Weinstein, David S.; Liu, Wen; Gu, Zhengxiang; Langevine, Charles; Ngu, Khehyong; Fadnis, Leena; Combs, Donald W.; Sitkoff, Doree; Ahmad, Saleem; Zhuang, Shaobin; Chen, Xing; Wang, Feng-Lai; Loughney, Deborah A.; Atwal, Karnail S.; Zahler, Robert; Macor, John E.; Madsen, Cort S.; Murugesan, Natesan published the artcile< Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase>, Application In Synthesis of 112-63-0, the main research area is tryptamine homotryptamine sulfonamide preparation structure lipoxygenase 15 inhibitor.
A series of inhibitors of mammalian 15-lipoxygenase based on tryptamine and homotryptamine scaffolds is described. Compounds with aryl substituents at C-2 of the indole core of tryptamine and homotryptamine sulfonamides proved to be potent inhibitors of the isolated enzyme. Selected compounds also demonstrated desirable inhibition selectivities over isoenzymes 5- and P-12-LO.
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics