Month: October 2022

Karmel, Caleb; Hartwig, John F. published the artcile< Mechanism of the Iridium-Catalyzed Silylation of Aromatic C-H Bonds>, Electric Literature of 2557-13-3, the main research area is arene silylation mechanism iridium catalysis.

Phenanthroline ligands and [Ir(cod)(OMe)]2 form complexes that catalyze the silylation of aromatic and aliphatic C-H bonds. However, no exptl. data on the identity of complexes related to the mechanism of this process or the mechanisms by which they react to functionalize C-H bonds have been reported. Herein, we describe our studies on the mechanism of the iridium-catalyzed silylation of aryl C-H bonds. The resting state of the catalyst is an iridium disilyl hydride complex (phenanthroline)Ir(SiMe(OTMS)2)2(H)(L), in which L varies with the arene and additives. An iridium disilyl hydride complex was isolated, characterized, and allowed to react with arenes to form aryl silanes. The kinetics of the reactions of electron-rich and electron-poor arenes showed that the rate-limiting step varies with the electronic properties of the arene. Computational studies on related iridium silyl complexes revealed that the high activity of iridium complexes with sterically encumbered phenanthroline ligands is due to a change in the number of silyl groups bound to iridium between the resting state of the catalyst containing the hindered phenanthroline and that containing less hindered phenanthroline.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Electric Literature of 2557-13-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Yang; Liu, Lei; Shan, Li-peng; Chen, Jiong published the artcile< Natural ingredient paeoniflorin could be a lead compound against white spot syndrome virus infection in Litopenaeus vannamei>, Application of C19H34O2, the main research area is paeoniflorin antiviral agent white spot virus infection; WSSV; antiviral; natural ingredient; paeoniflorin.

White spot syndrome virus (WSSV) is an important pathogen causing high mortality in the shrimp industry in aquaculture, yet there is no treatment available to date. In order to find a treatment against WSSV infection, this study examined the anti-WSSV activity of eight natural compounds using shrimp larvae as a model. Among the eight compounds, paeoniflorin showed the most obvious anti-WSSV effect, with a maximum protection efficiency of WSSV-infected shrimp >60% at 100μM. Furthermore, pretreatment and post-treatment experiments revealed that paeoniflorin could prevent and treat WSSV infection in shrimp. The antiviral activity of paeoniflorin in aquaculture water decreased rapidly with time, and the results showed that the stable anti-WSSV activity of paeoniflorin could only remain in water for 1 day. Thus, the dosing pattern of continuous medication changes was evaluated. Obviously, in the model of continuous change of paeoniflorin, WSSV copy numbers in the virus-treated shrimp group still progressively increased, while the virus content in WSSVpaeoniflorin-treated group continued to decrease. Interestingly, paeoniflorin inhibited horizontal transmission of WSSV to a certain extent. Notably, paeoniflorin significantly increased the expression of antimicrobial peptides of shrimp to resist WSSV. In conclusion, paeoniflorin has the potential to protect shrimp against WSSV.

Journal of Fish Diseases published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (ALF1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rodrigues, Jeisa Zielle de Souza; Passos, Manuela Ribeiro; Silva de Macedo Neres, Nayara; Almeida, Rafael Silva; Pita, Louise Soares; Santos, Iago Almeida; Santana Silveira, Paulo Henrique; Reis, Mariane Mares; Santos, Isabella Porto; Ricardo, Luccas de Oliveira Negrao; Lima, Brenda Oliveira; D’Orleans Farias Marinho, Patrick; Soares, Ananda Brito; Silva Bastos Andrade, Leonardo Oliveira; Brasileiro Pessoa, Stela Mares; Leles Silva, Marlon Mario; Oliveira, Milena Cardoso; Pinheiro da Silva, Jamile; Moura, Mariana Araujo; Cruz, Mariluze Peixoto; Marques, Lucas Miranda; Santos, Tiza Teles; Pires, Polyane Novais; Teixeira Dias, Joao Carlos; Rezende, Rachel Passos; Trovatti Uetanabaro, Ana Paula; Yatsuda, Regiane published the artcile< Antimicrobial activity of Lactobacillus fermentum TcUESC01 against Streptococcus mutans UA159>, Application In Synthesis of 112-63-0, the main research area is Lactobacillus fermentum Streptococcus mutans antimicrobial activity; Antimicrobial; Dental caries; Lactobacillusfermentum; Metabolites; Probiotics; Streptococcus mutans.

Dental caries is a multifactorial chronic-infection disease, which starts with a bacterial biofilm formation caused mainly by Streptococcus mutans. The use of probiotics has shown numerous health benefits, including in the fight against oral diseases. Strains of Lactobacillus fermentum have already shown probiotic potential against S. mutans, but there are still few studies. Thus, the aim of our study was to evaluate the antimicrobial activity of the inoculum and metabolites produced by L. fermentum TcUESC01 against S. mutans UA159. For this, a growth curve of L. fermentum was performed and both the inoculum and the metabolites formed in the fermentation were tested against the growth of S. mutans UA159 in agar diffusion tests, and only its metabolites were tested to determine the min. inhibitory concentration, minimal bactericidal concentration and inhibition of cell adhesion. Inhibition of biofilm formation, pH drop and proton permeability were also tested with the metabolites. The zone of inhibition began to be formed at 14 h and continued until 16 h. The inoculum containing L. fermentum also showed zone of inhibition. The MIC for the metabolites was 1280 mg/mL and the MBC was obtained with a concentration higher than the MIC equal to 5120 mg/mL. Half of the MIC concentration (640 mg/mL) was required to inhibit S. mutans adhesion to the surface of the microplates. In the biofilm analyzes, the treatment with the metabolites in the tested concentration was not able to reduce biomass, insoluble glucans and alkali soluble compared to the control biofilm (p > 0.05). The metabolites also did not affect acid production and acid tolerance of S. mutans cells in biofilms compared to saline group (p > 0.05). Lactic acid (50.38%) was the most abundant organic acid produced by L. fermentum. This is the first report showing that the metabolites produced by the Lactobacillus fermentum TcUESC01 have a potential to be used as an antimicrobial agent against S. mutans, showing anti-adherence and bactericidal activity against planktonic cells of S. mutans. Thus, further studies should be carried out in order to better understand the antimicrobial activity of metabolites of L. fermentum TCUESC01.

Microbial Pathogenesis published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yasui, Shinro; Itoh, Kenji; Ohno, Atsuyoshi published the artcile< Kinetic study on debromination of vic-dibromides with trivalent phosphorus compounds>, Application In Synthesis of 112-63-0, the main research area is vic dibromide debromination trivalent phosphorus kinetics; substituent effect vic dibromide debromination trivalent phosphorus.

Various types of trivalent phosphorus compounds PZ3 (PZ3 = P(2,6-OMe-C6H3)3, PPh3, PPh2OEt, PPh2OMe, PPh(OEt)2, PPh(OMe)2, P(OEt)3) brought about reductive debromination of vic-dibromides BrC(H)(Ph)-C(H)(R’)Br (R’ = Ph, COOEt, 4-NO2-C6H4) to afford olefins. The reaction was accelerated by either electron-releasing substituents on the phosphorus or electron-withdrawing substituents on the α-carbon of the vic-dibromides. The substituent effects, along with the stereochem. of the reaction, are consistent with an E1CB-like mechanism for the elimination of the two bromine atoms. That is, the phosphorus compounds initially undergo nucleophilic attack upon a bromine of the vic-dibromides. At the transition state, a fractional pos. charge is developed on the phosphorus and a fractional neg. charge on the carbon of the vic-dibromide. This mechanism suggests the importance of an electronic character of the vic-dibromide in determining the relative ease of bromophilicity, carbophilicity, and basicity of the phosphorus of a trivalent phosphorus compound in a reaction with the dibromide.

Heteroatom Chemistry published new progress about Bromides Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rubio-Garrido, Marina; Reina, Gabriel; Ndarabu, Adolphe; Rodriguez-Galet, Ana; Valades-Alcaraz, Ana; Barquin, David; Carlos, Silvia; Holguin, Africa published the artcile< High drug resistance levels could compromise the control of HIV infection in pediatric and adolescent population in Kinshasa, the Democratic Republic of Congo>, Application In Synthesis of 112-63-0, the main research area is human HIV infection drug resistance pediatric adolescent population Congo.

The inadequacy of HIV viremia and resistance monitoring in Africa leads to uncontrolled circulation of HIV strains with drug resistance mutations (DRM), compromising antiretroviral therapy (ART) effectiveness. This study describes the DRM prevalence and its therapeutic impact in HIV-infected pediatric patients from Kinshasa (Democratic Republic of Congo, DRC). From 2016-2018, dried blood were collected from 71 HIV-infected children and adolescents under ART in two hospitals in Kinshasa for HIV-1 DRM pol anal., predicted ARV-susceptibility by Stanford and phylogenetic characterization. HIV-1 sequences were recovered from 55 children/adolescents with 14 years of median-age. All had received nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI, NNRTI), 9.1% protease inhibitors (PI) and only one integrase inhibitor (INI). Despite the use of ART, 89.1% showed virol. failure and 67.3% carried viruses with major-DRM to one (12.7%), two (47.3%), or three (5.5%) ARV-families. Most children/adolescents harbored DRM to NNRTI (73.5%) or NRTI (61.2%). Major-DRM to PI was present in 8.3% and minor-DRM to INI in 15%. Dual-class-NRTI+NNRTI resistance appeared in 53.1% of patients. Viruses presented high/intermediate resistance to nevirapine (72.9% patients), efavirenz (70.9%), emtricitabine/lamivudine (47.9%), rilpivirine (41.7%), etravirine (39.6%), doravidine (33.3%), zidovudine (22.9%), among others. Most participants were susceptible to INI and PI. Great diversity of variants was found, with a high rate (40%) of unique recombinants. The high DRM prevalence observed among HIV-infected children and adolescents in Kinshasa could compromise the 95-95-95-UNAIDS targets in the DRC. It also reinforces the need for routine resistance monitoring for optimal rescue therapy election in this vulnerable population to control the spread of resistant HIV in the country.

PLoS One published new progress about Adolescent, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shivalingam, Arun; Taemaitree, Lapatrada; El-Sagheer, Afaf H.; Brown, Tom published the artcile< Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly>, Computed Properties of 112-63-0, the main research area is squaramide ureas flexible nucleic acid assembly; RNA detection; ligation; nucleic acids; polymerase chain reaction; squaramide.

Joining oligonucleotides together (ligation) is a powerful means of retrieving information from the nanoscale. To recover this information, the linkages created must be compatible with polymerases. However, enzymic ligation is restrictive and current chem. ligation methods lack flexibility. Herein, a versatile ligation platform based on the formation of urea and squaramide artificial backbones from minimally modified 3′- and 5′-amino oligonucleotides is described. One-pot ligation gives a urea linkage with excellent read-through speed, or a squaramide linkage that is read-through under selective conditions. The squaramide linkage can be broken and reformed on demand, while stable pre-activated precursor oligonucleotides expand the scope of the ligation reaction to reagent-free, mild conditions. The utility of the authors’ system is demonstrated by replacing the enzymically biased RNA-to-DNA reverse transcription step of RT-qPCR with a rapid nucleic-acid-template-dependent DNA chem. ligation system, that allows direct RNA detection.

Angewandte Chemie, International Edition published new progress about DNA Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), SPN (Synthetic Preparation), ANST (Analytical Study), USES (Uses), BIOL (Biological Study), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramadoss, Velayudham; Alonso-Castro, Angel J.; Campos-Xolalpa, Nimsi; Ortiz-Alvarado, Rafael; Yahuaca-Juarez, Berenice; Solorio-Alvarado, Cesar R. published the artcile< Total synthesis of kealiiquinone: the regio-controlled strategy for accessing its 1-methyl-4-arylbenzimidazolone core>, Application In Synthesis of 112-63-0, the main research area is kealiiquinone total synthesis.

A practical, concise and straightforward total synthesis of kealiiquinone, a naphtho[2,3-d]imidazole alkaloid obtained from the Micronesian marine sponge Leucetta sp. was accomplished. The squaric acid chem. to construct the 1,4-quinoid ring and the regioselective N-methylation through a benzo[c][1,2,5]selenadiazolium heterocycle are the key features in this report. The full details of the representative approaches involving the different attempted synthetic strategies are also presented. Finally a successful total synthesis of this complex secondary metabolite is described.

RSC Advances published new progress about Methylation, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gyomore, Adam; Bakos, Maria; Foldes, Tamas; Papai, Imre; Domjan, Attila; Soos, Tibor published the artcile< Moisture-Tolerant Frustrated Lewis Pair Catalyst for Hydrogenation of Aldehydes and Ketones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is moisture tolerant frustrated Lewis pair hydrogenation catalyst aldehyde ketone.

In this paper, we report on the development of a bench-stable borane for frustrated Lewis pair catalyzed reduction of aldehydes, ketones, and enones. The deliberate fine-tuning of structural and electronic parameters of Lewis acid component and the choice of Lewis base provided for the first time, a moisture-tolerant FLP catalyst. Related NMR and DFT studies underpinned the unique behavior of this FLP catalyst and gave insight into the catalytic activity of the resulting FLP catalyst.

ACS Catalysis published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Jing; Su, Guannan; Huang, Xinyue; Chang, Rui; Chen, Zhijun; Ye, Zi; Cao, Qingfeng; Kijlstra, Aize; Yang, Peizeng published the artcile< Metabolomic analysis of aqueous humor identifies aberrant amino acid and fatty acid metabolism in Vogt-Koyanagi-Harada and Behcet′s disease>, Category: esters-buliding-blocks, the main research area is Behcet disease metabolomic analysis fatty acid metabolism; Behcet’s disease; Vogt-Koyanagi-Harada disease; amino acids; fatty acids; metabolomics; pathway.

To investigate aqueous metabolic profiles in Vogt-Koyanagi-Harada (VKH) and Behcet′s disease (BD), we applied ultra-high-performance liquid chromatog. equipped with quadrupole time-of flight mass spectrometry in aqueous humor samples collected from these patients and controls. Metabolite levels in these three groups were analyzed by univariate logistic regression. The differential metabolites were subjected to subsequent pathway anal. by MetaboAnalyst. The results showed that both partial-least squares discrimination anal. and hierarchical clustering anal. showed specific aqueous metabolite profiles when comparing VKH, BD, and controls. There were 28 differential metabolites in VKH compared to controls and 29 differential metabolites in BD compared to controls. Amino acids and fatty acids were the two most abundant categories of differential metabolites. Furthermore, pathway enrichment anal. identified several perturbed pathways, including pantothenate and CoA biosynthesis when comparing VKH with the control group, and D-arginine and D-ornithine metabolism and phenylalanine metabolism when comparing BD with the control group. Aminoacyl-tRNA biosynthesis was altered in both VKH and BD when compared to controls. Our findings suggest that amino acids metabolism as well as two fatty acids, palmitic acid and oleic acid, may be involved in the pathogenesis of BD and VKH.

Frontiers in Immunology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Shicong; Liu, Xiaoyan; He, Jingyu; Liu, Menghua published the artcile< Insight into Seasonal Change of Phytochemicals, Antioxidant, and Anti-Aging Activities of Root Bark of Paeonia suffruticosa (Cortex Moutan) Combined with Multivariate Statistical Analysis>, Reference of 112-63-0, the main research area is Paeonia suffruticosa root bark phytochem antioxidant antiaging activity; root bark phytochem seasonal change multivariate statistical analysis; Cortex Moutan; anti-aging; antioxidant; collection period; composition; multivariate statistical analysis.

Chem. compositions, antioxidants, and anti-aging activities of Cortex Moutan (CM), from different collection periods and different producing areas, were measured and compared in order to obtain excellent CM extracts The bioactivities of CM extracts were examined by an in vitro antioxidant method and a UVB irradiated human dermal fibroblast (HDF) model. Phytochem. properties were obtained from ultra-fast liquid chromatog. quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF-MS) prior to the multivariate statistical anal. As for the results, the extracts of Heze CM (HZCM) and Luoyang CM (LYCM) collected in June had better in vitro antioxidant activities, significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA), compared to other CM extracts HZCM and LYCM extracts could upregulate the relative expression of SOD and GSH-Px mRNA. The extract of HZCM collected in June could significantly repress the production of matrix metalloproteinase 1 (MMP-1) and improve the production of procollagen type I (PCOL)-I in UVB irradiated HDF. In total, 50 compounds, including 17 monoterpenoids, 19 flavonoids, 13 phenols, and 1 amino acid were identified or tentatively identified in the CM extracts Gallic acid, p-hydroxybenzoic acid, oxypaeoniflorin, paeoniflorin, 1,2,3,4,6-O-pentagalloyl glucose, and paeonol were predominant compounds in the CM extracts Taken together, CM collected from Apr. to Sept. had better antioxidant and anti-aging effects for external usage.

Molecules published new progress about Amino acids Role: ANT (Analyte), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics