Berger, Michael L.; Schoedl, Clemens; Noe, Christian R. published the artcile< Benzimidazole-type glycine antagonists: the role of the ring nitrogen atoms>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is benzimidazole preparation glycine antagonist.
Several derivatives of 1H-benzimidazole-2-carboxylic acid (BICA, I) were tested in vitro in comparison to 1H-indole-2-carboxylic acid (ICA, II) for their ability to displace [3H]glycine from rat hippocampal membranes. Compound I was 8 times more potent than II (Ki 5.3 μM, as compared to 42 μM). However, introduction of a carboxymethyl group or a corresponding ester at position 3 had no pos. effect on the potency of I, while this type of structural modification increased the potency of II significantly. Nevertheless, 1-carboxymethyl-BICA displaced [3H]glycine with similar potency as the corresponding 3-carboxymethyl-ICA, indicating that a nitrogen atom lacking a hydrogen atom can be engaged in glycine receptor interaction. N-Methylation strongly reduced the potencies of both BICA and ICA derivatives
Archiv der Pharmazie (Weinheim, Germany) published new progress about Glutamate receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics