1 and soluble endoglin in preeclampsia via VEGFA upregulation.>, HPLC of Formula: 112-63-0, the main research area is endothelial dysfunction; paeoniflorin; preeclampsia; soluble endoglin; soluble fms-like tyrosine kinase 1.

This study assessed the protective effects of paeoniflorin against preeclampsia-related endothelial damage (ED). Human umbilical vein endothelial cells (HUVECs) isolated from healthy puerperae were identified by immunofluorescence assay. After paeoniflorin treatment, HUVECs were induced by soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) to establish ED. Cell viability, migration, invasion, tube formation, and apoptosis were assessed by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium MTT assay, Scratch assay, Transwell assay, tube formation assay, and flow cytometry. VEGFA expression in HUVECs was analyzed by Western blot. HUVECs were successfully isolated and identified as Von Willebrand factor (vWF) positive. Individual treatment or cotreatment of sFlt-1 and sEng inhibited migration, invasion and tube formation, enhanced apoptosis, and decreased VEGFA expression in HUVECs. Paeoniflorin pretreatment partially reversed the effects delivered by cotreatment of sFlt-1 and sEng in HUVECs. Paeoniflorin alleviated preeclampsia-related ED caused by overexpression of sFlt-1 and sEng by upregulating VEGFA.

Bioscience, biotechnology, and biochemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meimetis, Labros G.; Boros, Eszter; Carlson, Jonathan C.; Ran, Chongzhao; Caravan, Peter; Weissleder, Ralph published the artcile< Bioorthogonal Fluorophore Linked DFO-Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies>, Electric Literature of 112-63-0, the main research area is zirconium 89 DFO BODIPY trastuzumab PET fluorescence imaging.

Herein we describe the development and application of a bioorthogonal fluorogenic chelate linker that can be used for facile creation of labeled imaging agents. The chelate linker is based on the trans-cyclooctene(TCO)-tetrazine(Tz) chem. platform and incorporates deferoxamine (DFO) as a 89Zr PET tracer and a BODIPY fluorophore for multimodal imaging. The rapid (<3 min) ligation between mAb-TCO and Tz-BODIPY-DFO chelator is monitored using fluorescence and allows for determination of labeling completion. Utilizing BODIPY as the linker between mAb and DFO facilitates in chelator quantification using spectrophotometry, allowing for an alternative to traditional methods (mass and isotope dilution assay). Radiolabeling with 89Zr to form 89Zr-DFO-BODIPY-trastuzumab was found to be quant. after incubation at room temperature for 1 h (1.5 mCi/mg specific activity). The cell binding assay using HER2+ (BT474) and HER2- (BT20) cell lines showed significant binding to 89Zr-DFO-BODIPY-trastuzumab (6.45 ± 1.87% in BT474 vs. 1.47 ± 0.39% in BT20). In vivo PET imaging of mice bearing BT20 or BT474 xenografts with 89Zr-DFO-BODIPY-trastuzumab showed high tumor conspicuity, and biodistribution confirmed excellent, specific probe uptake of 237.3 ± 14.5% ID/g in BT474 xenografts compared to low, nonspecific probe uptake in BT20 xenografts (16.4 ± 5.6% ID/g) 96 h p.i. . Ex vivo fluorescence (465ex/520em) of selected tissues confirmed superb target localization and persistence of the fluorescence of 89Zr-DFO-BODIPY-trastuzumab. The described platform is universally adaptable for simple antibody labeling. Bioconjugate Chemistry published new progress about Chelating agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nakai, Diogo K.; Ribeiro, Jose A. A.; Martins, Pedro A.; Soares, Itania P.; Salum, Thais F. C.; Costa, Patricia P. K. G. published the artcile< Evaporative light scattering detection based reversed-phase ultra-high-performance liquid chromatography method to quantify intermediates and end products of biodiesel production>, Formula: C19H34O2, the main research area is biodiesel production evaporative light scattering high performance liquid chromatog; Acylglycerol; Biodiesel; ELSD; Ester; Free fatty acid; UHPLC.

A fast method based on reversed-phase ultra-high-performance liquid chromatog. using evaporative light scattering detection (RP-UHPLC-ELSD) was developed for monitoring the intermediates and end products of biodiesel production Gradient elution of water, acetonitrile, and a mixture of acetonitrile:2-propanol:n-hexane was used. With a minimal and easy sample preparation, fatty acid Me esters (FAME), fatty acid Et esters (FAEE), free fatty acids (FFA), monoacylglycerols (MAG), diacylglycerols (DAG), and triacylglycerols (TAG) were successfully separated The developed method was used to monitor an ethylic enzymic transesterification of soybean oil and to characterize the ester content of Me and Et biodiesel. The ester content obtained was compared with the reference method by gas chromatog. and flame ionization detector (GC-FID), with similar results for both Me and Et biodiesel. The presented method is a simple and fast alternative, a 17 min run, to monitor the transesterification process, simultaneously quantifying all the analytes produced in the reaction: biodiesel and its intermediates. Limits of detection (LOD, between 29 and 307 ng) and quantification (LOQ, between 48 and 614 ng), linearity (R2>0.99), precision (between 0.30 and 6.58%), and accuracy (between 81.6 and 119.9%) were determined for the twenty-one compounds

Journal of Chromatography A published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Holm Hansen, Rikke; Hoejsgaard Chow, Helene; Sellebjerg, Finn; Rode von Essen, Marina published the artcile< Dimethyl fumarate therapy suppresses B cell responses and follicular helper T cells in relapsing-remitting multiple sclerosis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dimethyl fumarate follicular helper T B cell multiple sclerosis; B cells; Multiple sclerosis; cytokines; dimethyl fumarate; follicular helper T cells.

Background:: Di-Me fumarate (DMF) is a disease-modifying therapy used for patients with relapsing-remitting multiple sclerosis (RRMS). B cells are important contributors to the pathogenesis of RRMS, where they regulate the inflammatory immune responses and participate in development of lesions in the central nervous system (CNS). The impact of DMF on B cell subpopulations remains incompletely understood. Objectives:: In this study, we evaluated the effects of DMF on B cell subpopulations and their effector functions. Methods:: Blood from 21 DMF-treated and 18 untreated patients with RRMS was analyzed by flow cytometry. Results:: We found that DMF reduces the frequency of circulating antigen-experienced B cells, a reduction likely related to a reduced frequency of follicular helper T (TFH) cells and an increased frequency of follicular regulatory T (TFR) cells. Studying the impact of monomethyl fumarate (MMF), the primary metabolite of DMF, on B cell effector function in vitro showed that MMF increased the frequency of transforming growth factor (TGF)-β-producing B cells and decreased the frequency of B cells secreting lymphotoxin (LT)-α, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and to a lesser extent IL-10. Conclusion:: In summary, these data suggest an anti-inflammatory role of DMF and its metabolite MMF on the B cell compartment.

Multiple Sclerosis Journal published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Junheng; Gong, Zhangjie; Wu, Cheng; Li, Tingcheng; Tang, Yuanyu; Wu, Jingde; Jiang, Can; Miao, Menghe; Zhang, Daohong published the artcile< Itaconic acid-based hyperbranched polymer toughened epoxy resins with rapid stress relaxation, superb solvent resistance and closed-loop recyclability>, Electric Literature of 112-63-0, the main research area is itaconic acid hyperbranched polymer toughened epoxy resin stress relaxation.

The development of epoxy vitrimers with excellent overall properties and recyclability has been a great challenge. In this work, an itaconic acid-based hyperbranched polymer (IAHBP) was synthesized and incorporated as a curing agent for diglycidyl ether of bisphenol-A (DGEBA) to prepare epoxy vitrimers. The tensile strength, flexural strength and impact strength of DGEBA/IAHBP were 91.0 MPa, 121.8 MPa and 18.4 kJ m-2 resp. The hyperbranched topol. structure of IAHBP promoted dynamic transesterification and DGEBA/IAHBP exhibited outstanding malleability, shape reconfiguration and reprocessibility. DGEBA/IAHBP showed high shape fixity (Rf ∼ 97%) and recovery ratio (Rr ∼ 99%) over ten shape memory cycles, which involved grasping and loosening motions and the recovery of complex objects such as flower-shaped and 3D butterfly-shaped objects. Due to the increased free volume and crosslinking d., DGEBA/IAHBP demonstrated excellent solvent resistance. DGEBA/IAHBP can be efficiently degraded using sodium hydroxide aqueous solution, with the degraded epoxy reused to cure DGEBA to produce new epoxy vitrimers. The recycled epoxy vitrimers presented similar mech. properties and Tg to the original samples. This work demonstrated a green and convenient strategy for the production of epoxy vitrimers with excellent mech. performance and environment friendly reprocessibility.

Green Chemistry published new progress about Bending strength. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Leizhi; Yang, Guoqiang; Liu, Jia; Jiang, Bowen; Yu, Ting; Hu, Xingbang; Zhang, Zhibing published the artcile< Efficient chemical fixation of CO2 to form switchable ionic liquid to synthesize benzimidazolones under mild conditions>, Application of C19H34O2, the main research area is dihydrobenzimidazolone green preparation; benzene diamine carbon dioxide carbonylation catalyst diazabicyclononene.

In this work, a novel pathway to synthesize benzimidazolone derivatives I [R = 5-Me, 5-MeO, 5,6-di-Me] via the carbonylation of o-phenylenediamines with carbon dioxide under mild conditions (e.g., 50°C, 0.5 MPa) in the presence of 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) was reported. In this progress, the DBN, acting as superbase, could form strong intermol. hydrogen bonds with o-phenylenediamines. The carbon dioxide was chem. fixed to form switchable ionic liquids (SILs). Then, CH2Br2 as a dehydrant easily involved parallel attack carbamates salts to form leaving group. To the best of our knowledge, this protocol provided a sustainable technique for the production of benzimidazolones under mild conditions.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parzuchowski, Pawel G.; Swiderska, Aleksandra; Roguszewska, Marlena; Rolinska, Karolina; Wolosz, Dominik; Maminski, Mariusz published the artcile< Hyperbranched poly(ether-siloxane)s containing ammonium groups: Synthesis, characterization and catalytic activity>, Reference of 112-63-0, the main research area is trimethylammonium polyether siloxane hyperbranched polymer anionic ring opening copolymerization; carbon dioxide oxirane ethylene carbonate cycloaddition catalyst; carbon dioxide; catalysis; cycloaddition; ethylene carbonate; hyperbranched polymer; oxirane; polyglycidol; polysiloxane.

In this article we report an easy synthetic route towards hyperbranched polyglycerols (Amm-HBPGs) containing trimethylammonium groups and siloxane or hydroxyl end-groups. Siloxane derivatives of Amm-HBPGs were synthesized in an efficient five-step procedure including an anionic ring opening copolymerization of the phthalimide-epoxy monomer with glycidol, followed by reactions with allyl bromide, hydrosilylation with hydrogenheptamethyltrisiloxane, hydrazinolysis of phthalimide groups and quaternization of resulting amine groups with Me iodide. Hydroxyl derivatives were obtained by quaternization of previously reported aminated HBPG’s with Me iodide. Polymeric products were characterized using various NMR techniques, FTIR, and elemental anal. Both Amm-HBPGs were shown to be effective in catalysis of addition of CO2 to oxirane. The hydrophilic catalysts showed higher efficiency but synthesis of ethylene carbonate was accompanied by formation of small amounts of ethylene glycol. The siloxane-containing catalyst was easily separable from reaction mixture showing high potential in the process of converting carbon dioxide into valuable chem. raw materials.

Polymers (Basel, Switzerland) published new progress about Anion exchange. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics