Month: October 2022

Zhang, Liangliang; Oestreich, Martin published the artcile< Diastereotopic Group-Selective Intramolecular Aldol Reactions Initiated by Enantioselective Conjugate Silylation: Diastereodivergence Controlled by the Silicon Nucleophile>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silyl benzoyl dihydroxyoctahydroindenone preparation isomerization crystal structure; crystal structure silyl benzoyl dihydroxyoctahydroindenone; mol structure silyl benzoyl dihydroxyoctahydroindenone; aryloxopentenyl cyclopentanedione enantioselective copper catalyzed silylation aldol cyclization; indenone silyl benzoyl preparation.

A reaction sequence consisting of enantioselective Cu-catalyzed conjugate silylation and diastereotopic group-selective aldol cyclization is reported. The diastereoselectivity of the intramol. aldol reaction depends on the Si nucleophile used, either Me2PhSiZnX·2LiX (trans) or Me2PhSiBpin (cis). The more basic Zn reagent and as such the very basic reaction medium also enable thermodynamically driven cis-to-trans isomerization by a retro-aldol-aldol process. A broad range of electron-withdrawing groups including electron-deficient heterocycles is compatible with the different procedures developed.

ACS Catalysis published new progress about Aldehydes, hydroxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kajimoto, Tetsuya; Hidaka, Mitsuharu; Shoyama, Kayoko; Nohara, Toshihiro published the artcile< Iridoids from Scrophularia ningpoensis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iridoid Scrophularia root structure.

Three new compounds (e.g., I and II) were isolated from Scrophulariae Radix, the dried root of S. ningpoensis, together with the known compounds harpagide and harpagoside. The structure of one was shown to be similar to acetoside and angoroside A; the other two were characterized as iridial derivatives by spectroscopic means.

Phytochemistry published new progress about Scrophularia ningpoensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kayahara, Eiichi; Yamada, Hiroto; Yamago, Shigeru published the artcile< Generation of Carbanions through Stibine-Metal and Bismuthine-Metal Exchange Reactions and Its Applications to Precision Synthesis of ω-End-Functionalized Polymers>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is stibine metal exchange reaction carbanion generation; polyhydroxyethyl methacrylate terminal functionalization stibine metal exchange reaction; polyisopropylacrylamide terminal functionalization stibine metal exchange reaction; polybutyl acrylate terminal functionalization stibine metal exchange reaction; PMMA terminal functionalization stibine metal exchange reaction; magnesium stibine exchange reaction carbanion generation; zinc stibine exchange reaction carbanion generation; bismuthine metal exchange reaction carbanion generation; lithium stibine exchange reaction carbanion generation.

Generation of carbanions from organostibines and organobismuthines through heteroatom-metal exchange reactions was examined from synthetic and mechanistic viewpoints. The exchange reaction proceeded spontaneously upon treatment with various organometallic reagents, such as alkyllithiums, tetraalkylzincates, and alkylmagnesium halides to afford the corresponding carbanions quant. Due to the high reactivity of these heteroatom compounds, the exchange reactions took place exclusively even in the presence of various polar functional groups, which potentially react with organometallic species. The advantage of this method was exemplified by the end-group transformation of living polymers that bear these heteroatom species at the ω-polymer end, prepared by using organostibine- and bismuthine-mediated living radical polymerizations Various polymers that bear polar functional groups and acidic hydrogen-for example, poly(Me methacrylate), poly(Bu acrylate), poly(N-iso-Pr acrylamide), and poly(2-hydroxyethyl methacrylate)-could be used in the exchange reactions, and subsequent trapping with electrophiles afforded the corresponding polymers with controlled mol. weights, mol. weight distributions, and end-group functionalities. Competition experiments showed that organostibines and organobismuthines were among the most reactive heteroatom compounds towards organometallic reagents and that their high reactivity was responsible for the high chemoselectivity in the exchange reaction.

Chemistry – A European Journal published new progress about Carbanions Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santschi, Nico; Nauser, Thomas published the artcile< Rate of single electron reduction of Togni's reagent>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Togni reagent single electron reduction rate.

We report on the rate of reduction of a popular electrophilic trifluoromethylating agent, Togni’s reagent (T-CF3), with solvated electrons (e-aq) generated by pulse radiolysis. By means of competition experiments against Me viologen (MV2+) and direct observation of the decay of e-aq we determined k(T-CF3 + e-aq) ≈ 2 × 1010 M-1 s-1. To the best of our knowledge, this constitutes the first report on a reduction of T-CF3 with an unambiguously clear outer-sphere mechanism. Furthermore, we studied the oxidation of 2-(2-iodophenyl)propan-2-ol (ROH) by peroxyl-radicals to a presumably cyclic iodanyl radical RI·. This species RI· was not detected during the reduction of T-CF3 with e-aq and therefore, this reduction does not proceed via heterolytic I-CF3 bond cleavage to CF3- and RI·. More likely, a CF3 radical is formed, as was observed in numerous synthesis studies reported to date.

Journal of Fluorine Chemistry published new progress about Intermediates Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), FORM (Formation, Nonpreparative), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kisszekelyi, Peter; Alammar, Abdulaziz; Kupai, Jozsef; Huszthy, Peter; Barabas, Julia; Holtzl, Tibor; Szente, Lajos; Bawn, Carlo; Adams, Ralph; Szekely, Gyorgy published the artcile< Asymmetric synthesis with cinchona-decorated cyclodextrin in a continuous-flow membrane reactor>, Category: esters-buliding-blocks, the main research area is cinchona cyclodextrin organocatalyst synthesis asym Michael diketone nitrostyrene; synthesis separation integrated flow reactor cinchona cyclodextrin Michael organocatalyst.

This work presents a cyclodextrin-enhanced organocatalytic method from mol. to process design. Cinchona-thiourea and -squaramide catalysts were covalently anchored to inherently large, stable and well-defined permethyl-β-cyclodextrins. The asym. catalysis was successfully demonstrated on the Michael reaction of 1,3-diketones and trans-β-nitrostyrene. Both emerging green and conventional solvents were screened for the asym. addition (up to 99% ee), and the Kamlet-Taft solvent parameters were correlated to the enantioselectivity. Quantum chem. modeling revealed that the catalyst anchoring resulted in favorable structural changes, and stronger intermol. interactions between the catalyst and the reagents. Continuous organocatalysis was performed in coiled tube flow reactor coupled with a membrane separation unit, which allowed complete recovery of the catalyst and 50% solvent (2-MeTHF) recycling. The 100% conversion, 98% purity, 99% ee, 100% in-line catalyst recovery, and 80 g L-1 h-1 productivity makes it an attractive catalytic platform.

Journal of Catalysis published new progress about Addition reaction, stereoselective (catalysts). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Piesche, L.; Hilse, H.; Oehlke, J.; Schroetter, E.; Oehme, P. published the artcile< Substituted picolinic acids as DBH [dopamine β-hydroxylase] inhibitors. Inhibition of dopamine β-hydroxylase and antihypertensive effect>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is picolinate derivative antihypertensive dopamine hydroxylase; fusarate derivative antihypertensive dopamine hydroxylase; copper complexing picolinate derivative antihypertensive.

Twenty-seven substituted picolinic acids and fusaric acids (I and II, resp.; R = various small groups, as well as halogen) were characterized as weak-to-moderately strong acids which form stable Cu(II) complexes in solution and in the solid state. The concentrations required for 50% inhibition of purified bovine adrenal dopamine β-hydroxylase  [9013-38-1] were 10-6-10-5M; I were stronger inhibitors than II. The inhibition was noncompetitive with respect to tyramine but was transitional between competitive and noncompetitive with respect to ascorbic acid. The mechanism of enzyme inhibition could not be explained solely by a complexing of the enzyme Cu. Most I and II had antihypertensive activity in spontaneously hypertensive rats, but some further increased the blood pressure. No correlation was observed between antihypertensive activity and dopamine β-hydroxylase inhibition.

Pharmazie published new progress about Antihypertensives. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiu, Di; Zhang, Yan; Wang, Jianbo published the artcile< Direct synthesis of arylboronic pinacol esters from arylamines>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is pinacol arylboronate aryloxaborolane preparation metal free arylamine borylation.

A metal-free synthetic method based on Sandmeyer-type transformation for preparation of arylboronic pinacol esters from easily available aromatic amines as starting materials was described. This novel transformation affords borylation products in good yields under mild reaction conditions. This strategy can be easily carried out in gram-scale, demonstrating the practical usefulness of the method. Moreover, the Sandmeyer-type transformation can be followed by Suzuki-Miyaura cross-coupling reaction without purification of the arylboronate products.

Organic Chemistry Frontiers published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Jianling; Zou, Xiaoyan; Liu, Pandao; Cardoso, Juan Andres; Schultze-Kraft, Rainer; Liu, Guodao; Luo, Lijuan; Chen, Zhijian published the artcile< Differential expressions and enzymatic properties of malate dehydrogenases in response to nutrient and metal stresses in Stylosanthes guianensis>, Reference of 112-63-0, the main research area is Stylosanthes malate dehydrogenase nutrient metal stress; Enzymatic properties; Gene expression; Malate; Malate dehydrogenase; Metal stress; Nutrient deficiency; Stylosanthes guianensis.

Malate dehydrogenase (MDH, EC 1.1.1.37) is a key enzyme that catalyzes a reversible NAD-dependent dehydrogenase reaction from oxaloacetate (OAA) to malate. Although MDH has been documented to participate in cellular metabolism and redox homeostasis in plants, the roles of MDH members in the tropical legume Stylosanthes guianensis (stylo) remain less definitive. In this study, except SgMDH1 that had been previously characterized, six novel MDH genes were isolated from stylo and were then designated as SgMDH2 to SgMDH7. All of the SgMDH proteins possessed the common features of NAD binding, dimerization interface and substrate binding sites. Expression anal. showed that three SgMDHs exhibited preferential expressions in leaves, and one SgMDH was mainly expressed in roots. Furthermore, SgMDHs were regulated by nutrient deficiencies in stylo roots, especially for phosphorus (-P) and potassium (-K) deficiencies. Differential responses of SgMDHs to trace metal stress and heavy metal toxicity were observed in stylo roots, suggesting the involvement of SgMDHs in the response of stylo to metal stresses. The six novel SgMDHs were subsequently expressed and purified from Escherichia coli to analyze their biochem. properties. Although SgMDHs exhibited variations in subcellular localizations, each SgMDH protein displayed a high level of catalytic efficiency towards OAA and NADH but a low level of catalytic efficiency towards malate and NAD+. In addition, the activities of recombinant SgMDH proteins were pH-dependent and temperature-sensitive, and exhibited differential regulations by various metal ions. These results together suggest the potential roles of SgMDHs in stylo coping with nutrient and metal stresses. The sequence data of the six novel SgMDHs were deposited in GenBank under accession numbers OK188912, OK188913, OK188914, OK188915, OK188916 and OK188917 for SgMDH2 to SgMDH7, resp.

Plant Physiology and Biochemistry (Issy-les-Moulineaux, France) published new progress about Chlorophylls Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balakrishnan, Remya; Nallaperumal, Agasthiyalingom Meenakshi; Manu, Saraswathy Kesava Pillai; Varghese, Lity Alen; Sekkar, Venkataraman published the artcile< DSC assisted kinetic analysis on the urethane network formation between castor oil based ester polyol and poly(methylene di phenyl isocyanate) (pMDI)>, Electric Literature of 112-63-0, the main research area is castor oil polyol pMDI urethane network formation kinetics.

Kinetics of the reaction between castor oil based ester polyol (CEP) and poly(methylene di Ph isocyanate) (pMDI) was studied adopting differential scanning calorimetry (DSC). DSC scans were recorded at various heating rates, viz.: 5, 10, 15 and 20 K.min-1. Hydroxyl and isocyanato compounds were taken at stoichiometric ratio [r=[NCO/OH]=1] Both single heating rate methods (Coats-Redfern, Chatterjee-Conrad) and multiple heating rate based iso-conversional methods (Ozawa, Freidman and Kissinger) were adopted to calculate the kinetic parameters. DSC thermograms consist of two exothermic peaks at temperatures 343 and 393 K, for all heating rates. Kinetic parameters were calculated using input parameters deduced from DSC thermogram. The reaction was assumed to be second order and the corresponding second order equations were applied for evaluating the kinetic parameters.

International Journal of Polymer Analysis and Characterization published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vodicka, Petr; Streinz, Ludvik; Vavra, Jan; Koutek, Bohumir; Budesinsky, Milos; Ondracek, Jan; Cisarova, Ivana published the artcile< Synthesis of (R)- and (S)-3,3,3-trifluoro-2-phenylpropanoyl isocyanates and their use as reactive analogues of Mosher's acid>, SDS of cas: 617-55-0, the main research area is isocyanate trifluorophenylpropanoyl Mosher preparation alc addition; carbamate preparation.

The title isocyanates have been prepared from the resp. 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acids (MTPA) by a three-step synthesis with MTPA chloride and MTPA amide as reaction intermediates. The requested compounds were obtained in high chem. yields without any change in optical purity during the preparation To ascertain the usefulness of this auxiliary agent in the chiral anal., both 3,3,3-trifluoro-2-phenylpropanoyl isocyanates were subjected in NMR tubes to non-catalyzed reactions with 16 different com. available chiral alcs. The steric arrangement of all diastereomers prepared correlated well with their NMR spectral nonequivalence data (Δδ), thus demonstrating the regular sign distribution of Δδ of particular groups according to the devised mol. model.

Chirality published new progress about Alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, SDS of cas: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics