Haefliger, Joel; Livingstone, Keith; Daniliuc, Constantin G.; Gilmour, Ryan published the artcile< Difluorination of α-(bromomethyl)styrenes via I(I)/I(II) catalysis: facile access to electrophilic linchpins for drug discovery>, Category: esters-buliding-blocks, the main research area is bromomethyl styrene catalysis electrophilic linchpin drug discovery difluorination.
Simple α-(bromomethyl)styrenes can be processed to a variety of 1,1-difluorinated electrophilic building blocks via I(I)/I(III) catalysis. This inexpensive main group catalysis strategy employs p-TolI as an effective organocatalyst when combined with Selectfluor and simple amine·HF complexes. Modulating Bronsted acidity enables simultaneous geminal and vicinal difluorination to occur, thereby providing a platform to generate multiply fluorinated scaffolds for further downstream derivatization. The method facilitates access to a tetrafluorinated API candidate for the treatment of amyotrophic lateral sclerosis. Preliminary validation of an enantioselective process is disclosed to access α-phenyl-β-difluoro-γ-bromo/chloro esters.
Chemical Science published new progress about Amyotrophic lateral sclerosis. 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics