Month: October 2022

Widmer, Ulrich published the artcile< A convenient benzylation procedure for β-hydroxy esters>, Formula: C6H10O5, the main research area is benzylation hydroxy ester; ether benzyl.

Benzylation of β-hydroxy esters, containing primary and secondary alc. functions, with benzyl 2,2,2-trichloroacetamidate (I) gives the corresponding benzyl ethers in good yield. In the case of chiral substrates non racemization is observed Treatment of Me(CH2)10CH(OH)CH2CO2Me with I in the presence of a catalytic amount of F3CSO3H gave 79% Me(CH2)10CH(OCH2Ph)CH2CO2Me. Among the 5 other compounds similarly prepared were MeO2CCH2CH(OCH2Ph)CO2Me and PhCH2OCH2CH(Me)CO2Me.

Synthesis published new progress about Benzylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Xiyue; Xu, Hui; Li, Fosheng; Zou, Yijun; Ran, Yulu; Ma, Xiaorui; Cao, Yu; Xu, Qingrui; Qiao, Dairong; Cao, Yi published the artcile< One-step direct transesterification of wet yeast for biodiesel production catalyzed by magnetic nanoparticle-immobilized lipase>, Related Products of 112-63-0, the main research area is lipase wet yeast biodiesel magnetic nanoparticle transesterification.

To develop a method for direct transesterification of wet yeast using immobilized lipase, the oleaginous yeast Saitozyma podzolica Zwy-2-3 and the lipase producing Burkholderia pyrrolica WZ10-3 were used as materials for production of biodiesel. Fe3O4@SiO2-CHO prepared by modifying Fe3O4 with TEOS, APTES and glutaraldehyde. The biocatalysts covalently cross-linked with WZ10-3 lipase by Fe3O4@SiO2-CHO were characterized by FTIR, XRD and TEM. When the enzyme dosage, glutaraldehyde concentration, temperature and time were 30.22 mL, 2.0%, 40°C and 4 h, the immobilized lipase activity and immobilization rate reached 10038.0 U/g and 96.9%, resp. The optimum temperatures for immobilized and free lipase were 60 degrees and 40 degrees. The immobilized enzyme still had 80% enzymic activity after 48 d storage at 4°C. The optimized conditions for the direct conversion of immobilized lipase to esterified wet yeast (one-step) were: enzyme dosage 2.5 g, reaction temperature 35°C; water content 15%; and molar ratio of n-hexane to methanol 3: 1. The transesterification rates of one-step method for oil and biomass were 98.12% and 56.11%, resp. In contrast, the two-step method was only 88.75% and 51.21%. The immobilized enzyme had 90% enzyme activity after 10 times of reuse.

Renewable Energy published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Feng; Wang, Tengfei; Gao, Meixiang; Zhang, Xia; Liu, Zhuqing; Zhao, Shi Jia; Lv, Zao Sheng; Xiao, Jiaqi published the artcile< Benzofuran-isatin-imine hybrids tethered via different length alkyl linkers: Design, synthesis and in vitro evaluation of anti-tubercular and anti-bacterial activities as well as cytotoxicity>, Product Details of C11H12O3, the main research area is benzofuran isatin imine preparation antitubercular antibacterial cytotoxicity; Anti-bacterial; Anti-tubercular; Benzofuran; Hybrid compounds; Imine; Isatin; Multi-drug resistant; Structure-activity relationship.

The design and synthesis of twenty-two novel benzofuran-isatin-imine hybrids I [R1 = H, F, OCH3; X = (CH2)n; Y = NOCH3, NOC2H5, NNHC(S)NH2, NOH; R3 = H, OCH3, F; n = 1, 2, 3, 4] tethered through propylene, butylene, pentylene and hexylene, and for the evaluation of their in vitro anti-tubercular and anti-bacterial activities as well as cytotoxicity were reported. All benzofuran-isatin-imine hybrids exhibited considerable in vitro anti-TB (MIC: <0.016-0.218 μg/mL and 0.062-14.15 μg/mL against drug-sensitive and MDR MTB, resp.) and anti-bacterial (MIC: 0.25-64 μg/mL and 0.06-16 μg/mL against Gram-pos. and Gram-neg. strains, resp.) activities. All of them also showed acceptable cytotoxicity towards VERO (CC50: 8-128 μg/mL). The most active hybrid I (R1 = H; X = CH2CH2; Y = NOCH3; R3 = OCH3) (MIC: <0.016, 0.062 and 0.16 μg/mL, resp.) was >4.8 and >48 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H37Rv and MDR-TB isolates, resp. Moreover, hybrid I (R1 = H; X = CH2CH2; Y = NOCH3; R3 = OCH3) also demonstrated promising anti-bacterial activities with MIC values of ≤1 μg/mL against the majority of the tested Gram-neg. and Gram-pos. pathogens, which was comparable to vancomycin (MIC: 0.5-4 μg/mL) and CPFX (MIC: 0.125-8 μg/mL) against Gram-pos. bacteria, but slightly less potent than CPFX (MIC: ≤0.03-0.5 μg/mL) against Gram-neg. bacteria. The results indicated that benzofuran-isatin-imine hybrids could act as candidates for the development of anti-TB and anti-bacterial agents.

European Journal of Medicinal Chemistry published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Kedong; Zhang, Yingbo; Li, Libo; Zhang, Jingyan; Rong, Hua; Liu, Deshui; Wang, Junping; Jin, Ming; Luo, Nan; Zhang, Xiaojie published the artcile< Neuroprotective effect of paeoniflorin in the mouse model of Parkinson′s disease through α-synuclein/protein kinase C δ subtype signaling pathway>, Category: esters-buliding-blocks, the main research area is Parkinsons disease alpha synuclein protein kinase C paeoniflorin neuroprotective.

Paeoniflorin, an active component of Radix Paeoniae Alba, has a neuroprotective effect in Parkinson′s animal models. However, its mechanism of action remains to be determined In this study, we hypothesized that the neuroprotective effect of paeoniflorin occurs through the α-synuclein/protein kinase C δ subtype (PKC-δ) signaling pathway. We tested our hypothesis in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson′s disease. We evaluated the effects of paeoniflorin on the expression levels of signal components of the α-synuclein/PKC-δ pathway, cellular apoptosis and motor performance. Our results demonstrated that paeoniflorin restored the motor performance impairment caused by MPTP, inhibited apoptosis, and protected the ultrastructure of neurons. Paeoniflorin treatment also resulted in the dose-dependent upregulation of an antiapoptotic protein, B-cell lymphoma-2, at the mRNA and protein levels, similar to the effects of the pos. control, selegiline. In contrast, paeoniflorin treatment downregulated the expression of pro-apoptotic proteins BCL2-Associated X2, α-synuclein, and PKC-δ at the mRNA and protein levels, as well as the level of the activated form of nuclear factor kappa B (p-NF-κB p65). Thus, our results showed that paeoniflorin exerts its neuroprotective effect by regulating the α-synuclein/PKC-δ signaling pathway to reduce neuronal apoptosis.

NeuroReport published new progress about Antiapoptotic proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Jia-Shu; Clarke, Ross; Haddad, Alexander F.; Wang, Elaina J.; Lacroix, Michel; Sarkar, Indra Neil; Zand, Ramin; Chen, Elizabeth S.; Toms, Steven A. published the artcile< The effect of levetiracetam treatment on survival in patients with glioblastoma: a systematic review and meta-analysis>, HPLC of Formula: 112-63-0, the main research area is human glioblastoma levetiracetam treatment meta analysis; Anti-epileptic; Glioblastoma; Levetiracetam; Survival; Temozolomide.

Levetiracetam (LEV) is an anti-epileptic drug (AED) that sensitizes glioblastoma (GBM) to temozolomide (TMZ) chemotherapy by inhibiting O6-methylguanine-DNA methyltransferase (MGMT) expression. Adding LEV to the standard of care (SOC) for GBM may improve TMZ efficacy. This study aimed to pool the existing evidence in the literature to quantify LEV’s effect on GBM survival and characterize its safety profile to determine whether incorporating LEV into the SOC is warranted. A search of CINAHL, Embase, PubMed, and Web of Science from inception to May 2021 was performed to identify relevant articles. Hazard ratios (HR), median overall survival, and adverse events were pooled using random-effect models. Meta-regression, funnel plots, and the Newcastle-Ottawa Scale were utilized to identify sources of heterogeneity, bias, and statistical influence. From 20 included studies, 5804 GBM patients underwent meta-anal., of which 1923 (33%) were treated with LEV. Administration of LEV did not significantly improve survival in the entire patient population (HR 0.89, p = 0.094). Significant heterogeneity was observed during pooling of HRs (I2 = 75%, p < 0.01). Meta-regression determined that LEV treatment effect decreased with greater rates of MGMT methylation (RC = 0.03, p = 0.02) and increased with greater proportions of female patients (RC = - 0.05, p = 0.002). Concurrent LEV with the SOC for GBM did not increase odds of adverse events relative to other AEDs. Levetiracetam treatment may not be effective for all GBM patients. Instead, LEV may be better suited for treating specific mol. profiles of GBM. Further studies are necessary to identify optimal GBM candidates for LEV. Journal of Neuro-Oncology published new progress about Anticonvulsants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mecwan, Marvin M.; Dong, Xia; Shi, Galen H.; Ratner, Buddy D. published the artcile< Plasma Polymerized HMDSO Coatings For Syringes To Minimize Protein Adsorption>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is coating hexamethyldisiloxane plasma polymerization syringe protein adsorption IgG; Glass vials; HMDSO; Hypodermic syringes; IgG; Protein adsorption; Protein retention; RFGD plasma polymerization; Silicone oil.

Current parenteral containers used for the storage and delivery of protein-based drugs, contain silicone oil which may seep into the protein solution and can result in adsorption, aggregation and denaturation of the protein. Tightly adherent surface coatings prepared by radio frequency glow-discharge (RFGD) plasma polymerization are described in this paper. Using this robust technique, methacrylic acid (MA) (hydrophilic), hexamethyldisiloxane (HMDSO) (hydrophobic), tetraglyme (TG) (hydrophilic) were plasma polymerized onto glass. In addition, HMDSO and MA were copolymerized to create a plasma polymerized HMDSO-MA (hydrophobic) surface. Untreated glass and glass dip-coated in PDMS were used as controls. TG and MA plasma coatings adsorbed the least amount of protein in all pH conditions. Interestingly HMDSO-MA retained significantly lesser protein compared to HMDSO and dip-coated PDMS samples. In the presence of Polysorbate 80 (PS80) all plasma polymerized coatings adsorbed and retained negligible amounts of protein, compared to controls. Furthermore, the peak glide force of plasma coated syringes did not significantly increase compared to syringes without plasma coating. Due to the versatility of RFGD plasma, this process is scalable and could potentially be used for the treatment of hypodermic syringes used for the storage and delivery of protein-based therapeutics.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Adsorption (of proteins). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Franchino, Allegra; Marti, Alex; Nejrotti, Stefano; Echavarren, Antonio M. published the artcile< Silver-Free Au(I) Catalysis Enabled by Bifunctional Urea- and Squaramide-Phosphine Ligands via H-Bonding>, SDS of cas: 112-63-0, the main research area is gold phosphine thiourea urea squaramide substituted complex preparation; crystal mol structure gold phosphine thiourea urea squaramide complex; cyclization cycloisomerization catalyst gold phosphine thiourea urea squaramide complex; kinetics cyclization cycloisomerization gold phosphine thiourea urea squaramide catalyst; chloride abstraction; gold; hydrogen bond; kinetics; phosphine ligands.

A library of gold(I) chloride complexes I and II [R = H, CF3; Ar = Ph, 3,5-(CF3)2C6H3; X = CH2, (CH2)2, (CH2)3; Y = O, S] with phosphine ligands incorporating pendant (thio)urea and squaramide H-bond donors was prepared with the aim of promoting chloride abstraction from Au(I) via H-bonding. In the absence of silver additives, complexes bearing squaramides and trifluoromethylated aromatic ureas displayed good catalytic activity in the cyclization of N-propargyl benzamides, as well as in a 1,6-enyne cycloisomerization, a tandem cyclization-indole addition reaction and the hydrohydrazination of phenylacetylene. Kinetic studies and DFT calculations indicate that the energetic span of the reaction is accounted by both the chloride abstraction step, facilitated by the bidentate H-bond donor via an associative mechanism, and the subsequent cyclization step.

Chemistry – A European Journal published new progress about Abstraction reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seebach, Dieter; Aebi, Johannes; Wasmuth, Daniel published the artcile< Diastereoselective α-alkylation of β-hydroxycarboxylic esters through alkoxide enolates: (+)-diethyl (2S,3R)-3-allyl-2-hydroxysuccinate from (-)-diethyl S-malate (butanedioic acid, 2-hydroxy-3-(2-propenyl)-, diethyl ester, [S-(R,S)])>, Application In Synthesis of 617-55-0, the main research area is diastereoselective alkylation hydroxycarboxylate; alkylation diastereoselective ethyl malate; alkoxide enolate alkylation diastereoselective.

The reaction of di-Et (S)(-)-malate with LiN(CHMe2)2 at -78 to -20° under 100 mm Hg argon pressure, followed by treatment with CH2:CHCH2Br gave 92% u-CH2:CHCH2CH(CO2Et)CH(OH)CO2Et (u-I) and 8% l-I. Similarly prepared were 14 other I analogs.

Organic Syntheses published new progress about Alkylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Yu; Shi, Xiao; Liu, Wei published the artcile< Transition-metal-free, chemoselective aerobic oxidations of sulfides and alcohols with potassium nitrate and pyridinium tribromide or bromine>, Electric Literature of 112-63-0, the main research area is sulfoxide preparation chemoselective aerobic oxidation sulfide; aldehyde preparation alc chemoselective aerobic oxidation; ketone preparation chemoselective aerobic oxidation alc.

An efficient oxidation of sulfides with air catalyzed by the combination of potassium nitrate with pyridinium tribromide under transition-metal-free conditions was reported. By replacing pyridinium tribromide with bromine, the reaction system was also useful in the oxidation of alcs. All reactions afforded the corresponding products in good to excellent yields with high chemoselectivities.

Synlett published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Hong; Lu, Jiantao; Feng, Pinzhen published the artcile< Synthesis and free radical polymerization of new spirocyclic monomer>, Reference of 112-63-0, the main research area is spirocyclic pentadecane derivative monomer preparation polymerization; radical polymerization spirocyclic pentadecane derivative monomer; ring opening polymerization spirocyclic pentadecane derivative.

A new type of monomer, 2-methylene-1,4-dioxo-dispiro[4.2.5.2]pentadecane was prepared through a series of organic reactions from simple com. materials. This spirocyclic monomer could undergo free radical ring-opening polymerization at 120° with dibenzoyl peroxide as initiator. The driving force for ring-opening was the relief of the strain at the central spiro atom as well as the formation of stable carbonyl group. However, it copolymerized with MMA (Me methacrylate) at the same condition without any ring opening. The structures of the monomer, resulting polymer and copolymer were determined by IR, NMR and MS. Mol. weight and its distribution of the polymers were estimated by GPC.

Gaofenzi Xuebao published new progress about Radical polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics