Month: October 2022

Su, Huaigang; Zhao, Qin; Wang, Yanan; Zhao, Qilong; Cheng, Jang; Niu, Yongfang; Lou, Wenjing; Qi, Yanxing published the artcile< SnO nanoparticles on graphene oxide as an effective catalyst for synthesis of lubricating ester oils>, SDS of cas: 112-63-0, the main research area is tinoxide nanoparticle graphene oxide esterification lubricating ester oil.

In this paper, nanosized SnO was deposited on graphene oxide (GO) by adopting hydrothermal technique to fabricate a new composite material SnO@GO, which was characterized by TEM, BET, XPS, XRD and FE-SEM. The SnO@GO composite exhibits excellent catalytic performance for esterifying fatty acids and trimethylolpropane at stoichiometric ratio. The yield of resulting polyol esters could reach 99%. Addnl., the SnO@GO composition can be recycled for 6 cycles without obvious deactivation. The outstanding catalytic performance was attributed by the active Lewis acid of SnO and the increase of specifc surface area with the loading of SnO onto GO.

Catalysis Communications published new progress about Adsorption (isotherms). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ferreira de Lima, Nayana; de Andrade Picanco, Guaraciara; Costa, Tatiane Luiza; Vinaud, Marina Clare published the artcile< In vitro metabolic stress induced by nitazoxanide and flubendazole combination in Taenia crassiceps cysticerci>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Taenia crassiceps nitazoxanide flubendazole antiparasitic cysticercosis; Experimental cysticercosis; Flubendazole; Metabolism; Nitazoxanide.

Taenia crassiceps is often used as exptl. model for T. solium cysticercosis studies. Currently cysticercosis antiparasitic treatment is based on albendazole and praziquantel which may present side effects and parasitic resistance. The search for other antiparasitic drugs is necessary. Nitazoxanide (NTZ) and flubendazole (FLB) are broad spectrum antiparasitic drugs that present anti-cysticercosis effect. Metabolic analyses help to determine the impact of these drugs on parasites. The aim of this study was to determine the impact on the production and excretion of organic metabolites in T. crassiceps cysticerci after in vitro exposure to NTZ and FLB, isolated or in combination. T. crassiceps cysticerci were culture in RPMI medium and exposed to 10μg/mL of NTZ, 10μg/mL of FLB or 10μg/mL of NTZ +10μg/mL of FLB. 24 h after exposure, the parasites were chromatog. analyzed to determine the impact of these drugs on glycolysis, homolactic fermentation, tricarboxylic acid cycle, fatty acids oxidation and proteins catabolism. It was possible to determine that the drugs combination induced greater metabolic impact on cysticerci in comparison to the isolated drugs exposure. The drugs combination induced gluconeogenesis, metabolic acidosis, increase in tricarboxylic acid cycle and in proteins catabolism. While the NTZ isolated exposure induced metabolic acidosis and protein catabolism and the FLB isolate exposure induced gluconeogenesis and protein catabolism. These results show that the combination of drugs with different modes of action increase the antiparasitic effect and may be indicated as alternative cysticercosis treatments.

Experimental Parasitology published new progress about Cysticercosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brouwer, T.; van Lin, R.; ten Kate, A. J. B.; Schuur, B.; Bargeman, G. published the artcile< Influence of Solvent and Acid Properties on the Relative Volatility and Separation Selectivity for Extractive Distillation of Close-Boiling Acids>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is selectivity extractive distillation mixture organic acid solvent volatility.

The increasing need for sustainable processes stimulates the production and recovery of renewable organic acids. The purification of these acids is often difficult because of similar acid volatilities but can be improved through extractive distillation Generic insights into solvent effects on the separation efficiency for close-boiling acids are however lacking. This study provides insights into the effect of acidity, the acidity difference between the acids, the hydrogen-bonding strength of the solvent, and the solvent-to-feed ratio on organic acid separation efficiency. For an acetic acid-formic acid (AA-FA) mixture, the addition of high-boiling organic acids increases the relative volatility of FA over AA significantly. The addition of a Lewis base reverses the relative volatility, which depends on the applied solvent-to-feed ratio and the Lewis base BF3 affinity. For several binary acid mixtures (such as AA-FA and monochloroacetic acid-dichloroacetic acid), where the acids have a relatively big difference in acidity (ΔpKa ≥ 1), the separation selectivity appears practically independent of the acid strength of the individual acids and increases with increasing BF3 affinity of the Lewis base. For acid mixtures with a lower ΔpKa, a lower separation selectivity is obtained, as observed for separation of the pivalic acid-butyric acid and valeric acid-2-Me butyric acid mixtures When one of the acids in the mixture contains a secondary ketone group (i.e., levulinic acid in a levulinic acid-octanoic acid mixture), the strongest acid based on pKa is not necessarily attracted most by the added Lewis base. This, at first sight, unexpected behavior is most likely the result of complex intra- and intermol. interactions and is quant. in line with COSMO-RS-based selectivity predictions.

Industrial & Engineering Chemistry Research published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Poulsen, Thomas B.; Bell, Mark; Jorgensen, Karl Anker published the artcile< Organocatalytic asymmetric allylic carbon-carbon bond formation>, Synthetic Route of 112-63-0, the main research area is malononitrile cycloalkylidene enantioselective Michael addition nitroalkene cinchona alkaloid catalyst; allylic carbon bond formation asym organocatalytic.

Organocatalytic allylic C-C bond-forming addition of activated alkylidenes I [X = O, CH2, CH2CH2, R1 = H; X = CH2, R1 = 7-MeO, 6-MeO, 5,7-Me2, 6,7-(MeO)2] to alkyl and aryl nitroalkenes R2CH:CHNO2 (R2 = n-pentyl, cyclohexyl, Ph, 4-MeOC6H4, 2-naphthyl, 2-thienyl, etc.) has been achieved with high diastereo- and enantioselectivity. Chiral tertiary amine catalysts are used to give allyl intermediates which exhibit γ-selectivity in the C-C bond forming step. The reactions proceed with up to >99:1 syn:anti ratio for both the alkyl- and aryl nitroalkenes with up 96% and 98% ee, resp. The products II of this conjugate addition are transformed into a range of intermediates, such as optically active conjugated dienes and 1-substituted tetralones, which are difficult to access via alternative methods.

Organic & Biomolecular Chemistry published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondratenko, N. V.; Matyushecheva, G. I.; Yagupol’skii, L. M. published the artcile< Halomethylbenzenes>, Application In Synthesis of 112-63-0, the main research area is halomethyl fluorobenzenes; fluorobenzenes halomethyl; inductive effect halomethyl substituents; conjugative effect halomethyl substituents.

19F NMR spectroscopy of m- and p-substituted fluorobenzenes was used to determine the inductive and conjugative effects of CH2X, CHX2, and CX3 groups (X = F, Cl, Br, I, SCF3). Almost no conjugative interaction was observed between these substituents and the aromatic nucleus. The inductive effect increased with increasing number of X in the substituent group, and was greatest for X = SCF3.

Zhurnal Organicheskoi Khimii published new progress about Conjugation (bond). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Golubeva, M. A. published the artcile< In Situ Generated Nickel Phosphide Based Catalysts for Hydroprocessing of Levulinic Acid>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nickel phosphide catalyst levulinic acid hydroconversion.

This article describes the production of unsupported nickel phosphide catalysts generated in situ in a reaction mixture from water-soluble and oil-soluble precursors during the hydroconversion of levulinic acid. These catalysts contain crystalline phases, specifically Ni12P5 and Ni(PO3)2. During the hydrogenation of levulinic acid in toluene in the presence of NiP-TOP, a lower temperature and a shorter reaction time contribute to the formation of γ-valerolactone (100% selectivity). A higher temperature and a longer reaction time favor the formation of valeric acid (94% selectivity). In the hydrogenation of levulinic acid in ethanol in the presence of NiP-H3PO2, the main reaction product is Et levulinate (95% selectivity).

Petroleum Chemistry published new progress about Deoxidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Xiaolong; Jin, Yujuan; Huang, Jian; Tian, Huafeng; Guo, Maolin published the artcile< Highly toughening modification of hyperbranched polyester with environment-friendly caprolactone as end group on poly(3-hydroxybutyrate-co-3-hydroxyvalerate)>, Quality Control of 112-63-0, the main research area is hyperbranched polyester toughening modifier polyhydroxybutyrate hydroxyvalerate blend preparation property.

Hyperbranched polymer with flexible long chains (ε-CL) were synthesized based on hydroxyl terminated hyperbranched polyesters (HBPEs). The prepared HBP-CLs were used to toughen poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) by melt-blending. Comparing with pure PHBV, the crystallinity (Xc) of the PHBV/3.0phr HBP-CLs blends decreased by 10.2% (from 67.8 to 60.9%), the impact strength increased by 533.3% (from 5.1 kJ·m-2 to 32.3 kJ·m-2), and the elongation at break increased by 160.5% (from 1.62 to 4.22%). With the increase of HBP-CLs, the fracture surface of the PHBV/HBP-CLs blends became rough and a significant decrease in crystallization area can be seen from POM images. Even filamentous structures and tiny holes was formed, which further demonstrated that HBP-CLs acted as an excellent toughening effect on PHBV.

Journal of Polymers and the Environment published new progress about Branched polymers, hyperbranched dendritic polymers Role: MOA (Modifier or Additive Use), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Zhanhui; Hao, Yongjin; Yang, Chengkui; Yang, Qing; Wu, Shuwei; Ma, Haikuo; Tian, Sheng; Lu, Haohao; Wang, Jingrui; Yang, Tao; He, Sudan; Zhang, Xiaohu published the artcile< Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity>, Category: esters-buliding-blocks, the main research area is RIPK1 antiinflammatory agent necroptosis signalling inflammation; Inflammatory; Kinase inhibitor; Necroptosis; RIPK1.

RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, we report a series of potent RIPK1 inhibitors, represented by compound 70. Compound 70 efficiently blocks necroptosis induced by TNFα in both human and mouse cells (EC50 = 17-30 nM). Biophys. assay demonstrates that compound 70 potently binds to RIPK1 (Kd = 9.2 nM), but not RIPK3 (Kd > 10,000 nM). Importantly, compound 70 exhibits greatly improved metabolic stability in human and rat liver microsomes compared to compound 6 (PK68), a RIPK1 inhibitor reported in our previous work. In addition, compound 70 displays high permeability in Caco-2 cells and excellent in vitro safety profiles in hERG and CYP assays. Moreover, pre-treatment of 70 significantly ameliorates hypothermia and lethal shock in SIRS mice model. Lastly, compound 70 possesses favorable pharmacokinetic parameters with moderate clearance and good oral bioavailability in SD rat. Taken together, our work supports 70 as a potent RIPK1 inhibitor and highlights its potential as a prototypical lead for further development in necroptosis-associated inflammatory disorders.

European Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eeza, Muhamed N. H.; Bashirova, Narmin; Zuberi, Zain; Matysik, Joerg; Berry, John P.; Alia, A. published the artcile< An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Danio embryo ochratoxin A hepatotoxicity NMR metabolic profiling.

Ochratoxin A (OTA) is one of the most widespread mycotoxin contaminants of agricultural crops. Despite being associated with a range of adverse health effects, a comprehensive systems-level mechanistic understanding of the toxicity of OTA remains elusive. In the present study, metabolic profiling by high-resolution magic angle spinning (HRMAS) NMR, coupled to intact zebrafish embryos, was employed to identify metabolic pathways in relation to a systems-level model of OTA toxicity. Embryotoxicity was observed at sub-micromolar exposure concentrations of OTA. Localization of OTA, based on intrinsic fluorescence, as well as a co-localization of increased reactive oxygen species production, was observed in the liver kidney, brain and intestine of embryos. Moreover, HRMAS NMR showed significant alteration of metabolites related to targeting of the liver (i.e., hepatotoxicity), and pathways associated with detoxification and oxidative stress, and mitochondrial energy metabolism Based on metabolic profiles, and complementary assays, an integrated model of OTA toxicity is, thus, proposed. Our model suggests that OTA hepatotoxicity compromises detoxification and antioxidant pathways, leading to mitochondrial membrane dysfunction manifested by crosstalk between pathways of energy metabolism Interestingly, our data addnl. aligns with a possible role of mitochondrial fusion as a “”passive mechanism”” to rescue mitochondrial integrity during OTA toxicity.

Scientific Reports published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Chengwei; Prichard, Mark N.; Korba, Brent E.; Drach, John C.; Zemlicka, Jiri published the artcile< Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine. [Erratum to document cited in CA148:552730]>, Related Products of 112-63-0, the main research area is erratum fluorinated methylenecyclopropane analog nucleoside preparation antiviral; fluoromethyl hydroxymethyl cyclopropylidene adenine guanine preparation antiviral structure erratum.

There are multiple typog. errors throughout the article; the correct to these are given.

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics