Month: October 2022

Buker, Nicholas; Firestone, Kimberly A.; Haller, Marnie; Purvis, Lafe; Lao, David; Snoeberger, Robert; Jen, Alex K.-Y.; Dalton, Larry R. published the artcile< Functionalized guanidines for electro-optic materials>, Computed Properties of 112-63-0, the main research area is guanidine imidazole benzimidazole preparation nonlinear optical chromophore; UV visible absorption hyperpolarizability guanidine containing nonlinear optical chromophore; functionalized guanidine electrooptical material.

Guanidines derived from imidazoles or benzimidazoles such as I are prepared as potential nonlinear optical chromophores. Condensation of 4-nitrobenzaldehyde with 4,5,5-trimethyl-3-cyano-2,5-dihydrofuranylidenemalononitrile, reduction of the nitro group, and substitution of 1,3-dimethyl-2-chloroimidazolidinium chloride by the aromatic amine yields I. Olefination of 3,4-dibutyl-2-thiophenecarboxaldehyde with di-Et 4-nitrophenylphosphonate, formylation of the thiophene ring, condensation with 4,5,5-trimethyl-3-cyano-2,5-dihydrofuranylidenemalononitrile, reduction of the nitro group, and reaction with either 1,3-dimethyl-2-chloroimidazolidinium chloride or 1,3-dimethyl-2-chlorobenzimidazolium chloride provides the thiophene-containing chromophores. I has both a lower UV-visible absorption wavelength maximum and a higher hyperpolarizability than the comparable chromophore lacking the guanidine; guanidine-containing chromophores with a divinylthiophene linker have decreased hyperpolarizabilities compared to the chromophore lacking the guanidine. Guanidine-containing chromophores are more stable to heat than the related diethylamino chromophores.

Materials Research Society Symposium Proceedings published new progress about Chromophores. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scott, Nicholas A.; Lawson, Melissa A. E.; Hodgetts, Ryan James; Le Gall, Gwenaelle; Hall, Lindsay J.; Mann, Elizabeth R. published the artcile< Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is intestine macrophage metabolism microbiota; gut; macrophage; metabolism; microbiota.

Intestinal macrophages play a vital role in the maintenance of gut homeostasis through signals derived from the microbiota. We previously demonstrated that microbial-derived metabolites can shape the metabolic functions of macrophages. Here, we show that antibiotic-induced disruption of the intestinal microbiota dramatically alters both the local metabolite environment and the metabolic functions of macrophages in the colon. Broad-spectrum antibiotic administration in mice increased the expression of the large neutral amino acid transporter LAT1 and accordingly, amino acid uptake. Subsequently, antibiotic administration enhanced the metabolic functions of colonic macrophages, increasing phosphorylation of components of mammalian/mechanistic target of rapamycin signalling pathways, with increased expression of genes involved in glycolysis and oxidative phosphorylation (OXPHOS), increased mitochondrial function, increased rate of extracellular acidification (ECAR; measure of glycolysis) and increased rate of oxygen consumption (OCR; measure of OXPHOS). Small bowel macrophages were less metabolically active than their colonic counterparts, with macrophage metabolism in the small intestine being independent of the microbiota. Finally, we reveal tissue-resident Tim4+ CD4+ macrophages exhibit enhanced fatty acid uptake alongside reduced fatty acid synthesis compared to recruited macrophages. Thus, the microbiota shapes gut macrophage metabolism in a compartment-specific manner, with important implications for monocyte recruitment and macrophage differentiation.

Immunology published new progress about Acidification (extracellular). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Curd, Matthew E.; Morrison, Neil F.; Smith, Michael J. A.; Gajjar, Parmesh; Yousaf, Zeshan; Parnell, William J. published the artcile< Geometrical and mechanical characterization of hollow thermoplastic microspheres for syntactic foam applications>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hollow thermoplastic microsphere syntactic foam property.

Recently, hollow thermoplastic microspheres, have emerged as an innovative filler material for use in polymer-matrix composites. The resulting all-polymer syntactic foam takes on excellent damage tolerance properties, strong recoverability under large strains, and favorable energy dissipation characteristics. Aside from syntactic foams, thermoplastic microspheres are finding increasing usage in a variety of applications and industries. Despite this, there is an absence of statistical geometrical and mech. data for certain classes of thermoplastic microspheres. In this work we characterize two classes of thermoplastic microsphere using X-ray computed tomog., focused ion beam and electron microscopy. We observe the spatial distribution of these microspheres within a polyurethane-matrix syntactic foam and show that the volume-weighted polydisperse shell diameters follow a normal distribution. Interestingly, polydispersity of the shell wall thickness is not observed and furthermore the wall thickness is not correlated to the shell diameter We utilize the geometrical information obtained in anal. micromech. techniques in the small strain regime to determine, for the first time, estimates of the Young’s modulus and Poisson’s ratio of the microsphere shell material itself. Our results contribute to potential future improvements in the design and fabrication of materials that employ thermoplastic microspheres, including syntactic foams.

Composites, Part B: Engineering published new progress about Bulk modulus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Muraoka, Osamu; Toyooka, Naoki; Ohshima, Yumiko; Narita, Norihiko; Momose, Takefumi published the artcile< Synthesis of natural (S)-(-)-tulipalin B starting from L-malic acid as a chiral pool>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is tulipalin B total synthesis enantioselectivity; malic acid chiral synthon tulipalin B.

Naturally occurring tulipalin B (I) was prepared enantioselectively from chiral synthon L-malic acid (II) in 15% yield.

Heterocycles published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Muqun; Liang, Shaofeng; Gao, Wei; Qin, Yuxuan published the artcile< The effect of promoting hydrogen bond aggregation based on PEMTC on the mechanical properties and shape memory function of polyurethane elastomers>, COA of Formula: C19H34O2, the main research area is polyurethane elastomer carbamate hydrogen bond aggregation shape memory property; hydrogen bond elastomer; polyurethane; shape memory; toughness.

In this work, small mol. diols named PEMTC were synthesized from isophorone diisocyanate, N-(2-hydroxyethyl) acrylamide and trimethylolpropane by a semi-directional method. PEMTC (2-(prop-2-enamido)ethyl N-{3-[({[2-ethyl-3-hydroxy-2(hydroxymethyl)propoxy]carbonyl}amino)methyl]-3, 5,5-trimethylcyclohexyl}carbamate) contains hydrogen bond active site and light-initiated C=C. We introduced it as a branch chain block into poly(ε-caprolactone) (PCL). By feeding and monitoring the reaction process, we synthesized a large number of polyurethane elastomers, hydrogen bonds PCL-based elastomer (HPE), which contain a large number of dynamic hydrogen bonds. Under UV irradiation, PEMTC can make HPE mols. aggregate and crosslink, improve the degree of internal hydrogen bonding interaction of HPE materials and endow HPE materials with good elasticity, toughness, heat resistance and shape memory ability. After 270 nm UV irradiation, the elongation at break of HPE materials decreased from 607.14-1463.95% to 426.60-610.36%, but the strength at break of HPE materials increased from 3.36-13.52 to 10.28-41.52 MPa, and the toughness increased from 16.36-129.71 to 40.48-172.22 MJ m-3. In addition, the highest shape fixation rate of HPE after UV irradiation was 98.0%, and the recovery rate was 93.7%.

Royal Society Open Science published new progress about Breaking strength. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Jinmeng; Liu, Yuhang; Liu, Lei; He, Song; Du, Zhuzhu; Wang, Ke; Xie, Linghai; Du, Hongfang; Ai, Wei published the artcile< Expediting Sulfur Reduction/Evolution Reactions with Integrated Electrocatalytic Network: A Comprehensive Kinetic Map>, COA of Formula: C19H34O2, the main research area is lithium sulfur battery reduction evolution reaction electrocatalytic kinetics; Electrocatalytic network; Li−S batteries; kinetic evolution map; practical conditions; versatile catalytic capability.

Electrocatalysts are considered the most promising candidates in ameliorating the slow kinetics of Li-S batteries (LSBs), however, the issue of insufficient catalytic capability remains to be addressed. Herein, we report an integrated catalytic network comprising graphitic carbon-encapsulated/bridged ultrafine NiCoP embedded in N, P-codoped carbon (GC-uNiCoP@NPC) as a highly competent catalyst for sulfur-based species conversions. By profiling the evolution map of Li-S chem. via operando kinetic analyses, GC-uNiCoP@NPC is demonstrated to possess versatile yet efficient catalytic activity for sulfur reduction/evolution reactions, especially the rate-determining heterogeneous phase transitions. As a result, GC-uNiCoP@NPC enables high capacity and stable cycling of sulfur cathode under high areal loading and lean electrolyte. Moreover, pouch cells assembled under practical conditions present promising performance with a specific energy of 302 Wh kg-1. This work not only conceptually expands the catalyst design for LSBs but also provides a comprehensive insight into the catalyst performance for Li-S chem.

Nano Letters published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Yifan; Li, Chao; Zhang, Shu; Li, Qiaoling; Gholizadeh, Mortaza; Wang, Yi; Hu, Song; Xiang, Jun; Hu, Xun published the artcile< Pyrolysis of soybean residue: Understanding characteristics of the products>, Formula: C19H34O2, the main research area is soybean residue pyrolysis product.

Soybean residue (SR) is a main solid waste produced during the extraction of soybean oil with bulk volume In addition to the use as vegetable protein feed, SR could also be used as feedstock for producing biofuels and carbon materials via pyrolysis. In this study, the pyrolysis behaviors of SR at varied temperatures and heating rates were investigated. The results show that the pyrolysis of the organic components in SR could reach completion even at 500°C, due to the lower thermal stability of the organic component than that in the typical biomass. This also leads to the bio-oil with little heavy organics and also low carbon content of the resulting biochar, as the organic components decomposed to a significant extent while the charring reactions were insignificant. This leads to the biochar with low heating value and low energy yield when compared with that in the pyrolysis of typical biomass. In addition, the high content of proteins, amino acids and other nitrogen-containing nutrients make the SR derived bio-oil nitrogen-rich and a significant portion of nitrogen could also be retained in the biochar. These specialties have to be considered during their applications as either biofuels or functional carbon materials.

Renewable Energy published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russo, Vincenzo; Rossano, Carmelina; Salucci, Emiliano; Tesser, Riccardo; Salmi, Tapio; Di Serio, Martino published the artcile< Intraparticle diffusion model to determine the intrinsic kinetics of ethyl levulinate synthesis promoted by Amberlyst-15>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Levulinic acid esterification kinetics Amberlyst catalyst intraparticle diffusion model.

Levulinic acid and its esters are considered very versatile chem. compounds used for a wide range of derivatives Traditionally Et levulinate is synthesized in batch reactors, using homogeneous catalysts (H2SO4, H3PO4). Several investigations were reported on solid acid catalysts, as zeolites, sulfated oxides, sulfonic ion-exchange resins. Amberlyst-15 showed high potentials: to design a continuous reactor, it is necessary to investigate the stability of the catalyst and the kinetics of the reaction. In the present work, we demonstrated that the resin is stable for more than 5 days. Kinetic and mass transfer phenomena were studied, evaluating the partition and take-up of the used resin when put in contact with reactants and products. Two different samples of Amberlyst-15 were used, characterized by different size, demonstrating that bigger particles lead to higher intraparticle diffusion limitations.

Chemical Engineering Science published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Listowsky, Irving; Avigad, Gad; Englard, Sasha published the artcile< Conformational equilibria and stereochemical relations among carboxylic acids>, HPLC of Formula: 617-55-0, the main research area is acyclic acid conformation; conformation acyclic acid; circular dichroism acyclic acid.

The CO spectra of certain acyclic carboxylic acids were surveyed in an effort to study their conformation in solution In aqueous solution the spectra of many α-hydroxy acids were characterized by two overlapping ellipticity bands; a weak one in the 240-mμ spectral region and a more intense one of opposite sign near 210 mμ. At elevated temperatures or in solvents of low dielec. constant, the band of longer wavelength increased in intensity with an attendant decrease in the short-wavelength band. These properties are compatible with the presence of two structural species in equilibrium, and could be related to the contributions of specific rotational isomers of the acids. Conformations with the hydroxyl and carbonyl groups in an eclipsed alignment are designated as preferred. In contrast to the α-hydroxy acids, carboxylic acids with α-alkyl substituents generally showed only a single dichroic band centered near 210 mμ. In general, coplanarity of the carboxyl group and α-substituents was assumed, and interpretations in terms of the preferred orientation of substituents adjacent to the carboxyl group are suggested. The proposed population of rotational isomers was consistent with the observed effects of solvent polarity, temperature, polarity of substituents, and predicted steric interactions. An empirical rule relating the sign of ellipticity and the conformation of these classes of carboxylic acids was applied.

Journal of Organic Chemistry published new progress about Acids Role: PRP (Properties). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Rodrigues-Junior, Dorival Mendes; Liu, Sijia; Webb, Anna Taylor; Gomez-Puerto, Maria Catalina; ten Dijke, Peter; Heldin, Carl-Henrik; Moustakas, Aristidis published the artcile< The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma>, Application of C19H34O2, the main research area is protein kinase LKB1 self renewal invasiveness glioblastoma; LKB1; cancer stem cells; glioblastoma; invasion; metformin.

The role of liver kinase B1 (LKB1) in glioblastoma (GBM) development remains poorly understood. LKB1 may regulate GBM cell metabolism and has been suggested to promote glioma invasiveness. After analyzing LKB1 expression in GBM patient mRNA databases and in tumor tissue via multiparametric immunohistochem., we observed that LKB1 was localized and enriched in GBM tumor cells that co-expressed SOX2 and NESTIN stemness markers. Thus, LKB1-specific immunohistochem. can potentially reveal subpopulations of stem-like cells, advancing GBM patient mol. pathol. We further analyzed the functions of LKB1 in patient-derived GBM cultures under defined serum-free conditions. Silencing of endogenous LKB1 impaired 3D-gliomasphere frequency and promoted GBM cell invasion in vitro and in the zebrafish collagenous tail after extravasation of circulating GBM cells. Moreover, loss of LKB1 function revealed mitochondrial dysfunction resulting in decreased ATP levels. Treatment with the clin. used drug metformin impaired 3D-gliomasphere formation and enhanced cytotoxicity induced by temozolomide, the primary chemotherapeutic drug against GBM. The IC50 of temozolomide in the GBM cultures was significantly decreased in the presence of metformin. This combinatorial effect was further enhanced after LKB1 silencing, which at least partially, was due to increased apoptosis. The expression of genes involved in the maintenance of tumor stemness, such as growth factors and their receptors, including members of the platelet-derived growth factor (PDGF) family, was suppressed after LKB1 silencing. The defect in gliomasphere growth caused by LKB1 silencing was bypassed after supplementing the cells with exogenous PFDGF-BB. Our data support the parallel roles of LKB1 in maintaining mitochondrial homeostasis, 3D-gliomasphere survival, and hindering migration in GBM. Thus, the natural loss of, or pharmacol. interference with LKB1 function, may be associated with benefits in patient survival but could result in tumor spread.

Journal of Cellular Physiology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics