Lange, Heiko; Huenerbein, Robert; Wibbeling, Birgit; Froehlich, Roland; Grimme, Stefan; Hoppe, Dieter published the artcile< Comprehensive experimental and theoretical studies of configurationally labile epimeric diamine complexes of α-lithiated benzyl carbamates>, Category: esters-buliding-blocks, the main research area is carbamate stereoselective electrophilic substitution chiral oxazolidinone ligand.
Different primary benzyl-type carbamates were deprotonated by sec-butyllithium in the presence of a tert-leucinol-derived bis(oxazoline) ligand. The resulting configurationally labile epimeric complexes equilibrated and one diastereomer was strongly favored in the equilibrium After dynamic thermodn. resolution, the complexes could be trapped with different classes of electrophiles to yield highly enantioenriched secondary benzyl carbamates. The stereochem. course of the substitution reactions was elucidated. High-level quantum chem. investigations were performed and allowed a prediction of both the favored complex and the enantiomeric excess that could be expected within the reactions.
Synthesis published new progress about Carbamates Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics