Suzuki, Takayoshi; Nagae, Osamu; Kato, Yuka; Nakagawa, Hidehiko; Fukuhara, Kiyoshi; Miyata, Naoki published the artcile< Photoinduced Nitric Oxide Release from Nitrobenzene Derivatives>, Formula: C19H34O2, the main research area is nitrobenzene derivative preparation photoinduced NO donor antitumor cancer.
A new type of photoinduced nitric oxide (NO) donors was designed from nitrobenzene derivatives Visible-light irradiation of 2,6-dimethylnitrobenzenes bearing extended π-electron systems at the 4-position revealed efficient NO release using ESR anal. and the Griess assay. Computational study and UV spectrum anal. suggested that the NO-releasing activity was closely related to the conformation of the nitro group, the absorption intensity, and the length of the conjugated π-electron system. Employing the photodependent cytotoxicity of compound 14 against HCT116 human colon cancer cells, it was demonstrated that 4-substituted-2,6-dimethylnitrobenzene analogs are useful NO donors for the time- and site-controlled NO treatment.
Journal of the American Chemical Society published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics