Month: October 2022

Chen, Guangming; Ren, Hongyu; Zhang, Nanjing; Lennox, William; Turpoff, Anthony; Paget, Steven; Li, Chunshi; Almstead, Neil; Njoroge, F. George; Gu, Zhengxian; Graci, Jason; Jung, Stephen P.; Colacino, Joseph; Lahser, Fred; Zhao, Xin; Weetall, Marla; Nomeir, Amin; Karp, Gary M. published the artcile< 6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B>, Application In Synthesis of 112-63-0, the main research area is azaindolylpyridinesulfonamide preparation antiviral hepatitis virus pharmacokinetics; 6-(Azaindol-2-yl)pyridine-3-sulfonamides; HCV inhibitors; NS4B; Replicon; Structure–activity relationship.

A structure-activity relationship investigation of various 6-(azaindol-2-yl)pyridine-3-sulfonamides using the HCV replicon cell culture assay led to the identification of a potent series of 7-azaindoles that target the hepatitis C virus NS4B. Compound I, identified via further optimization of the series, has excellent potency against the HCV 1b replicon with an EC50 of 2 nM and a selectivity index of >5000 with respect to cellular GAPDH RNA. Compound I also has excellent oral plasma exposure levels in rats, dogs and monkeys and has a favorable liver to plasma distribution profile in rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schroeder, Chad E.; Yao, Tuanli; Sotsky, Julie; Smith, Robert A.; Roy, Sudeshna; Chu, Yong-Kyu; Guo, Haixun; Tower, Nichole A.; Noah, James W.; McKellip, Sara; Sosa, Melinda; Rasmussen, Lynn; Smith, Layton H.; White, E. Lucile; Aube, Jeffrey; Jonsson, Colleen B.; Chung, Donghoon; Golden, Jennifer E. published the artcile< Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus>, Electric Literature of 112-63-0, the main research area is amidinophenylbenzamide preparation venezuelan equine encephalitis virus inhibitor antiviral.

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that can cause significant disease in humans. Given the absence of therapeutic options available and the significance of VEEV as a weaponized agent, an optimization effort was initiated around a quinazolinone screening hit with promising cellular antiviral activity (EC50 = 0.8 μM), limited cytotoxic liability (CC50 > 50 μM), and modest in vitro efficacy in reducing viral progeny (63-fold at 5 μM). Scaffold optimization revealed a novel rearrangement affording amidines, specifically compound I, which was found to potently inhibit several VEEV strains in the low nanomolar range without cytotoxicity (EC50 = 0.02-0.04 μM, CC50 > 50 μM) while limiting in vitro viral replication (EC90 = 0.17 μM). Brain exposure was observed in mice with I. Significant protection was observed in VEEV-infected mice at 5 mg kg-1 day-1 and viral replication appeared to be inhibited through interference of viral nonstructural proteins.

Journal of Medicinal Chemistry published new progress about Amidines Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peerzada, Zoya; Kanhed, Ashish M.; Desai, Krutika B. published the artcile< Effects of active compounds from Cassia fistula on quorum sensing mediated virulence and biofilm formation in Pseudomonas aeruginosa>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cassia fruit phytoconstituent quorum sensing biofilm formation antimicrobial Pseudomonas.

Pseudomonas aeruginosa infections are attributed to its ability to form biofilms and are difficult to eliminate with antibiotic treatment. Biofilm formation is regulated by quorum sensing (QS), an intracellular bacterial communication mechanism that allows the activation of numerous virulence factors and secondary metabolites. Targeting the QS pathway is a potential approach that prevents QS-controlled phenotypes and biofilm formation. For the first time, the current work has identified antiquorum sensing activity in the partially purified four fractions from the hot Et acetate extract of Cassia fistula fruit pods. Of the four fractions, only fraction-1 gave decreased AHL activity; the phytoconstituents in this fraction were identified as rhein, 3-aminodibenzofuran, 5-(hydroxymethyl)-2-(dimethoxymethyl)furan, and dihydrorhodamine. Fraction-1 (1 mg ml-1) and rhein (0.15 mg ml-1) showed 63% and 42.7% reduction in short-chain AHL production, resp., without hindering the bacterial growth. Fraction-1 inhibited QS-mediated extracellular virulence factors viz. protease, elastase, pyocyanin, and rhamnolipid (p < 0.05). Quant. anal. of biofilm formation showed 77% & 62.4% reduction by fraction-1 (1 mg ml-1) and rhein (0.15 mg ml-1) resp. Confocal laser microscopy (CLMS) & SEM (SEM) confirmed the reduction of biofilm formation in Pseudomonas aeruginosa upon treatment with fraction-1 and rhein. Moreover, the in vivo study displayed that fraction-1 and rhein (standard) significantly enhanced the survival of Caenorhabditis elegans by suppressing the potency of virulence factors of Pseudomonas aeruginosa. Quant. real-time polymerase chain reaction results demonstrated the down-regulation of QS-related genes, lasI, lasR, rhlI, and rhlR. In addition, in silico anal. divulged that a component identified by GC-MS displayed a strong affinity towards LasI and LasR. These findings suggest that potent phytochems. from fraction-1, including rhein, could serve as novel phytotherapeutics in controlling emerging infections of antibiotic-resistant bacterial pathogens like Pseudomonas aeruginosa. RSC Advances published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tsai, Cheng-Che; Chuang, Wei-Tsung; Tsai, Yow-Fu; Li, Jyun-Ting; Wu, Yu-Fa; Liao, Chun-Chen published the artcile< Intra- and intermolecular hydrogen bonds enhance the fluoride-responsiveness of functionalized glycolipid-based gelators>, Application In Synthesis of 617-55-0, the main research area is glycolipid preparation supramol gel assembly hydrogen bond fluoride.

The authors propose a facile approach toward enhancing the efficiency of fluoride-responsive gels through the positioning of functionalized receptor units, allowing tunable intra- and intermol. hydrogen bonding, in the gelator mols. The authors have prepared the new glycolipid-based gelator 2 and its hydroxy and methoxy derivatives 2a and 2b, resp., to study the effects of three types modes of supramol. assembly: solely intermol. hydrogen bonding in 2, solely intramol. hydrogen bonding in 2b, and both inter- and intramol. hydrogen bonding in 2a. 1H NMR spectra confirmed the self-assembly interactions of these glycolipid-based gelators. The authors measured the min. gel concentrations and sol-gel transitions and recorded x-ray diffraction patterns and electron micrographs to characterize the gelation behavior and structural organization of each of these supramol. gels. Among these three gelators, only 2 and 2a could form organogels in the test solvents, indicating that intermol. hydrogen bonding plays a determinant role in the supramol. assemblies leading to gelation. The self-assembly of 2 resulted in a bilayer-packed lamellar structure within ribbon-like fibers, whereas that of 2a resulted in hexagonally packed cylindrical micelles within tree-like fibers. A min. amount of 0.3 equiv of F- was required for complete disruption of the gel formed from 2a, which was approx. four times lower than that required for the gel formed from 2. Thus, the incorporation of a β-hydroxy motif-the only difference in the chem. structures of 2 and 2a-led to interesting variations in the resulting gel morphologies and enhanced the gel’s fluoride-responsiveness.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Gelation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Claveau, Romain; Twamley, Brendan; Connon, Stephen J. published the artcile< Dynamic kinetic resolution of bis-aryl succinic anhydrides: enantioselective synthesis of densely functionalised γ-butyrolactones>, Product Details of C19H34O2, the main research area is butyrolactone enantioselective preparation; bisarylsuccinic anhydride preparation arylaldehyde dynamic kinetic resolution organocatalyst.

The efficient Dynamic Kinetic Resolution (DKR) of disubstituted anhydrides has been shown to be possible for the first time. Using an ad hoc designed organocatalyst and an enantio- and diastereoselective cycloaddition process with aldehydes, stereochem. complex γ-butyrolactone derivatives can be obtained – with control over three contiguous stereocentres, one of which is all carbon quaternary.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garcia, Edzna S.; Xiong, Thao M.; Lifschitz, Abygail; Zimmerman, Steven C. published the artcile< Tandem catalysis using an enzyme and a polymeric ruthenium-based artificial metalloenzyme>, Application In Synthesis of 71195-85-2, the main research area is tandem catalysis polymeric ruthenium catalyst.

A Ru-containing single chain nanoparticle (SCNP) was prepared in three steps using radical polymerization of pentafluorophenylacrylate, post-polymerization functionalization with three different alkylamines, and coordination of Ru. The polymer was characterized by 1H NMR, 19F NMR, UV-vis, and DLS. The catalytic activity of the Ru-SCNP for Ru-catalyzed cleavage of allylcarbamates was evaluated by fluorescence spectroscopy and a higher percent conversion and initial rate of reaction was observed when compared to that of the free catalyst in buffer and cell media. The catalytic SCNP was also shown to perform tandem catalysis with β-galactosidase.

Polymer Chemistry published new progress about Acrylic polymers, fluorine-containing Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application In Synthesis of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Patane, Emanuele; Pittala, Valeria; Guerrera, Francesco; Salerno, Loredana; Romeo, Giuseppe; Siracusa, Maria Angela; Russo, Filippo; Manetti, Fabrizio; Botta, Maurizio; Mereghetti, Ilario; Cagnotto, Alfredo; Mennini, Tiziana published the artcile< Synthesis of 3-Arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione Derivatives as Novel, Potent, and Selective α1-Adrenoceptor Ligands>, COA of Formula: C7H10N2O2, the main research area is pyrrolopyrimidine dione piperazinylalkyl preparation selective adrenoceptor ligand QSAR.

Novel compounds I [X = (CH2)2, (CH2)3; R1 = H, Ph, 2-ClC6H4, 4-MeC6H4, etc.; R2 = 2-MeOC6H4, 4-MeOC6H4, 2-ClC6H4], characterized by a pyrrolo[3,2-d]pyrimidine-2,4-dione (PPm) system connected through an alkyl chain to a phenylpiperazine (PPz) residue, were designed as structural analogs of the α1-adrenoceptor (α1-AR) ligand RN5. In this new series of derivatives, the indole nucleus of RN5 was replaced by an arylpyrrolo moiety. Several structural modifications were performed on the PPm and PPz moieties and the connecting alkyl chain. These compounds were synthesized and tested in radioligand binding experiments where many of them showed interesting binding profiles. Some compounds, including I [X = (CH2)2; R1 = 2-ClC6H4, 4-ClC6H4, 4-MeC6H4; R2 = 2-ClC6H4], displayed substantial α1-AR selectivity with respect to serotoninergic 5-HT1A and dopaminergic D1 and D2 receptors. Two different mol. modeling approaches (pharmacophoric mapping and quant. structure-affinity relationship anal.) have been applied to rationalize, at a quant. level, the relationships between affinity toward α1-ARs and the structure of the studied compounds Several QSAR models have been reported and described, accounting for the influence of various mol. portions on such affinity data.

Journal of Medicinal Chemistry published new progress about Pharmacophores. 252932-48-2 belongs to class esters-buliding-blocks, and the molecular formula is C7H10N2O2, COA of Formula: C7H10N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ying; Belt, Katharina; Alqahtani, Saad F.; Saha, Saurabh; Fenske, Ricarda; Van Aken, Olivier; Whelan, James; Millar, A. Harvey; Murcha, Monika W.; Huang, Shaobai published the artcile< The mitochondrial LYR protein SDHAF1 is required for succinate dehydrogenase activity in Arabidopsis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Arabidopsis mitochondrial LYR protein succinate dehydrogenase activity; assembly factors; complex II; iron-sulfur cluster insertion; mitochondrial metabolism; succinate dehydrogenase.

Succinate dehydrogenase (SDH, complex II), which plays an essential role in mitochondrial respiration and tricarboxylic acid metabolism, requires the assembly of eight nuclear-encoded subunits and the insertion of various cofactors. Here, we report on the characterization of an Arabidopsis thaliana leucine-tyrosine-arginine (LYR) protein family member SDHAF1, (At2g39725) is a factor required for SDH activity. SDHAF1 is located in mitochondria and can fully complement the yeast SDHAF1 deletion strain. Knockdown of SDHAF1 using RNA interference resulted in a decrease in seedling hypocotyl elongation and reduced SDH activity. Proteomic analyses revealed a decreased abundance of various SDH subunits and assembly factors. Protein interaction assays revealed that SDHAF1 can interact exclusively with the Fe-S cluster-containing subunit SDH2 and HSCB, a cochaperone involved in Fe-S cluster complex recruitment. Therefore, we propose that in Arabidopsis, SDHAF1 plays a role in the biogenesis of SDH2 to form the functional complex II, which is essential for mitochondrial respiration and metabolism

Plant Journal published new progress about Arabidopsis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Bin; Ma, Jiawei; Ren, Hongyuan; Lu, Shuo; Xu, Jingkai; Liang, Yong; Lu, Changsheng; Yan, Hong published the artcile< Chemo-, site-selective reduction of nitroarenes under blue-light, catalyst-free conditions>, HPLC of Formula: 112-63-0, the main research area is aryl amine preparation chemoselective green chem; nitroarene photoinduced double hydrogen atom transfer deoxygenative transborylation reduction.

The tandem reaction of photoinduced double hydrogen-atom transfer and deoxygenative transborylation for chemo- and site-selective reduction of nitroarenes into aryl amines under catalyst-free, room temperature conditions was disclosed in excellent yields. In this reaction, isopropanol (iPrOH) was used as hydrogen donor and tetrahydroxydiboron [B2(OH)4] as deoxygenative reagent with green, cheap, and com. available credentials. In particular, a wide range of reducible functional groups such as halogen (-Cl, -Br and even -I), alkenyl, alkynyl, aldehyde, ketone, carboxyl, and cyano are all tolerated. Moreover, the reaction preferentially reduces the nitro group at the electron-deficient site over another nitro group in the same mol. A detailed mechanistic investigation in combination of experiments and theor. calculations gave a reasonable explanation for the reaction pathway.

Chinese Chemical Letters published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gilmour, Sandra; Marder, Seth R.; Tiemann, Bruce G.; Cheng, Lap Tak published the artcile< Synthesis and second-order nonlinear optical properties of various acceptor-substituted biologically derived chromophores>, HPLC of Formula: 112-63-0, the main research area is nonlinear optical property apocarotenal.

The title study of β-apo-8′-carotenal compounds is reported. Elec.-field-induced second harmonic generation measurements give values of β(0) 2-6 times greater than for 4-(dimethylamino)-4′-nitrostilbene.

Proceedings of SPIE-The International Society for Optical Engineering published new progress about Dipole moment. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics