Month: October 2022

Nogales-Delgado, Sergio; Encinar, Jose Maria; Gonzalez Cortes, Alvaro published the artcile< High oleic safflower oil as a feedstock for stable biodiesel and biolubricant production>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biodiesel biolubricant oleic acid safflower oil feedstock.

Biodiesel and other derivative compounds which could act as biolubricants, can be a suitable alternative for petroleum products, which are less sustainable and harmful to the environment. However, especially when vegetable oils are used as raw materials (for instance Carthamus Tinctorius), these products can show poor oxidative stabilities, depending on their fatty acid composition Apart from adding antioxidants as additives, a good alternative might be the use of genetically modified seeds to facilitate high ratios of stable fatty acids like oleic acid. The aim of this work was to produce biodiesel and biolubricant from high oleic safflower through transesterification with methanol and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, resp. The efficiency of these processes and the quality characterization of biodiesel and biolubricant were assessed. As a result, the biodiesel obtained (HOSBD) complied with the standard, with a high oxidative stability value (8.2 h) and not requiring any antioxidant addition The biolubricant obtained (HOSBL) showed higher oxidative stability (6.72 h) compared to their equivalent produced from rapeseed (Brassica Napus) or cardoon (Cynara Cardunculus L.). Consequently, two stable bioproducts were obtained and the role of fatty acid composition of raw material was vital (oleic/linoleic ratio had a strong influence on oxidative stability). In that sense, the use of stable raw materials like high oleic safflower might avoid antioxidant addition in biodiesel or biolubricants, which implies a cleaner and more sustainable production

Industrial Crops and Products published new progress about Artichoke. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Tingting; Ju, Zhaoyang; Zhang, Yuxuan; Han, Lujia; Xiao, Weihua published the artcile< Specific role of aluminum site on the activation of carbonyl groups of methyl levulinate over Al(OiPr)3 for γ-valerolactone production>, Related Products of 112-63-0, the main research area is valerolactone methyl levulinate production aluminum isopropoxide activation.

The high-efficiency synthesis of biofuel γ-valerolactone (GVL) from biomass-derived levulinates is a challenging task. The Meerwein-Ponndorf-Verley (MPV) reduction with its extraordinary chemoselectivity is advantageous for the hydrogenation process, compared to the mol.-hydrogen-based process using noble metal catalysts. Therefore, we used a classical Al-based isopropoxide to catalyze transfer hydrogenation (CHT) of Me levulinate (ML) to GVL. A high yield of GVL up to 97.6% could be achieved using 2-proponal as the H-donor and solvent under mild conditions (150°C, 30 min). Besides, three reaction stages were observed in the conversion, including transesterification, hydrogenation and cyclization. LC/MS anal. and the d. functional theory (DFT) caculations revealed that Al atom of Al(OiPr)3 as the electron transfer center activated ester carbonyl of the substrate via fourmembered transition states before activating the ketone carbonyl, resulting in the occurrence of transesterification prior to the hydrogenation. In addition, 2-propanol as proton transfer carrier assisting the cyclization process was proved to be the lowest-energy pathway. Our work shed light on the role of Al(OiPr)3 in the MPV reduction of ML, providing a comprehensive understanding on the metal alkoxide catalysis mechanism for GVL production

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Hydrogenation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Hao; Xia, Huiyun; Chen, Huaxin; Mi, Haichen published the artcile< Influence of moisture-curing reaction on the mechanical properties of one-component polyurethane mixtures>, Electric Literature of 112-63-0, the main research area is polyurethane curing reaction mech property.

One-component, moisture-curing polyurethane mixture is a potential cold repair material for pavement because of its simple application method and excellent road performance. However, a large amount of CO2 is produced in the moisture-curing reaction of polyurethane, which destroys the mixture’s interlocked-denseness structure and reduces its mech. properties. In this paper, a one-component polyurethane mixture with AC-13 gradation was prepared, and the mixture used the one-component polyurethane synthesized with diphenylmethane diisocyanate and polyether polyol as the binder. The Marshall stability of the mixture was tested according to polyurethane content, temperature, air humidity, and number of compactions. Results showed that polyurethane content, moisture-curing rate of the polyurethane mixture, and mixture air-void content are key factors affecting the Marshall stability of a polyurethane mixture When the polyurethane content was 5.5%, the polyurethane mixture had the highest mech. strength. As the content of polyurethane increased, more CO2 accumulated in the mixture and the mixture strength decreased. When the polyurethane content was increased by 1.5%, the Marshall stability of the mixture was reduced by 41.8%. The increase of temperature and air humidity accelerated the moisture-curing rate of polyurethane, accelerating the production of CO2, and reducing the Marshall stability of the mixture When the temperature rose from 0 to 60°C and the air relative humidity increased from 30 to 90%, the expansion rate of the mixture increased by 247.55% and 40.08%, resp., while the Marshall stability decreased by 17.8% and 11.16%, resp. At appropriate polyurethane content and curing conditions, a higher number of compactions enhanced the interlocked-denseness structure of the mixture, which improved the Marshall stability. As the number of compactions increased from 40 to 70, the air-void content of the polyurethane mixture was reduced by 44.99%, and the Marshall stability was increased by 157.36%. This paper serves as a reference study for the application of one-component, moisture-curing polyurethane mixtures

Journal of Materials Science published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aziz, Nur Atiqah Mohamad; Yunus, Robiah; Hamid, Hamidah Abd; Ghassan, Alsultan Abdul Kareem; Omar, Rozita; Rashid, Umer; Abbas, Zulkifly published the artcile< An acceleration of microwave-assisted transesterification of palm oil-based methyl ester into trimethylolpropane ester>, Application of C19H34O2, the main research area is palm oil fatty acid trimethylolpropane ester preparation transesterification.

Microwave-assisted synthesis is known to accelerate the transesterification process and address the issues associated with the conventional thermal process, such as the processing time and the energy input requirement. Herein, the effect of microwave irradiation on the transesterification of palm oil Me ester (PME) with trimethylolpropane (TMP) was evaluated. The reaction system was investigated through five process parameters, which were reaction temperature, catalyst, time, molar ratio of TMP to PME and vacuum pressure. The yield of TMP triester at 66.9 weight% and undesirable fatty soap at 17.4% were obtained at 130°C, 10 mbar, sodium methoxide solution at 0.6 weight%, 10 min reaction time and molar ratio of TMP to PME at 1:4. The transesterification of palm oil-based Me ester to trimethylolpropane ester was 3.1 folds faster in the presence of microwave irradiation The total energy requirement was markedly reduced as compared to the conventional heating method. The findings indicate that microwave-assisted transesterification could probably be an answer to the quest for a cheaper biodegradable biolubricant.

Scientific Reports published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luginina, Jevgenija; Vasiljevs, Deniss; Ivanovs, Ilgvalds; Mishnev, Anatoly; Turks, Maris published the artcile< Diastereoselective aza-Michael addition for synthesis of carbohydrate-derived spiropiperazinones>, Quality Control of 2743-40-0, the main research area is glycoside spiropiperazinone diastereoselective synthesis aza Michael addition; aza Michael addition nitromethylene glucofuranoside amino acid ester.

3-Deoxy-3-C-nitromethylene-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose reacts with amino acid esters according to the aza-Michael addition pathway. The obtained adducts after reduction of the nitro group spontaneously lactamize and provide novel carbohydrate-derived spiropiperazinones.

Monatshefte fuer Chemie published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 2743-40-0 belongs to class esters-buliding-blocks, and the molecular formula is C8H18ClNO2, Quality Control of 2743-40-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pilmark, Nanna S.; Oberholzer, Laura; Halling, Jens F.; Kristensen, Jonas M.; Boending, Christina P.; Elkjaer, Ida; Lyngbaek, Mark; Elster, Grit; Siebenmann, Christoph; Holm, Niels F. R.; Birk, Jesper B.; Larsen, Emil L.; Lundby, Anne-Kristine M.; Wojtaszewski, Joergen; Pilegaard, Henriette; Poulsen, Henrik E.; Pedersen, Bente K.; Hansen, Katrine B.; Karstoft, Kristian published the artcile< Skeletal muscle adaptations to exercise are not influenced by metformin treatment in humans: secondary analyses of 2 randomized, clinical trials>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human skeletal muscle metformin clin trials; AMPK; Complex-1; Complexe-1; ROS; entraînement; exercice; exercise; healthy lean males; hommes maigres en bonne santé; impaired glucose tolerance; interaction; metformin; metformine; muscle squelettique; prediabetes; prédiabète; skeletal muscle; tolérance au glucose altérée; training.

Metformin and exercise both improve glycemic control, but in vitro studies have indicated that an interaction between metformin and exercise occurs in skeletal muscle, suggesting a blunting effect of metformin on exercise training adaptations. Two studies (a double-blind, parallel-group, randomized clin. trial conducted in 29 glucose-intolerant individuals and a double-blind, cross-over trial conducted in 15 healthy lean males) were included in this paper. In both studies, the effect of acute exercise ± metformin treatment on different skeletal muscle variables, previously suggested to be involved in a pharmaco-physiol. interaction between metformin and exercise, was assessed. Furthermore, in the parallel-group trial, the effect of 12 wk of exercise training was assessed. Skeletal muscle biopsies were obtained before and after acute exercise and 12 wk of exercise training, and mitochondrial respiration, oxidative stress and AMPK activation was determined Metformin did not significantly affect the effects of acute exercise or exercise training on mitochondrial respiration, oxidative stress or AMPK activation, indicating that the response to acute exercise and exercise training adaptations in skeletal muscle is not affected by metformin treatment. Further studies are needed to investigate whether an interaction between metformin and exercise is present in other tissues, e.g., the gut. Trial registration: ClinicalTrials.gov (NCT03316690 and NCT02951260). Novelty:Metformin does not affect exercise-induced alterations in mitochondrial respiratory capacity in human skeletal muscle. Metformin does not affect exercise-induced alterations in systemic levels of oxidative stress nor emission of reactive oxygen species from human skeletal muscle. Metformin does not affect exercise-induced AMPK activation in human skeletal muscle.

Applied Physiology, Nutrition, and Metabolism published new progress about Biopsy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Qi-Fan; Zhao, Bin; Fan, Zhi-Jin; Zhao, Jia-Bao; Guo, Xiao-Feng; Yang, Dong-Yan; Zhang, Nai-Lou; Yu, Bin; Kalinina, Tatiana; Glukhareva, Tatiana published the artcile< Design, synthesis and fungicidal activity of isothiazole-thiazole derivatives>, Formula: C19H34O2, the main research area is Psilocybe Phytophthora isothiazole thiazole derivative fungicidal.

3,4-Dichloroisothiazoles can induce systemic acquired resistance (SAR) to enhance plant resistance against a subsequent pathogen attack, and oxathiapiprolin exhibits excellent anti-fungal activity against oomycetes targeting at the oxysterol-binding protein. To discover novel chems. with systemic acquired resistance and fungicidal activity, 21 novel isothiazole-thiazole derivatives were designed, synthesized and characterized according to the active compound derivatization method. Compound 6u, with EC50 values of 0.046 mg L-1 and 0.20 mg L-1 against Pseudoperonospora cubensis (Berk. et Curt.) Rostov and Phytophthora infestans in vivo, might act at the same target as oxysterol binding protein (PcORP1) of oxathiapiprolin; this result was validated by cross-resistance and mol. docking studies. The expression of the systemic acquired resistance gene pr1 was significantly up-regulated after treating with compound 6u for 24 h (43-fold) and 48 h (122-fold). These results can help the development of isothiazole-thiazole-based novel fungicides.

RSC Advances published new progress about Agrochemical fungicides. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Lanlan; Yang, Chaoran; Chen, Yawei; Pu, Zhichen; Zhang, Zhenzhen; Jie, Yulin; Zheng, Xiang; Xiao, Yunlong; Jiao, Shuhong; Li, Qi; Xu, Dongsheng published the artcile< Hybrid MgCl2/AlCl3/Mg(TFSI)2 Electrolytes in DME Enabling High-Rate Rechargeable Mg Batteries>, COA of Formula: C19H34O2, the main research area is magnesium battery cathode electrolyte aluminum chloride magnesium TFSI; DME electrolyte; conductivity; rechargeable magnesium batteries; volumetric energy.

Rechargeable magnesium batteries (RMBs) are considered as one of the most promising next-generation secondary batteries due to their low cost, safety, dendrite-free nature, as well as high volumetric energy d. However, the lack of suitable cathode material and electrolyte is the greatest challenge facing practical RMBs. Herein, a hybrid electrolyte MgCl2/AlCl3/Mg(TFSI)2 (MACT) in di-Me ether (DME) is developed and exhibits excellent electrochem. performance. The high ionic conductivity (6.82 mS cm-1) and unique solvation structure of [Mg2(μ-Cl)2(DME)4]2+ promote the fast Mg kinetics and favorable thermodn. in hybrid Mg salts and DME electrolyte, accelerating mass transport and the charge transfer process. Therefore, the great rate capability can be realized both in sym. Mg/Mg cell and in CuS/Mg full cell.

ACS Applied Materials & Interfaces published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamada, S.; Nakayama, K.; Takayama, H. published the artcile< Stereoselective synthesis of (23R,25S)- and (23S,25R)-25-hydroxyvitamin D3 26,23-lactone: determination of the configuration of a metabolite of vitamin D3, calcidiol lactone>, Formula: C6H10O5, the main research area is calcidol lactone stereoselective synthesis; hydroxyvitamin D3 lactone preparation configuration; vitamin D3 hydroxy lactone.

The title diastereoisomeric vitamin D3 lactones I were prepared via the condensation of aldehyde II and dioxolanylethyl sulfone III. (23S,25R)-I was identical with the natural metabolite calcidol lactone.

Proceedings of the Workshop on Vitamin D published new progress about 9,10-Secosteroids Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Huai-Wei; Deng, Cheng-Long; Li, Dan-Dan; Liu, Dan-Dan; Chai, Shao-Meng; Wang, Wei; Zhang, Yan; Chen, Kai; Li, Xin; Wang, Jian; Song, Shao-Jiang; Song, Hong-Rui published the artcile< Design, synthesis and biological evaluation of novel 4-aminoquinazolines as dual target inhibitors of EGFR-PI3Kα>, SDS of cas: 112-63-0, the main research area is amino quinazoline preparation dual EGFR PI3K inhibitor cancer; 4-aminoquinazolines; Anticancer agents; Antiproliferative effects; Dual target; EGFR; PI3K.

The overexpression of EGFR correlates with rapidly progressive disease, resistance to chemotherapy and poor prognosis. In certain human cancers, PI3K works synergistically with EGFR to promote proliferation, survival, invasion and metastasis. Development of dual-target drugs against EGFR and PI3K has therapeutic advantage and was an attractive approach against tumors. In this work, based on the mol. docking and previous studies, a series of 4-aminoquinazolines derivatives containing 6-sulfonamide substituted pyridyl group were rationally designed and identified as potent EGFR and PI3K dual inhibitors. The cytotoxicity experiment results showed that this series of compounds could effectively inhibit cell growth. The kinase assay demonstrated that 6c and 6i had high inhibition for EGFR and selectivity for PI3Kα distinguished from other isoforms. Further experiments showed that 6c could induce cell cycle arrest in G1 phase and apoptosis in BT549 cells. The western blot assay indicated that 6c inhibited the proliferation of BT549 cell through EGFR and PI3Kα/Akt signaling pathway. Our study suggested that compound 6c was a potential dual inhibitors of EGFR and PI3Kα.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics