Murphy, Jaclyn M.; Liao, Xuebin; Hartwig, John F. published the artcile< Meta Halogenation of 1,3-Disubstituted Arenes via Iridium-Catalyzed Arene Borylation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nicotine regioselective halogenation; pyridine regioselective halogenation; chloro arene preparation; bromo arene preparation; borylation bromination chlorination arene regiochem; halogenation meta regioselective arene iridium borylation catalyst.
We report the meta halogenation of 1,3-disubstituted arenes to form 3,5-disubstituted aryl bromides and chlorides by using iridium-catalyzed arene borylation chem. Iridium-catalyzed borylation of arenes with B2pin2 [bis(pinacolato)diborane], followed by reaction of the boronic ester with copper(II) bromide or chloride converts the arylboronic esters to the corresponding aryl halides. A variety of arenes containing alkoxy, alkyl, halogen, nitrile, ester, amide, and pivaloyl and TIPS-protected alcs. were converted to the corresponding 3,5-disubstituted aryl bromides and chlorides in yields ranging from 46% to 85%. In addition, 2,6-disubstituted and 3-substituted pyridines were converted to the 4-halo and 5-halopyridines, resp. The utility of this methodol. was demonstrated by the formal conversion of nicotine to Altinicline in three steps with an overall yield of 61% using meta bromination of nicotine as the first step.
Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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