Month: October 2022

Kennedy, Kim R.; Turner, John Harvey; MacDonald, William B. G.; Claringbold, Phillip G.; Boardman, Glenn; Ransom, David T. published the artcile< Long-term survival and toxicity in patients with neuroendocrine tumors treated with 177Lu-octreotate peptide radionuclide therapy>, HPLC of Formula: 112-63-0, the main research area is lutetium octreotate anticancer agent radionuclide toxicity neuroendocrine tumor; myelodysplasia; neuroendocrine tumor; peptide receptor radionuclide therapy.

Peptide receptor radionuclide therapy (PRRT) has shown favorable results in neuroendocrine tumors (NETs). Long-term safety and efficacy data for 177Lu-octreotate PRRT, particularly in combination with chemotherapy, is lacking. The authors conducted a retrospective review of the long-term toxicity and survival outcomes of 104 patients with advanced NETs treated on 4 phase 2 clin. trials with Lutetium-177-octreotate (177Lu-octreotate) PRRT, mostly in combination with chemotherapy. Median follow-up was 68 mo, which represents the longest follow-up study of 177Lu-octreotate PRRT for NETs to date. Median progression-free survival (PFS) was 37 mo, and median overall survival (OS) was 71 mo. Five- and 10-yr OS were 62% and 29%, and 5- and 10-yr PFS were 36% and 21%, resp., demonstrating 177Lu-octreotate can provide durable responses. PRRT was well tolerated with 1.9% of patients developing chronic renal impairment and 1% of patients developing long-term thrombocytopenia. Interestingly, there was a relatively high rate of myelodysplasia (MDS)/leukemia (6.7%), possibly attributable to the longer follow-up (with all except 1 case occurring more than 4 years after PRRT treatment) or to the addition of concurrent chemotherapy. Lutetium-177-Octreotate PRRT remains an efficacious and well tolerated treatment in long-term follow-up. For clinicians deciding on the timing of PRRT for individual patients, the 6.7% long-term risk of MDS/leukemia needs to be balanced against the 21% PFS at 10 years.

Cancer (Hoboken, NJ, United States) published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Kai; Jiang, Li; Zhong, Yueyang; Zhang, Yin; Yin, Qichuan; Li, Su; Zhang, Xiaobo; Han, Haijie; Yao, Ke published the artcile< Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis>, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is ferrostatin liposome treatment corneal alkali burn targeting ferroptosis; corneal alkali burn; corneal neovascularization; ferroptosis; ferrostatin‐1; liposome.

Alkali burn is a potentially blinding corneal injury. During the progression of alkali burn-induced injury, overwhelmed oxidative stress in the cornea triggers cell damage, including oxidative changes in cellular macromols. and lipid peroxidation in membranes, leading to impaired corneal transparency, decreased vision, or even blindness. In this study, we identified that ferroptosis, a type of lipid peroxidation-dependent cell death, mediated alkali burn-induced corneal injury. Ferroptosis-targeting therapy protected the cornea from cell damage and neovascularization. However, the specific ferroptosis inhibitor ferrostatin-1 (Fer-1) is hydrophobic and cannot be directly applied in the clinic. Therefore, we developed Fer-1-loaded liposomes (Fer-1-NPs) to improve the bioavailability of Fer-1. Our study demonstrated that Fer-1-NPs exerted remarkable curative effects regarding corneal opacity and neovascularization in vivo. The efficacy was comparable to that of dexamethasone, but without appreciable side effects. The significant suppression of ferroptosis (induced by lipid peroxidation and mitochondria disruption), inflammation, and neovascularization might be the mechanisms underlying the therapeutic effect of Fer-1-NPs. Moreover, the Fer-1-NPs treatment showed no signs of cytotoxicity, hematol. toxicity, or visceral organ damage, which further confirmed the biocompatibility. Overall, Fer-1-NPs provide a new prospect for safe and effective therapy for corneal alkali burn.

Bioengineering & Translational Medicine published new progress about Bioavailability. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ariba, Houda; Wang, Yanjun; Devouge-Boyer, Christine; Stateva, Roumiana P.; Leveneur, Sebastien published the artcile< Physicochemical Properties for the Reaction Systems: Levulinic Acid, Its Esters, and γ-Valerolactone>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is physicochem property reaction system levulinate ester valerolactone.

The use of biomass, particularly, a second-generation one, as a renewable raw material is crucial to sustain the chem. industry. To favor the development of such processes, one needs to make a cost evaluation, which requires the knowledge of process thermodn. and kinetics. In this paper, measurements of different physicochem. properties (viscosity, d., refractive index, and sp. heat capacity) were done for the systems: hydrogenation of levulinic acid or its esters to γ-valerolactone. From those physicochem. measurements, it was possible to extract the ones of the intermediates and perform a thermodn. model assessment by using Aspen Plus. The Redlich-Kwong-Soave cubic equation of state and Benedict-Webb-Rubin-Starling virial equation of state are suitable to describe these chem. systems.

Journal of Chemical & Engineering Data published new progress about Biomass refining. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ho, Junming; Zheng, Jingjing; Meana-Paneda, Ruben; Truhlar, Donald G.; Ko, Eun Jung; Savage, G. Paul; Williams, Craig M.; Coote, Michelle L.; Tsanaktsidis, John published the artcile< Chloroform as a Hydrogen Atom Donor in Barton Reductive Decarboxylation Reactions>, HPLC of Formula: 112-63-0, the main research area is chloroform hydrogen atom donor Barton reductive decarboxylation.

The utility of chloroform as both a solvent and a hydrogen atom donor in Barton reductive decarboxylation of a range of carboxylic acids was recently demonstrated. In the present work, a combination of electronic structure calculations, direct dynamics calculations, and exptl. studies was carried out to investigate how chloroform acts as a hydrogen atom donor in Barton reductive decarboxylations and to determine the scope of this process. The results from this study show that hydrogen atom transfer from chloroform occurs directly under kinetic control and is aided by a combination of polar effects and quantum mech. tunneling. Chloroform acts as an effective hydrogen atom donor for primary, secondary, and tertiary alkyl radicals, although significant chlorination was also observed with unstrained tertiary carboxylic acids.

Journal of Organic Chemistry published new progress about Ab initio methods. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garnier, Louis; Vidal, Chrystelle; Chinot, Olivier; Cohen-Jonathan Moyal, Elisabeth; Djelad, Apolline; Bronnimann, Charlotte; Bekaert, Lien; Taillandier, Luc; Frenel, Jean-Sébastien; Langlois, Olivier; Colin, Philippe; Menei, Philippe; Dhermain, Frédéric; Carpentier, Catherine; Gerazime, Aurélie; Curtit, Elsa; Figarella-Branger, Dominique; Dehais, Caroline; Ducray, François published the artcile< Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study.>, Category: esters-buliding-blocks, the main research area is Karnofsky Performance Status; age; anaplastic oligodendroglioma; chemotherapy; proliferation; radiotherapy; seizure; surgery.

BACKGROUND: Anaplastic oligodendrogliomas IDH-mutant and 1p/19q codeleted (AO) occasionally have a poor outcome. Herein we aimed at analyzing their characteristics. METHODS: We retrospectively analyzed the characteristics of 44 AO patients with a cancer-specific survival <5 years (short-term survivors, STS) and compared them with those of 146 AO patients with a survival ≥5 years (classical survivors, CS) included in the POLA network. RESULTS: Compared to CS, STS were older (P = .0001), less frequently presented with isolated seizures (P < .0001), more frequently presented with cognitive dysfunction (P < .0001), had larger tumors (P = .= .003), a higher proliferative index (P = .= .0003), and a higher number of chromosomal arm abnormalities (P = .= .02). Regarding treatment, STS less frequently underwent a surgical resection than CS (P = .= .0001) and were more frequently treated with chemotherapy alone (P = .= .009) or with radiotherapy plus temozolomide (P = .= .05). Characteristics independently associated with STS in multivariate analysis were cognitive dysfunction, a number of mitosis > 8, and the absence of tumor resection. Based on cognitive dysfunction, type of surgery, and number of mitosis, patients could be classified into groups of standard (18%) and high (62%) risk of <5 year survival. CONCLUSION: The present study suggests that although STS poor outcome appears to largely result from a more advanced disease at diagnosis, surgical resection may be particularly important in this population. The oncologist published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bartholomew, Glenn P.; Bazan, Guillermo C. published the artcile< Synthesis, Characterization, and Spectroscopy of 4,7,12,15-[2.2]Paracyclophane Containing Donor and Acceptor Groups: Impact of Substitution Patterns on Through-Space Charge Transfer>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hexylaminostyrylcyclophane preparation charge transfer structure.

The synthesis of 4,7,12,15-tetra(4′-dihexylaminostyryl)[2.2]paracyclophane (I), 4-(4′-dihexylaminostyryl)-7,12,15-tri(4”-nitrostyryl)[2.2]paracyclophane (II), 4,7-bis(4′-dihexylaminostyryl)-12,15-bis(4”-nitrostyryl)-[2.2]paracyclophane (III), 4,7,12-tris(4′-dihexylaminostyryl)-15-(4”-nitrostyryl)[2.2]paracyclophane (IV), 4,15-bis(4′-dihexylaminostyryl)-7,12-bis(4”-nitrostyryl)[2.2]paracyclophane (V), and 4,12-bis(4′-dihexylaminostyryl)-7,15-bis(4”-nitrostyryl)[2.2]paracyclophane (VI) is reported. These mols. represent different combinations of bringing together distyrylbenzene chromophores containing donor and acceptor groups across a [2.2]paracyclophane (pCp) bridge. X-ray diffraction studies show that the lattice arrangements of I and III are considerably different from those of the parent chromophores 1,4-bis(4′-dihexylaminostyryl)benzene and 1,4-di(4′-nitrostyryl)benzene. Differences are brought about by the constraint by the pCp bridge and by virtue of chirality in the paired species. The absorption and emission spectra of I-VI are also presented. Clear evidence of delocalization across the pCp structure is observed Further, in the case of II-IV, emission from the second excited state takes place.

Journal of the American Chemical Society published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Powers, David C.; Lee, Eunsung; Ariafard, Alireza; Sanford, Melanie S.; Yates, Brian F.; Canty, Allan J.; Ritter, Tobias published the artcile< Connecting binuclear Pd(III) and mononuclear Pd(IV) chemistry by Pd-Pd bond cleavage>, Related Products of 112-63-0, the main research area is oxidation palladium cyclometalated binuclear benzoquinoline complex mechanism; trifluoromethylation electrophilic palladium cyclometalated binuclear benzoquinoline complex.

Exptl. and theor. evaluation of oxidation of Pd(II) cyclometalated benzo[h]quinoline carboxylato-bridged binuclear complexes with trifluoromethylating electrophilic reagents is presented. Oxidation of binuclear Pd(II) μ-carboxylate complexes with PhICl2 or PhI(OAc)2 has previously been shown to afford binuclear Pd(III) complexes featuring a Pd-Pd bond. In contrast, oxidation of binuclear Pd(II) complexes with electrophilic trifluoromethylating (“”CF3+””) reagents has been reported to afford mononuclear Pd(IV) complexes. These studies suggest that a mononuclear Pd(IV) complex is generated by an oxidation-fragmentation sequence proceeding via fragmentation of an initially formed, formally binuclear Pd(III), intermediate. The observation that binuclear Pd(III) and mononuclear Pd(IV) complexes are accessible in the same reactions offers an opportunity for understanding the role of nuclearity in both oxidation and subsequent C-X bond-forming reactions.

Journal of the American Chemical Society published new progress about Aromatic nitrogen heterocycles Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), FORM (Formation, Nonpreparative), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation) (benzo[h]quinolines, palladium complexes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Perlow, Haley K; Prasad, Rahul N; Yang, Mike; Klamer, Brett; Matsui, Jennifer; Marrazzo, Livia; Detti, Beatrice; Scorsetti, Marta; Clerici, Elena; Arnett, Andrea; Beyer, Sasha; Ammirati, Mario; Chakravarti, Arnab; Raval, Raju R; Brown, Paul D; Navarria, Pierina; Scoccianti, Silvia; Grecula, John C; Palmer, Joshua D published the artcile< Accelerated hypofractionated radiation for elderly or frail patients with a newly diagnosed glioblastoma: A pooled analysis of patient-level data from 4 prospective trials.>, HPLC of Formula: 112-63-0, the main research area is elderly; frail; glioblastoma; hypofractionation; radiation.

BACKGROUND: The standard of care for elderly or frail patients with glioblastoma (GBM) is 40 Gy in 15 fractions of radiotherapy. However, this regimen has a lower biological effective dose (BED) compared with the Stupp regimen of 60 Gy in 30 fractions. It is hypothesized that accelerated hypofractionated radiation of 52.5 Gy in 15 fractions (BED equivalent to Stupp) is safe and efficacious. METHODS: Elderly or frail patients with GBM treated with 52.5 Gy in 15 fractions were pooled from 3 phase 1/2 studies and a prospective observational study. Overall survival (OS) and progression-free survival (PFS) were defined time elapsing between surgery/biopsy and death from any cause or progression of disease. RESULTS: Sixty-two newly diagnosed patients were eligible for this pooled analysis of individual patient data. The majority (66%) had a Karnofsky performance status (KPS) score <70. The median age was 73 years. The median OS and PFS were 10.3 and 6.9 months, respectively. Patients with KPS scores ≥70 and <70 had a median OS of 15.3 and 9.5 months, respectively. Concurrent chemotherapy was an independent prognostic factor for improved PFS and OS. Grade 3 neurologic toxicity was seen in 2 patients (3.2%). There was no grade 4/5 toxicity. CONCLUSIONS: This is the only analysis of elderly/frail patients with GBM prospectively treated with a hypofractionated radiation regimen that is isoeffective to the Stupp regimen. Treatment was well tolerated and demonstrated excellent OS and PFS compared with historical studies. This regimen gives the elderly/frail population an alternative to regimens with a lower BED. Randomized trials are needed to validate these results. Cancer published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brown, Richard T.; Dauda, Bukar E. N.; Kandasamy, Mythily; Santos, Cid A. M. published the artcile< Lonitoside: a novel monoterpenoid macrolide diglycoside from Lonicea nitida>, Electric Literature of 112-63-0, the main research area is lonitoside Lonicea mol structure.

Lonitoside has been isolated from L. nitida E. H. Wilson (Caprifoliaceae), and its structure elucidated as (E)-(6S)-8-[β-L-arabinopyranosyl-(1”→6′)-β-D-glucopyranosyloxy]-2,6-dimethyloct-2-eno-1,4”-lactone (I) by spectroscopic and degradation methods.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Lonicera nitida. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yang; Zhang, Zetian; Fan, Weiwei; Yang, Kaifeng; Li, Zhengjun published the artcile< Preparation of renewable gallic acid-based self-healing waterborne polyurethane with dynamic phenol-carbamate network: toward superior mechanical properties and shape memory function>, Computed Properties of 112-63-0, the main research area is isophorone diisocyanate gallic acid trimethylolpropane polyurethane mech property morphol.

Endowing thermoset self-healing polymers with excellent mech. properties and shape memory function by utilizing bio-based monomers is highly desirable for the development of the next-generation smart materials. To achieve this goal, herein, we developed a novel thermally induced self-healing system with robust mech. properties and shape memory function by incorporating dynamic phenol-carbamate bond formed by the polymerization reaction of the renewable gallic acid (GA) and isocyanate into waterborne polyurethane (GA-WPU) with excellent emulsion stability. Significantly, a good balance can be achieved between desirable self-healing ability (healing efficiency 81.1%) and robust mech. properties (tensile strength 45.1 MPa and elongation at break 576.5%) by adjusting dynamic phenol-carbamate bonds incorporated into the polymer networks, and compared with the reported self-healing polymers, the recovered tensile strength of our target polymer shows an overwhelming superiority. Furthermore, taking the advantage of the crystalline PBA (switching segment) and phenol-carbamate crosslinkages, the prepared GA-WPU polymer can rapidly recover from temporary shape to original shape by thermal energy (less than 30 s, and the shape fixity and recovery ratio remain above 91.5%). We envision that this elaborate strategy is instructive for designing mech. robust polymeric materials with self-healing, shape memory function and environmentally friendly characteristics.

Journal of Materials Science published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics