Pauton, Mathilde; Aubert, Catherine; Bluet, Guillaume; Gruss-Leleu, Florence; Roy, Sebastien; Perrio, Cecile published the artcile< Development, Optimization, and Scope of the Radiosynthesis of 3/5-[18F]Fluoropyridines from Readily Prepared Aryl(pyridinyl) Iodonium Salts: The Importance of TEMPO and K2CO3>, Category: esters-buliding-blocks, the main research area is fluoropyridine radiopreparationarylpyridinyl iodonium salt TEMPO potassium carbonate radiolabeling.
A robust process for the radiosynthesis of 3/5-[18F]fluoropyridines was developed by radiofluorination of iodonium triflates using K18F/K2CO3/K222 complex in the presence of TEMPO. Both electronically deficient and enriched iodonium salts were readily obtained from the corresponding 3/5-iodopyridines and afforded the corresponding 3/5-[18F]fluoropyridines in 6-78% yields. The concentrations of K2CO3 and TEMPO are crucial for the radiofluorination efficiency. The process was validated using two automated systems for the 18F-radiolabeling of 2-chloro and 2-carboxamido-5-fluoropyridines carried out in 10-20% yields.
Organic Process Research & Development published new progress about Iodonium compounds, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics