Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 611-13-2, formula is C6H6O3, Name is Methyl furan-2-carboxylate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Name: Methyl furan-2-carboxylate.
Wang, Shuyuan;Xu, Yue;Zhao, Yan;Zhang, Shun;Li, Min;Li, Xiaowei;He, Jinzhao;Zhou, Hong;Ge, Zemei;Li, Runtao;Yang, Baoxue research published 《 N-(4-acetamidophenyl)-5-acetylfuran-2-carboxamide as a novel orally available diuretic that targets urea transporters with improved PD and PK properties》, the research content is summarized as follows. Urea transporters (UTs) have been identified as new targets for diuretics. Functional deletion of UTs led to urea-selective urinary concentrating defects with relative salt sparing. In our previous study, a UT inhibitor with a diarylamide scaffold, which is denoted as I, was demonstrated as the first orally available UT inhibitor. However, the oral bioavailability of I was only 4.38%, which obstructed its clin. application. In this work, by replacing the nitro group of I with an acetyl group, II was obtained. Compared with I, II showed a 10 times stronger inhibitory effect on UT-B (0.14μM vs. 1.41μM in rats, and 0.48μM vs. 5.82μM in mice) and a much higher inhibition rate on UT-A1. Moreover, the metabolic stability both in vitro and in vivo and the drug-like properties (permeability and solubility) of II were obviously improved compared with those of I. Moreover, the bioavailability of II was 15.18%, which was 3 times higher than that of I, thereby resulting in significant enhancement of the diuretic activities in rats and mice. II showed excellent potential for development as a promising clin. diuretic candidate for targeting UTs to treat diseases that require long-term usage of diuretics, such as hyponatremia.
611-13-2, Methyl 2-furoate has been identified as one of the volatile flavor compounds in tequila, okra, berrycactus and black currant juice.
Methyl 2-furoate, also known as fema 2703 or methyl pyromucate, belongs to the class of organic compounds known as furoic acid esters. These are ester derivatives of furoic acid. Methyl 2-furoate is soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Within the cell, methyl 2-furoate is primarily located in the cytoplasm. Methyl 2-furoate is a sweet, fruity, and fungal tasting compound that can be found in a number of food items such as cocoa and cocoa products, potato, tamarind, and fruits. This makes methyl 2-furoate a potential biomarker for the consumption of these food products.
Methyl 2-furoate is a reactive compound that belongs to the family of sesquiterpene lactones. It has been shown to have phosphotungstic acid and hydrochloric acid reactivity, as well as nitrous and water vapor sensitivity. Methyl 2-furoate also reacts with radiation, which can be used for structural analysis. The compound is an intermediate in the synthesis of pluronic p123, which is used in fabricating biomedical devices. Methyl 2-furoate has been shown to have anti-inflammatory properties through its inhibitory effect on prostaglandin synthesis., Name: Methyl furan-2-carboxylate
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Ester – an overview | ScienceDirect Topics