Month: October 2022

Hass, Daniel T.; Bisbach, Celia M.; Robbings, Brian M.; Sadilek, Martin; Sweet, Ian R.; Hurley, James B. published the artcile< Succinate metabolism in the retinal pigment epithelium uncouples respiration from ATP synthesis>, Electric Literature of 112-63-0, the main research area is retinal pigment epithelium respiration ATP synthesis succinate metabolism; CP: metabolism; anion transport; cell metabolism; energy metabolism; mitochondrial respiratory chain; retinal metabolism; retinal pigment epithelium; succinate; uncoupling.

Fumarate can be a surrogate for O2 as a terminal electron acceptor in the electron transport chain. Reduction of fumarate produces succinate, which can be exported. It is debated whether intact tissues can import and oxidize succinate produced by other tissues. In a previous report, we showed that mitochondria in retinal pigment epithelium (RPE)-choroid preparations can use succinate to reduce O2 to H2O. However, cells in that preparation could have been disrupted during tissue isolation. We now use multiple strategies to quantify intactness of the isolated RPE-choroid tissue. We find that exogenous 13C4-succinate is oxidized by intact cells then exported as fumarate or malate. Unexpectedly, we also find that oxidation of succinate is different from oxidation of other substrates because it uncouples electron transport from ATP synthesis. Retinas produce and export succinate. Our findings imply that retina succinate may substantially increase O2 consumption by uncoupling adjacent RPE mitochondria.

Cell Reports published new progress about Choroid. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lei, Beilei; Li, Jiazhong; Liu, Huanxiang; Yao, Xiaojun published the artcile< Accurate prediction of aquatic toxicity of aromatic compounds based on genetic algorithm and least squares support vector machines>, Product Details of C19H34O2, the main research area is aquatic toxicity aromatic compound genetic algorithm statistics.

Quant. Structure – Toxicity Relationship (QSTR) plays an important role in ecotoxicol. for its fast and practical ability to assess the potential neg. effects of chems. The aim of this investigation was to develop accurate QSTR models for the aquatic toxicity of a large set of aromatic compounds through the combination of Least Squares Support Vector Machines (LS-SVMs) and a Genetic Algorithm (GA). Mol. descriptors calculated by DRAGON package and log P were used to describe the mol. structures. The most relevant descriptors used to build QSTR models were selected by a GA-Variable Subset Selection procedure. Multiple Linear Regression (MLR) and nonlinear LS-SVMs methods were employed to build QSTR models. The predictive ability of the derived models was validated using both the test set, selected from the whole data set by the Kennard – Stone Algorithm, and an external prediction set. The model applicability domain was checked by the leverage approach and the external prediction set was used to verify the predictive reliability of the models. The results indicated that the proposed QSTR models are robust and satisfactory, and can provide a feasible and promising tool for the rapid assessment of the toxicity of chems.

QSAR & Combinatorial Science published new progress about Aquatic toxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shahedi, Mansour; Habibi, Zohreh; Yousefi, Maryam; Brask, Jesper; Mohammadi, Mehdi published the artcile< Improvement of biodiesel production from palm oil by co-immobilization of Thermomyces lanuginosa lipase and Candida antarctica lipase B: Optimization using response surface methodology>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Thermomyces lanuginose Candida antarctica lipase biodiesel response surface methodol; Biodiesel; Co-immobilization; Enzyme; Lipase; Multicomponent reactions.

Candida antarctica lipase B (CALB) and Thermomyces lanuginose lipase (TLL) were co-immobilized on epoxy functionalized silica gel via an isocyanide-based multicomponent reaction. The immobilization process was carried out in water (pH 7) at 25°, rapidly (3 h) resulting in high immobilization yields (100%) with a loading of 10 mg enzyme/g support. The immobilized preparations were used to produce biodiesel by transesterification of palm oil. In an optimization study, response surface methodol. (RSM) and central composite rotatable design (CCRD) methods were used to study the effect of five independent factors including temperature, methanol to oil ratio, t-butanol concentration and CALB:TLL ratio on the yield of biodiesel production The optimum combinations for the reaction were CALB:TLL ratio (2.1:1), t-butanol (45 wt%), temperature (47°), methanol:oil ratio (2.3). This resulted in a FAME yield of 94%, very close to the predicted value of 98%.

International Journal of Biological Macromolecules published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Suntae; Jeon, Jang Su; Choi, Yong June; Baek, Ga Hee; Kim, Sang Kyum; Kang, Keon Wook published the artcile< Heterogeneity of glutamine metabolism in acquired-EGFR-TKI-resistant lung cancer>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lung cancer glutamine metabolism heterogeneity; Acquired EGFR-TKI-resistant lung cancer; CB-839; CB-839 (Telaglenastat; Glutamine metabolism; PubChem CID: 71577426).

The purpose of this study was to evaluate the heterogeneities of glutamine metabolism in EGFR-TKI-resistant lung cancer cells and its potential as a therapeutic target. Cell proliferation and cell cycle assays was performed by IncuCyte real-time anal. and flow cytometry, resp. Tumor growth was assessed in xenografts implanted with HCC827 GR. An isotopologue anal. was conducted by LC-MS/MS using 13C-(U)-glutamine labeling to determine the amounts of metabolites. Cellular ATP and mitochondrial oxidative phosphorylation were determined by XFp anal. We found that the cell growth of the two acquired EGFR-TKI-resistant lung cancer cells lines (HCC827 GR and H292 ER) depends on glutamine. In HCC827 GR, glutamine deficiency caused reduced GSH synthesis and, subsequently, enhanced ROS generation relative to their parental cells, HCC827. On the other hand, in H292 ER, glutamine mainly acted as a carbon source for TCA-cycle intermediates, and its depletion led to reduced mitochondrial ATP production CB-839, a specific GLS inhibitor, inhibited the latters conversion of glutamine to glutamate and exerted enhanced anti-proliferating effects on the two acquired EGFR-TKI-resistant lung cancer cell lines vs. their parental cell lines. Moreover, oral administration of CB-839 significantly suppressed HCC827 GR tumor growth in the xenograft model. These findings suggest that glutamine dependency in acquired EGFR-TKI-resistant lung cancer is heterogeneous and that inhibition of glutamine metabolism by CB-839 may serve as a therapeutic tool for acquired EGFR-TKI-resistant lung cancer.

Life Sciences published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Haiwei; Yan, Rongwei; Cai, Chang; Chen, Xingfan; Zhao, Fenghua; Fan, Liangliang; Xu, Chunbao Charles; Yang, Weiran published the artcile< Hydrothermal liquefaction of Cd-enriched Amaranthus hypochondriacus L. in ethanol-water co-solvent: Focus on low-N bio-oil and heavy metal/metal-like distribution>, Computed Properties of 623-50-7 , the main research area is hydrothermal liquefaction cadmium amaranthus hypochondriacus; ethanol water nitrogen bio oil heavy metal.

The high nitrogen content in bio-oil from protein-rich biomass will cause the possible pollution problems by NOX emissions during combustion. In this study, Cd-enriched Amaranthus hypochondriacus L. (AHL) was treated by hydrothermal liquefaction (HTL) in ethanol-water co-solvent aiming to reduce the nitrogen content of the bio-oil. Besides, aqueous phase recycling (APR) was applied to achieve a higher bio-oil yield. HTL in ethanol-water co-solvent with APR three times resulted in the maximum bio-oil yield (47.26%) and greatly reduced the nitrogenous compounds content of bio-oil. During the APR process, the increase of total nitrogen (TN) content in the aqueous phase indicated that organic-N in the organic phase transformed into NH+4 to the aqueous phase. Acetic acid (13.87-22.37 mg/mL) was dominated in the aqueous phase, leading to a low pH value (6.27-5.29), which could serve as the possible catalyst for the HTL process during APR that can be the reason for the higher bio-oil yield. After the HTL process, Cr, Cu, Cd and Pb remained mostly in bio-char while As was present largely in the aqueous phase. Thus, this study demonstrated that the APR for HTL process in ethanol-water co-solvent can be a hopeful method to dispose the high-protein biomass for improved bio-oil yield and quality.

Fuel published new progress about Alcohols Role: TEM (Technical or Engineered Material Use), USES (Uses). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Computed Properties of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kammarabutr, Jirayu; Mahalapbutr, Panupong; Okumura, Hisashi; Wolschann, Peter; Rungrotmongkol, Thanyada published the artcile< Structural dynamics and susceptibility of anti-HIV drugs against HBV reverse transcriptase>, Formula: C19H34O2, the main research area is stavudine didanosine HBV reverse transcriptase structural dynamics; Antiviral drug discovery; hepatitis B virus; nucleoside analogue inhibitors; reverse transcriptase.

Hepatitis B virus (HBV), a small enveloped DNA virus, attacks the human liver causing both acute and chronic diseases. Current therapeutic drugs use the nucleos(t)ide analogs (NAs) as a competitive inhibitor against HBV reverse transcriptase (HBV-RT), an essential enzyme pivotally involved in viral replication. Unfortunately, this treatment still causes the development of resistant variants of HBV against NAs. As HBV-RT is homologous to the human immunodeficiency virus reverse transcriptase (HIV-RT), it is reasonable to treat HBV-RT with anti-HIV drugs. In the present study, we aimed to investigate the structural dynamics and susceptibility of the known anti-HIV drugs (stavudine [d4T], didanosine [DDI], and zidovudine [ZDV]) against HBV-RT enzyme in comparison to the anti-HBV drug lamivudine (3TC) and deoxythymidine triphosphate (dTTP) substrate using several computational approaches. The calculations revealed that seven polar residues (K32, R41, D83, S85, D205, N236, and K239) and three hydrophobic residues (A86, A87, and F88) of HBV-RT as well as the adjacent DNA strands play an important role in the ligand binding. In addition, the H-bond pattern of d4T is similar to that of 3TC, especially at the residues A86 and A87. Such interactions promote the favorable conformation of ligand in the HBV-RT binding pocket, while the several different conformations of ligand are found in the unbound state. The predicted binding free energy results based on QM/MM-GBSA and MM/GB(PB)SA methods suggested that the susceptibility towards HBV-RT of d4T and ZDV is higher than that of 3TC and dTTP. Altogether, this work sheds light on the potentiality of d4T and ZDV as a promising drug for HBV-infected patients harboring 3TC resistance.

Journal of Biomolecular Structure and Dynamics published new progress about Anti-hepatitis B virus agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Melo, M. J.; Pina, Fernando; Macanita, Antonio L.; Melo, Eurico C.; Herrmann, Christiane; Foerster, Rolf; Koch, Helmut; Wamhoff, Heinrich published the artcile< Photochemistry of 2-(2-furyl)benzimidazole (Fuberidazole)>, COA of Formula: C19H34O2, the main research area is photolysis furylbenzimidazole; benzimidazole furyl photolysis; Fuberidazole photolysis.

The photodegradation of 2-(2-furyl)benzimidazole (Fuberidazole) has been reinvestigated employing advanced HPLC-UV/VIS technique and fluorescence emission and excitation spectroscopy in methanol at natural pH, in acidic medium and in aqueous solutions at pH 7 and 3; four main products, benzimidazole-2-carboxylic acid, its Me ester, 1-methoxybenzimidazole, and Me 4-oxo-2-benzimidazolecrotonate (cis and trans isomers), besides benzimidazole and 2,2′-bibenzimidazole and other side products, have been isolated and characterized. The kinetics of the photodegradation process were followed independently by HPLC-UV and fluorescence emission and showed significant similarity; this allowed monitoring of a photodegradation at very low concentrations (5 × 10-5-5 × 10-6 M). The quantum yield of disappearance of Fuberidazole has been determined

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about Photolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beichel, Witali; Skrotzki, Julian; Klose, Petra; Njel, Christian; Butschke, Burkhard; Burger, Stephan; Liu, Lili; Thomann, Ralf; Thomann, Yi; Biro, Daniel; Thiele, Simon; Krossing, Ingo published the artcile< An Artificial SEI Layer Based on an Inorganic Coordination Polymer with Self-Healing Ability for Long-Lived Rechargeable Lithium-Metal Batteries>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is rechargeable lithium metal battery SEI layer coordination polymer.

Upon immersion of a lithium (Li) anode into a diluted 0.05 to 0.20 M dimethoxyethane solution of the phosphoric-acid derivative (CF3CH2O)2P(O)OH (HBFEP), an artificial solid-electrolyte interphase (SEI) is generated on the Li-metal surface. Hence, HBFEP reacts on the surface to the corresponding Li salt (LiBFEP), which is a Li-ion conducting inorganic coordination polymer. This film exhibits – due to the reversibly breaking ionic bonds – self-healing ability upon cycling-induced volume expansion of Li. The presence of LiBFEP as the major component in the artificial SEI is proven by ATR-IR and XPS measurements. SEM characterization of HBFEP-treated Li samples reveals porous layers on top of the Li surface with at least 3μm thickness. Li-Li sym. cells with HBFEP-modified Li electrodes show a three- to almost fourfold cycle-lifetime increase at 0.1 mA cm-2 in a demanding model electrolyte that facilitates fast battery failure (1 M LiOTf in TEGDME). Hence, the LiBFEP-enriched layer apparently acts as a Li-ion conducting protection barrier between Li and the electrolyte, enhancing the rechargeability of Li electrodes.

Batteries & Supercaps published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Junheng; Xu, Guangyang; Tang, Shengbiao; Chen, Qun; Sun, Jiangtao published the artcile< Site-Selective Functionalization of 7-Azaindoles via Carbene Transfer and Isolation of N-Aromatic Zwitterions>, Category: esters-buliding-blocks, the main research area is regioselective functionalization azaindole carbene transfer isolation zwitterion; azaindole diazoester alkylation ruthenium catalysis dearomatization aromatization.

The first systematic study on metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization-aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters.

Organic Letters published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Graham, Samuel L.; Scholz, Thomas H. published the artcile< A new mode of reactivity of N-methoxy-N-methylamides with strongly basic reagents>, HPLC of Formula: 112-63-0, the main research area is methoxymethylamide decomposition formaldehyde; Weinreb ketone synthesis byproduct; thiophenesulfonamide ketone synthesis byproduct; lithium diisopropylamide decomposition methoxymethylamide.

Weinreb ketone synthesis using a thiophenesulfonamide (I, R = R1 = H) and (Me2CH)2NLi followed by MeOCH2CONMeOMe (II) gave, in addition to 49% the expected ketone (I, R = H, R1 = COCH2OMe), 15% an alc. (I, R = H, R1 = CH2OH). A mechanism involving a base catalyzed E2 elimination of CH2O from II followed by reaction with lithiated I (R = R1 = Li) is proposed for the byproduct.

Tetrahedron Letters published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics