Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Application In Synthesis of 87-13-8.
Mao, Qing;Dai, Xiwen;Xu, Gaoyang;Su, Yu;Zhang, Bing;Liu, Dan;Wang, Shaojie research published 《 Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors》, the research content is summarized as follows. A series of 2-(4-alkoxy-3-cyano)phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivatives I [R = O, NH; R1 = i-Pr, allyl, Bn, etc.; R2 = H, Me] was synthesized as novel xanthine oxidase (XO) inhibitors. These compounds exhibited remarkable in vitro XO inhibitory potency with IC50 values ranging from 0.0181 μM to 0.5677 μM. Specifically, compounds I [R = NH; R1 = (CH2)2CH(CH3)2, 2-methylallyl], with IC50 values of 0.0240 μM and 0.0181 μM, resp., emerged as the most potent XO inhibitors and their potencies were comparable to that of febuxostat. Structure-activity relationship anal. revealed that the Me group at 4-position of pyrimidine ring could damage the potency and the XO inhibitory potency was maintained when carbonyl group was changed to an imino group. Lineweaver-Burk plot anal. revealed that the representative compound I [R = NH; R1 = (CH2)2CH(CH3)2] acted as a mixed-type inhibitor. A potassium oxonate induced hyperuricemia model in rats was chosen to further confirm the hypouricemic effect of compound I [R = NH; R1 = (CH2)2CH(CH3)2] and the results showed that compound I [R = NH; R1 = (CH2)2CH(CH3)2] (5 mg/kg) was able to significantly lower the serum uric acid level. Furthermore, in acute oral toxicity study, no sign of toxicity was observed when the mice were administered with a single 2000 mg/kg oral dose of compound I [R = NH; R1 = (CH2)2CH(CH3)2]. These results suggested that compound I [R = NH; R1 = (CH2)2CH(CH3)2] was a potent and promising uric acid-lowing agent for the treatment of hyperuricemia.
Application In Synthesis of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics