Month: October 2022

Thakur, Subhash; Kumar, Narendra; Salunke, Pravin; Ahuja, Chirag; Madan, Renu published the artcile< A randomized study of short course (one week) radiation therapy with or without temozolomide in elderly and/or frail patients with newly diagnosed glioblastoma (GBM)>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Glioblastoma; Short Course Radiotherapy; Temozolomide.

Objective: Short-course radiotherapy (25 Gy in 5 fractions) has been shown to be non-inferior to standard course radiotherapy in elderly and frail patients (60 Gy in 30 fractions). The purpose of this study was to determine the effects of temozolomide combined with short-course radiotherapy on the outcome of elderly and frail patients. Methods: Between Jan. 2017 and Nov. 2018, 90 patients (65 years old and KPS score of 50-70; 65 years old and KPS score of 80-100; and 65 years old and KPS score of 50-70) were assessed for eligibility. Nine patients were excluded because they did not meet the inclusion criteria, six patients declined to participate, and four patients were unable to complete the quality-of-life questionnaire. The remaining 71 patients were divided into two arms at random in a 1:1 ratio. Short-course radiotherapy with concurrent temozolomide and adjuvant temozolomide was given to Arm 1, while short-course radiotherapy alone was given to Arm 2. Results: In terms of overall survival and progression-free survival, radiotherapy with concurrent temozolomide and adjuvant temozolomide outperformed short-course radiotherapy alone. The median overall survival in arm 1 was 146 days and 121 days in arm 2 (P=0.146). The median progression-free survival in arm 1 was 109.50 days, while it was 77 days in arm 2 (P=0.028). With a median follow-up time of 6 mo, the quality of life at 4 wk and 12 wk after treatment was not different between the two arms. Conclusion: We concluded that adding temozolomide to short-course radiotherapy significantly improved progression-free survival and showed an increasing trend in overall survival without compromising the quality of life.

Asian Pacific Journal of Cancer Prevention published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yefeng; Liu, Peng; Majonis, Daniel; Winnik, Mitchell A. published the artcile< Polymeric dipicolylamine based mass tags for mass cytometry>, Computed Properties of 71195-85-2, the main research area is polymeric dipicolylamine mass tag cytometry.

Mass cytometry is an emerging powerful bioanal. technique for high-dimensional single-cell anal. In this technique, cells are stained with metal-isotope-tagged antibodies and are analyzed by an inductively coupled plasma time-of-flight mass spectrometer. While there are more than 100 stable isotopes available in the m/z 75 to 209 detection range of the instrument, only about 50 parameters can be measured per cell because current reagents are metal-chelating polymers with pendant aminocarboxylate chelators that only bind hard metal ions such as the rare earths and Bi3+. Here we describe the synthesis and characterization of a new type of metal-chelating polymer with pendant dipicolylamine chelators suited to binding intermediate to soft metals such as rhenium and platinum. We introduce two different conjugation strategies, a thiol-maleimide reaction that works well for rhenium, and a DBCO-azide click reaction designed to avoid potential complications of Pt and other heavy metals interacting with thiol groups. We show that these polymers can serve as new elemental mass tags for mass cytometry. Antibody-polymer conjugates of CD20 and CD8a prepared by both coupling reactions were employed in conjunction with com. metal-conjugated antibodies for multi-parameter single-cell immunoassays.

Chemical Science published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Computed Properties of 71195-85-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, MouPing; Chen, YuanMao; Ke, Xi; Huang, ZeXi; Chen, YouChen; Wu, WenLi; Qu, XiaoFeng; Shi, ZhiCong; Guo, ZaiPing published the artcile< In situ growth of NiS2 nanosheet array on Ni foil as cathode to improve the performance of lithium/sodium-sulfur batteries>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nickel disulfide nanosheet foil growth lithium sodium sulfur battery.

The NiS2 nanosheet array on Ni foil (NiS2/NF) was prepared using an in situ growth strategy and sulfidation method and was used as the cathode of lithium sulfur battery. The unique nanostructure of the NiS2nanosheet array can provide abundant active sites for the adsorption and chem. action of polysulfides. Compared with the sulfur powder coated pure NF (pure NF-S) for lithium sulfur battery, the sulfur powder coated NiS2/NF (NiS2/NF-S) electrode exhibits superior electrochem. performance. Specifically, the NiS2/NF-S delivered a high reversible capacity of 1007.5 mAh g-1 at a c.d. of 0.1 C (1 C= 1675 mA g-1) and kept 74.5% of the initial capacity at 1.0 C after 200 cycles, indicating the great promise of NiS2/NF-S as the cathode of lithium sulfur battery. In addition, the NiS2/NF-S electrode also showed satisfactory electrochem. performance when used as the cathode for sodium sulfur battery.

Science China: Technological Sciences published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Blauenstein, Peter; Remy, Nathalie; Buck, Alfred; Ametamey, Simon; Haberli, Marc; Schubiger, P. August published the artcile< In vivo properties of N-(2-aminoethyl)-5-halogeno-2-pyridinecarboxamide 18F- and 123I-labeled reversible inhibitors of monoamine oxidase B>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iodo 123 pyridinecarboxylate brain imaging; fluoro 18 pyridinecarboxylate brain imaging; brain PET single photon emission tomog; MAO inhibitor brain imaging.

The reversible and highly selective monoamine oxidase B (MAO-B) inhibitor Ro 19-6327, a picolinic acid derivative, was selected for the development of new radiopharmaceuticals, whereby in place of Cl either 123I or 18F was introduced. The resp. labeling procedures have been described earlier. In this study, some metabolic properties were investigated. Blood and urine samples were analyzed, and halogenated picolinylglycine, a more hydrophilic compound, was identified as the main metabolite. This shows that the amine is oxidized to the resp. carboxylate, but the intermediate imine or aldehyde that was proposed earlier could not be detected. First experiments with single photon emission tomog. and positron emission tomog. (PET) showed that the iodo compound can be used to investigate MAO-B in vivo while the fluoro compound is accumulated in the brain to such a low degree that no PET studies can be performed. We conclude that the main reason for the poor uptake of the fluoro compound is its lower lipophilicity as compared to the iodo compound and, to a lesser degree, its metabolism, which is similar for both compounds

Nuclear Medicine and Biology published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ming-Shuang; Quan, Mao; Yang, Xi-Ran; Jiang, Wei published the artcile< Cucurbit[n]urils (n = 7, 8) can strongly bind neutral hydrophilic molecules in water>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cucurbituril crown ether dioxane inclusion reaction kinetics hydrogen bond.

It is challenging to recognize neutral hydrophilic mols. in water. Effective use of hydrogen bonds in water is generally accepted to be the key to success. In contrast, hydrophobic cavity is usually considered to play an insignificant role or only to provide a nonpolar microenvironment for hydrogen bonds. Herein, we report that hydrophobic cavity alone can also strongly bind neutral, highly hydrophilic mols. in water. We found that cucurbit[n]urils (n = 7, 8) bind 1,4-dioxane, crown ethers and monosaccharides in water with remarkable affinities. The best binding constant reaches 107 M-1 for cucurbit[8]uril, which is higher than its binding affinities to common organic cations. D. functional theory (DFT) calculations and control experiments reveal that the hydrophobic effect is the major contributor to the binding through releasing the cavity water and/or properly occupying the weakly hydrated cavity. However, hydrophobic cavity still prefers nonpolar guests over polar guests with similar size and shape.

Science China: Chemistry published new progress about Enthalpy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Shuai; Deng, Youmei; Xu, Feng published the artcile< An inorganic-organic hybrid MnIII{MnII6}2 cluster consisting of rare Lindqvist-like Mn6 subunits with high proton conductivity>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tris hydroxymethylpropane organic hybrid manganese cluster Lindqvist preparation structure; proton conductivity tris hydroxymethylpropane organic hybrid manganese cluster Lindqvist.

A new inorganic-organic hybrid MnIII{MnII6}2 with rare Lindqvist-like Mn6 subunits was synthesized. Authors studies reveal the distinct advantages of the MnIII{MnII6}2 compound as a potential material of proton exchange membranes, including its facile and cost-effective synthesis, insolubility in water, and most importantly, its maximum proton conductivity of 4.69 x 10-3 S cm-1 at 368 K and 97% RH.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chatterjee, Abhishek; Bhadane, Manish; Manjali, Jifmi Jose; Dasgupta, Archya; Epari, Sridhar; Sahay, Ayushi; Patil, Vijay; Moiyadi, Aliasgar; Shetty, Prakash; Gupta, Tejpal published the artcile< Optimizing Postoperative Adjuvant Therapy in Elderly Patients with Newly Diagnosed Glioblastoma: Single-Institution Audit of Clinical Outcomes from a Tertiary-Care Comprehensive Cancer Center in India.>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Elderly; Fractionation; Glioblastoma; Radiotherapy; Survival; Temozolomide.

BACKGROUND: There is lack of consensus regarding optimal adjuvant therapy in elderly glioblastoma (GBM). We have been treating elderly (≥60 years) GBM patients with normofractionated or hypofractionated radiotherapy (RT) plus temozolomide (TMZ) based on Karnofsky performance status (KPS). Herein we report clinical outcomes in this cohort treated at our institute using this approach. METHODS: Medical records of elderly GBM patients (≥60 years) treated between 2013 and 2017 with either normofractionated RT (59.4-60 Gy/30-33 fractions/6-6.5 weeks) or hypofractionated RT (35 Gy/10 fractions/2 weeks) plus TMZ were reviewed retrospectively. Outcomes of interest included progression-free survival (PFS), overall survival (OS), and ≥grade 3 myelotoxicity. Time-to-event outcomes were analyzed with Kaplan-Meier methods, compared using log-rank test, and reported as point estimates with 95% confidence interval (CI). RESULTS: The normofractionated cohort (n = 126) was characterized by a higher proportion of patients younger than age 65 years, KPS ≥70, methylated O6-methylguanine DNA methyltransferase (MGMT), and receiving adjuvant TMZ including extended adjuvant TMZ (>6 cycles) compared with the hypofractionated cohort (n = 20), confirming selection bias. At a median follow-up of 13 months, 1-year Kaplan-Meier estimates of PFS and OS were 43% (95% CI: 36%-52%) and 56% (95% CI: 48%-64%), yielding median PFS and OS of 11.0 months and 13.1 months, respectively. Higher KPS, methylated MGMT, normofractionated RT, and extended adjuvant TMZ emerged as favorable prognostic factors. TMZ was well tolerated with a low risk of ≥grade 3 myelotoxicity. CONCLUSIONS: Our single-institution clinical audit confirms poor survival in elderly GBM with suboptimal performance status but demonstrates acceptably fair outcomes in patients with preserved KPS comparable with the nonelderly cohort.

World neurosurgery published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Katayama, Seiji; Ae, Nobuyuki; Kodo, Toru; Masumoto, Shuji; Hourai, Shinji; Tamamura, Chika; Tanaka, Hiroyasu; Nagata, Ryu published the artcile< Tricyclic Indole-2-carboxylic Acids: Highly in Vivo Active and Selective Antagonists for the Glycine Binding Site of the NMDA Receptor>, Product Details of C9H9NO4, the main research area is benzindoleacetanilide preparation NMDA receptor antagonist.

A series of tricyclic indole-2-carboxylic acid derivatives were synthesized and evaluated by the radioligand binding assay and the anticonvulsant effects in the mouse NMDA-induced seizure model. Among them, I [R = OCH2CO2H, CH2CO2H, (R)-OCHMeCO2H] showed high affinity to the NMDA-glycine binding site. The absolute configuration of the parent acid was confirmed by X-ray crystallog. anal. In particular, I [R = (R)-CHMeCO2H] was found to be a highly active glycine antagonist for both in vitro and in vivo assays (Ki = 1.0 ± 0.1 nM, ED50 = 2.3 mg/kg, i.v.) and also showed high selectivity for the glycine site. In addition, I [R = (R)-CHMeCO2H] was soluble enough in aqueous media (>10 mg/mL at pH 7.4) to use for medications by i.v. injection.

Journal of Medicinal Chemistry published new progress about NMDA receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nakata, Keisuke; Hatakeyama, Yuto; Erra-Balsells, Rosa; Nonami, Hiroshi; Wada, Hiroshi published the artcile< Dynamics and stabilization mechanism of mitochondrial cristae morphofunction associated with turgor-driven cardiolipin biosynthesis under salt stress conditions>, Formula: C19H34O2, the main research area is mitochondrial cristae morphofunction turgor cardiolipin biosynthesis salt stress.

Maintaining energy production efficiency is of vital importance to plants growing under changing environments. Cardiolipin localized in the inner mitochondrial membrane plays various important roles in mitochondrial function and its activity, although the regulation of mitochondrial morphol. to various stress conditions remains obscure, particularly in the context of changes in cellular water relations and metabolisms By combining single-cell metabolomics with transmission electron microscopy, we have investigated the adaptation mechanism in tomato trichome stalk cells at moderate salt stress to determine the kinetics of cellular parameters and metabolisms We have found that turgor loss occurred just after the stress conditions, followed by the contrasting volumetric changes in mitochondria and cells, the accumulation of TCA cycle-related metabolites at osmotic adjustment, and a temporal increase in cardiolipin concentration, resulting in a reversible topol. modification in the tubulo-vesicular cristae. Because all of these cellular events were dynamically observed in the same single-cells without causing any disturbance for redox states and cytoplasmic streaming, we conclude that turgor pressure might play a regulatory role in the mitochondrial morphol. switch throughout the temporal activation of cardiolipin biosynthesis, which sustains mitochondrial respiration and energy conversion even under the salt stress conditions.

Scientific Reports published new progress about Cardiolipins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hintermann, Lukas; Schmitz, Marco; Maltsev, Oleg V.; Naumov, Pance published the artcile< Organocatalytic stereoisomerization versus alkene isomerization: catalytic asymmetric synthesis of 1-hydroxy-trans-2,5-diphenylphospholane 1-oxide>, HPLC of Formula: 112-63-0, the main research area is organocatalysis stereoisomerization; catalytic asym synthesis hydroxydiphenyl phospholane oxide; McCormack cycloaddition diarylbutadiene dialkylamino dichlorophosphine; crystal mol structure hydroxydiphenyl phospholane oxide derivative.

The potential for an organocatalytic asym. stereoisomerization or alkene isomerization as atom-economic reaction with minimal structural change was investigated. The McCormack cycloaddition of 1,4-diarylbuta-1,3-dienes with (dialkylamino)dichlorophosphine and aluminum trichloride gives meso-2,5-diaryl-1-(dialkylamino)-1-oxo-2,5-dihydro-1H-phospholes, which were identified as suitable substrates for asym. isomerization to (1R,5R)-2,5-diaryl-1-(dialkylamino)-1-oxo-4,5-dihydro-1H-phospholes in the presence of bifunctional organocatalysts (cinchona alkaloids, Takemoto catalyst) in up to 91% ee and quant. yield. The substrate range and the mechanism of the catalysis were studied. The reaction involves proton abstraction by the base, but a primary deuterium KIE is absent. Enriched (1R,5R)-1-(diethylamino)-1-oxo-2,5-diphenyl-4,5-dihydro-1H-phosphole was hydrolyzed to (5R)-1-hydroxy-1-oxo-2,5-diphenyl-4,5-dihydro-1H-phosphole, which was hydrogenated diastereoselectively under dissolving metal conditions to give (2R,5R)-1-hydroxy-1-oxo-2,5-diphenylphospholane (Fiaud’s acid) in preference to meso-1-hydroxy-1-oxo-2,5-diphenylphospholane. An asym. catalytic total synthesis of Fiaud’s acid, which is a building block for chiral phospholane synthesis, has been realized in five steps from thiophene, using nickel-catalyzed Wenkert arylation, McCormack cycloaddition, asym. dihydro-1H-phosphole isomerization, hydrolysis, and diastereoselective hydrogenation.

Synthesis published new progress about Bifunctional catalysts, organocatalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics