Month: October 2022

Lv, Zhangming; Shen, Jiayun; Gao, Xuejiao; Ruan, Yonglan; Ling, Jinying; Sun, Rongwei; Dai, Jingya; Fan, Haizhen; Cheng, Xiaolan; Cao, Peng published the artcile< Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Huangqi Guizhi Wuwu neuroprotective agent peripheral neuropathy; Huangqi Guizhi Wuwu decoction; Inflammation; Network pharmacology; Oxidative stress; Paclitaxel; Peripheral neuropathy.

Paclitaxel-induced peripheral neuropathy (PIPN) is a challenging clin. problem during chemotherapy. Our previous work found that herbal formula Huangqi Guizhi Wuwu decoction (HGWD) could reduce oxaliplatin-induced neurotoxicity. However, its effect on PIPN remains unknown. In this study, we aim to investigate the therapeutic effect and the underlying mechanisms of HGWD against PIPN with pharmacol. experiment and network pharmacol. Male Wistar rats were used to establish an animal model of PIPN and treated with different doses of HGWD for 3 wk. Mech. allodynia, thermal hyperalgesia and body weight were measured to evaluate the therapeutic effect of HGWD on PIPN rats. On the day of the sacrifice, blood, DRGs, sciatic nerve, and hind-paw intra-plantar skins were collected to assess neuroprotective effect of HGWD on PIPN. Next, network pharmacol. was performed to decipher the potential active components and mol. mechanisms of HGWD, as were further verified by western blotting analyses in PIPN rats. Finally, the effect of HGWD on the chemotherapeutic activity of paclitaxel was evaluated in vitro and in vivo. In rats with PIPN, HGWD reversed mech. allodynia, thermal hyperalgesia, and ameliorated neuronal damage. Moreover, HGWD significantly increased the level of nerve growth factor, dramatically reduced IL-1β, IL-6, TNF-α levels and oxidative stress. Network pharmacol. anal. revealed 30 active ingredients in HGWD and 158 candidate targets. Integrated pathway anal. identified PI3K/Akt and toll-like receptor as two main pathways responsible for the neuroprotective effect of HGWD. Further exptl. validation demonstrated that HGWD expectedly inhibited the protein expression of TLR4, MyD88, IKKα, and p-NF-κB, and promoted PI3K, p-Akt, Nrf2, and HO-1 level in dorsal root ganglia. Last but not least, HGWD did not interfere with the antitumor activity of paclitaxel both in in vitro and in vivo models. These combined data showed that HGWD could inhibit paclitaxel-evoked inflammatory and oxidative responses in peripheral nervous system viaTLR4/NF-κB and PI3K/Akt-Nrf2 pathways involvement. The neuroprotective property of HGWD on PIPN provides fundamental support to the potential application of HGWD for counteracting the side effects of paclitaxel during chemotherapy.

Chinese Medicine (London, United Kingdom) published new progress about Body weight. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Zhaoxia; Huang, Jialiang; Luo, Jianbin; Hu, Deng; Yin, Zibin published the artcile< Performance enhancement and emission reduction of a diesel engine fueled with different biodiesel-diesel blending fuel based on the multi-parameter optimization theory>, Category: esters-buliding-blocks, the main research area is diesel engine fuel emission reduction optimization theory.

In this work, the biodiesel-diesel blending fuels (B20, B30 and B40) and pure diesel fuel (B0) were employed to investigate the effects of intake pressure and EGR ratio on the performance and emission characteristics of diesel engine. The 3D model is developed by the AVL-Fire coupled Chemkin code. In addition, an improved chem. kinetics mechanism of 134 species and 475 reactions is employed to simulate the fuel combustion process. The results show that the improved model improves the calculation accuracy and the high intake pressure and oxygen content in biodiesel are beneficial for the improvements of performance and emission characteristics. However, the NO emission increases. On the contrary, the EGR effectively reduces NOx emission. Finally, the performance and emission characteristics of diesel engine are optimized by the orthogonal principal component-optimization method. Moreover, the NOx mass fraction is reduced by 78.6% and the engine power is decreased by 5.60%. Therefore, the reasonable parameter is beneficial for alleviating the conflict between performance and emission characteristics of diesel engine.

Fuel published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramakrishna, Kankanala; Biswas, Jyoti Prasad; Jana, Sadhan; Achar, Tapas Kumar; Porey, Sandip; Maiti, Debabrata published the artcile< Coordination Assisted Distal C-H Alkylation of Fused Heterocycles>, Application of C19H34O2, the main research area is oxoalkylquinoline regioselective preparation; oxoalkylthiazole benzothiazole benzoxazole regioselective preparation; quinoline allyl alc regioselective alkylation palladium catalyst; C−H activation; alkylation; bifunctional; heterocycles; non-covalent.

Distal C-H bond functionalization of heterocycles remained extremely challenging with covalently attached directing groups (DG). Lack of proper site for DG attachment and inherent catalyst poisoning by heterocycles demand alternate routes for site selective functionalization of their distal C-H bonds. Utilizing non-productive coordinating property to hold the heterocycle into the cavity of a template system in a host-guest manner, we report distal C-H alkylation (C-5 of quinoline and thiazole, C-7 of benzothiazole and benzoxazole) of heterocycles. Upon complexation with heterocyclic substrate, nitrile DG in template directs the metal catalyst towards close vicinity of the specific distal C-H bond of the heterocycles. Our hypothesized pathway has been supported by various X-ray crystallog. characterized intermediates.

Angewandte Chemie, International Edition published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Jinhua; Lin, Shengyou; Lin, Zechen; Lin, Xianlei; Shen, Yuezhong; Su, Jingyang published the artcile< PPM1A as a key target of the application of Jiawei-Maxing-Shigan decoction for the attenuation of radiation-induced epithelial-mesenchymal transition in type II alveolar epithelial cells>, SDS of cas: 112-63-0, the main research area is type II alveolar epithelial cell mesenchymal transition radiation; Jiawei Maxing Shigan decoction PPM1A; Jiawei‑Maxing‑Shigan decoction; Radiation‑induced injury; TGF‑β1/Smad signaling; epithelial‑mesenchymal transition; protein phosphatase Mg2+/Mn2+‑dependent 1A.

Radiation-induced lung tissue injury is an important reason for the limited application of radiotherapy on thoracic malignancies. Previously, we reported that administration of Jiawei-Maxing-Shigan decoction (JMSD) attenuated the radiation-induced epithelial-mesenchymal transition (EMT) in alveolar epithelial cells (AECs) via TGF-β/Smad signaling. The present study aimed to examine the role of protein phosphatase Mg2+/Mn2+-dependent 1A (PPM1A) in the anti-EMT activity of JMSD on AECs. The components in the aqueous extract of JMSD were identified by high-performance liquid chromatog. coupled with electrospray mass spectrometry. Primary rat type II AECs were treated with radiation (60Co γ-ray at 8 Gy) and JMSD-medicated serum. PPM1A was overexpressed and knocked down in the AECs via lentivirus transduction and the effects of JMSD administration on the key proteins related to TGF-β1/Smad signaling were measured by western blotting. It was found that radiation decreased the PPM1A expression in the AECs and JMSD-medicated serum upregulated the PPM1A expressions in the radiation-induced AECs. PPM1A overexpression increased the E-cadherin level but decreased the phosphorylated (p-)Smad2/3, vimentin and α-smooth muscle actin (α-SMA) levels in the AECs. By contrast, the PPM1A knockdown decreased the E-cadherin level and increased the p-Smad2/3, vimentin and α-SMA levels in the AECs and these effects could be blocked by SB431542 (TGF-β1/Smad signaling inhibitor). JMSD administration increased the E-cadherin level and decreased the p-Smad2/3, vimentin and α-SMA levels in the AECs; however, these effects could be blocked by siPPM1A-2. In conclusion, PPM1A is a key target of JMSD administration for the attenuation of the radiation-induced EMT in primary type II AECs via the TGF-β1/Smad pathway.

Molecular Medicine Reports published new progress about Apricot. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Izquierdo, Isidoro; Plaza, Maria T.; Robles, Rafael; Mota, Antonio published the artcile< Synthesis of 4-octuloses. Part IV. Synthesis of 2-deoxy-4-octulose derivatives by highly diastereoselective alkylations of protected hexuloses>, COA of Formula: C6H10O5, the main research area is arabinohexosulopyranose xylohexosulofuranose Reformatskii reaction bromoacetate; deoxyoctulose preparation stereoselective alkylation.

Reformatskii reaction of 2,3:4,5-di-O-isopropylidene-β-D-arabino-hexos-2-ulopyranose with Me bromoacetate proceeded with high diastereoselectivity to give Me 2-deoxy-4,5:6,7-di-O-isopropylidene-β-D-manno-oct-4-ulo-4,8-pyranosonate and its -D-gluco isomer, in an ≈ 10:1 ratio. Configurations of the new stereogenic centers (C-3) were determined by reduction of their ester groups to the related 2-deoxy-4,5:6,7-di-O-isopropylidene-β-D-manno- and -D-gluco-oct-4-ulo-4,8-pyranose. When alkylation at C-1 was carried out with 2-lithio tert-Bu acetate, the corresponding tert-Bu esters were formed in an ≈ 5.4:1 ratio. The stereochem. of the esters was established by their reductions On the other hand, reaction of 2,3:4,5-di-O-isopropylidene-β-D-arabino-hexos-2-ulopyranose with Me methoxycarbonylmethylenedimethylsulfurane gave only Me 2,3-anhydro-4,5:6,7-di-O-isopropylidene-β-D-glycero-D-galacto-oct-4-ulo-4,8-pyranosonate. Reformatskii reaction of 2,3:4,6-di-O-isopropylidene-α-L-xylo-hexos-2-ulofuranose with Me bromoacetate proceeded with moderate diastereoselectivity to give Me 2-deoxy-4,5:6,8-di-O-isopropylidene-α-L-gulo-oct-4-ulo-4,7-furanosonate and its -L-ido isomer, in an ≈ 3.5:1 ratio. Configuration of the new stereogenic center (C-3) was determined by degradation to the known di-Me D-methoxymalate.

Tetrahedron: Asymmetry published new progress about Alkylation, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, COA of Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Jingke; Chen, Dezhao; Pan, Fenghua; Luo, Youshou published the artcile< Artificial neural system prediction of aryl fluoride yields in nucleophilic fluorinations>, Related Products of 112-63-0, the main research area is artificial neural network prediction aryl fluoride; halogen exchange fluorination reaction computer modeling.

Multilayered Feed-Forward Networks were employed to model on halogen-exchange fluorination reactions and predict the aryl fluoride product yields.

Journal of Fluorine Chemistry published new progress about Computer program (Artificial neural system). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gok, Dervis published the artcile< One-pot three-component synthesis of novel 2-(3-nitro-phenyl)-quinazoline-4-carboxylic acid derivatives>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is quinazoline carboxylic acid preparation; nitro phenyl quinazoline carboxylic acid preparation; sodium isatinate nitrobenzaldehyde ammonium acetate three component.

A simple and easy synthesis of compound I [R1 = HO; R2 = 3-O2NC6H4] was successfully developed through a one-pot three-component condensation reaction of (2-amino-phenyl)-oxo-acetic acid sodium salt obtained from the hydrolysis of isatin with ammonium acetate and 3-nitrobenzaldehyde. Some novel quinazoline-ester derivatives I [R1 = MeO, EtO, i-PrO, BuO; R2 = 3-O2NC6H4] were then obtained by the reaction between the new compound I [R1 = H; R2 = 3-O2NC6H4] and various alcs. Then, quinazoline-amide derivatives I [R1 = H2N, n-PrNH, i-PrNH, PhNH, 4-H2NSO2C6H4NH; R2 = 3-O2NC6H4] were synthesized from the reaction of various amines and compound I [R1 = Cl; R2 = 3-O2NC6H4], obtained by the reaction of compound I [R1 = HO; R2 = 3-O2NC6H4] with SOCl2. Finally, some novel quinazoline-azo derivatives II [R3 = Me, Ph; R4 = Me, EtO] were synthesized by the coupling reaction between β-dicarbonyl compounds and the novel amino-quinazoline derivative compound I [R1 = n-PrNH; R2 = 3-H2NC6H4], obtained by reduction of nitro-quinazoline derivative compound I [R1 = n-PrNH; R2 = 3-O2NC6H4]. Thus, a new series of quinazoline-4-carboxylic acid, ester, amide and azo derivatives was synthesized and fully characterized by 1H NMR, 13C NMR, IR and mass spectrometry anal.

Journal of Heterocyclic Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Re, Rebecca N.; Proessdorf, Johanna C.; La Clair, James J.; Subileau, Maeva; Burkart, Michael D. published the artcile< Tailoring chemoenzymic oxidation via in situ peracids>, Synthetic Route of 4098-06-0, the main research area is chemoenzymic oxidation peracid olefin lipid epoxidation.

Epoxidation chem. often suffers from the challenging handling of peracids and thus requires in situ preparation Here, we describe a two-phase enzymic system that allows the effective generation of peracids and directly translate their activity to the epoxidation of olefins. We demonstrate the approach by application to lipid and olefin epoxidation as well as sulfide oxidation These methods offer useful applications to synthetic modifications and scalable green processes.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chua, Giles B. H.; Roth, Peter J.; Duong, Hien T. T.; Davis, Thomas P.; Lowe, Andrew B. published the artcile< Synthesis and Thermoresponsive Solution Properties of Poly[oligo(ethylene glycol) (meth)acrylamide]s: Biocompatible PEG Analogues>, Recommanded Product: Perfluorophenyl acrylate, the main research area is methacrylamido copolymer biocompatible bioconjugated material.

A library of (meth)acrylamido (co)polymers was prepared by reacting poly(pentafluorophenyl (meth)acrylate) with α-amino, ω-methoxy functionalized di(ethylene glycol), tri(ethylene glycol), and poly(ethylene glycol) (PEG)-350, PEG-750, and PEG-5k, in combination with hexylamine or thyroxine. The resulting copolymers showed an improved solubility in water (higher or absent LCST values) and in alcs. (lower or absent UCST values) than the analogous common series of poly[oligo(ethylene glycol) Me ether (meth)acrylates]. The polyacrylamido species showed a better solubility than the corresponding polymethacrylamido derivatives of similar mol. weight with all polyacrylamides studied being water-soluble at temperatures exceeding 90.0°. Tunable thermosensitive behavior could be effected by the incorporation of the hydrophobic hexylamide comonomer. Similarly, an acrylamido backbone with grafted oligo(propylene glycol 600) amides exhibited a sharp LCST-type transition around 22.0°. The UCST-type transitions of the (meth)acrylamido homopolymers were evaluated in 2-propanol and 1-octanol and were found to increase with an increasing ethylene glycol side chain length, but were essentially independent of the alc. chain length with polymers exhibiting higher UCST transitions in 2-propanol vs. 1-octanol. Cytotoxicity tests on MRC5 fibroblast cells of the di- and tri(ethylene glycol) Me ether acrylamido homopolymers revealed no toxicity up to concentrations of 10.0 g/L. By employing mixtures of di(ethylene glycol) Me ether amine and the prohormone thyroxine (T4), water-soluble copolymers containing varying amounts of T4 could be easily synthesized. Because of enhanced solubility, low toxicity, and higher hydrolytic stability of amides vs. ester linkages, activated ester polymers in combination with amino-functionalized ethylene glycol based side chains are presented as a versatile platform for highly soluble, biocompatible, bioconjugated materials.

Macromolecules (Washington, DC, United States) published new progress about Biocompatibility. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Recommanded Product: Perfluorophenyl acrylate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Haocheng; Zhang, Weixuan; Yin, Xu; Wu, Yuling; Du, Chao; Zhao, Weigang; Zhao, Li; Liu, Cuirong published the artcile< TMP-based hyperbranched polyurethane elastomer (HBPUE) packaging material applied to anodic bonding>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hyperbranched polyurethane elastomer packaging material anodic bonding.

In this work, hyperbranched polyurethane elastomer (HBPUE) electrolyte and aluminum foil (Al) were joined together by anodic bonding. It provides a possibility for packaging of flexible devices to use anodic bonding. The HBPUEs were designed and prepared via prepolymerization method cured at room temperature using polypropylene glycol (PPG), toluene-2,4-diisocyanate(TDI), lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and the varying ratios of trimethylolpropane (TMP)/1,4-butanediol (BDO). All HBPUEs prepared exhibited low glass transition temperature (Tg) and good thermal stability. The highly branched structures increase the proportion of amorphous phase of HBPUEs, resulting in a high ionic conductivity with a highest value of 2.38 x 10-4 S cm-1 at 70°C when adding TMP and BDO at the ratio of 0.45:0.45 (HBPUE3). There are no obvious diffraction peaks of the LiTFSI in the XRD patterns, indicating that LiTFSI was dissolved in polyurethane matrix completely. XRD results show that the structures of PEO-PUEs are amorphous. The HBPUEs prepared have good mech. properties that can be used as packaging material. After bonded, the microstructures of the bonded interface between HBPUE and Al with a clear intermediate bonding layer could be observed by the cross-sectional SEM images, and the elements diffused were also detected by the energy-dispersive spectrometer (EDS), indicating that the HBPUEs and Al were bonded together successfully. The maximum tensile strength for HBPUE3/Al was up to 1.15 MPa. All results demonstrated that the HBPUEs prepared would be a promising packaging material for flexible devices applied to anodic bonding.

Chemical Papers published new progress about Anodic bonding. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics